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Review Article
Nephrology (Genitourinary)
Acute kidney injury and continuous renal replacement therapy in children; what pediatricians need to know
Myung Hyun Cho, Hee Gyung Kang
Clin Exp Pediatr. 2018;61(11):339-347.   Published online October 23, 2018
Acute kidney injury (AKI) is characterized by abrupt deterioration of renal function, and its diagnosis relies on creatinine measurements and urine output. AKI is associated with higher morbidity and mortality, and is a risk factor for development of chronic kidney disease. There is no proven medication for AKI. Therefore, prevention and early detection are important. Physicians should be aware of...
Original Article
Nephrology (Genitourinary)
Changes in the thyroid hormone profiles in children with nephrotic syndrome
Sun Hee Jung, Jeong Eun Lee, Woo Yeong Chung
Clin Exp Pediatr. 2019;62(3):85-89.   Published online October 4, 2018

Purpose: We compared thyroid hormone profiles in children with nephrotic syndrome (NS) during the nephrotic phase and after remission. Methods: This study included 31 pediatric NS patients. The thyroid hormone profiles included serum levels of triiodothyronine (T3), thyroxine (T4), thyroid-stimulating hormone (TSH), and free T4. Results: Of the 31 patients, 16 (51.6%) showed abnormal thyroid hormone profiles: 6 had overt hypothyroidism, 8...
General Pediatrics
Current use of safety restraint systems and front seats in Korean children based on the 2008–2015 Korea National Health and Nutrition Examination Survey
Seom Gim Kong
Clin Exp Pediatr. 2018;61(12):381-386.   Published online September 19, 2018

Purpose: The use of proper safety restraint systems by children is vital for the reduction of traffic accident-related injury and death. This study evaluated the rates of use of safety restraint systems and front seats by Korean children. Methods: Based on data from the National Health and Nutrition Examination Survey from 2008 to 2015, I investigated the frequencies of safety restraint...
Neurology
Clinical manifestations of headache in children younger than 7 years
Bu Seon Kang, Jinsun Lee, Jin Hyuk Choi, Hyeok Hee Kwon, Joon Won Kang
Clin Exp Pediatr. 2018;61(11):355-361.   Published online September 16, 2018

Purpose: Headache is a common symptom during childhood. It is usually persistent and requires special care. This study aimed to identify the characteristics of headache in children <7 years of age. Methods: We reviewed 3 years of clinical files on children <7 years of age with a chief complaint of headache. Results: This study included 146 children (66 males, 80 females; mean...
Comparison of conservative therapy and steroid therapy for Bell’s palsy in children
Hye Won Yoo, Lira Yoon, Hye Young Kim, Min Jung Kwak, Kyung Hee Park, Mi Hye Bae, Yunjin Lee, Sang Ook Nam, Young Mi Kim
Clin Exp Pediatr. 2018;61(10):332-337.   Published online September 12, 2018

Purpose: Bell’s palsy is characterized by sudden onset of unilateral facial weakness. The use of corticosteroids for childhood Bell’s palsy is controversial. This study aimed to identify clinical characteristics, etiology, and laboratory findings in childhood Bell’s palsy, and to evaluate the efficacy of corticosteroid treatment. Methods: We conducted a retrospective analysis of children under 19 years of age treated for Bell’s...
Nephrology (Genitourinary)
Renal involvement in children and adolescents with inflammatory bowel disease
Hea Min Jang, Hee Sun Baek, Jung-Eun Kim, Ju Young Kim, Yeon Hee Lee, Hee Yeon Cho, Yon Ho Choe, Ben Kang, Byung-Ho Choe, Bong Seok Choi, Min Hyun Cho
Clin Exp Pediatr. 2018;61(10):327-331.   Published online September 12, 2018

Purpose: The incidence of inflammatory bowel disease (IBD) is rapidly increasing, and several reports have described the renal complications of IBD. We sought to evaluate the clinical manifestations of renal complications in children with IBD in order to enable early detection and prompt treatment of the complications. Methods: We retrospectively reviewed the medical records of 456 children and adolescents aged <20...
Pulmonology
Increased procalcitonin level is a risk factor for prolonged fever in children with Mycoplasma pneumonia
Ji Eun Jeong, Ji Eun Soh, Ji Hee Kwak, Hye Lim Jung, Jae Won Shim, Deok Soo Kim, Moon Soo Park, Jung Yeon Shim
Clin Exp Pediatr. 2018;61(8):258-263.   Published online August 15, 2018

Purpose: Macrolide-resistant Mycoplasma pneumoniae pneumonia (MPP) is characterized by prolonged fever and radiological progression despite macrolide treatment. Few studies have examined serum procalcitonin (PCT) level in children with MPP. We aimed to investigate the association of acute inflammation markers including PCT with clinical parameters in children with MPP. Methods: A total of 147 children were recruited. The diagnosis of MPP...
General Pediatrics
Use of child safety seats during transportation of newborns
Seon Hyuk Kim, Sung Won Park, Yeon Kyung Lee, Sun Young Ko, Son Moon Shin
Clin Exp Pediatr. 2018;61(8):253-257.   Published online August 15, 2018

Purpose: Child safety seats (CSS) are critical for the protection of children, in case of motor vehicle accidents. Although the national legislation mandates that all newborns must be placed in an appropriately installed CSS during transportation, people often do not perceive the importance of CSS and do not use it as recommended. The purpose of this survey was to understand...
Endocrinology
Changes of the growth plate in children: 3-dimensional magnetic resonance imaging analysis
Hyung Ho Yun, Hyun-Jung Kim, Min-Sun Jeong, Yun-Sun Choi, Ji-Young Seo
Clin Exp Pediatr. 2018;61(7):226-230.   Published online July 15, 2018

Purpose: This pilot study assessed changes in the growth plate and growth rates in children during a 6-month period. Methods: The study included 31 healthy children (17 boys, 14 girls) under evaluation for growth retardation. Height, weight, bone age, insulin like growth factor-1 (IGF-1), and insulin like growth factor binding protein 3 (IGF-BP3) were measured at baseline and after 6 months....
Review Article
Nephrology (Genitourinary)
Pediatric kidney transplantation is different from adult kidney transplantation
Min Hyun Cho
Clin Exp Pediatr. 2018;61(7):205-209.   Published online July 15, 2018
Kidney transplantation (KT) is the gold standard for renal replacement therapy in pediatric patients with end-stage renal disease. Recently, it has been observed that the outcome of pediatric KT is nearly identical to that in adults owing to the development and application of a variety of immunosuppressants and newer surgical techniques. However, owing to several differences in characteristics between children...
Case Report
Allergy
Breast abscess caused by Staphylococcus aureus in 2 adolescent girls with atopic dermatitis
Sung Man Park, Won Sik Choi, YoonSun Yoon, Gee Hae Jung, Chang Kyu Lee, So Hyun Ahn, Yoon Wonsuck, Young Yoo
Clin Exp Pediatr. 2018;61(6):200-204.   Published online June 25, 2018

Atopic dermatitis (AD) is a chronic inflammatory skin disease in children. Patients with AD experience a high rate of colonization of the skin surface by Staphylococcus aureus. Because of a skin barrier defect, there is a potential risk of staphylococcal invasive infection in patients with AD. Here, we present 2 cases of breast abscess caused by S. aureus in 2...

Original Article
Infection
Clinical and laboratory profiles of hospitalized children with acute respiratory virus infection
Eunjin Choi, Kee-Soo Ha, Dae Jin Song, Jung Hwa Lee, Kwang Chul Lee
Clin Exp Pediatr. 2018;61(6):180-186.   Published online June 25, 2018
Purpose

Despite the availability of molecular methods, identification of the causative virus in children with acute respiratory infections (ARIs) has proven difficult as the same viruses are often detected in asymptomatic children.

Methods

Multiplex reverse transcription polymerase chain reaction assays were performed to detect 15 common respiratory viruses in children under 15 years of age who were hospitalized with ARI between January 2013...

Review Article
Gastroenterology
Esophageal perforation in children: etiology and management, with special reference to endoscopic esophageal perforation
Krishna Kumar Govindarajan
Clin Exp Pediatr. 2018;61(6):175-179.   Published online June 25, 2018

Perforation of the esophagus is an uncommon problem with significant morbidity and mortality. In children undergoing endoscopy, the risk of perforation is higher when interventional endoscopy is performed. The clinical features depend upon the site of esophageal perforation. Opinions vary regarding the optimal treatment protocol, and the role of conservative management in this context is not well established. Esophageal perforation...

General Pediatrics
The 2017 Korean National Growth Charts for children and adolescents: development, improvement, and prospects
Jae Hyun Kim, Sungha Yun, Seung-sik Hwang, Jung Ok Shim, Hyun Wook Chae, Yeoun Joo Lee, Ji Hyuk Lee, Soon Chul Kim, Dohee Lim, Sei Won Yang, Kyungwon Oh, Jin Soo Moon; for the Committee for the Development of Growth Standards for Korean Children and Adolescents, the Committee for School Health and Public Health Statistics; the Committee for School Health and Public Health Statistics; the Korean Pediatric Society, and Division of Health and Nutrition Survey; Korea Centers for Disease Control and Prevention
Clin Exp Pediatr. 2018;61(5):135-149.   Published online May 28, 2018

Growth charts are curves or tables that facilitate the visualization of anthropometric parameters, and are widely used as an important indicator when evaluating the growth status of children and adolescents. The latest version of the Korean National Growth Charts released in 2007 has raised concerns regarding the inclusion of data from both breastfed and formula-fed infants, higher body mass index...

Original Article
Nephrology (Genitourinary)
Hypercalciuria and febrile convulsion in children under 5 years old
Vahid Seddighi Gorabi, Bahram Nikkhoo, Obeidollah Faraji, Mona Mohammadkhani, Sattar Mirzaee, Mohammad Aziz Rasouli, Abdorrahim Afkhamzadeh
Clin Exp Pediatr. 2018;61(4):129-131.   Published online April 23, 2018
Purpose

The association between hypercalciuria and febrile convulsion is controversial. The present study aimed to investigate the statistical association between hypercalciuria and childhood febrile convulsions.

Methods

Overall, 160 children aged 6 months to 5 years, including 80 children with febrile convulsion and 80 febrile children without convulsion (comparison group), were recruited. All laboratory tests, including 24-hour urine calcium, were undertaken in an academic...

General Pediatrics
Sudden unexpected cardio-respiratory arrest after venipuncture in children
Goun Jeong, Son Moon Shin, Nam Su Kim, Young Min Ahn
Clin Exp Pediatr. 2018;61(4):108-113.   Published online April 23, 2018
Purpose

This study aimed to investigate the clinical and socioenvironmental characteristics of sudden cardiorespiratory arrest after venipuncture in children.

Methods

We conducted a retrospective email-based survey of all members of the Korean Pediatric Society. The questionnaire included items on patient demographics, socioenvironmental circumstances of the venipuncture, type of cardiorespiratory arrest, symptoms and signs, treatment, prognosis, and presumed cause of the arrest.

Results

Fourteen patients were...

Nephrology (Genitourinary)
Acute kidney injury in pediatric patients with rhabdomyolysis
Young Shin Lim, Heeyeon Cho, Sang Taek Lee, Yeonhee Lee
Clin Exp Pediatr. 2018;61(3):95-100.   Published online March 19, 2018
Purpose

This study aimed to evaluate the clinical findings in pediatric rhabdomyolysis and the predictive factors for acute kidney injury (AKI) in Korean children.

Methods

Medical records of 39 Korean children, who were newly diagnosed with rhabdomyolysis from January 2008 to December 2015, were retrospectively analyzed. The diagnosis was made from the medical history, elevated serum creatinine kinase level >1,000 IU/L, and plasma...

Infection
Association between vitamin D and urinary tract infection in children
Abolfazl Mahyar, Parviz Ayazi, Sara Safari, Reza Dalirani, Amir Javadi, Shiva Esmaeily
Clin Exp Pediatr. 2018;61(3):90-94.   Published online March 19, 2018
Purpose

The present study aimed to determine the relationship between serum 25-hydroxyvitamin D (25(OH)D) level and Urinary tract infections (UTIs) in children.

Methods

In this case-control study, 70 children with UTI (case group) were compared with 70 healthy children (control group) in terms of serum 25(OH)D levels. The children were between 1 month and 12 years of age. Serum 25(OH)D levels were measured...

Gastroenterology
Clinical manifestation of Campylobacter enteritis in children
Joon Yeol Bae, Dong Hyuk Lee, Kyung Ok Ko, Jae Woo Lim, Eun Jeong Cheon, Young Hwa Song, Jung Min Yoon
Clin Exp Pediatr. 2018;61(3):84-89.   Published online February 28, 2018
Purpose

Timely antibiotic therapy in selected cases of diarrhea associated with bacterial infections can reduce the duration and severity of illness and prevent complications. The availability of a predictive index before identification of causative bacteria would aid in the choice of a therapeutic agent.

Methods

The study included patients admitted to the pediatrics unit at Konyang University Hospital for acute inflammatory diarrhea from...

Review Article
Nephrology (Genitourinary)
Atypical hemolytic uremic syndrome and eculizumab therapy in children
Seong Heon Kim, Hye Young Kim, Su Young Kim
Clin Exp Pediatr. 2018;61(2):37-42.   Published online February 28, 2018

Hemolytic uremic syndrome (HUS) is often encountered in children with acute kidney injury. Besides the well-known shiga toxin-producing Escherichia coli-associated HUS, atypical HUS (aHUS) caused by genetic complement dysregulation has been studied recently. aHUS is a rare, chronic, and devastating disorder that progressively damages systemic organs, resulting in stroke, end-stage renal disease, and death. The traditional treatment for aHUS is...

Original Article
Developmental and Behavioral Medicine
Mid-upper-arm circumference as a screening measure for identifying children with elevated body mass index: a study for Pakistan
Muhammad Asif, Muhammad Aslam, Saima Altaf
Clin Exp Pediatr. 2018;61(1):6-11.   Published online January 22, 2018
Purpose

Mid-upper-arm circumference (MUAC) is considered an alternative screening method for obesity. The aims of this investigation were to examine the ability of MUAC to correctly identify children with elevated body mass index (BMI) and to determine the best MUAC cutoff point for identification of children with high BMI.

Methods

Anthropometric measurements (height, weight, and MUAC) from a cross-sectional sample of 7,921 Pakistani...

Cardiology
Radiofrequency catheter ablation of atrioventricular nodal reentry tachycardia in children and adolescents: a single center experience
Myung Chul Hyun
Clin Exp Pediatr. 2017;60(12):390-394.   Published online December 22, 2017
Purpose

Atrioventricular nodal reentry tachycardia (AVNRT) is less common in pediatric patients than in adult patients. Thus, data for pediatric AVNRT patients are insufficient. Hence, we aimed to analyze the patient characteristics, treatment, and any recurrences in pediatric AVNRT patients.

Methods

We reviewed the records of 50 pediatric AVNRT patients who had undergone radiofrequency catheter ablation (RFCA) between January 1998 and December 2016...

Review Article
Nutrition
How to approach feeding difficulties in young children
Hye Ran Yang
Clin Exp Pediatr. 2017;60(12):379-384.   Published online December 22, 2017

Feeding is an interaction between a child and caregiver, and feeding difficulty is an umbrella term encompassing all feeding problems, regardless of etiology, severity, or consequences, while feeding disorder refers to an inability or refusal to eat sufficient quantities or variety of food to maintain adequate nutritional status, leading to substantial consequences, including malnutrition, impaired growth, and possible neurocognitive dysfunction....

Original Article
Cardiology
A comparative study of established z score models for coronary artery diameters in 181 healthy Korean children
Kyungguk Ryu, Jeong Jin Yu, Hyun Ok Jun, Eun Jung Shin, Young Hee Heo, Jae Suk Baek, Young-Hwue Kim, Jae-Kon Ko
Clin Exp Pediatr. 2017;60(11):373-378.   Published online November 27, 2017
Purpose

The aim of this study was to investigate the statistical properties of four previously developed pediatric coronary artery z score models in healthy Korean children.

Methods

The study subjects were 181 healthy Korean children, whose age ranged from 1 month to 15 years. The diameter of each coronary artery was measured using 2-dimensional echocardiography and converted to the z score in the...

Subtle inflammation: a possible mechanism of future cardiovascular risk in obese children
Watchareewan Sontichai, Prapai Dejkhamron, Peraphan Pothacharoen, Prachya Kongtaweelert, Kevalee Unachak, Nuthapong Ukarapol
Clin Exp Pediatr. 2017;60(11):359-364.   Published online November 27, 2017
Purpose

The risk of cardiovascular disease (CVD) has been shown to be associated with systemic inflammation in obese adults with metabolic syndrome (MetS). The aims of this study were to evaluate the prevalence of MetS and its relation to inflammatory markers in obese Thai children.

Methods

A cross-sectional study was conducted. Children with history of endogenous obesity, chronic diseases, drug ingestion, and any...

Review Article
Psychiatric / Psychology
The opportunities of virtual reality in the rehabilitation of children with attention deficit hyperactivity disorder: a literature review
Azadeh Bashiri, Marjan Ghazisaeedi, Leila Shahmoradi
Clin Exp Pediatr. 2017;60(11):337-343.   Published online November 27, 2017

Attention deficit hyperactivity disorder (ADHD) is one of the most common psychiatric disorders in childhood. This disorder, in addition to its main symptoms, creates significant difficulties in education, social performance, and personal relationships. Given the importance of rehabilitation for these patients to combat the above issues, the use of virtual reality (VR) technology is helpful. The aim of this study...

Original Article
Developmental and Behavioral Medicine
Usefulness of the Korean Developmental Screening Test for infants and children for the evaluation of developmental delay in Korean infants and children: a single-center study
Chung-Hyuk Yim, Gun-Ha Kim, Baik-Lin Eun
Clin Exp Pediatr. 2017;60(10):312-319.   Published online October 20, 2017
Purpose

To evaluate the usefulness of the Korean Developmental Screening Test (K-DST) for infants and children for developmental delay assessment.

Methods

This study was based on retrospective studies of the results of the K-DST, Preschool Receptive-Expressive Language Scale (PRES), Sequenced Language Scale for Infants (SELSI), Childhood Autism Rating Scale (CARS), Modified Checklist for Autism in Toddlers (M-CHAT), electroencephalography, magnetic resonance imaging, and extensive...

Neurology
Serum neuron specific enolase is increased in pediatric acute encephalitis syndrome
Dian Pratamastuti, Prastiya Indra Gunawan, Darto Saharso
Clin Exp Pediatr. 2017;60(9):302-306.   Published online September 21, 2017
Purpose

This study aimed to investigate whether serum neuron-specific enolase (NSE) was expressed in acute encephalitis syndrome (AES) that causes neuronal damage in children.

Methods

This prospective observational study was conducted in the pediatric neurology ward of Soetomo Hospital. Cases of AES with ages ranging from 1 month to 12 years were included. Cases that were categorized as simple and complex febrile seizures...

Allergy
Accuracy of maximal expiratory flow-volume curve curvilinearity and fractional exhaled nitric oxide for detection of children with atopic asthma
Sang Hoo Park, Min Ji Im, Sang-Yong Eom, Youn-Soo Hahn
Clin Exp Pediatr. 2017;60(9):290-295.   Published online September 21, 2017
Purpose

Airway pathology in children with atopic asthma can be reflected by the concave shape of the maximal expiratory flow-volume (MEFV) curve and high fractional exhaled nitric oxide (FeNO) values. We evaluated the capacity of the curvilinearity of the MEFV curve, FeNO, and their combination to distinguish subjects with atopic asthma from healthy individuals.

Methods

FeNO and angle β, which characterizes the general...

Developmental and Behavioral Medicine
Application of array comparative genomic hybridization in Korean children under 6 years old with global developmental delay
Kyung Yeon Lee, Eunsim Shin
Clin Exp Pediatr. 2017;60(9):282-289.   Published online September 21, 2017
Purpose

Recent advancements in molecular techniques have greatly contributed to the discovery of genetic causes of unexplained developmental delay. Here, we describe the results of array comparative genomic hybridization (CGH) and the clinical features of 27 patients with global developmental delay.

Methods

We included 27 children who fulfilled the following criteria: Korean children under 6 years with global developmental delay; children who had...



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