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Case Report
Three Cases of Acute Focal Bacterial Nephritis
Yeon Soo Lim, Jae Kook Cha, Kon Hee Lee, Kwan Seop Le
Clin Exp Pediatr. 1999;42(1):138-142.   Published online January 15, 1999
Acute focal bacterial nephritis(AFBN) is an unusual form of localized renal infection, which has various imaging findings and should be distinguished from abscess or other renal masses. Clinical symptoms are similar to other urinary tract infections but the diagnosis needs a CT or sonographic confirmation. Treatment, which is nonoperative, consists of intensive antibiotic therapy. We report three cases of AFBN...
A Case of Acute Myeloblastic Leukemia Transformed from Transient Myeloproliferative Disorder with Down Syndrome
Jae Eun Lee, Seung Woo Baeck, Wan Seob Kim, Chun Hee Lee
Clin Exp Pediatr. 1999;42(1):128-132.   Published online January 15, 1999
Individuals with Down syndrome have a high incidence of hematologic diseases such as transient myeloproliferative disorder(TMD) & acute leukemia. Because it is difficult to distinguish TMD from acute myeloblastic leukemia, the diagnosis in neonate, who have Down syndrome, should be made with extreme caution. TMD usually undergoes spontaneous remission within a few months, but acute leukemia can develope after remission...
Original Article
The Utility of Serum Prealbumin Concentrations for Short-term Nutritional Assessment in Patients with Acute Diarrhea
Kyoung Ah Lim, Hae Soon Kim, Jeong Wan Seo, Seung Joo Lee
Clin Exp Pediatr. 1999;42(1):88-93.   Published online January 15, 1999
Purpose : To evaluate the usefulness of serum prealbumin concentration for the nutritional assessment of acute diarrhea. Methods : From February 1997 to August 1997, ninety patients with acute diarrhea(age, 4-24 months) were randomly assigned into two groups on the basis of their intakes for 2 days prior to admission : liquid diet group(N=56, clear liquid and/or oral electrolyte solutions), and...
A Nationwide Clinical Study of Acute Respiratory Distress Syndrome in Children
Soo Jung Choi, Do Suck Jeong, Jae Won Oh, Ha Baik Lee, Im Ju Kang, Kwang Woo Kim, Kyu Earn Kim, Ki Bok Kim, Young Ho Rah, Kang Seo Park, Byong Kwan Son, Ki Young Lee, Sang Il Lee, Ji Tai Choung, Young Mi Hong
Clin Exp Pediatr. 1999;42(1):23-31.   Published online January 15, 1999
Purpose : Acute respiratory distress syndrome(ARDS) is the final course of acute lung injury. It results from various etiological origins and pathophysiologic mechanisms, and has a mortality rate of approximately 60-70%. Although the confirmative incidence of ARDS in children is yet unknown, the increasing incidence of ARDS has been reported in Korea. In the present study, we report ARDS diagnosed...
A Clinical Analysis on Acute Lower Respiratory Tract Infections in Children Caused by Influenza Virus in Children
Kiehl Hyung Lee, Woo Kyung Kim, Mi Ran Kim, Dug Ha Kim, Hae Ran Lee, Chong Young Park, Kyu Man Lee
Clin Exp Pediatr. 1998;41(12):1623-1631.   Published online December 15, 1998
Purpose : Although annual epidemics occur, there are only a few clinical studies on influenza in Korea. We evaluated the epidemic and clinical features of acute lower respiratory tract infections in children by influenza virus. Methods : From Feb., 1995 to July, 1997, influenza virus isolations and clinical review were performed on hospitalized children with acute lower respiratory tract infections at...
Significance of Acute Phase Reactants(APR) Score for the Early Detection of Neonatal Bacterial Infection
Seong Woo Kim, Myung Ho Oh, Kee Hyuk Kim, Jay G. Sim
Clin Exp Pediatr. 1998;41(11):1491-1497.   Published online November 15, 1998
Purpose : We performed acute phase reactants(APR) test to evaluate as an appropriate screening test for the early detection of neonatal bacterial infection. Methods : We selected 174 neonates and divided into two groups; sepsis group and well-baby group. We performed APR test. Results : There are no significant difference in total leukocyte count, immature to mature rentrophil ratio, toxic granules, and...
A Clinical Study on Acute Lower Respiratory Tract Infections by Adenovirus in Children
Ui Chong Chong, Mi Ran Kim, Dug Ha Kim, Hae Ran Lee, Chong Young Park, Han Sung Kim, Kyu Man Lee
Clin Exp Pediatr. 1998;41(8):1070-1077.   Published online August 15, 1998
Purpose : This study was performed to characterize the epidemiologic and clinical features of acute adenoviral lower respiratory tract infections. Methods : Culture and indirect immunofluorescence for adenovirus was done with nasopharyngeal aspirates from patients with acute lower respiratory tract infections from April to September, 1996. Cultured virus was serotyped for type 3, 4, and 7a by neutralization test, and medical...
Case Report
The Lymphocyte Subset Change in a Case of Subacute Necrotizing Lymphadenitis
Ji Hyang Doh, Sung Taek Kim, Kyeong Shin Lee, So Young Jeong
Clin Exp Pediatr. 1998;41(7):994-1000.   Published online July 15, 1998
The subacute necrotizing lymphadenitis, also known as Kikuchi-Fujimoto disease, is a benign, self-limited disorder of unknown cause. This rare disease is characterized by fever, lymphadenopathy, leukopenia, and elevated sedimentation rate. This disease preferentially affects young women. The diagnosis of this disease is confirmed by involved lymphnodes biopsy. Evidence for autoimmune dysfunction has been reported, but is usually lacking. According to...
Rhabdomyolysis-induced Acute Renal Failure in a Child
Weon Sang Yun, Keun Mo Ki, Byung Ju Kim, Jae Sook Ma
Clin Exp Pediatr. 1998;41(5):707-710.   Published online May 15, 1998
Rhabdomyolysis has been reported as a cause of acute renal failure(ARF), and it can arise from traumatic and variable non-traumatic events. Rhabdomyolysis-induced ARF is very rare in children. We experienced a case of rhabdomyolysis-induced ARF in a 14-year-old boy who presented with generalized edema and oliguria following trauma, a compressed thigh by a cultivator. Laboratory tests showed marked elevation of muscle...
Two Cases of Acute Encephalopathy with Symmetrical Low Density Areas in Bilateral Thalami in Siblings
Soon Young Lee, Woo Jin Lee, Ji Eun Lee, So Yeon Kim, Jong Ho Lee, Seung Jae Lee
Clin Exp Pediatr. 1998;41(5):701-706.   Published online May 15, 1998
Original Article
Acute Renal Failure in Children : Underlying Disease and Management according to Age
Eun Joung Park, Joung Sim Kim, Jai Bok Yoo, Joung Sook Sul, Si Whan Koh, Phil Soo Oh, I Suk Kang, Moon Soo Park, Heung Jae Lee, Dong Kyoo Jin
Clin Exp Pediatr. 1998;41(5):654-662.   Published online May 15, 1998
Purpose : It has been stressed that age itself as well as multiple organ failure are important prognostic factors in acute renal failure(ARF) in children. This study was performed to find out the significance of age factor and underlying disease of ARF in children. Methods : We tried to review 58 pediatric ARF cases, retrospectively, in the pediatric intensive care unit(excluding...
Clinical and MRI Findings of Acute Disseminated Encephalomyelitis Associated with Preceding Infections Confirmed Serologically
Jung-Yeon Shim, Tae-Sung Ko, Hyung-Nam Moon, Chang-Yee Hong, Choong-Gon Choi,, Shi-Joon Yoo, Dae-Chul Suh
Clin Exp Pediatr. 1998;41(4):505-513.   Published online April 15, 1998
Purpose : Acute disseminated encephalomyelitis(ADEM) is an inflammatory demyelinating disease of the central nervous system. The pathogenesis is not well known, but it is thought to be an immune-mediated disease and may follow a viral infection or vaccinations. MRI demonstrates decreased signal on T1 weighting and increased signal on T2-weighted image. We report clinical features and characteristic MRI findings in seven patients with ADEM...
Case Report
A Case of Secondary Hemosiderosis and Hepatic Fibrosis in a Pateint with Acute Myelogenous Leukemia
Hyoung No Kim, Jae Won Huh, Jae Sun Park
Clin Exp Pediatr. 1998;41(3):420-424.   Published online March 15, 1998
Chronic iron overload is associated with life-threatening complications, such as cardiomyopathy, liver cirrhosis, diabetes, hypothyroidism, hypoparathyroidism and hypogonadism. We experienced a case of secondary hemosiderosis with hepatic fibrosis in a 8-year-old boy who had been transfused 56 pints of packed red blood cells for a supportive therapy of acute myelogenous leukemia for a 27-month period. Intramuscular injection of Desferroxamine(40mg/kg/day) was...
Two Cases of Leigh Disease
Seong Hun Kim, Soo En Park, Ju Seok Lee, Sang Ook Nam, Yeong Tak Lim
Clin Exp Pediatr. 1998;41(3):405-409.   Published online March 15, 1998
Leigh Disease, or subacute necrotizing encephalopathy(SNE), is a degenerative disorder characterized by lesions of the gray and white matter in the bran and spinal cord. The pathogenesis was known as mitochondrial enzyme defect of the respiratory chain system. We experienced 2 cases of Leigh disease. The first case, a seven-month old girl who was presented with weak respiration and failure...
A Case of Multiple Sclerosis
Young Hee Ha, Jong Hyun Kim, Soo Joong Lee, Dae Kyun Koh
Clin Exp Pediatr. 1998;41(2):264-269.   Published online February 15, 1998
Multiple sclerosis is a chronic inflammatory demyelinating disease of the central nervous system and its lesions are multiple in time as well as space. We experienced a case of a 14-year-old-girl with dysphagia, paresthesia and headache. Brain MRI scans demonstrated high signal intensities on T2-weighted images at the medulla and upper cervical cord. Acute disseminated encephalomyelitis was diagnosed and methylprednisolone pulse...
Original Article
Induction Chemotherapy with BH-AC, Idarubicin, and 6-Thioguanine in Childhood Acute Myelogenous Leukemia
Hyo Jeong Han, Hyoung Jin Kang, Jun Ah Lee, Hyoung Soo Choi, Hyeon Jin Park, Ki Woong Seong, Eun Sun Yoo, Hee Young Shin, Hyo Seop Ahn
Clin Exp Pediatr. 1998;41(2):209-215.   Published online February 15, 1998
Purpose : We have undertaken this study to evaluate the effects of induction chemotherapy involving BH-AC, idarubicin, and 6-thioguanine(6-TG). Methods : BH-AC 300mg/m2/day was administered intravenously over three hours for seven consecutive days. Idarubicin 12mg/m2/day was administered intravenously for three days. 6-TG 100 mg/m2/day was administered orally for seven days. Intrathecal ara-C was administered on the first day of treatment. Results...
Case Report
A Case of Choledochal Cyst Type IVa Complicated by Multiple Choledocholithiasis and Recurrent Cholangitis : Therapeutic Endoscopic Retrograde Cholangiopancreatography and Endoscopic Nasobiliary Drainage
Yong Joo Kim, Eon Woo Shin, Soo Jung Choi, Ho Soon Choi, Jeh Hoon Shin
Clin Exp Pediatr. 1998;41(1):115-119.   Published online January 15, 1998
A 5-year-old male patient was admitted due to fever, and right upper abdominal pain for 2 weeks. He showed severe right upper quadrant tenderness on palpation, hepatomegaly 5 cm below the right costal margin, no mass, and no splenomegaly. On biochemical studies, ALT was 380IU/ml, AST 462IU/ml, alkaline phosphatase 1,069IU/ml, γGTP 239IU/ml, and total bilirubin 2.1mg/dl. Endoscopic retrograde cholangiopancreatography (ERCP) showed cylindrical dilatations of...
Acute Renal Failure(ARF) Associated with Yersinia Pseudotuberculosis Infection Diagnosed by Polymerase Chain Reaction
Hyung Gyu Park, Byung Moon Ahn, Eun Ryoung Kim, Il Soo Kim, Jae Jong Kim, Sung Ok Kang, Han Ho Park, Ki Jeong Kim
Clin Exp Pediatr. 1997;40(8):1162-1168.   Published online August 15, 1997
The clinical significance of Yersinia pseudotuberculosis(Y. pseudotuberculosis) has recently recognized in various part of the world because it can cause a wide range of clinical problems such as mesenteric lymphadenitis, septicemia, reactive arthritis, terminal ileitis, erythema nodosum and acute renal failure. we experienced a case of acute renal failure associated with Y. pseudotuberculosis infection. We applied a nested polymerase chain reaction method for rapid diagnosis...
Original Article
Epidemiologic and Clinical Feature of Acute Lower Respiratory Tract Infections by Respiratory Syncytial Virus and Parainfluenza Virus in Children
Jeoung Jin Lee, Hyeon Seon Park, Mi Ran Kim, Dug Ha Kim, Hae Ran Lee, Chong Young Park, Woo Kap Chung, Kyu Man Lee
Clin Exp Pediatr. 1997;40(8):1071-1080.   Published online August 15, 1997
Purpose : This is to analyze epidemic and clinical features of acute respiratory tract infections(ALRTI) by respiratory syncytial virus(RSV) and parainfluenza virus(PIV), which are considered to be the major respiratory pathogens in children. Methods : Nasopharyngeal aspirates were collected from 515 patients with ALRTI hospitalized at Hangang Sacred Heart Hospital between Apr. ’94 and Oct. ’96. Nasopharyngeal aspirates were inoculated to...
The Retrospective Study on Antibiotics Treatment in Acute Gastroenteritis
Ji Hye Kim, Sung Hee Oh
Clin Exp Pediatr. 1997;40(6):826-834.   Published online June 15, 1997
Purpose : Most of the gastroenteritis due to viruses and some bacteria can be successfully managed by oral and/or intravenous fluid-electrolyte replacement and antibiotic therapy is unnecessary and even harmful. It is, however, not uncommon practice to prescribe antibiotics when acute gastroentritis is suspected. Therefore authors analysed the clinical courses of the patients treated for acute non-bacterial gastroenteritis in a university hospital to assess...
Case Report
A Case of Congenital Acute Megakaryoblastic Leukemia with Down Syndrome
Nan Yee Kye, Kon Hee Lee, Jae Kook Cha, Hye Sun Yoon, Won Keun Song
Clin Exp Pediatr. 1997;40(4):578-583.   Published online April 15, 1997
We experienced a case of congenital acute megakaryoblastic leukemia with Down syndrome. The patient was admitted due to characteristic facial figure of Down syndrome and abdominal distension. Acute megakaryoblastic leukemia was diagnosed with abundant megakaryoblast in peripheral blood smear, severe myelofibrosis in bone marrow biopsy and positive platelet glycoprotein Ⅲa receptor. On third hospital day, the patient expired due to DIC...
A Case of Granular Acute Lymphoblastic Leukemia with t(5p;5p) Arising in Down Syndrome Infant
Soon Ja Lee, Young Ho An, Hai Lee Chung
Clin Exp Pediatr. 1997;40(3):417-422.   Published online March 15, 1997
Granular lymphoblast which is characterized by the presence of clearly defined azurophilic cytoplasmic granules are a relatively uncommon finding and indicate a negative impact on prognosis of childhood ALL. Granular ALL is more common in FAB L2 cases but there is no significant difference by immunophenotype and no specific cytogenetic abnormality correlated with clinical significance of granular ALL has been reported. We present a case...
Original Article
Diagnostic Value of 99mTc-DMSA Renal Scan for Early Diagnosis of Acute Pyelonephritis in Children with Febrile Urinary Tract Infection
Soo Ja Hwang, Eun Ae Park, Jeong Wan Seo, Seung Joo Lee, Sun Whan Lee
Clin Exp Pediatr. 1996;39(11):1586-1593.   Published online November 15, 1996
Purpose : For prevention of renal scar, early diagnosis and treatement of acute pyelonephritis are important in children with febrile urinary tract infection. But it has been difficult to differentiate acute pyelonephritis from lower urinary tract infection. We have performed this study to evaluate the diagnostic value of 99mTc-DMSA renal scan and to clarify the relationship among acute pyelonephritis, vesico-ureteral reflux and renal scar. Methods...
Case Report
Subacute Necrotizing Lymphadenitis in a 3 Year-Old Male Child
You Mee Heo, Seong Koo Kim, Young Ah Lee, Dae Gil Lee, Ha Ju Choi, Woo Kap Chung, Jung Won Shin
Clin Exp Pediatr. 1996;39(10):1443-1447.   Published online October 15, 1996
Subacute necrotizing lymphadenitis is a benign form of lymphadenitis that was first described in Japan by Kikuchi in 1972. It mainly affects young women and usually manifests as fever and lymphadenopathy. Although it is a benign self-limited lymphadenitis, it has been misdiagnosed as malignant lymphoma. Histologically, involved lymph nodes contain a necrotizing process characterized by patch, well-circumscribed area with eosinophilic fibrinoid material. There is...
Original Article
The Study of Serum Aminotransferase and AST/ALT Ratio in Pediatric Patients with Acute Hepatitis
Soo Mi Jung, Chang Rang Kang, Man Taeg Oh, Jong Duck Kim
Clin Exp Pediatr. 1996;39(10):1364-1370.   Published online October 15, 1996
Purpose : Serum level of the aminotransferase is the most common test in use to assess hepatocellular injury and are sensitive test of hepatocyte necrosis, but both AST and ALT level in serum rise in a variety of hepatic disorders. Some clinical study reports that AST/ALT ratio was possible to predict prognostic outcome of infants with liver disease. We have tried to assess whether...
Case Report
A Case of Infantile Acute Hemorrhagic Edema
Hyun Jeong Lee, Dong Won Lee, Si Yong Kim, Baik Kee Cho, Chang Kyu Oh
Clin Exp Pediatr. 1996;39(8):1168-1172.   Published online August 15, 1996
Infantile acute hemorrhagic edema(IAHE) is a variant of leukocytoclastic vasculitis which is characterized by painful edematous purpura of cockade pattern on the head and distal extremities. The lesions are limited to the skin and complete recovery occurs within 1 to 3 weeks. Recently, it is accepted as a separate entity from Henoch-Schönlein purpura. A nine month-old boy presented multiple cockade ecchymotic plaques and inflammatory...
Acute Tyrosinemia Type 1 in a 5 Month Old Korean Boy
Si Houn Hahn, Ki Soo Pai, Ki Bum Lee, Kwang Hwa Park, Ok Hwa Kim, Chang Ho Hong, Baek Lin Eun, Seiji Yamaguchi
Clin Exp Pediatr. 1996;39(6):866-872.   Published online June 15, 1996
Tyrosinemia type 1 is an autosomal recessive disorder caused by deficiency of the enzyme fumarylacetoacetate hydrolase(FAH). The disease is characterized by hepatic dysfuntion, hepatocellular carcinomas, renal tubular dysfunction, rickets, and neurologic crises. Two forms of the disease, acute and chronic, are thought to be from the residual enzyme activity in the liver. The diagnosis of the tyrosinemia type 1 is suggested by...
Original Article
A Study of Radiocontrast Media Induced Nephrotoxicit
Chong Guk Lee, Jae Ho Cho, Se Wook Oh, Yong Won Park
Clin Exp Pediatr. 1996;39(4):503-511.   Published online April 15, 1996
Purpose : This study was aimed at determining whether tri-iodinated compounds with greater solubility and low osmolality, Na or meglumine ioxaglate(Hexabrix 320, Guerbet Lab., France) had deleterious effects on renal function after cardiac angiography for the evaluation of congenital heart disease(CHD) and determining whether correction of dehydration using iv hydration given before cardiac angiography were effective in prventing renal dysfunction. Methods...
Ultrasonography for Diagnosis of Acute Appendicitis in Children
Mi Kyoung Lee, Chang Sung Im, Sun Mi An, Chang Hee Kim, Dong Jin Lee, Jung Hyouk Kwon
Clin Exp Pediatr. 1996;39(4):497-502.   Published online April 15, 1996
Purpose : Accurate clinical diagnosis of acute appendicitis is more difficult in children since they may not be able to communicate their complaints adequately, and findings on physical examination may be nonspecific.The uncertainty in diagnosis may lead to a delay of surgery or to unnecessary laparotomy. Prompt diagnosis is important due to their complications such as perforation, abscess formation, and...
Mucormycosis in Leukemic Children
Seung Ghon Nam, Eun Wha Choi, Jin Young Park, Jong Jae Kim, Hee Young Shin, Hoan Jong Lee, Hyo Seop Ahn
Clin Exp Pediatr. 1996;39(3):379-388.   Published online March 15, 1996
Purpose : Mucormycosis is an opportunistic fungal infection caused by one of the ubiquitous fungi of the order Mucorales, occurring almost exclusively in immunocompromised hosts such as patients with diabetes, leukemia and lymphoma. Recently the incidence of mucormycosis is rising associated with the increasing predisposing factors such as cytotoxic drugs and immunosuppressive agents. Though mucormycosis is frequently fatal, there has...
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