| The Lymphocyte Subset Change in a Case of Subacute Necrotizing Lymphadenitis |
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Ji Hyang Doh1, Sung Taek Kim1, Kyeong Shin Lee2, So Young Jeong3 |
1Department of Pediatrics, Dong-Eui Medical Center, Pusan, Korea
2Department of Pathology, Dong-Eui Medical Center, Pusan, Korea
3Department of Clinical Pathology, Dong-Eui Medical Center, Pusan, Korea |
| 아급성 괴사성 림프절염 1례에서 말초혈 림프구 아형 변화 |
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도지향1, 김성택1, 이경신2, 정소영3 |
1동의의료원 소아과
2동의의료원 해부병리과
3동의의료원 임상병리과 |
Correspondence:
Ji Hyang Doh, Email: 1
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| Abstract |
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The subacute necrotizing lymphadenitis, also known as Kikuchi-Fujimoto disease, is a benign, self-limited disorder of unknown cause. This rare disease is characterized by fever, lymphadenopathy, leukopenia, and elevated sedimentation rate. This disease preferentially affects young women. The diagnosis of this disease is confirmed by involved lymphnodes biopsy. Evidence for autoimmune dysfunction has been reported, but is usually lacking. According to the review of the literatures, a total of 192 cases of subacute necrotizing lymphadenitis were reported in Korea since 1983 mostly in literatures of pathology or internal medicine and only 7 cases in pediatrics. There was female predominance in a 141:51 ratio. However, among 25 cases of under 20 years of age, there was male predominance in a 16:9 ratio. The patients of under and over 20 years of age were 29 and 82, respectively among the age-known 111 cases of 192 reported. We experienced a 13-year-old boy, who had right cervical lymphadenitis with persisting high temperature and pain on lymph nodes for more than 10 days. An excisional cervical lymph node biopsy was performed and pathologic diagnosis was compatible with subacute necrotizing lymphadenitis. Most antibiotics were not effective, but fever subsided with one day of oral prednisolone therapy. Various laboratory studies for prolonged fever were negative except leukopenia and increased sedimentation rates. The CD4/CD8 ratios in acute and recovery stages were 1.1 and 1.5 respectively, showing mild decrease of CD4/CD8 ratio in the acute stage. Decreased T cell proportions in the acute stage were also noted. |
| Key Words:
Lymphocyte Subset, Subacute necrotizing lymphadenitis |
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