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Editorial
Neonatology (Perinatology)
Strategies to improve outcomes of bronchopulmonary dysplasia
Young Hwa Jung, Chang Won Choi, Beyong Il Kim
Clin Exp Pediatr. 2019;62(10):380-381.   Published online September 11, 2019
Original Article
Nephrology (Genitourinary)
Clinical manifestations of BK virus infection in pediatric kidney transplant patients
Yiyoung Kwon, Jeong Yeon Kim, Yeonhee Lee, Heeyeon Cho
Clin Exp Pediatr. 2019;62(11):422-427.   Published online September 5, 2019
Background: Polyomavirus BK (BKV) infection is an important cause of graft loss in kidney transplant patients.
Purpose: The purpose of this study was to evaluate clinical findings and risk factors for BKV in pediatric patients after kidney transplantation. Methods: This retrospective single-center study included 31 pediatric kidney transplant recipients from January 2002 to December 2017. Two patients received 2 transplantations during the...
Critical Care Medicine
Assessment of interhospital transport care for pediatric patients
Krittiya Chaichotjinda, Marut Chantra, Uthen Pandee
Clin Exp Pediatr. 2020;63(5):184-188.   Published online August 29, 2019
Background: Many critically ill patients require transfer to a higher-level hospital for complex medical care. Despite the publication of the American Academy of Pediatrics guidelines for pediatric interhospital transportation services and the establishment of many pediatric transport programs, adverse events during pediatric transport still occur.
Purpose: To determine the incidence of adverse events occurring during pediatric transport and explore their complications...
Neonatology (Perinatology)
Placental histopathology in late preterm infants: clinical implications
Kristina Ericksen, Joshua Fogel, Rita P. Verma
Clin Exp Pediatr. 2020;63(2):48-51.   Published online August 19, 2019
Question: Placental histopathology and its clinical implications in late preterm infants.
Finding: Placental vascular anomalies are more, and placental inflammation less common in late preterm infants compared to term. Higher maternal age, magnesium sulfate therapy and hypertension are clinical risk factors associated with late preterm delivery.
Meaning: Prevention and aggressive management of hypertension, and conception before 30 years of age might be effective in preventing late preterm births.
Review Article
Neurology
Autoimmune encephalitis and epilepsy: evolving definition and clinical spectrum
Joo Hee Seo, Yun-Jin Lee, Ki Hyeong Lee, Elakkat Gireesh, Holly Skinner, Michael Westerveld
Clin Exp Pediatr. 2020;63(8):291-300.   Published online August 16, 2019
Advances in autoimmune encephalitis studies in the past 10 years have led to the identification of new syndromes and biomarkers that have transformed the diagnostic approach to the disorder. The disorder or syndrome has been linked to a wide variety of pathologic processes associated with the neuron-specific autoantibodies targeting intracellular and plasma membrane antigens. However, current criteria for autoimmune encephalitis...
Original Article
Neonatology (Perinatology)
Effectiveness of various nonpharmacological analgesic methods in newborns
Pancham Kumar, Rakesh Sharma, Sukhdev Rathour, Sunidhi Karol, Mohit Karol
Clin Exp Pediatr. 2020;63(1):25-29.   Published online August 16, 2019
Question: Can nonpharmacological methods be used for neonatal pain management.
Finding: Nonpharmacological methods like Sucrose, breastfeeding etc have shown to significantly reduce the pain caused by intramuscular hepatitis B vaccination.
Meaning: Nonpharmacological methods are the safe and cheap potential modalities of analgesia which can be used during mild to moderate pain in newborns.
Editorial
Neonatology (Perinatology)
Practical considerations when administering surfactants to preterm infants with respiratory distress syndrome
Heui Seung Jo
Clin Exp Pediatr. 2019;62(12):440-441.   Published online August 16, 2019
Original Article
Critical Care Medicine
Comparative validity of microalbuminuria versus clinical mortality scores to predict pediatric intensive care unit outcomes
Shifa Nismath, Suchetha S. Rao, B.S. Baliga, Vaman Kulkarni, Gayatri M. Rao
Clin Exp Pediatr. 2020;63(1):20-24.   Published online August 12, 2019
Question: Does microalbuminuria predict mortality in pediatric intensive care unit?
Finding: Positive correlation was found between albumin-creatinine ratio and pediatric intensive care unit stay, organ dysfunction and need of inotropes. Area under the receiver operating characteristic curve for albumin-creatinine ratio was comparable to mortality scores.
Meaning: Microalbuminuria is a good predictor of outcome in pediatric intensive care unit and is comparable with mortality scores.
Gastroenterology
Association between Body Mass Index and Hepatitis B antibody seropositivity in children
Yoowon Kwon, Su Jin Jeong
Clin Exp Pediatr. 2019;62(11):416-421.   Published online August 12, 2019
Background: The seropositivity rate of hepatitis B surface antigen (anti-HBs) antibodies is known to be ≥95% after hepatitis B virus vaccination during infancy. However, a low level or absence of anti-HBs in healthy children is discovered in many cases. Recent studies in adults reported that a reduced anti-HBs production rate is related to obesity.
Purpose: To investigate whether body mass index...
Editorial
Cardiology
Can the accurate epidemiological study help to search the etiology of Kawasaki disease?
Ji Whan Han
Clin Exp Pediatr. 2020;63(3):96-97.   Published online August 7, 2019
Genetics and Metabolism
Considerations for evaluating the effectiveness and long-term outcome of enzyme replacement therapy in Pompe disease
Chong Kun Cheon
Clin Exp Pediatr. 2020;63(1):14-15.   Published online August 7, 2019
Neonatology (Perinatology)
Central line-associated bloodstream infections in the neonatal intensive care unit
Woo Ryoung Lee
Clin Exp Pediatr. 2019;62(10):382-383.   Published online July 17, 2019
Review Article
Recommended immunization schedule for children and adolescents: Committee on Infectious Diseases of the Korean Pediatric Society, 2018
Eun Hwa Choi, Su Eun Park, Yae-Jean Kim, Dae Sun Jo, Yun-Kyung Kim, Byung-Wook Eun, Taek-Jin Lee, Jina Lee, Hyunju Lee, Ki Hwan Kim, Hye-Kyung Cho, Eun Young Cho, Jong-Hyun Kim
Clin Exp Pediatr. 2019;62(7):252-256.   Published online July 15, 2019
The Committee on Infectious Diseases of the Korean Pediatric Society recommended immunization schedule for children and adolescents aged 18 years or younger in the 9th (2018) edition of Immunization guideline. This report provides the revised recommendations made by the committee and summarizes several changes from the 2015 guideline. National immunization program (NIP) launched a human papillomavirus (HPV) immunization for girls...
Editorial
Neonatology (Perinatology)
Eosinophil count and neutrophil-to-lymphocyte count ratio as biomarkers for predicting early-onset neonatal sepsis
Jang Hoon Lee
Clin Exp Pediatr. 2019;62(12):438-439.   Published online July 9, 2019
Endocrinology
Correlation between genetic heterogeneity and variability for response to growth hormone in Noonan syndrome
Young-Lim Shin
Clin Exp Pediatr. 2019;62(11):412-413.   Published online July 9, 2019
Allergy
Is determining nasal eosinophil count and nasal eosinophil peroxidase concentration clinically useful in children with rhinits?
Bong Seok Choi
Clin Exp Pediatr. 2019;62(9):342-343.   Published online July 9, 2019
Review Article
Cardiology
Reality of Kawasaki disease epidemiology
Gi Beom Kim
Clin Exp Pediatr. 2019;62(8):292-296.   Published online July 9, 2019
Epidemiologic studies of Kawasaki disease (KD) have shown a new pattern or change of its occurrence suggestive of its pathophysiology or risk factors from the first patient with KD reported in 1961. The incidence of KD in Northeast Asian countries including Japan, South Korea, China, and Taiwan is 10–30 times higher than that in the United States and Europe. Knowing...
Original Article
Gastroenterology
Influence of proton pump inhibitor therapy on intestinal inflammation assessed by fecal calprotectin in pediatric patients
Su Yeong Kim, Na Mi Lee, Sin Weon Yun, Soo Ahn Chae, In Seok Lim, Eung Sang Choi, Dae Yong Yi
Clin Exp Pediatr. 2019;62(10):400-404.   Published online July 3, 2019
Background: An increase in the numbers of patients with gastrointestinal symptoms has recently been observed.
Purpose: To investigate the effects of proton pump inhibitor (PPI) therapy on intestinal inflammation in children and adolescents as confirmed by clinical manifestations and objectively assessed by fecal calprotectin (FC) level measurement. Methods: Consecutive children (aged 3–18 years) who presented with gastrointestinal symptoms and were treated with...
Endoscopic postdilatation application of Mitomycin C in children with resistant esophageal strictures
Yasser K. Rashed, Mohamed El-Guindi
Clin Exp Pediatr. 2019;62(10):395-399.   Published online June 24, 2019
Background: The esophagus is the most common part of gastrointestinal (GI) tract at the risk of stricture. Benign disorders are the leading causes of narrowing. Caustic ingestion is the most common cause of esophageal stricture in children, especially in developing countries. Clinical responses to the topical application of Mitomycin C in various medical procedures have been reported.
Purpose: The study aimed...
General Pediatrics
Prevalence of hyperuricemia and its association with metabolic syndrome and cardiometabolic risk factors in Korean children and adolescents: analysis based on the 2016–2017 Korea National Health and Nutrition Examination Survey
Jung Hyun Lee
Clin Exp Pediatr. 2019;62(8):317-323.   Published online June 24, 2019

Purpose: Investigating the prevalence of hyperuricemia and its association with metabolic syndrome (MetS) and cardiometabolic risk factors (CMRFs) in Korean children and adolescents. Methods: This cross-sectional survey used data from the 7th Korea National Health and Nutrition Examination Survey (2016–2017); 1,256 males and females aged 10–18 years were included. Hyperuricemia was defined as serum uric acid levels were >6.6 mg/dL at...
Editorial
Allergy
Why should we monitor for hematologic adverse drug reactions to oxcarbazepine?
Gwang Cheon Jang
Clin Exp Pediatr. 2019;62(8):299-300.   Published online June 24, 2019
Neonatology (Perinatology)
Controversy in the diagnosis and treatment of hemodynamically significant patent ductus arteriosus in preterm infants
Se In Sung
Clin Exp Pediatr. 2019;62(11):410-411.   Published online June 21, 2019
Systematic review and meta-analysis
General Pediatrics
The maternal prepregnancy body mass index and the risk of attention deficit hyperactivity disorder among children and adolescents: a systematic review and meta-analysis
Ensiyeh Jenabi, Saied Bashirian, Salman Khazaei, Zohreh Basiri
Clin Exp Pediatr. 2019;62(10):374-379.   Published online June 14, 2019
Background: Attention deficit hyperactivity disorder (ADHD) symptoms have a major impact on individuals, families, and society. Therefore identification risk factors of ADHD are a public health priority.
Purpose: This is meta-analysis evaluated the association between maternal prepregnancy body mass index and the risk of ADHD among the resulting offspring. Methods: The search identified studies published through December 2018 in the PubMed, Web...
Corrigendum: Correction of the fourth author’s name and institution
Corrigendum: Cardiac function associated with home ventilator care in Duchenne muscular dystrophy
Sangheun Lee, Heeyoung Lee, Lucy Youngmin Eun, Seung-Woong Gang
Clin Exp Pediatr. 2019;62(6):244-244.   Published online June 14, 2019
Editorial
Cardiology
Can iron be a risk factor for coronary lesions in Kawasaki disease?
Kyung Lim Yoon
Clin Exp Pediatr. 2019;62(8):297-298.   Published online June 7, 2019
Original Article
Neonatology (Perinatology)
Clinical impact of admission hypothermia in very low birth weight infants: results from Korean Neonatal Network
Na Hyun Lee, Soo Kyung Nam, Juyoung Lee, Yong Hoon Jun
Clin Exp Pediatr. 2019;62(10):386-394.   Published online May 22, 2019
Background: Preterm infants have difficulty maintaining body temperature after birth. However, clinical guidelines advocate that neonatal body temperature should be maintained at 36.5°C–37.5°C.
Purpose: We aimed to investigate the incidence of admission hypothermia in very low birth weight (VLBW) infants and to determine the association of admission temperature with in-hospital mortality and morbidities. Methods: A cohort study using prospectively collected data involving...
Developmental and Behavioral Medicine
Effect of omega-3 plus methylphenidate as an alternative therapy to reduce attention deficit-hyperactivity disorder in children
Soleiman Mohammadzadeh, Narmin Baghi, Fayegh Yousefi, Bahar Yousefzamani
Clin Exp Pediatr. 2019;62(9):360-366.   Published online May 20, 2019
Background: Attention deficit-hyperactivity disorder (ADHD) is one of the most common chronic behavioral disorders in school-aged children.
Purpose: This study aimed to evaluate the effect of omega-3 supplementation as an alternative therapy for ADHD, which can be caused by vitamin and mineral deficiencies. Methods: This was a double-blinded clinical trial study. Sixty-six children with ADHD (aged 6–12 years) referred to our child...
Review Article
Neonatology (Perinatology)
Bronchopulmonary dysplasia: how can we improve its outcomes?
Tae-Jung Sung
Clin Exp Pediatr. 2019;62(10):367-373.   Published online May 17, 2019
Bronchopulmonary dysplasia (BPD) is a chronic lung disease of preterm infants with multiple factors affected from prenatal to postnatal periods. Despite significant advances in neonatal care over almost 50 years, BPD rates have not decreased; in fact, they may have even increased. Since more preterm infants, even at periviable gestational age, survive today, different stages of lung development affect the...
Editorial
Allergy
Should partially hydrolyzed infant formula be given to the general infant population for the primary prevention of allergic disease?
Tae Won Song
Clin Exp Pediatr. 2019;62(9):340-341.   Published online May 17, 2019
Review Article
Cardiology
Understanding the importance of cerebrovascular involvement in Kawasaki disease
Jung Sook Yeom, Jae Young Cho, Hyang-Ok Woo
Clin Exp Pediatr. 2019;62(9):334-339.   Published online May 16, 2019
Kawasaki disease (KD) is a systemic vasculitis in infants and young children. However, its natural history has not been fully elucidated because the first case was reported in the late 1960s and patients who have recovered are just now entering middle age. Nevertheless, much evidence has raised concerns regarding the subclinical vascular changes that occur in post-KD patients. KD research...
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