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Review Article
Overseas adoption in Korea
Jae Yoon Kim
Clin Exp Pediatr. 2009;52(4):410-416.   Published online April 15, 2009
In Korea, overseas adoption has been practiced for more than 50 years. Initially, overseas adoption began with the objective to provide permanent homes for Korean war orphans, including mixed-blood children. From 1953 to 2007, about 160,000 Korean children were placed worldwide through overseas adoption and approximately 70,000 children were adopted in Korea. During that period, Korea developed into one of...
Case Report
A case of antiepileptic drug hypersensitivity syndrome by lamotrigine mimicking infectious mononucleosis and atypical Kawasaki disease
Su Jung Yoo, Ihl Sung Park, Eun Sook Suh
Clin Exp Pediatr. 2009;52(3):389-391.   Published online March 15, 2009
AHS는 항경련제에 의한 부작용으로 드물게 발생하지만 생명을 위협할 수 있는 지연형 면역반응이다. 보통 항경련제 복용 후 1-8주 사이에 고열, 피부발진, 림프절병증의 임상 증세를 나타내고, 혈액, 간, 신장, 또는 폐 등의 내부 장기를 침범한다. AHS는 항경련제에 의한 부작용으로 증상이 전신적으로 다양하게 나타날 수 있다. 그리고 전염성 단핵구증이나 가와사키병과 같은 전신적 질환들과도 유사한 임상증상들을 보이기 때문에 이런 질환들과 감별하는 것이 중요하고 사망률도...
Original Article
The usefulness of diagnostic tests in children with language delay
Seung Taek Oh, Eun Sil Lee, Han Ku Moon
Clin Exp Pediatr. 2009;52(3):289-294.   Published online March 15, 2009
Purpose : To assess the usefulness of magnetic resonance imaging (MRI), karyotyping, brainstem auditory evoked potential (BAEP), electroencephalogram (EEG), tandem mass screening test, and newborn metabolic screening test in children with language delay for diagnosing underlying diseases. Methods : From January 2000 to June 2007, a retrospective chart review was performed for 122 children with language delay who visited the...
Review Article
Antibiotics for bacterial pneumonia in children
Hye-yung Yum
Clin Exp Pediatr. 2009;52(3):283-288.   Published online March 15, 2009
Pneumonia remains the leading cause of mortality in children. Diagnosis depends on a combination of factors, including clinical assessment, radiological and laboratory findings. Although Streptococcus pneumoniae remains the most important cause of childhood bacterial pneumonia, the great majority of cases of community-acquired pneumonia (CAP) are of viral etiology. A new, rapid, and inexpensive test that differentiates viral from bacterial pneumonia...
Original Article
Low T3 syndrome in Kawasaki disease: Relation to serum levels of tumor necrosis factor-α, interleukin-6 and NT-proBNP
Hye Kyung Cho, Jin A Sohn, Hae Soon Kim, Sejung Sohn
Clin Exp Pediatr. 2009;52(2):234-241.   Published online February 15, 2009
Purpose : We investigated the relationship between thyroid hormone and serum tumor necrosis factor (TNF-α), interleukin (IL-6) and N-terminal fragment of pro-brain natriuretic peptide (NT-proBNP) in patients with Kawasaki disease (KD). Methods : Serum levels of thyroid hormone, TNF-α, IL-6, and NT-proBNP were measured in 52 KD patients in the acute and subacute phase and 10 patients with acute...
Clinical aspects of chronic urticaria in children
Hye Seon Kang, Mee Yong Shin
Clin Exp Pediatr. 2009;52(2):205-212.   Published online February 15, 2009
Purpose : Chronic urticaria is a disorder characterized by the appearance of wheals for more than 6 weeks; in most cases, the etiology is unknown. This study was aimed to discover the clinical aspects, the etiologic factors, and the course of chronic urticaria. Methods : 51 children who were diagnosed with chronic urticaria in the past 4 years, and who...
Case Report
Changes in N-terminal pro-B-type natriuretic peptide in a neonate with symptomatic isolated left ventricular noncompaction
Ji Hyeun Song, Yeo Hyang Kim, Chun Soo Kim, Sang Lak Lee, Tae Chan Kwon
Clin Exp Pediatr. 2009;52(1):129-132.   Published online January 15, 2009
We describe here our experience with a neonate presenting with cyanosis, grunting, and cardiomegaly, who was diagnosed with isolated left ventricular noncompaction (IVNC) by echocardiography. The patient had high levels of N-terminal pro-B-type natriuretic peptide (NT pro-BNP) and symptoms of heart failure including poor feeding and tachypnea. During the period in which NT pro-BNP levels steadily increased, the patient suffered...
Original Article
Usefulness of DTI-based three dimensional corticospinal tractography in children with hemiplegic cerebral palsy
Ji Hyun Yeo, Su Min Son, Eun Sil Lee, Han Ku Moon
Clin Exp Pediatr. 2009;52(1):99-104.   Published online January 15, 2009
Purpose : Magnetic resonance diffusion tensor imaging-based three-dimensional fiber tractography (DTI-FT) is a new method which demonstrates the orientation and integrity of white matter fibers in vivo. However, clinical application on children with cerebral palsy is still under investigation. We present various abnormal patterns of DTI-FT findings and accordance rate with clinical findings in children with hemiplegic cerebral palsy, to...
The relationship between catechol-O-methyltransferase gene polymorphism and coronary artery abnormality in Kawasaki disease
Hyo Jin Lee, Myung Sook Lee, Ji Sook Kim, Eun Ryoung Kim, Sung Wook Kang, Soo Kang Kim, Joo Ho Chun, Kyung Lim Yoon, Mi Young Han, Seong Ho Cha
Clin Exp Pediatr. 2009;52(1):87-92.   Published online January 15, 2009
Purpose : Many gene polymorphisms are associated with coronary artery abnormalities in Kawasaki disease. Catechol-O- methyltransferase (COMT) plays an important role in the metabolism of catecholamines, catechol estrogen, and catechol drugs. Polymorphisms of the COMT gene are reported to be associated with myocardial infarction and coronary artery abnormalities. The aim of this study was to evaluate the relationship between COMT...
Complex febrile convulsions: A clinical study
Jeong Sic Kang, Sa-Ra Kim, Dong Wook Kim, Tae Won Song, Nam Hee Kim, Jong Hee Hwang, Jin Soo Moon, Chong Guk Lee
Clin Exp Pediatr. 2009;52(1):81-86.   Published online January 15, 2009
Purpose : Febrile convulsions are classified into simple or complex types, the latter being characterized by increased risk of recurrence and progression to epilepsy. This study aimed to delineate the clinical characteristics of complex febrile convulsions. Methods : Between January 2003 and December 2006, 550 children were diagnosed with febrile convulsions at the Department of Pediatrics, Ilsan Paik Hospital. Their...
Case Report
A case of megalencephalic leukoencephalopathy with subcortical cysts
Eun Young Park, Young Ok Kim, Ji Youn Kim, Chae Young Yeo, Hee Jo Baek, Chan Jong Kim, Eun Young Kim, Young Jong Woo
Clin Exp Pediatr. 2008;51(12):1342-1345.   Published online December 15, 2008
Megalencephalic leukoencephalopathy with subcortical cysts (MLC) is a rare white matter disorder, first described in the early 1990s. The brain in patients with MLC appears swollen on MRI, with diffuse white matter abnormalities; in addition, there is an invariable presence of subcortical cysts, primarily in the anterior temporal region sparing the deep white matter, basal ganglia, thalami, and cerebellum. Patients...
Original Article
Distribution of CD4＋CD25＋ T cells and graft-versus-host disease in human hematopoietic stem cell transplantation
Dae Hyoung Lee, Nak Gyun Chung, Dae Chul Jeong, Bin Cho, Hack Ki Kim
Clin Exp Pediatr. 2008;51(12):1336-1341.   Published online December 15, 2008
Purpose : This study aimed to determine the frequencies of CD4＋CD25＋ T cells in donor graft and peripheral blood CD4＋CD25＋ T cells in recipients after hematopoietic stem cell transplantation (HSCT) and their association with graft-versus-host disease (GVHD). Methods : Seventeen children who underwent HSCT were investigated. CD4＋CD25＋ T cells in samples from donor grafts and recipient peripheral blood were assessed...
Intraosseous line insertion education effectiveness for pediatric and emergency medicine residents
Jung Woo Lee, Jun Seok Seo, Do Kyun Kim, Ji Sook Lee, Seonguk Kim, Jeong-Min Ryu, Young Ho Kwak
Clin Exp Pediatr. 2008;51(10):1058-1064.   Published online October 15, 2008
Purpose : This study aimed to assess current knowledge of and training experiences with the intraosseous (IO) line among emergency medicine (EM) and pediatric residents who care for critically ill children and to evaluate the educational effectiveness of the IO line workshop. Methods : During May and June 2008, a workshops on IO line insertion was held for EM and...
Case Report
A case of testicular adrenal rest tumor in a male child with congenital adrenal hyperplasia
Joo Hwa Kim, Kyong Ah Yun, Choong Ho Shin, Sei Won Yang
Clin Exp Pediatr. 2008;51(9):1018-1022.   Published online September 15, 2008
Testicular adrenal rest tumors are a well-known complication in male patients with congenital adrenal hyperplasia. Corticosteroid suppressive therapy usually results in the regression of these tumors. We describe a patient with 21-hydroxylase deficiency who developed bilateral testicular masses. Despite steroid suppressive therapy, the tumors did not regress and hormonal control was poor. Consequently, bilateral partial orchiectomies were performed.
Original Article
Detection of HHV6 and EBV in histiocytic necrotizing lymphadenitis
Kyung Hee Park, Sung Shik Park, Ji Yeon Kim, Su Eun Park
Clin Exp Pediatr. 2008;51(9):987-991.   Published online September 15, 2008
Kikuchi-Fujimoto disease (KFD), also known as histiocytic necrotizing lymphadenitis (HNL), is a self-limited disease characterized by cervical lymphadenopathy and fever. The etiology of KFD remains unknown; however, the self-limiting nature of HNL suggests the cause of this disease could be viral infection. For this reason, several viruses have been evaluated as possible etiologies of HNL, including Epstein-Barr virus (EBV), human...
Comparison of occurrence rate of the epileptiform discharge between awake EEG and sleep EEG in childhood epilepsy
Yu Jin Jung, Kyoung Ah Kwon, Sang Ook Nam
Clin Exp Pediatr. 2008;51(8):861-867.   Published online August 15, 2008
Purpose : We carried out this study to determine if there is any difference in the occurrence rate of the epileptiform discharge between awake EEG and sleep EEG and if there are any factors influencing on the occurrence rate of EEG. Methods : This study included 178 epileptic children who had visited neurology clinic of the department of pediatrics, Pusan National...
Reticulocyte hemoglobin content for the diagnosis of iron deficiency in young children with acute infection
Jon Soo Kim, Jun Seok Choi, Doo Young Choi, Chur Woo You
Clin Exp Pediatr. 2008;51(8):827-833.   Published online August 15, 2008
Purpose : Early identification of iron deficiency in young children is essential to prevent damaging long-term consequences. It is often difficult for the pediatrician to know which indices should be used when diagnosing these conditions especially in hospitalized young children. This study investigated the clinical significances of reticulocyte hemoglobin content in young children with acute infection. Methods : We studied...
Is routine screening examination necessary for detecting thromboembolism in childhood nephrotic syndrome?
Mun Sub Kim, Ja Wook Koo, Soung Hee Kim
Clin Exp Pediatr. 2008;51(7):736-741.   Published online July 15, 2008
Purpose : The incidence of thromboembolic episodes in children with nephrotic syndrome (NS) is low; however, these episodes are often severe. Moreover, both pulmonary thromboembolism (PTE) and renal vein thrombosis (RVT) rarely show clinical symptoms. This study was performed to determine the benefits of routine screening in the detection of thrombosis in childhood NS. Methods : Among 62 children with...
Clinical manifestations patterns of allergic disease in Korean children under the age of 6 : multi-center study
Dong Il Kim, Hyeon Jong Yang, Young Mean Park, Yeong Ho Rha, Ji Tai Choung, Bok Yang Pyun
Clin Exp Pediatr. 2008;51(6):640-645.   Published online June 15, 2008
Purpose : It is widely known that allergic diseases progress through an allergic march. However, there have not been any recent reports in Korea on how the diseases progress. Methods : Parents who visited one of the Pediatric Allergy Clinics of four university hospitals in Seoul with a child under the age of 6 years during the period from May...
Case Report
A case of midgut volvulus due to mesenteric lymphangioma, not associated with malrotation in a 13-year-old boy
Jung Ho Lee, Seok Ju Choi, Tae Yoon Kim, Young Tong Kim, Hyun Deuk Cho, Joon Soo Park
Clin Exp Pediatr. 2008;51(4):431-434.   Published online April 15, 2008
A 13-year-old boy, complained of an intermittent suddenly aggravated severe abdominal pain and diarrhea, was diagnosed as a small bowel volvulus without an intestinal malrotation, due to mesenteric lymphangioma. He took abdominal ultrasonography, abdominal CT scanning, upper gastrointestinal study and got an operation. The small bowel volvulus with cystic lymphangioma was confirmed by gross and pathologic findings.
Cytogenetic evaluation of a patient with ring chromosome 9 presenting failure to thrive and developmental delay
Yun Mi Park, Han Nae Nho, Sook Za Kim, Young Min Ahn
Clin Exp Pediatr. 2008;51(4):426-430.   Published online April 15, 2008
We report clinical, cytogenetic, and fluorescence in situ hybridization (FISH) studies of a patient with ring chromosome 9. She presented with failure to thrive, facial dysmorphysm and mild psychomotor development delay in the absence of major malformations. Peripheral blood karyotype of the patient was 46,XX,r(9)(p24q34). G-band analysis suggested no loss of material in the ring chromosomes. FISH analysis using the...
Original Article
Epidemic acute interstitial pneumonia in children occurred during the early 2006s
Chong Kun Cheon, Hyun-Seung Jin, Eun Kyeong Kang, Hyo Bin Kim, Byoung-Joo Kim, Jinho Yu, Seong Jong Park, Soo-Jong Hong, June Dong Park
Clin Exp Pediatr. 2008;51(4):383-390.   Published online April 15, 2008
Purpose : This study was aimed to analyze the clinical characteristics of patients with acute interstitial pneumonia who had presented similar clinical patterns from March to June, 2006 and to describe our experience of treatment and to identify risk factors associated with prognosis. Methods : The clinical characteristics, radiologic and histopathologic findings and response to steroids of 15 patients (non-survival...
Clinical characteristics and prognostic factors for survival in hemophagocytic lymphohistiocytosis
Khi Joo Kim, Ki Hwan Kim, Taek Jin Lee, Jin-Kyong Chun, Chuhl Joo Lyu, Dong Soo Kim
Clin Exp Pediatr. 2008;51(3):299-306.   Published online March 15, 2008
Purpose : Hemophagocytic lymphohistiocytosis (HLH) is a rare but fatal disorder characterized by fever, splenomegaly, pancytopenia, and hemophagocytosis in the bone marrow and other tissues. In this study, we investigated the clinical manifestations and prognostic factors in patients with HLH. Methods : We retrospectively analyzed the data from 29 patients who were diagnosed whit HLH in the Severance Children's Hospital from...
Therapeutic response of cyclosporine and outcome in steroid resistant nephrotic syndrome
Hyung Soon Choi, Joo Hoon Lee, Young Seo Park
Clin Exp Pediatr. 2008;51(3):293-298.   Published online March 15, 2008
Purpose : The aim of our study was to evaluate the therapeutic response to cyclosporine, time to remission and side effects in steroid resistant nephrotic syndrome (SRNS). Methods : This study included 22 children with idiopathic SRNS who were treated with cyclosporine between June 1989 and August 2006. Medical records were reviewed retrospectively. Results : The mean age of patients at diagnosis...
Neuroprotective effects of geneticin (G418) via apoptosis in perinatal hypoxic-ischemic brain injury
Mi Ju, Hyun Ju Lee, Sun Ju Lee, Eo Su Seo, Hye Jin Park, Kye Yang Lee, Gyeong Hoon Lee, Eun Jin Choi, Jin Kyung Kim, Jong Won Lee, Hai Lee Chung, Woo Taek Kim
Clin Exp Pediatr. 2008;51(2):170-180.   Published online February 15, 2008
Purpose : Some antibiotics were known to exert neuroprotective effects in the animal model of hypoxic-ischemic (H-I) brain injury, but the mechanism is still unclear. A recent study reported that geneticin (G418), an aminoglycoside antibiotic, increased survival of human breast cancer cells by suppressing apoptosis. We investigated the neuroprotective effects of systemically administrated geneticin via anti-apoptosis following the H-I brain...
Case Report
Pheochromocytoma associated with cyanotic congenital heart disease
Seung Joon Chung, Young Ah Lee, Choong Ho Shin, Sei Won Yang, Eun Jung Bae, Jung Il Noh
Clin Exp Pediatr. 2008;51(1):93-97.   Published online January 15, 2008
Pheochromocytoma is a rare tumor of childhood, arising from adrenal medullary and chromaffin tissue. Because chronic hypoxia may induce pheochromocytoma, there have been several reports of pheochromocytoma development in cyanotic patients after corrective or palliative cardiac surgery. The variable clinical presentation of pheochromocytoma is obscured by both underlying heart disease and medications. If sudden hypertension, aggravation of a heart condition,...
Original Article
Clinical significance of loss of p16 protein by immunohistochemical staining in acute lymphoblastic leukemia
Hye Young Jin, Kyoung In Kang, Sun Young Kim, You Sook Youn, Joon Won Kang, Deog Yeon Jo, Kye Chul Kwon, Kyung Duk Park
Clin Exp Pediatr. 2008;51(1):73-77.   Published online January 15, 2008
Purpose : p16 gene, mapped to the 9p21 chromosomal region, has emerged as a candidate tumor suppressor gene in human neoplasm. It is an inhibitor of cyclin-dependent kinase and inhibits Rb phosphorylation. In a variety of tumors including childhood acute lymphoblastic leukemia (ALL), deletion and/or mutation of the p16 gene has been found. Despite their high frequency, the prognostic importance...
Clinical outcomes of hematopoietic stem cell transplantation from HLA-matched parental donor in childhood acute leukemia
Eun Young Cha, Moon Hee Lee, Jae Wook Lee, Young Joo Kwon, Dae Hyoung Lee, Young-Shil Park, Nak Gyun Chung, Dae Chul Jeong, Bin Cho, Hack Ki Kim
Clin Exp Pediatr. 2008;51(1):67-72.   Published online January 15, 2008
Purpose : In this study, we retrospectively analyzed the clinical outcomes of patients who underwent allogeneic hematopoietic stem cell transplantation (HSCT) grafted from HLA-matched parents. Methods : Seven children with acute leukemia (4 acute lymphoblastic leukemia, 3 acute myeloid leukemia) in first complete remission received allogeneic HSCT from their respective parents at the St. Marys Hospital between April, 1999 and October,...
Usefulness of video-EEG monitoring in paroxysmal nonepileptic events of children and adolescents
Jee Yeon Lee, Hee Sun Lee, Wook Sun Choi, So Hee Eun, Ki Hyung Lee, Baik Lin Eun, Joo Won Lee
Clin Exp Pediatr. 2008;51(1):62-66.   Published online January 15, 2008
Purpose : This study was designed to clarify the mechanism of proteinuria in nephrotic syndrome patients by using puromycin aminonucleoside (PAN) nephrosis model. Methods : Following administration of various concentrations of PAN and antioxidants we observed the changes of podocyte cytoskeletons in cultured rat glomerular epithelial cells (GEpC) by method of scanning electron microscope, reactive oxyten species (ROS) analysis, permeability assay,...
Effects of puromycin aminonucleoside on the cytoskeletal changes of glomerular epithelial cells
Jun Ho Lee, Tae Sun Ha
Clin Exp Pediatr. 2008;51(1):54-61.   Published online January 15, 2008
of microvilli, but also separated the intercellular gaps and linear ZO-1. PAN induced oxidative stresses in time and dose dependent manners and increases of intercellular permeability in anti-oxidants inhibitable manners. High concentration of PAN induced not only actin polymerization and disorganization, but also the conglomerulation and internal dislocation of α-actinin protein. The intensities of fluorescences of ZO-1 protein were diminished...
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