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Congenital Heart Disease and Associated Extracardiac Anomalies in Autopsies
Soon Seong Park, Myeong Ja Yoon, Jeong Sun Kim, Jeong Wook Seo, Chung Il Noh, Jung Yun Choi, Yong Soo Yoon, Byung Il Kim, Joong Hwan Choi, Chong Ku Yoon
Clin Exp Pediatr. 1998;41(3):354-362.   Published online March 15, 1998
Purpose : In order to find out how frequently and what kind of extra-cardiac anomalies (CAs) is associated with congenital heart disease(CHD) in general and in each CAs, autopsies with congenital cardiovascular malformations were studied. Methods : Autopsy files of Seoul National University Children' s Hospital from 1991 to 1995 were reviewed to find cases of CHDs. Other extra-CAs were tabulated from the records...
Total Anomalous Pulmonary Venous Connection : The Results of 23 Consecutive Patients
Young-Hwue Kim, Jae-Kon Ko, In-Sook Park, Tae-Jin Yun, Dong-Man Seo, Chang-Yee Hong
Clin Exp Pediatr. 1998;41(3):346-353.   Published online March 15, 1998
Purpose : Surgical risk of total anomalous pulmonary venous connection(TAPVC) is high, especially in patients with early presentation resulting from pulmonary venous obstruction or with advanced pulmonary vascular obstructive disease(PVOD). We reviewed our experience of primary correction of TAPVC and examined the surgical outcome and risk factors. Methods : From June 1991 to Sept. 1996, 23 neonates or infants who were...
Normal Predicted Values of Pulmonary Function Test in Healthy Korean Children
Seung Yeon Nam, Kyung Hyo Kim, Young Mi Hong, Gyoung Hee Kim
Clin Exp Pediatr. 1998;41(3):338-345.   Published online March 15, 1998
Purpose : We performed a pulmonary function test with simple, computerized spirometry composed of pneumotachometry and evaluated the predicted normal values of air flow rates and lung volumes in healthy Korean children. We calculated each of the simple and complex linear and logarithmic regression equations setting the predicted values. Methods : Four hundred and fifty-two healthy children were enrolled from December, 1994 to August, 1995....
The Treatment of Croup with Nebulized Budesonide and Intramuscular Dexamethasone
Jung Woo Lee, Young Ho Rah, Chong-Woo Bae, Sa Jun Chung, Yong Mook Choi
Clin Exp Pediatr. 1998;41(3):331-337.   Published online March 15, 1998
Purpose : Steroids have anti-inflammatory effects which reduces inflammation and edema of the tissue. Thus, corticosteroids have been used for treatment of croup. The aim this study is to compare and assess the effects of intramuscularly injected dexamethasone and nebulized budesonide in treatment of moderate or severe croup. Methods : Between July 1995 to June 1996, we have assessed 44 inpatients...
Therapeutic Efficacy of Dual Therapy and Triple Therapy for Helicobacter pylori Infection in Children
Sun-Hwan Bae, Jae-Sung Koh, Jeong-Kee Seo
Clin Exp Pediatr. 1998;41(3):323-330.   Published online March 15, 1998
Purpose : An optimal treatment for Helicobacter pylori (H. pylori ) infection in children has not yet been established. In this study, the efficacy and the tolerability of triple therapy with colloidal bismuth subcitrate(CBS), amoxicillin and metronidazole, were evaluated in comparison with dual therapy with CBS and amoxicllin. Methods : Eighty-six children with H. pylori infection, aged 6 years to 14...
Clinical Change of Mycoplasma Pneumonia
Jae Bum Lee, Kyong Tae Whang, Jeong Hyun Kim, Kyong Og Ko, Ji Hee Cho, Yun Duk Yoo
Clin Exp Pediatr. 1998;41(3):315-322.   Published online March 15, 1998
Purpose : It was noted some changes of clinical manifestations of mycoplasma pneumonia. we reviewed and compared these changes and saught any clues causes for proper dignosis and treatment. Methods : We divided patients with mycoplasma pneumonia into two groups, Group 1(from Jan. to Dec. 1996) and Group 2(from Jan. to Dec. 1994), and analyzed clinical, radiologic, and serologic differences. Results :...
A Survey on the Attitudes toward Premature Infants
Oh Hyuk Kwon, Son Moon Shin
Clin Exp Pediatr. 1998;41(3):307-314.   Published online March 15, 1998
Purpose : We studied the attitudes of general population and medical personnels toward premature infants to establish basic data about prematurity. Methods : Ten students from Yeungnam University College of Medicine conducted field surveys on the general population at residential and commercial districts, and on medical personnels at private local clinics and hospitals in Taegu with a prepared questionaire from July...
The Efficacy of Fetal Ultrasonography and Postnatal Abdominal Ultrasonography for the Diagnosis of Neonatal Abdominal Mass
Hee Eun Lee, Ee Kyung Kim, Hee Seok Kim, Yun Kyoung Lee, Chan Hwu Park, Kyung Ran Park, June Dong Park, Beyong Il Kim, Woong Heum Kim, Jung Hwan Choi, Gui Won Park, Hwang Choi, Yong Choi, Chong Ku Yun
Clin Exp Pediatr. 1998;41(3):299-306.   Published online March 15, 1998
Purpose : Most neonatal abdominal masses are benign in nature, but early detection and management is important to avoid the development of complications. So, we studied the causes of neonatal abdominal masses and the efficacy of ultrasonography for early detection and diagnosis. Methods : We reviewed 36 newborn infants with abdominal masses who had been admitted to the nursery and Neonatal...
The Effect of Acanthopanax koreanum Extract on the Induction of Collagen Induced Arthritis for DBA/1J Mice
Dong Soo Kim, Chang Ho Song, Soo Kon Lee
Clin Exp Pediatr. 1998;41(2):247-254.   Published online February 15, 1998
Purpose : It is well known that the Acanthopanax koreanum extract has an anti-inflammatory action without any adverse effects reported. We conducted this study to see whether the Acanthopanax koreanum extract has a preventive effect on the development of collagen induced arthritis in DBA/1J mice. Methods : Three groups of BDA/1J mice were immunized by intradermal injection of 2mg/kg bovine type...
The Diagnostic Significance of MCV, MCH, and RDW in Anemia of Kawasaki Disease
Ji Eun Lee, Yoon Hyung Park, Seung Baik Han, Soon Ki Kim, Sei Woo Chung, Jeung Gyu Kim, Byong Kwan Son
Clin Exp Pediatr. 1998;41(2):230-236.   Published online February 15, 1998
Purpose : We investigated what kind of factors are the most stable among hemoglobin(Hb), hematocrit(Hct), MCV, MCH and RDW as a marker of discriminating anemia due to an acute inflammation from anemia of different origins. Methods : We evaluated 141 patients with Kawasaki disease who had been admitted to the Department of Pediatrics, Inha hospital from 1990 to 1995. We...
Etiological Analysis of Gynecomastia in Children
Jai Keun Kim, Ki Keun Oh, Choon Sik Yoon, Jae Hyun Park
Clin Exp Pediatr. 1998;41(2):224-229.   Published online February 15, 1998
Purpose : The purpose of this study is to analyze the etiology of gynecomastia confirmed by breast operation among children under the age of 15 exhibiting clinical symptoms. Methods : Twenty patients under the age of 15 were diagnosed as having gynecomastia in the past 10 years. The number of pathologically confirmed gynecomastia patients was 15. The causes or related...
High Dose of Amphotericin B in Intralipid Emulsion-based Delivery System in Immunocompromised Children with Invasive Fungal Infections
Geun Mo Kim, Hoon Kook, Sung Ho Cho, Ji Yong Park, Young Jong Woo, Tai Ju Hwang
Clin Exp Pediatr. 1998;41(2):216-223.   Published online February 15, 1998
Purpose : Fungal infections are an important cause of morbidity and mortality in patients with hematologic malignancies. The therapy of choice in documented or suspected invasive fungal infections has been intravenous Amphotericin B(AmB). Adverse effects such as fever, chills, thrombophlebitis, nausea or vomiting are common. A more serious adverse effect is potential renal impairment. As AmB administration mixed with Intralipid(AmB/Intralipid)...
Induction Chemotherapy with BH-AC, Idarubicin, and 6-Thioguanine in Childhood Acute Myelogenous Leukemia
Hyo Jeong Han, Hyoung Jin Kang, Jun Ah Lee, Hyoung Soo Choi, Hyeon Jin Park, Ki Woong Seong, Eun Sun Yoo, Hee Young Shin, Hyo Seop Ahn
Clin Exp Pediatr. 1998;41(2):209-215.   Published online February 15, 1998
Purpose : We have undertaken this study to evaluate the effects of induction chemotherapy involving BH-AC, idarubicin, and 6-thioguanine(6-TG). Methods : BH-AC 300mg/m2/day was administered intravenously over three hours for seven consecutive days. Idarubicin 12mg/m2/day was administered intravenously for three days. 6-TG 100 mg/m2/day was administered orally for seven days. Intrathecal ara-C was administered on the first day of treatment. Results...
Serum Pepsinogen Ⅰ, Ⅱ Levels and Upper Gastrointestinal Diseases in Children with H. pylori Infection
Je Woo Kim, Ki Sup Chung
Clin Exp Pediatr. 1998;41(2):200-208.   Published online February 15, 1998
Purpose : In H. pylori infection serum pepsinogen Ⅰ/Ⅱ ratio decreases and pepsinogen Ⅱ level is increased. Increased serum pepsinogen Ⅱ level correlates with pathologic severity of gastritis. We assayed serum pepsinogen Ⅰ, Ⅱ levels and pepsinogen Ⅰ/Ⅱ ratio to evaluate the relationship between the serum pepsinogen level and upper gastrointestinal diseases. Methods : One hundred and sixty-five children who had...
Left Ventricular Mass Estimated by Three Methods of Echocardiography in Normal Children
Yae Jean Kim, Soo Ja Hwang, Dong Hee Shin, Young Mi Hong
Clin Exp Pediatr. 1998;41(2):192-199.   Published online February 15, 1998
Purpose : Left ventricular hypertrophy is an important diagnostic and prognostic finding in children with various cardiovascular diseases. Echocardiographic determination of the left ventricular mass is the most accurate method for assessing left ventricular hypertrophy non-invasively. The purposes of this study are 1) to establish a reproducible, validated method for determining left ventricular mass in children by echocardiography, 2) to...
Treatment of Supraventricular Tachycardia by Catheter Ablation Using Radiofrequency Currents in Children and Adolescents
Sung Jae Lee, Mi Jin Jung, Dieter Gonska
Clin Exp Pediatr. 1998;41(2):186-191.   Published online February 15, 1998
Purpose : Catheter ablation using radiofrequency currents have been proven to be an effective and safe tool for the treatment of adult patients with accessory atrioventricular pathways. This study was designed to analyze the efficacy of this method in childern and adolescents. Methods : Using radiofrequency currents, cathether ablation of an accessory pathway was performed in 54 patients(mean age 11.8 years)...
Efficacy of Mycoplasma Antibody Test and Cold Agglutinin Test in the Diagnosis of Mycoplasma Pneumonia in Children
Jung Ae Son, Weon Par, Dong Jin Lee
Clin Exp Pediatr. 1998;41(2):179-185.   Published online February 15, 1998
Purpose : This study was done to compare the diagnostic value of the Mycoplasma antibody (M- Ab) test and the cold agglutinin(CA) test from the onset of Mycoplasma pneumoniae pneumonia to its diagnosis in children. Methods : We analyzed 48 cases of M. pneumoniae pneumonia in children who were admitted to the Pediatric Department of Ulsan Dongkang General Hospital for 1...
Humoral and Cell Mediated Immune Response After Immunization with Varicella Vaccine(Oka/LG)
Young Mo Sohn, Hye Ok Roh, Mi Lim Goo, Bok Ryeon Park, Joo Hong Park, Gook Jin Lim
Clin Exp Pediatr. 1998;41(2):170-178.   Published online February 15, 1998
Purpose : We evaluated the humoral and cellular immune response to varicella-zoster virus after vaccination with varicella vaccine(Oka/LG strain). Methods : The seroprevalence rate of fluorescent antibody to membrane antigen(FAMA) was evaluated among 178 children and 15 adults. After vaccination, seroconversion rate of FAMA, varicella-zoster virus(VZV) specific IgG and cell mediated immune response to glycoprotein Ⅰwas performed. Results : The seropositive rate...
Congenital Asymptomatic Cytomegalovirus Infection; A Comparison of Specific IgM Antibody Test and pp65 Antigenemia Assay
Jong Hyun Kim, Eun Ah Seo, Ji Hyang Lim, Sang Hee Park, Won Bae Lee, Kyong Su Lee, Sin Ho Jung
Clin Exp Pediatr. 1998;41(2):163-169.   Published online February 15, 1998
Purpose : It is increasingly important to diagnosis asymptomatic infections which make up a majority(90%) of congenital cytomegalovirus(CMV) infections and that they may have sequeles such as sensorineural hearing loss and mental retardation. Recently antigenemia assay has been developed by using monoclonal antibodies against early structural protein pp65 of CMV. This CMV antigenemia assay seems to be more quicker to...
Developmental mRNA Expression of Cellular Retinoic Acid Binding Protein I and Ⅱ in Rat
Young Yoo, Hyung Suk Kim, Chang Sung Son, Young Chang Tockgo, Young Hyuk Jeon
Clin Exp Pediatr. 1998;41(2):154-162.   Published online February 15, 1998
Purpose : Retinoic acid(RA) is well known as a potent teratogenic agent in both deficiency and excess. Cellular retinoic acid binding proteins(CRABPs) are involved in RA. We carried this study in order to determine the possible relations of CRABPs with RA-induced teratogenesis through observation of the expression patterns of CRABP Ⅰand Ⅱ in developing rats. Methods : 35S-labeled RNA probes were...
A Study of Homocysteine Metabolism related Neural Tube Defect
Baeck Hee Lee
Clin Exp Pediatr. 1998;41(1):110-114.   Published online January 15, 1998
Purpose : Methylenetetrahydrofolate reductase is an important enzyme in homocysteine metabolism. Since the identification of the gene locus and mutation of methylenetetrahydrofolate reductase, an increasing number of reports have suggested that elevated levels of homocysteine were associated with various kinds of arteriovascular disease and neural tube defect. Our research plans to investigate whether elevated levels of homocysteine are more common with neural tube defect and...
Basophil Histamine Releasability in Asthmatic Children
Seon Mi Jin, Jin Hwa Jung, Yong Han Sun, Myung Hyun Lee, Joong Gon Kim, Young Yull Koh
Clin Exp Pediatr. 1998;41(1):99-109.   Published online January 15, 1998
Purpose : The release of histamine from human basophils is controlled by an intrinsic, as yet unidentified, cellular property termed “releasability.” We carried out this study to ascertain whether there was any difference in the releasability of basophils from asthmatic children compared to those from normal children. We intended also to clarify the correlation between the releasability and the atopic status of asthma. Methods :...
The Relationships of Pretreatment IGF-I SDS, Delay in Bone Age and Response to Recombinant Human Growth Hormone(rhGH) Therapy in Children with Growth Hormone Deficiency
Seon-Young You, Ki-Joong Kim, Jeh-Hoon Shin, Jin-Nyoung Park, Hee-Jeong Ahn, Yong-Joo Kim
Clin Exp Pediatr. 1998;41(1):90-98.   Published online January 15, 1998
Purpose : To assess whether pretreatment IGF-I SDS and pretreatmental bone age are useful indicators in the response of rhGH therapy in children with GH deficiency(GHD), the relationship between pretreatment IGF-I SDS, delay in bone age and the growth response during the first year of rhGH treatment was analyzed. Methods : This study included 12 children with GHD. We measured IGF-I levels by RIA...
Causes of Syncope in Children
Jae Young Lee, Chung Il Noh, Eun Jung Chun, Sun Sung Park, Myung Ja Yun, Hong Ryang Gil, Ho Sung Kim, Jung Yun Choi, Yong Su Yun
Clin Exp Pediatr. 1998;41(1):81-89.   Published online January 15, 1998
Purpose : Syncope is not rare and is caused by various conditions ranging from common physiologic derangements to life-threatening conditions. However, there are limited reports regarding syncope in children. We retrospectively analyzed our experiences of the syncope in children. Methods : Retrospective analysis of the medical records of patients with syncopal episodes between October 1985 and June 1996. Results : Sixty-eight patients(male; 36, female; 32,...
Clinical Study and Diagnostic Value of the Lung Perfusion Scan in Foreign Body Aspiration
Gyo-Dang Koo, Young-Ho Rah, Chong-Woo Bae, Sa-Jun Chung, Yong-Mook Choi
Clin Exp Pediatr. 1998;41(1):74-80.   Published online January 15, 1998
Purpose : Early diagnosis of foreign body aspiration and removal of the inhaled material may save the patient from chronic illness and may prevent serious complications. At present the diagnostic problems of bronchial foreign bodies are being solved by using the lung scanning technique. Therefore, we investigated the clinical study and diagnositic value of the lung perfusion scan in foreign body aspiration. Methods : Eighteen...
A Clinical Study on the Etiology and the Characteristics of Pleural Effusion in Children
Jin Hwa Jeong, Song Yi Rah, Yong Han Sun, Myung Hyun Lee, Young Yull Koh
Clin Exp Pediatr. 1998;41(1):62-73.   Published online January 15, 1998
Purpose : Many different conditions result in pleural effusions(PEs) and making the differential diagnosis of PE is difficult. The purpose of the present study was to document the change of incidence and compare the etiologies of PEs with regards to age, the sidedness and characteristics of PE. Methods : During the 10-year period from 1986 to 1995, thoracentesis was performed in 197 children with PEs...
Seroepidemiology of Hepatitis A in Taejon, Korea 1996
Kyung-Yil Lee, Ki-Hun Song, Jin-Han Kang
Clin Exp Pediatr. 1998;41(1):53-61.   Published online January 15, 1998
Purpose : We experienced an outbreak of hepatitis A in Taejon, Korea for the summer of 1996. Recently a shift in hepatitis A incidence from children to adults has been well noted in Korea. For the purpose of possible measures in preventing hepatitis A, we studied a seroepidemiology of hepatitis A in Taejon. Methods : We measured IgG anti-HAV antibody(HAVAB MEIA, Abbott) from 722...
Mumps and Rubella-Specific IgG Levels of Term Pregnant W omen and Their Neonates
Young Kyoo Shin, Hae Won Cheon, Kee Hyoung Lee, Ji Tae Choung, Young Chang Tockgo
Clin Exp Pediatr. 1998;41(1):47-52.   Published online January 15, 1998
Purpose : This study was performed to evaluate seropositivities in term pregnant women and their neonates, and the transplacental transfer rate of maternal mumps and rubella- specific IgG from term pregnant women to their neonates. Methods : During Jun. 1, 1994 to Mar. 31. 1995, we collected 44 pairs of sera from pregnant women and their neonates in Anam Hospital of Korea University Medical...
Clinical Studies of Aseptic Meningitis in Pusan Area in 1996
Ji Yeon Hur, Tag Soo Kim, Woo Je Cho, Sung Won Kim
Clin Exp Pediatr. 1998;41(1):38-46.   Published online January 15, 1998
Purpose : We report clinical features and viral studies on 153 children with aseptic meningitis in the Pusan area in 1996 and compare the results of this study with those of other reports in 1990 and 1993. Methods : One hundred fiffy-three children with aseptic meningitis who have been admitted to the Department of Pediatrics, St. Benedict Hospital between July and October 1996 were...
Diurnal Variation in Serum Bilirubin Concentration of Normal Newborn Infant
Cheol Am Kim, Jin Geong Jeong, Eui Tak Oh, Hong Ja Gang, Gil Seu Kim
Clin Exp Pediatr. 1998;41(1):33-37.   Published online January 15, 1998
Purpose : We investigated whether there are independent intradaily changes in bilirubin levels in normal neonates. Methods : During the period of January 1996 till July 1996, 100 healthy newborn infants were studied for at least 3 consecutive days. Starting from the third day of life, consistent intradaily changes of bilirubin concentration were observed. And obstetric history, birth history, weight change at 3 days were...
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