Journal of the Korean Pediatric Society 1998;41(2):230-236.
Published online February 15, 1998.
The Diagnostic Significance of MCV, MCH, and RDW in Anemia of Kawasaki Disease
Ji Eun Lee, Yoon Hyung Park, Seung Baik Han, Soon Ki Kim, Sei Woo Chung, Jeung Gyu Kim, Byong Kwan Son
Department of Pediatrics, Inha Hospital, College of Medicine, Inha University, Seongnam, Korea
가와사키 질환의 빈혈에서 MCV, MCH, RDW의 진단적 의의
이지은, 박윤형, 한승백, 김순기, 정세우, 김정규, 손병관
인하대학교 의과대학 소아과학교실
Correspondence: 
Ji Eun Lee, Email: 1
Abstract
Purpose
: We investigated what kind of factors are the most stable among hemoglobin(Hb), hematocrit(Hct), MCV, MCH and RDW as a marker of discriminating anemia due to an acute inflammation from anemia of different origins.
Methods
: We evaluated 141 patients with Kawasaki disease who had been admitted to the Department of Pediatrics, Inha hospital from 1990 to 1995. We analyzed their blood four times each week.
Results
: Of the patients, 132 cases(93.6%) were less than 5 years of age and the median age was 2 years 3 months. After one week of hospitalization, Hb dropped a mean of 0.6g/dl compared to when first admitted. After three weeks of hospitalization, Hb increased a mean of 1.1g/dl compared to when first admitted. Coefficient of variation(CV) mean was Hct> Hb> RDW> MCH> MCV. The CV mean of Hb, Hct, MCV, MCH and RDW showed a significant difference (P=0.0001). In groups, there was an insignificant difference between Hb and Hct, there was a significant difference among the Hb-Hct group and MCV, MCH and RDW. Except for MCV, every RBC indices were changed in accordance with the measured time. But only MCV was relatively unchanged as time went by(P<0.5).
Conclusion
: Our finding indicate that MCV, MCH and RDW can be used as a useful marker for discriminating temporary anemia of acute inflammation from the other anemia of different origins, because MCV, MCH and RDW showed little change in measured values in comparison with the change of Hb and Hct in Kawasaki disease. The MCV is an useful factor among factors.
Key Words: Anemia, Kawasaki disease, MCV, MCH, RDW


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