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Original Article
A Clinico-pathologic Study of Childhood Lupus Nephritis
Youn-Sook Rho, Sung-Hoo Cha, Byoung-Soo Cho
Clin Exp Pediatr. 2000;43(2):236-240.   Published online February 15, 2000
Purpose : Systemic lupus erythematosus(SLE) is a disease of immunologic origin, affecting multiple organs including joints, skin, kidneys, nervous system, heart and blood, with rare involvement of gut and liver. The incidence of renal disease in children with SLE was approximately 70 percent and tended to be more severe than in adults. Accordingly we have retrospectively studied on the prognostic...
Long-term Clinical Study of Total Anomalous Pulmonary Venous Return
Jin Young Song, Yong Soo Yoon
Clin Exp Pediatr. 2000;43(2):229-235.   Published online February 15, 2000
Purpose : Total anomalous pulmonary venous return is a rare congenital heart disease, which is fatal if untreated, especially, if the obstruction in pulmonary venous return is obstructed. With the technical development of echocardiogram, we are now able to do an early diagnosis if TAPVR and perform surgery. Accordingly, this report was aimed to evaluate patients with TAPVR as well...
A Clinical Study of Intravenous Gamma Globulin Re-treatment in Kawasaki Disease
Na Yeon Kim, Chun Hyuk Chang, Dong Seok Lee, Doo Kwun Kim, Sung Min Choi, Woo Taek Kim
Clin Exp Pediatr. 2000;43(2):223-228.   Published online February 15, 2000
Purpose : Intravenous gamma globulin(IVGG) treatment has reduced symptoms and complications in Kawasaki disease(KD). However, fever persisted in 20-30% of the patients, and there are no reliable data on the indication and dosage of IVGG re-treatment. Therefore, we tried to reveal the effectiveness of IVGG re-treatment and to find risk factors in predicting the re-treatment. Methods : Among 57 patients with...
Lipid Profile Changes in Kawasaki Disease Patients
Ye-Jhin Lee, Young-Seok Lee, Myung-Chul Hyun, Sang-Bum Lee
Clin Exp Pediatr. 2000;43(2):216-222.   Published online February 15, 2000
Purpose : Abnormality in the composition of lipid metabolism is well known to be a main cause of atherosclerosis. Accordingly the abnormality in lipid metabolism after suffering from Kawasaki disease may lead to premature coronary atherosclerosis. The aim of this study is to investigate the abnormalities of lipid metabolism in patients with Kawasaki disease. We studied 67 patients with Kawasaki...
Treatment of Tachycardia by Radiofrequency Catheter Ablation in Children and Adolescents
Sung Jae Lee, Mi Jin Jung, Sung Ho Kim, Walter C. Schueller, Gil Hyun Kim, Hak Soo Lee
Clin Exp Pediatr. 2000;43(2):210-215.   Published online February 15, 2000
Purpose : RFCA has been proven to be an effective and safe tool for treating different kinds of tachycardia in adults. This study was designed to analyze the efficacy of this method in children and adolescents. Methods : Seventy-eight patients referred to Gachon Medical School, Gil Hospital for ablation of supraventricular(SVT) and ventricular tachycardia(VT) between January 1997 and February 1999 were...
Short-term Result of Radiofrequency Catheter Ablation in Pediatric Patients with Paroxysmal Tachycardia
Hee Suk Jang, Hee Jung Cho, Myung Chul Hyun, Sang Bum Lee, Young Keun Cho, Chang Ho Han
Clin Exp Pediatr. 2000;43(2):203-209.   Published online February 15, 2000
Purpose : To find out the efficacy, safety and early complication of radiofrequency catheter ablation(RFCA) in pediatric patients with paroxysmal tachycardia, we compared short-term results of RFCA in pediatric patients to adult patients. Methods : We studied 25 patients(11 pediatric patients, 14 adult patients), who underwent RFCA due to paroxysmal supraventricular tachycardia(PSVT) or idiopathic ventricular tachycardia(VT) from November 1997 to August...
A Clinical Study of Adenoviral Respiratory Infection in Children
Hong Keun Kim, Se Chang Ham, Seung Yeon Nam, Young Jae Koh, Kang Mo Ahn, Sang Il Lee
Clin Exp Pediatr. 2000;43(2):195-202.   Published online February 15, 2000
Purpose : Adenoviral respiratory infection can develop a life threatening condition similar to severe bacterial pneumonia. Despite adequate intensive care, this infection progresses to acute respiratory distress syndrome and causes permanent lung damage in some patients. In this study, we analyzed clinical features and long-term follow-up clinical data of this infection in children. Methods : Forty-seven cases of inpatients were diagnosed...
Effects of Cisapride on QTc Interval and QT Dispersion in Preterm Infants
Heui Seung Jo, Chang Won Choi, Yun Kyung Lee, Hee Seok Kim, Jun Dong Park, Jun Huh, Beyong Il Kim, Chung Il Noh, Jung-Hwan Choi
Clin Exp Pediatr. 2000;43(2):188-194.   Published online February 15, 2000
Purpose : Cisapride, a prokinetic agent, is widely used in preterm infants with feeding intolerance or gastroesophageal reflux. Although cisapride is regarded as a safe drug, increased QTc interval or ventricular arrhythmia has been reported in adults and neonates. So we prospectively examined the effects of cisapride on the QTc interval and QT dispersion in preterm infants. Methods : QTc interval...
Construction and Application of Painting probe for Chromosome band 5q14-q15, 6q23, 16p11.2 and 22q12
Soo-Yeun Park, So Young Park, Joon-Il Kil, Yong-Hyuck Chun, Sun-Hwa Park
Clin Exp Pediatr. 2000;43(2):179-187.   Published online February 15, 2000
Purpose : Chromosome microdissection has become a very powerful approach to generate chromosome band-specific library and painting probes for physical mapping or cytogenetic analysis. We have constructed here band-specific painting probes for human chromosomes by microdissection and polymerase chain reaction(PCR). Methods : We pretreated the microdissected fragments with Topoisomerase I(Topo I) which catalyzes the relaxation of supercoiled DNA, and performed...
Adolescent Depression in a Provincial City
Ki Young Ryoo, Young Kyu Shin, Baik Lin Eun, Sang Hee Park, Young Chang Tocko
Clin Exp Pediatr. 2000;43(2):172-178.   Published online February 15, 2000
Purpose : Most studies of depression in adolescents, have been conducted in western countries. Accordingly, we took a survey in the city of Ansan to discover the actual state of depression in adolescents and found a solution. Methods : Twelve questions of modified diagnostic criteria for DSM-Ⅳ(Diagonstic and Statistical Mannual of Mental Disorders, 4th ed.) major depressive disorder were filled out...
The Apoptosis and Expression of Bcl-2, Bcl-xS, Bax Proteins in Fetal Brain after Treating Pregnant Mice with Endotoxin
Sung Min Cho, Seung Sook Kim, Young Seung Hwang
Clin Exp Pediatr. 2000;43(1):97-104.   Published online January 15, 2000
Purpose : Apoptosis is active cell death which plays an important role in developing normal tissues. Various conditions such as genetic defects, drugs, ischemia or infections are known to induce apoptosis. We studied the effect of maternal infection on fetal brain development during pregnancy. Methods : We treated 46 C3H pregnant mice with lipopolysaccharide(LPS) or phosphat-buffered saline and observed the changes in apoptosis and...
Apoptosis, P53, bax and Bcl-2 Protein Expressions in Neonatal rat Hippocampus by Kainic Acid-induced Seizure
Shin Weon Yun, Soo Ahn Chae, Eung sang Choi, Byoung Hoon Yoo
Clin Exp Pediatr. 2000;43(1):85-96.   Published online January 15, 2000
Purpose : Apoptosis is a process of active cell death which has been suggested to be part of hippocampal cell loss caused by kainic acid(KA). Immature rats showed higher susceptibility and mortality to KA but did not develop recurrent seizure, long term behavioral or neuropathologic changes. We investigated whether this was due to age-dependent resistance, and elucidated the molecular mechanics which mediate P53-induced apoptosis,...
Predicting of Aneurysm with Learning Vector Quantization in Patients with Kawasaki Disease
Jae Hyun Kwon, Myung Kul Yum, Nam Su Kim
Clin Exp Pediatr. 2000;43(1):78-84.   Published online January 15, 2000
Purpose : We applied Learning Vector Quantization(LVQ) in the analysis of data from Kawasaki disease patients with coronary artery aneurysm in an attempt to achieve accurate predictions of outcome for individual patients. Methods : One hundred and seventy-five patients with Kawasaki disease were recruited. First, data of 75 patients(of which 60 patients had no aneurysm and 15 patients had aneurysm) were trained using the network....
A Clinical Study of Atypical Kawasaki Disease - A Rate of Coronary Artery Involvement -
Jin-Sook Kim, Young-Yoo Kim, Jong-Wan Kim, Won-Bae Lee, Jin-Han Kang, Kyung-Tai Whang
Clin Exp Pediatr. 2000;43(1):70-77.   Published online January 15, 2000
Purpose : Without a specific diagnostic method, the clinical diagnostic criteria for atypical Kawasaki disease is known as the presence of coronary artery changes in a patient who did not meet the already estabilished clinical criteria. With this criteria, we are put into dilemma because atypical Kawasaki disease should exhibit coronary artery disease. So, we demonstrated the rate of coronary artery involvement in atypical...
A Catalogue of Gene Expression Difference in Biliary Cirrhosis due to Biliary Atresia Using Differential Expressed Sequence Tags(EST) Screening
Byung-Ho Choe, Hyun-Mi Lee, Moon-Kyu Kim, Jung-Chul Kim
Clin Exp Pediatr. 2000;43(1):60-69.   Published online January 15, 2000
Purpose : Extrahepatic biliary atresia is the most common indication for liver transplantation in children, but the etiology of this disorders remains unknown. It would be very signficant to identify genes that are specifically expressed in pathologic liver tissue of biliary atresia and analyze the pattern of expression in those genes. Methods : We made dot blot panels consisting of 1,730 different EST(expressed sequence...
Diagnostic Value of Urine Latex Test In Bacterial Meningitis
Seung Min Lee, Eun Ae Park, Seung Joo Lee
Clin Exp Pediatr. 2000;43(1):55-59.   Published online January 15, 2000
Purpose : Bacterial meningitis in childhood carries significant mortality and morbidity, so accurate and rapid diagnosis is important. Cerebrospinal fluid(CSF) latex agglutination test has been used for rapid diagnosis of bacterial meningitis. However, urine may be the best specimen for a latex test, because bacterial antigens are concentrated in the urine. The study tried to determine the diagnostic value of urine latex test in...
The Annual and Seasonal Changes in the Prevalence of Rotaviral Infection from; 1993 to 1998
Young Joo Son, Hong Sun Park, Soon Lee Jung, Mira Park, Kyuchul Choeh
Clin Exp Pediatr. 2000;43(1):49-54.   Published online January 15, 2000
Purpose : Rotavirus infection is a leading cause of severe gastroenteritis among infants and young children worldwide. In temperate regions, institutional outbreaks of the disease occur mainly in cold dry weather, whereas in tropical settings its seasonal course is less well defined. We studied the annual changes in the seasonal prevalence of rotavirus infection for 5 years. Methods : The study was conducted on...
Clinical and Molecular-epidemiologic Analysis of A Nosocomial Outbreak of Acinetobacter baumannii in a Neonatal Intensive Care Unit
Hye Kyung Lee, Han Jin Kim, Young Chang Kim, Sung Ran Cho, Hwi Jun Kim, Wee Gyo Lee
Clin Exp Pediatr. 2000;43(1):43-48.   Published online January 15, 2000
Purpose : Acinetobacter species are aerobic gram-negative rods that can be widely found in nature and are a part of the normal flora of humans. The most clinical isolates of A. baumannii reflect infection rather than colonization. Recent reports suggest that the organisms cause serious and often fetal nosocomial infection such as ventilator-associated pneumonia. Methods : From March to September 1998, we experienced thirty...
The Effect of Erythromycin on Gastric Antrum and Low Esophageal Sphincter in the Newborn Rabbit
Sung Dong Choi, Chung Sik Chun
Clin Exp Pediatr. 2000;43(1):34-42.   Published online January 15, 2000
Purpose : We studied smooth muscle strips from rabbit gastric antrum and low esophageal sphincter(LES) to explore the difference between newborn and adult rabbit on erythromycin(EM)- induced contractions. Another aim of this study was to determine the mechanism of LES contractile activities induced by erythromycin(EM). Methods : Muscle strips prepared from newborn and adult rabbits were stimulated with agonists such as KCl, motilin and EM,...
The Prognosis and Factors of Neonatal Thyroid Dysfunction
Yun Yee Kim, Kyoung Sim Kim, Yong Wook Kim, Ki Bok Kim
Clin Exp Pediatr. 2000;43(1):23-33.   Published online January 15, 2000
Purpose : The function of the neonatal thyroid is affected transiently or consistently by various maternal thyroid diseases, neonatal diseases, drugs, and more as well as thyroid dysgenesis. In this study, we analyzed several factors of neonatal thyroid dysfunction through neonatal screening test and investigated the prognosis. Methods : From January 1992 to July 1997, we reviewed 66 newborn patients, who showed abnormal thyroid function...
Comparison of Preventive Effect of RDS and Neonatal Morbidity between Antenatal Dexamethasone versus Ambroxol Administration
Eun Jeong, Kim, Seong Sook Jeon, Son Sang Seo
Clin Exp Pediatr. 2000;43(1):13-22.   Published online January 15, 2000
Purpose : Antenatal dexamethasone administration is associated with a significant lowering respiratory distress syndrome(RDS) incidence, but can increase neonatal infection. Ambroxol has been accepted as an alternative treatment to dexamethasone and is of at least equal efficacy but without adverse reaction. The aim of this study was to evaluate the effectiveness of ambroxol versus dexamethasone in RDS incidence and neonatal...
Usefulness of Brain Tc-99m HMPAO SPECT in Establishing Lateralization of Intractable Seizure in Children
Suck-Hee Ahn, Young-Ho Rah, Sa-Jun Chung, Eu-Hyun Cho
Clin Exp Pediatr. 1999;42(12):1711-1716.   Published online December 15, 1999
Purpose : To determine the role of Tc-99m HMPAO SPECT imaging in children with intractable seizure by evaluating the interictal period. Methods : We compared the EEG, CT and MRI medical records with those of Tc-99m HMPAO SPECT in 42 patients with intractable seizure referred to Kyunghee University Hospital, from April 1983 to September 1998, retrospectively. Results : Mean age was 8.3 years...
Central Diabetes Insipidus in Children Related to Craniotomy for a Brain Tumor
Seung Mi Song, Eun Jung Park, Jung Sim Kim, Hong Hoe Koo, Mun Hyang Lee, Hyung Jin Shin, Dong Kyu Jin
Clin Exp Pediatr. 1999;42(12):1702-1710.   Published online December 15, 1999
Purpose : Diabetes insipidus(DI) has been known to be a relatively common complication after craniotomy. We have investigated the incidence and clinical course of DI in children related to craniotomy for a brain tumor and determined the risk factors of postoperative DI. Methods : Sixty-two pediatric patients, who have undergone craniotomy for a brain tumor(including stereotactic biopsy) from February 1995 through...
Comparison between Pathologically and Clinically Diagnosed Group of Acute Postinfectious Glomerulonephritis
Chul Hong Kim, Su Yung Kim
Clin Exp Pediatr. 1999;42(12):1696-1701.   Published online December 15, 1999
Purpose : Postinfectious acute glomerulonephritis usually needs no renal biopsy. But atypical clinical course and laboratory results indicate a need for renal biopsy. Therefore, to investigate clinicopathological characteristics of postinfectious acute glomerulonephritis, we compared clinical manifestations of biopsy group with those of non-biopsy group. Methods : We reviewed the records of clinical and pathological data of 20 cases diagnosed by...
Clinical Effects of Cyclic Parenteral Nutrition on Total Parenteral Nutrition Induced Cholestasis in Infants
Eun-Hee Chung, Kang Mo Ahn, Yun-Sil Chang, Won-Soon Park, Nam-Sun Beck, Jae-Hyun Lee
Clin Exp Pediatr. 1999;42(12):1689-1695.   Published online December 15, 1999
Purpose : This study was designed to assess the effects of cyclic parenteral nutrition(CP) on parenteral nutrition induced liver diseases. Methods : Before and after CP, data were collected on diagnosis, age, duration of parenteral nutrition, macronutrients and biochemical parameters. Initially parenteral nutrition was cycled off for 1-2 hours and the off-time was advanced by 0.5-1 hour daily over 1 week....
Postoperative Doppler Echocardiographic Study of Total Anomalous Pulmonary Venous Return
Nam Cheol Cho, Hyoung Doo Lee, Si Chan Sung
Clin Exp Pediatr. 1999;42(12):1683-1688.   Published online December 15, 1999
Purpose : We conducted this study to evaluate the efficacy of Doppler study by examining obstruction at the site of anastomosis in patients with total anomalous pulmonary venous return(TAPVR). Methods : Retrograde analysis of the postoperative echocardiography results was done in 14 patients with simple TAPVR, who were operated at Dong-A University Hospital from January 1993 to July 1998. The peak...
Changes of Interleukin-10 and Granulocyte Colony-Stimulating Factor in Cerebrospinal Fluid of Children with Aseptic Meningitis
Byeong Chan Park, Jung-Yeon Shim, Jeong Mi Lee, Jin-Young Park, Myung Ja Yoon, Hye Rim Jung, Moon Soo Park, Dong Hyeuk Keum, Dong Keug Keum
Clin Exp Pediatr. 1999;42(12):1676-1682.   Published online December 15, 1999
Purpose : Interleukin(IL)-10 is an antiinflammatory cytokine produced by monocytes/macrophages. Granulocyte colony-stimulating factor(G-CSF) plays an important role, not only as a hemopoietic factor but also as a regulating factor for a biologic defense system by neutrophils, in the foci of infection. We studied G-CSF and IL-10 levels in the serum and cerebrospinal fluid(CSF) of patients with aseptic meningitis and investigated...
Inhalation of Bronchodilator Aerosol by Metered-dose Inhaler and Spacer in Neonatal Respiratory Distress Syndrome
Hyeon-Soo Lee
Clin Exp Pediatr. 1999;42(12):1668-1675.   Published online December 15, 1999
Purpose : To examine the clinical effects of two bronchodilator agents, salbutamol and ipratropium bromide, administered by metered-dose inhaler(MDIS) to preterm infants with respiratory distress syndrome(RDS) during mechanical ventilation. Methods : This study included 8 ventilated preterm infants with RDS, at a postnatal age of 1 week. The effects of single doses of salbutamol(2puffs, 200mcg) and ipratropium bromide(2 puffs, 36mcg) and...
Clinical Evaluation of Diagnostic Criteria for Early Prediction of Bacterial Infection in Febrile Neonates
Jai Il Cho, Sang Chun Lee, Hwan Il Kim, Cheol Am Kim, Kil Seo Kim
Clin Exp Pediatr. 1999;42(12):1661-1667.   Published online December 15, 1999
Purpose : A retrospective study was undertaken to test the hypothesis that febrile neonates, who have bacterial infections, can be accurately predicted early by diagnostic criteria. Methods : We conducted a retrospective study of 152 infants, 28 days or less of age, whose rectal temperature was at least 38℃. Past history, family history, finding on physical examinations and results of CBC,...
Distribution and Expression of Kainate(KA) Receptor Subunits in Moderate Hypoxic Newborn Piglet Brain
Chun Hyuk Chang, Woo Taek Kim
Clin Exp Pediatr. 1999;42(12):1651-1660.   Published online December 15, 1999
Purpose : The mechanism of hypoxic damage is mainly intracellular influx of calcium ions through the glutamate ionotropic receptor. This study was performed to determine alterations in distribution and expression of kainate receptor subunits after 1 hour of moderate hypoxia in the newborn piglet brain, as in a condition of mild to moderate perinatal hypoxic-ischemic encephalopathy. Methods : Ten newborn piglets...
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