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Effects of Cisapride on QTc Interval and QT Dispersion in Preterm Infants

Journal of the Korean Pediatric Society 2000;43(2):188-194.
Published online February 15, 2000.
Effects of Cisapride on QTc Interval and QT Dispersion in Preterm Infants
Heui Seung Jo, Chang Won Choi, Yun Kyung Lee, Hee Seok Kim, Jun Dong Park, Jun Huh, Beyong Il Kim, Chung Il Noh, Jung-Hwan Choi
Department of Pediatrics, College of Medicine, Seoul National University, Seoul, Korea
미숙아에서 Cisapride가 QTc 간격 및 QT 분산에 미치는 영향
조희승, 최창원, 이윤경, 김희석, 박준동, 허준, 김병일, 노정일, 최중환
서울대학교 의과대학 소아과학교실
Abstract
Purpose
: Cisapride, a prokinetic agent, is widely used in preterm infants with feeding intolerance or gastroesophageal reflux. Although cisapride is regarded as a safe drug, increased QTc interval or ventricular arrhythmia has been reported in adults and neonates. So we prospectively examined the effects of cisapride on the QTc interval and QT dispersion in preterm infants.
Methods
: QTc interval and QT dispersion were determined just before and 4.9¡¾1.7days after the start of the cisapride treatment in 15 preterm infants with cisapride between April 1, 1998 and August 31, 1998.
Results
: Cisapride significantly increased QTc interval(P<0.05), and this had no correlation with birthweight or gestational age. Three(20%) of the 15 cases were found to have QTc interval above 0.450, but they were clinically asymptomatic. QT dispersion did not increase significantly.
Conclusion
: Cisapride use in preterm infants is associated with an increase in QTc interval. High dose or longterm use of cisapride in preterm infants should be used cautiously, and when used, monitoring the QTc interval should be considered.
Key Words: Cisapride, QTc interval, QT dispersion, Preterm infants


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