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Original Article
Analysis of cow's milk specific IgE positive patients in newborns
Gil Sang Lee, Nam Kyung Baek, Won Duck Kim
Clin Exp Pediatr. 2006;49(10):1061-1066.   Published online October 15, 2006
Purpose : The purpose of this study was to research whether measurement of cow's milk specific IgE on the newborn would be helpful in the diagnosis of cow's milk allergy. We tried to find out the relation between cow's milk specific IgE and other allergy diseases by following up cases. Methods : We reviewed clinical features of 87 episodes in infants...
Analysis of newborn hearing screening using automated auditory brainstem response
Sung Won Park, Byung Ho Yun, Kyung Ah Kim, Sun Young Ko, Yeon Kyung Lee, Son Moon Shin, Sung Hwa Hong
Clin Exp Pediatr. 2006;49(10):1056-1060.   Published online October 15, 2006
Purpose : As hearing ability affects language and cognitive development, early detection and intervention of congenital hearing defects is very important. We analyzed the result of newborn hearing screening using automated auditory brainstem response and estimated the incidence of congenital hearing defects in newborn infants in Korea. Methods : Hearing screening tests were done on 7,218 newborn infants who were...
Changes of neurodevelopmental outcomes and risk factors of very low birth weight infants below 1,500 g, in the last 10 years
Se Kyu Lee, Ji Hyun Lee, Sang Geel Lee
Clin Exp Pediatr. 2006;49(10):1050-1055.   Published online October 15, 2006
Purpose : As a result of advances in neonatal intensive care and perinatal care, neurodevelopmental outcomes of very low birth weight infant(VLBWIS) is expected to lead to improvement. The aim of this study was to report neurodevelopmental outcomes and risk factors of neurologic impairment of very low birth weight infants during the past 10 years. Method : We performed a retrospective...
Health and risk taking behaviors of freshmen in college
Hong Ki Ko, Jae Joon Han, Yoon Lee, Young Yoo, Kee Hyoung Lee, Ji Tae Choung, Sang Hee Park
Clin Exp Pediatr. 2006;49(10):1042-1049.   Published online October 15, 2006
Purpose : This study was conducted to survey the preliminary data on risk behaviors and to identify the factors that prevent risk-behaviors in late adolescence. Methods : Freshmen(n=1,297) beginning the first semester in Korea University, Seoul, Korea completed self-administered risk behavior questionnaires, comprising 5 domains : demographics, smoking, drinking, drug abuse and sexual behavior. Results : The rate of smoking experience was...
Adolescent obesity and the elevation of aminotransferase levels
Su Yeon Kim, Ho Jun Lee, Tae Su Park, Soo Geun Kim, Hye Jung Shin
Clin Exp Pediatr. 2006;49(10):1037-1041.   Published online October 15, 2006
Purpose : The prevalence of obesity and nonalcoholic steatohepatitis(NASH) was increased in adolescents. This study was performed to observe the prevalence of elevated aminotransferase levels in adolescents and to assess the correlations between aminotransferase levels and obesity related parameters(body mass index, waist circumference, hip circumference, waist to hip ratio and insulin level). Methods : We obtained weight, height, waist circumference and...
Molecular detection of Bartonella henselae DNA from fleas obtained from dogs, Korea
Tae Hee Han, Ju-Young Chung, Hee Kyung Seong, Sang Woo Kim
Clin Exp Pediatr. 2006;49(9):983-986.   Published online September 15, 2006
Purpose : The purpose of this study was to investigate the presence of Bartonella henselae DNA, which is known as an etiologic agent of lymphadenitis, in fleas from dogs. Methods : The Bartonella henselae infection was investigated in 42 fleas from 22 dogs in Korea. By using seminested PCR targeting pap31 gene, B. henselae DNA was amplified from fleas. Results :...
Mycoplasma pneumoniae-induced production of proasthmatic mediators in airway epithelium
Kyung Won Kim, Byung Chul Lee, Kyung Eun Lee, Eun Soo Kim, Tae Won Song, Mi Yeoun Park, Myung Hyun Sohn, Kyu-Earn Kim
Clin Exp Pediatr. 2006;49(9):977-982.   Published online September 15, 2006
Purpose : There has been an increasing amount of literature concerning the association between Mycoplasma pneumoniae and asthma pathogenesis. Interleukin(IL)-6 stimulates the differentiation of monocytes, and can promote Th2 differentiation and simultaneously inhibit Th1 polarization. IL-8 is a potent chemoattractant and, it has been suggested, has a role in asthma pathogenesis. Nitric oxide (NO) synthesized by airway epithelium may be...
Comparison of total parenteral nutrition-associated cholestasis according to amino acid mixtures in very low birth weight infants
Jin-Sung Choi, Yun-Jin Bae, Young Ah Lee
Clin Exp Pediatr. 2006;49(9):972-976.   Published online September 15, 2006
Purpose : The purpose of this study was to evaluate the effect of amino acid mixtures on incidence and severity of total parenteral nutrition associated-cholestasis(PNAC) in very low birth weight infants. Methods : Retrospective review of 63 very low birth weight infants(birth weight ≤1,500 g) who received total parenteral nutrition(TPN) in our neonatal intensive care unit from January 2000 to...
The influence of some intrauterine growth variables on neonatal blood pressure
Jungwon Min, Eun Ae Park, Kyoungae Kong, Bohyun Park, Juhee Hong, Young Ju Kim, Hwayoung Lee, EunHee Ha, Hyesook Park
Clin Exp Pediatr. 2006;49(9):966-971.   Published online September 15, 2006
Purpose : ‘Programming’ describes the process that stimulus at a critical period of development has lifelong effects. The fact that low birth weight links to the risk of elevated blood pressures in adult life is well known. This study aims to examine whether this link is evident in the newborn by investigating the relationship of the intrauterine growth indices and...
Effect of prophylactic indomethacin in extremely low birth weight infants
Bo Lyun Lee, Su Jin Kim, Soo Hyun Koo, Ga Won Jeon, Yun Sil Chang, Won Soon Park
Clin Exp Pediatr. 2006;49(9):959-965.   Published online September 15, 2006
Purpose : The purpose of this study was to investigate the effect of prophylactic indomethacin on reduction of patent ductus arteriosus(PDA) and intraventricular hemorrhage(IVH) in extremely low birth weight infants(ELBWI). Methods : Retrospective review of 84 ELBWI who were admitted to our neonatal intensive care unit from June 2004 to April 2006 was performed. Patients were divided into prophylactic group(n=28) and...
Recent outcome of extremely low birth weight infants - The use of CRIB(clinical risk index for babies) Ⅱ score foranalyzing the survival rate -
Do-Hyeon Kim, So-Yeon Shim, Jae-Ri Kim, Seung-Han Shin, Eun Sun Kim, Kyoung-Eun Joung, Sang Duk Kim, Jin A Lee, Chang Won Choi, Ee-Kyung Kim, Han-Suk Kim, Beyong Il Kim, Jung-Hwan Choi
Clin Exp Pediatr. 2006;49(9):952-958.   Published online September 15, 2006
Purpose : The survival rate of infants weighing less than 1,000 g at birth(extremely low birth weight infants, ELBWI) has increased due to recent advances in perinatal and neonatal intensive care. The purpose of this study was to evaluate the survival rates of ELBWI born at Seoul National University Hospital during the last six years. Methods : A total of...
Effect of combined exercise on metabolic bio-marker in overweight and obese children
Hyun-Jun Kim, Tae-Un Kim, Sangyeoup Lee, Goon-Soo Shin, Young-Joo Kim, Su-Yung Kim
Clin Exp Pediatr. 2006;49(9):946-951.   Published online September 15, 2006
Purpose : The purpose of this study was to demonstrate the effectiveness of combined exercise for 12 weeks on the adiponectin and obesity related variables in overweight and obese children. Methods : Eighteen children in 5th grade in a certain elementary school in Busan were recruited. They were all overweight or obese children(more than 85 percentile in body mass index). Nine...
Relationship of serum IL-13 and eotaxin level with airway hyperresponsiveness in children with asthma
Eun Young Park, Jung Yeon Shim, Myung Hwan Yoo, Deok Soo Kim, Jae Won Shim, Hye Lim Jung, Moon Soo Park
Clin Exp Pediatr. 2006;49(8):889-894.   Published online August 15, 2006
Purpose : Asthma is characterized by the presence of airway hyperresponsiveness(AHR) and inflammation. The extensive eosinophil infiltration into the lung is the hallmark of asthma and contributes to the damage of respiratory epithelium during late phase airway responses. Eotaxin is the major eosinophil chemoattractant found in bronchoalveolar lavage(BAL) fluid of allergic inflammation. IL-13 has been known to induce the...
Bacteremia in pediatric cancer patients : A single center study
Sun Mi Park, Byung Kyu Choe, Chun Soo Kim, Joon Sik Kim, Heung Sik Kim, Nam-Hee Ryoo
Clin Exp Pediatr. 2006;49(8):882-888.   Published online August 15, 2006
Purpose : Bacteremia is one of the major concerns in the treatment of pediatric cancer patients. This study was to determine the etiologic agents and the pattern of antibiotic susceptibilities in a single tertiary medical center. Methods : We retrospectively reviewed the medical records of the cases of bacteremia in pediatric cancer patients from 1998 to 2005 in Keimyung University Dongsan...
Histiocytic necrotizing lymphadenitis in children : association of human herpes virus 8 and Epstein Barr virus
Hyun A Kim, Ju-Young Chung, Sang Woo Kim, Sung Jig Lim, Haeng Seop Shin
Clin Exp Pediatr. 2006;49(8):875-881.   Published online August 15, 2006
Purpose : The aims of this study were to analyze the clinical characteristics of children with Kikuchi's disease(KD) at a medical center and to investigate the etiologic role of human herpesvirus 8(HHV 8) or Epstein-Barr virus(EBV) in children with KD. Methods : Twenty six children who were diagnosed as KD between Jan. 1998 and Dec. 2005 were included....
Frequency and clinical characteristics of prenatally diagnosed congenital hydronephrosis and outcomes of ureteropelvic junction stenosis
Hyun Soo Kang, June Seung Sung, Sun Hui Kim, Hee Jo Back, Young Ok Kim, Chan Jong Kim, Young Youn Choi, Tai Ju Hwang
Clin Exp Pediatr. 2006;49(8):870-874.   Published online August 15, 2006
Purpose : Popular use of fetal ultrasonography has increased to detect congenital hydronephrosis(CH) which is the most common anomaly prenatally detected. We'd like to determine the frequency and clinical characteristics of prenatally diagnosed CH and outcome of ureteropelvic junction stenosis(UPJS). Methods : The records of births between January 1994 and June 2003 in Chonnam National University Hospital(CNUH), and the records of...
Immunogenicity and safety of enhanced-inactivated poliovaccine(eIPV) in healthy Korean infants
Jung Soo Kim, Young Jin Hong, Jong Duk Kim, Young Taek Jang, Jin Han Kang
Clin Exp Pediatr. 2006;49(8):864-869.   Published online August 15, 2006
Purpose : We evaluated the immunogenicity and safety of eIPV(Imovax PolioⓇ) in a group of healthy Korean infants on a three-dose primary vaccination. Methods : Eighty one healthy infants aged 8-10 weeks were enrolled, and 79(male 42, female 37) completed the study. Three doses of eIPV were injected intramuscularly at 2, 4 and 6 months of age as of primary...
Immune responses of hepatitis B vaccination among very low birth weight infant
Young-Deuk Kim, Myung-Ki Han, Ai-Rhan E. Kim, Ki-Soo Kim, Soo-Young Pi
Clin Exp Pediatr. 2006;49(8):857-863.   Published online August 15, 2006
Purpose : To evaluate the immunogenicity of hepatitis B vaccine among very low birth weight infants(VLBWI) who were vaccinated at 0, 1, 6 months of chronological age and to determine the factors associated with antibody formations. Methods : A total of 243 VLBWI admitted to Seoul and Gangneung Asan Medical Center neonatal intensive care units from 1997 to 2004 were...
The diagnostic significance of serum bile acid on total parenteral nutrition induced cholestasis in premature infants
Kyoung Soo Park, Myung Seok Shin, Mea Young Chang
Clin Exp Pediatr. 2006;49(8):851-856.   Published online August 15, 2006
Purpose : The purpose of this study is to find out the diagnostic significance of serum bile acid on total parenteral nutrition induced cholestasis in premature infants. Methods : Infants without cholestasis were classified into postnatal days and each change of serum bile acid was measured and analyzed. Also, the serum direct bilirubin, serum bile acid, γ-glutamic acid transferase, and alkaline...
Incidence of hearing loss and importance of risk factors in the neonatal intensive care unit
Seung Hyun Kong, Jang Hee Kang, Kwang Su Hwang, Joong Pyo Kim, Hyeon Jung Lee, Hyeon Choi, Ji Sun Mok, Jung Young Kim
Clin Exp Pediatr. 2006;49(8):845-850.   Published online August 15, 2006
Purpose : To assess the incidence of neonatal hearing loss in a neonatal intensive care unit and the relative importance of risk factors for hearing imparement in a neonatal intensive care unit which the Joint Committee on Infant Hearing(JCIH) had recommended. Methods : One thousand, two hundred and one newborns admitted to the Good Moonhwa Intensive Care Unit from May...
Clinical analysis of febrile infants and children presenting to the pediatric emergency department
Byeong Gon Kwak, Hyun Oh Jang
Clin Exp Pediatr. 2006;49(8):839-844.   Published online August 15, 2006
Purpose : We studied clinical patterns of the febrile infants and children presenting to the Pediatric Emergency Department(ED) in the general pediatric population. Method : We analyzed 1,764 infants and children who had a history of measured body temperature of 38.3℃ or higher, before or after arrival at Pediatric ED of Ilsan Paik Hospital from September 2004 to August 2005....
Comparative study of therapeutic effects according to duration of medium-dose aspirin therapy at the acute stage of Kawasaki disease
Jung Hwa Lee, So Hee Lee, Sang Taek Lee, Yong Hyun Park, Seong Jin Hong
Clin Exp Pediatr. 2006;49(7):790-795.   Published online July 15, 2006
Purpose : This study was performed to compare the therapeutic effects according to duration of medium-dose aspirin(50-60 mg/kg/day) therapy at the acute stage of Kawasaki disease(KD). Methods : Total 87 patients with KD were enrolled in this study. We performed retrospective analysis of clinical characteristics and echocardiographic findings based on medical records. Patient were randomly divided into 2 groups according to...
Intravenous immunoglobulin for severe gastrointestinal manifestation of Henoch-Sch nlein purpura refractory to corticosteroid therapy
Hye Ran Yang, Won Jung Choi, Jae Sung Ko, Jeong Kee Seo
Clin Exp Pediatr. 2006;49(7):784-789.   Published online July 15, 2006
Purpose : Henoch-Schönlein purpura(HSP) is a systemic vasculitis involving small vessels of skin, gastrointestinal(GI) tract and kidney. Digestive involvement of HSP can be serious with massive GI bleeding, perforation, and intussusception. However, some patients do not respond to conventional corticosteroid therapy. In this study, we investigated the efficacy of intravenous immunoglobulin (IVIG) for serious digestive manifestations not responding to steroid. Methods...
Susceptibility tests of oral antibiotics including cefixime against Escherichia coli, isolated from pediatric patients withcommunity acquired urinary tract infections
Soo Young Lee, Jung Hyun Lee, Jong Hyun Kim, Jae Kyun Hur, Sun Mi Kim, Sang Hyuk Ma, Jin Han Kang
Clin Exp Pediatr. 2006;49(7):777-783.   Published online July 15, 2006
Purpose : Urinary tract infection(UTI) is one of the most frequent infections in children. E. coli is the most frequent etiological micropathogen in pediatric community UTI, and E. coli has developed resistance to many antibiotics, highlighting the need for regular surveys of this organism resistant patterns in the community. The aim of this study was to determine the oral antibiotic...
Pulse wave velocity and ankle brachial index in adolescents with essential hypertension
Sun Young Joo, Ki Young Cho, Su Jin Cho, Young Mi Hong
Clin Exp Pediatr. 2006;49(7):769-776.   Published online July 15, 2006
Purpose : Pulse wave velocity(PWV) and ankle brachial index(ABI) are not only noninvasive methods used to assess arterial stiffness in adults, but also useful, simple ways to estimate the severity of hypertension, end stage renal disease and atherosclerosis in adults. But there are few studies on PWV and ABI in adolescents and children. In this study, hypertensive adolescents were compared...
The evaluation of risk for aspiration using lipid-laden macrophage index in infants with bronchiolitis
Ji Yeon Koh, Hee Kang, Ju Young Chung, Tae Hee Han, Chang Keun Kim
Clin Exp Pediatr. 2006;49(7):763-768.   Published online July 15, 2006
Purpose : We investigated the risk of aspiration using the lipid-laden macrophage index(LLMI) from laryngeal lavages in infants with bronchiolitis. Methods : Laryngeal lavages from 22 infants with acute bronchiolitis caused by respiratory syncytial virus(RSV) were evaluated during the acute stage. Repeat studies were performed at 3 to 4 weeks after the initial study(remission stage). Lavage cell counts and differentials were...
Database study for clinical guidelines of children with pneumonia who visited an emergency department
Dae Young Hong, Kyung Mi Lee, Ji Hye Kim, Jun Sig Kim, Seung Baik Han, Dae-Hyun Lim, Byoung Kwan Son, Hun Jae Lee, Kyung-Hee Lee
Clin Exp Pediatr. 2006;49(7):757-762.   Published online July 15, 2006
Purpose : Pneumonia is one of the most common infections in children who visit emergency departments(ED), but standard clinical guidelines for children with pneumonia in Korea have not been studied. This study was performed to collect and evaluate a data-base of children with pneumonia for establishing clinical guidelines in ED. Methods : This study reviewed 304 children who were diagnosed...
A study for headaches and backaches occurrence after diagnostic lumbar puncture in children
In Young Choi, Kyong Yun Park, Young Taek Jang
Clin Exp Pediatr. 2006;49(7):751-756.   Published online July 15, 2006
Purpose : Our goals were to determine the frequency of headaches and backaches occurring as a side effect following lumbar puncture in children, and to investigate various factors that might influence the frequency of headaches and backaches. Methods : From October 2004 to February 2006, we enrolled 148 patients aged 2 to 15 years who received diagnostic lumbar puncture at the...
Utility of polymerase chain reaction(PCR) according to sampling time in CSF and stool specimens from patient with aseptic meningitis
Myo Jing Kim, Hye Jin Lee, Jung Mi Choi, Soo Jin Jung, Jae Won Huh
Clin Exp Pediatr. 2006;49(7):745-750.   Published online July 15, 2006
Purpose : Enteroviruses are the most common cause of aseptic meningitis in patients of all ages. A definite diagnosis of enteroviral meningitis can be established by detection of virus directly in CSF specimens. But this is time-consuming and lacks sensitivity, so polymerase chain reaction(PCR) detecting of viral RNA in patient specimens such as CSF, stool has been demonstrated. But little...
Diagnostic limitation and usefulness of 99mTc-DISIDA hepatobiliary scanning on neonatal cholestasis
Jung Mi Kim, Byung-Ho Choi, You Cheol Jang, Ki Won Oh, Min Hyun Cho, Kyung Hee Lee, Jin-Young Park, Heng Mi Kim
Clin Exp Pediatr. 2006;49(7):737-744.   Published online July 15, 2006
Purpose : To assess the usefulness of 99mTc-DISIDA scanning in the early evaluation of neonatal cholestasis and to verify the diagnostic value of this test in the differential diagnosis of biliary atresia. Methods : DISIDA scannings were performed and analyzed in 87 children(58 males and 29 females; age, 18-139 days, mean, 59.1 days) with neonatal cholestasis. Five groups according to the...
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