Korean Journal of Pediatrics 2006;49(7):790-795.
Published online July 15, 2006.
Comparative study of therapeutic effects according to duration of medium-dose aspirin therapy at the acute stage of Kawasaki disease
Jung Hwa Lee1, So Hee Lee1, Sang Taek Lee1, Yong Hyun Park2, Seong Jin Hong1
1Department of Pediatrics, School of Medicine, Konkuk University,
2Department of Nursing*, Chungju Hospital, Konkuk University, Chungju, Korea
가와사끼병의 급성기 중용량 aspirin 투여 기간에 따른 치료 효과 비교 연구
이정화1, 이소희1, 이상택1, 박용현2, 홍성진1
1건국대학교 의학전문대학원 소아과학교실
2건국대학교 충주병원 간호과
Correspondence: 
Seong Jin Hong, Email: sjhong@kku.ac.kr
Abstract
Purpose
: This study was performed to compare the therapeutic effects according to duration of medium-dose aspirin(50-60 mg/kg/day) therapy at the acute stage of Kawasaki disease(KD).
Methods
: Total 87 patients with KD were enrolled in this study. We performed retrospective analysis of clinical characteristics and echocardiographic findings based on medical records. Patient were randomly divided into 2 groups according to the duration of aspirin therapy at the acute stage of KD. Long-term group(LG, n=55) was administered medium-dose aspirin for 2 weeks after diagnosis of KD, and short-term group(SG, n=32) for 48 hours after intravenous immunoglobulin(IVIG) administration. The parameters of therapeutic effects were duration of fever after IVIG administration, incidence of unresponsive patients to single administration of IVIG, and development of transient dilatation or aneurysm of coronary arteries.
Results
: There was no significant difference in the duration of fever after IVIG between the both group(LG 1.7¡¾1.1 days, SG 1.8¡¾1.1 days; P=0.588). The incidences of unresponsive patient to the single administration of IVIG were 5.5 percent, 6.3 percent in the each group. Transient dilatation of coronary arteries occurred at 18.2 percent(10/55) in the LG, and 15.6 percent(5/32) in the SG(P= 0.761). Prevalence of coronary aneurysm after subacute stage were 7.3 percent(4/55) in the LG, and 9.4 percent(3/32) in the SG(P=0.728).
Conclusion
: There was no significant difference in the therapeutic effects between long-term(2 weeks) and short-term(48 hours) administration of medium-dose aspirin at the acute stage of KD.
Key Words: Kawasaki disease , Aspirin , Therapeutic effects


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