Korean Journal of Pediatrics 2006;49(8):875-881.
Published online August 15, 2006.
Histiocytic necrotizing lymphadenitis in children : association of human herpes virus 8 and Epstein Barr virus
Hyun A Kim1, Ju-Young Chung1, Sang Woo Kim1, Sung Jig Lim2, Haeng Seop Shin3
1Departments of Pediatrics, College of Medicine, Inje University, Seoul, Korea
2Departments of Pathology, College of Medicine, Inje University, Seoul, Korea
3Division of AIDS, National Institute for Health, Seoul, Korea
소아에서의 조직구성 괴사성 림프절염 : human herpesvirus 8과 Epstein Barr virus와의 연관성
김현아1, 정주영1, 김상우1, 임성직2, 신행섭3
1인제대학교 의과대학 소아과학교실
2인제대학교 의과대학 병리학교실
3국립보건연구원 에이즈종양바이러스팀
Correspondence: 
Ju-Young Chung, Email: pedchung@sanggyepaik.ac.kr
Abstract
Purpose
: The aims of this study were to analyze the clinical characteristics of children with Kikuchi's disease(KD) at a medical center and to investigate the etiologic role of human herpesvirus 8(HHV 8) or Epstein-Barr virus(EBV) in children with KD.
Methods
: Twenty six children who were diagnosed as KD between Jan. 1998 and Dec. 2005 were included. Medical records were reviewed on the clinical characteristics of children with KD. Follow up data were collected by chart review and telephone contact. Polymerase chain reaction(PCR) was performed in order to detect HHV 8 DNA, and in situ hybridization(ISH) was perfomed in order to detect EBV RNA from 20 lymph node tissues.
Results
: There were 15 girls and 11 boys with a mean age of 13 years. Posterior cervical lymph nodes were involved in 72 percent(18/25) of the patients. Extracervical lymphadenopathy was associated in one patient. Fever was an associated symptom in 31 percent(8/26) of the patients. Leukopenia was observed in six (46 percent) patients. The cervical lymphadenopathy usually resolved spontaneously within 6 months. Only one patient had a recurrence of lymphadenopathy with fever during follow-up. No children with KD in our series developed systemic lupus erythematosus. HHV 8 DNA was not amplified by nested PCR in any of the cases, and all cases were negative for EBV RNA by ISH.
Conclusion
: KD should be differentiated as a cause of cervical lymphadenopathy in children. HHV 8 and EBV may not play major causative roles in KD in children.
Key Words: Histiocytic necrotizing lymphadenitis , Child, Herpesvirus 8 , Human , Epstein-Barr virus


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