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Original Article
Production and Characterization of Monoclonal Antibodies to Perchloric Acid Extract Antigen of M. bovis BCG(BCG Ⅱ)
Kyung Hyo Kim, Dong Soo Kim, Jeon Soo Shin
Clin Exp Pediatr. 1992;35(9):1183-1192.   Published online September 15, 1992
Mycobacteria causes disease which occur over the world. The development of reliable serological teset for the diagnosis of tuberculosis in humans has been complicated by the large degree of cross reactivitiy between antigens of Mycobacteria species can be used as a tool for serodiagnosis of tuberculosis. Fourteen monoclonal antibodies to perchloric acid extract antigen of M. bovis BCG were produced....
A Comparison of Reagent Test Strip-photometer and Laboratory Plasma Glucose Values in Newborns
Jin Kyung Kim, Myung Chul Hyun, Sang Bum Lee, Heng Mi Kim
Clin Exp Pediatr. 1992;35(8):1501-1058.   Published online August 15, 1992
Although reagent test strip-photometer method is frequently used to estimate plasma glucose values in nurseries, the accuracy in newborns have not been evaluated previously. In this study values of 44 samples of laboratory glucose were compared with values simultaneously obtained by reagent test strip-photometer. Laboratory values were determined by glucose oxidase method using veous plasma. Reagent test strip-photometer values were determined...
Effects of Adriamycin on Membrane Potential and Intracellular Sodium Activity in Canine Purkinje fibers
Chan Uhng Joo, Soo Wan Chae
Clin Exp Pediatr. 1992;35(8):1107-1112.   Published online August 15, 1992
Anthracycline antibiotic adriamycin (doxorubicin) is presently considered to be a very effective chemotherapeutic agent in the treatment of many human tumors. Adriamycin induced cardiomyopathy limits its clincal use. A number of hypotheses have been proposed to explain the mechanism of cardiotoxicity with adriamycin, but none has yet been demonstrated. The effects of adriamycin on membrane potential and intracellular sodium ion...
The Comparison of Coronary Arterial Dimensions Measured by Cross-sectional Echocardiography with Values Obtained by Coronary Angiography in Kawasaki Disease
Mi Jin Jung, Jung Yun Choi, Shung Il Noh, Yong Soo Yun, I Seok Kang
Clin Exp Pediatr. 1992;35(8):1102-1106.   Published online August 15, 1992
In order to assess accuracy of cross-sectional echocardiographic measurements of coronary arterial dimension, measured values of coronary arterial dimensions by cross-sectional echocardiography were compared with the angiographic results. Twenty eight patients with Kawasaki diseas (male: female= 3:1, age range, 7 months-8 years) were studied by both coronary arteriography and crossleft anterior descending coronary artery, and left circumflex coronary artery) were...
HDL Cholesterol, Copper, Ceruloplasmin, Zinc, Iron Values of the Blood in Newborn
Kyeong Sang Kim, Chun Hang Lee, Hong Jin Lee, Won Ill Park, Kyung Ja Lee, Tae Hyon Yoon, Won Chan Tae
Clin Exp Pediatr. 1992;35(8):1096-1101.   Published online August 15, 1992
HDL choleaterol, copper, ceruloplasmin, zinc, and iron values of the blood of 85 newborns delivered at hallym University hospital from September, 1989 to February, 1991 were analysed. The results were as follows: 1) The mean value of HDL cholesterol in 50 normal newborns was 31.37¡¾9.47mg/dl, that of copper 80.54¡¾17.54ug/dl, that of ceruloplasmin 11.34¡¾6.37mg/dl, that of zinc 92.81¡¾79.74ug/dl, that of iron 198.98¡¾86.07 ug/dl. 2)...
Standard of Ear Size in Korean Children
Heon Seok Han, Hyung Ro Moon
Clin Exp Pediatr. 1992;35(8):1089-1095.   Published online August 15, 1992
Measurement of 1298 Korean Children in Seoul (male 661; female 637) resulted in normal standard data for ear length and width by their age and sex. 1) Ear length and width were as follows respectively : 36.0¡¾2.5mm 21.5¡¾2.5mm in male neonate, 56.3¡¾3.1mm 30.6¡¾3.2mm at 6yr boy, 63.2¡¾3.5mm 33.4¡¾3.2mm in 14 yr adolescent male, 35.5¡¾2.0mm 21.2¡¾2.1mm in female neonate, 54.6¡¾3.1mm 28.7¡¾2.4mm in...
A Clinical Study of Mycoplasma Pneumonia in Children During Recent 5 Years
In Seung Park, Ha Baik Lee
Clin Exp Pediatr. 1992;35(8):1082-1088.   Published online August 15, 1992
Mycoplasma pneumoniae infections are among the most frequent respiratory diseases of school-aged children, adolescents and young adults. However in preschool children a persistent nonproductive cough, fever and interstitial or lobular infiltrates on the chest radiograph can recently be recognized as presenting features of M. pneumoniae. We studied to find out the recent trends in epidermiologic and clinical variabilities of M. pneumoniae...
A Clinical and Statistical Analysis on Acute Appendicitis in Children
Eui Tak Oh, Kang Youl Bae, Sang Bong Lee, Hong Ja Kang, Hyung Kuk Kim, Woo Sik Chung, Kil Seo Kim
Clin Exp Pediatr. 1992;35(8):1073-1081.   Published online August 15, 1992
Thjis report is a clinical analysis of 367 cases of acute appendicitis in children under the age of 15, which were treated at Dae Dong Hospital during the past 5 year period from January 1986 to December 1990. The results were summerized as follows: 1) The incidence was low (0.5%) under the age of 3. 2) The sex ratio of male to female...
The Effects of RU 41.740, a Glycoprotein Extract from Klebsiella pneumoniae, on Peripheral Blood Mononuclear Cells
Moon Kyu Kim, Dong Soo Kim, Hyun Ok Kim
Clin Exp Pediatr. 1992;35(8):1066-1072.   Published online August 15, 1992
RU 41.740 is extract of Klebsiella pneumoniae K2O1 stain with immunomodulatory properties. It was composed of two glycoproteins, each being 31 KD and 33 KD in their molecular weight, on SDS-PAGE analysis. RU 41.740 was observed to augment cell mediated immunity of human peripheral blood mononulear cells measured by tritiated thymidine uptake method. Maximal augmentation was observed after 72 hours...
Production, Characterization, and Clinical Application of Perchloric Acid Extract of M. bovis BCG (BCG I)
Kyung Hyo Kim, Dong Soo Kim
Clin Exp Pediatr. 1992;35(8):1059-1065.   Published online August 15, 1992
Tuberculosis has been an important world-wide infectious disease. The prevalence of radiologically active tuberculosis was 1.8% of population in Korea. Probably the most important aspect of the pathogenesis of tuberculosis is the nature and specificity of the response of the immune system to the antigens of tubercle bacilli. Preparation of purified antigens from Mycobacteria with specific antigenic deterninants would improve...
Acquired Renal Cystic Disease in Childhood Chronic Renal Failure
Tae Sun Ha, Seong Hoon Ha, Il Soo Ha, Hae Il Cheong, Yong Choi, Kwang Wook Ko, Woo Sun Kim, Kim In One
Clin Exp Pediatr. 1992;35(8):1044-1050.   Published online August 15, 1992
The authors evaluated 19 childrenwith chronic renal failure patients diagnosed and followed up at the Department of Pediatrics, Seoul National University Hospital for the detection of acquired renal cystic disease (ARCD) with two radiologists by the means of ultrasonography. The results were as follows: 1) Of the 19 patients, male to femals ratio was 14:5 and of them, hemodialysis and peritoneal dialysis...
Urinary Tract Infection and Neonatal Circumcision
Seung Joo Lee
Clin Exp Pediatr. 1992;35(8):1035-1043.   Published online August 15, 1992
An association between urinary tract infection in male infants and uncircumcised status has been suggested recently. Male predominance of UTI in most reports in Korea may be related to this uncircumcised status. The present study was prospectively performed between Mar. 1989 and May. 1991 to investigate this relationship and the effect of neonatal circumcision on the intraurethral bacterial flora. 1) The...
Late Asthmatic Responses(LARs) and Consequences on Nonspecific Bronchial Reactivity(NSBR) after Exercise and Allergen Challenges in the Children with Bronchial Asthma
Kyung A Yoon, Young Y. Koh
Clin Exp Pediatr. 1992;35(7):957-970.   Published online July 15, 1992
Exercise and allergen challenges are the main tools to investigate the bronchial responsiveness in experimentally provoked asthma. It is recognized that LAR, which often follows early asthmatic response(EAR) by 3 to 10 hours after challenge, is more closely related to the basic pathogenetic mechanisms operating in bronchial asthma. Although exercise induces an EAR within the first hour similar to allergen...
A Clinical Study on Cardiovascular Disease of Children Taken Cardiac Catheterization and Cineangiography
Gi Yeon Song, Seog Beom Cho, Pyoung Han Hwang, Chan Uhng Joo, Jung Soo Kim
Clin Exp Pediatr. 1992;35(7):949-956.   Published online July 15, 1992
A clinical study was made on 533 patients with cardiovascular disease who were admitted to pediatric department of Chonbuk National University Hospital and performed cardiac catheterization and cineangiography from February 1984 to August 1991. The results were as follows; 1) The ratio of male to female was about 0.81:1; among 533 cases, male 283cases, male 283cases, female 295cases. 2)The age distribution of the...
The Left Parasternal Movement in Children with Heart Diseases
Dae Ho Choi, Byung Hyun Kim, Hyang Suk Yoon, Kwang Soo Oh, Yeon Gyun Oh, Jong Duck Kim
Clin Exp Pediatr. 1992;35(7):942-948.   Published online July 15, 1992
When we are examining a cardiac patient, we want to make a physical diagnosis including involved ventricles, type of overload(volume or pressure), its degree, and the status or degree of pulmonary hypertension. Among various physical examinations of the cardiac patients, a left parasternal movement can give us a status of various degree of the volume and pressure overload of the ventricles....
Permanent Epicardial Pacing in Pediatric Patients
I Seok Kang, Chung Il Noh, Jung Yun Choi, Yong Soo Yun
Clin Exp Pediatr. 1992;35(7):933-941.   Published online July 15, 1992
From September 1982 to July 1991, 40 infants and children aged 3 days to 13 years(mean 3.1 years) underwent implantation of 45 cardiac pacemakers using epicardial leads(40 primary implants, 5 re-implants). Nineteen patients required pacing for surgically acquired heart block, 1 for surgically acquired sinus node dysfunction, 11 for congenital complete atrio-ventricular(AV) block, 7 for nonsurgical sinus node dysfunction, and...
Clinical Experiences with Total Nutrient Admixture in 26 Cases
Yong Soon Kwon, Eun Jin Choi, Soon Ok Byun, Ji Sub Oh, Hwan Seon Ryu, Charles D. Sands
Clin Exp Pediatr. 1992;35(7):921-932.   Published online July 15, 1992
Total Nutrient Admixture(TNA) is an intravenous nutrient system composed of dextrose, amino acid, fat, electrolytes, vitamins and trace elements in a single container which is administered over 24 hours. Twenty six seriously ill or premature neonatal patients reciving parenteral nutrition with TNA were studied by analyzing anthropometric parameters, laboratory values, and complications. The objective of the study was to test the...
A Clinical Aspect of the Hemolytic Uremic Syndrome
Hye Won Park, Tae Sun Ha, Il Soo Ha, Hae Il Cheong, Yong Choi, Kwang Wook Ko
Clin Exp Pediatr. 1992;35(7):909-920.   Published online July 15, 1992
We reviewed the medical records of 14 children (8 girls, 6 boys), diagnosed as hemolytic uremic syndrome at Seoul National University Children뭩 Hospital from 1981 to 1990. The age at presentation ranged from 1 month to 10 years, with a mean age of 2.7 years. Only eight (57.1%) of the children had diarrheal prodrome and five (35.7%) had grossly bloody...
In Vitro Immunization-IV: Antibody Response of Mouse Splenocytes Grown in a Mixture of Conditioned Media, Thymocytes, and Bone Marrow Cells
Dong Soo Kim, Geun Woong Noh
Clin Exp Pediatr. 1992;35(7):902-908.   Published online July 15, 1992
We have previously reported several methods of in vitro immunization using different conditioned media, and the highest antibody titer was observed when a mixture of three conditioned media[PHA-stimulated adherent splenocytes conditioned medium (ASM-P), ASM-p-stimulated non-adherent splenocyte conditioned medium (NASM-A), ASM-P-stimulated thymocyte conditioned medium (TM-A)] was used. In this experiment, thymocytes and/or bone marrow cells was added instead of above conditioned media...
Cytomegalovirus Infection in Children: The Significance of CMV Specific IgM Antibody Test and Virus Isolation in the Urine
Dong Wook Kim, Hyun Kwack, Seong Hee Jang, I Seok Kang, Hoan Jong Lee, Jung-Hwan Choi, Jeong Kee Seo, Chong Ku Yun
Clin Exp Pediatr. 1992;35(7):890-901.   Published online July 15, 1992
The clinical pictures of 44 children with IgM antibody to CMV (cytomegalovirus) by ELISA(enzyme linked immunosorbent assay) were reviewed retrospectively, and the significance of serum CMV specific IgM antibody and virus isolation in the urine was analyzed. Age of the patients with IgM antibody to CMV ranged from 23 days to 8 years 7 months, and median age was 2 months....
Short-Term Results of Arterial Switch Operation for Transposition of Great Arteries
Yong Soo Yun, Yong Won Park, Chul Il Noh, Jung Yun Choi, Yong Jin Kim, Joon Ryang Rho, Kyung Pil Suh
Clin Exp Pediatr. 1992;35(6):795-803.   Published online June 15, 1992
The operative results of 50 cases who underwent arterial switch operation from January, 1986 to March, 1991 were evaluated. The results were summarized as follows ; 1) Three main combined cardiac defects of ASO cases were PDA(60%), VSD(56%) and ASD(46%), and most common type of VSD was perimembranous(64.3%) and most frequent pattern of coronary artery was usual pattern of TGA (84%). 2)...
Clinical Observation on Reye syndrome According to the Onset of Age in Children
Kyung Hee Kim, Baik Hee Lee, Myung Ik Lee, Don Hee Ahn, Keun Chan Sohn
Clin Exp Pediatr. 1992;35(6):788-794.   Published online June 15, 1992
A clinical observation according to the age of onset was made on 40 children with Reye syndrome who had been admitted to pediatric department of National Medical Center during 11 year period from January 1979 to December 1989. 1) Annual distribution showed the largest number in 1982. There was no significant difference in seasonal distribution. 2) Cases of infant comprised 22 (55.0%)...
The Perceptions and Attitudes of Parents and Medical Personnel Toward Fever of Children
Hyo Nam Cho, Jung-Hwan Choi, Chong Ku Yun
Clin Exp Pediatr. 1992;35(6):776-787.   Published online June 15, 1992
Children commonly complain of suffering fever ; however, as studies have demonstrated, parents of a febrile infant or young child are inclined to become overly concerned. The pupose of this study was to investigate the perceptions and attitudes of medical personnel as well as parents. The parents of 189 children and 150 medical personnel (47 nurse-aides, 56 nurses, and 47 doctors)...
Exercise Induced Delayed Bronchoconstriction in children with Asthma
Eun Jin Choi, Hyo Kung Shin, Un Ki Yoon, Ji Sub Oh
Clin Exp Pediatr. 1992;35(6):769-775.   Published online June 15, 1992
This study was performed to investigate delayed bronchoconstriction in 17 extrinsic asthmatic children with exercise induced asthma. Pulmonary function was monitored by PEFR and FEV1 prior to exercise and serially for ten hours after about 8 minutes up and down stairs exercise. Delayed bronchoconstriction was noted in four of seventeen patients (23.5%) at 5∼9hours after exercise and % fall in PEFR...
Statistical Observation for the Pediatric Patients in ICU
Ki Hun Eum, Chang Ho Hong, Young Mo Sohn, Chul Lee, Pyung Kil Kim
Clin Exp Pediatr. 1992;35(6):762-768.   Published online June 15, 1992
A statistical study was performed on 221 ICU cared pediatric patients who were admitted to the department of pediatrics, Yonsei university college of medicine, Seoul, Korea from Apr. 1983 to Mar. 1991. The results were as follows : 1) Total number of subject were 221, it was 7.5% of total ICU patients and 1.3% fo total admitted pediatric patients. The male to...
Significance of Brain CT in Children with Chief Complaints of Neurological Symptoms and Signs of Intracranial Disorders
Chun Ho Cho, Chung Hyun Yoon, Young Wook Kim, Ki Bok Kim
Clin Exp Pediatr. 1992;35(6):753-761.   Published online June 15, 1992
Because of its accuracy, rapidity as well as non-invasiveness, brain CT (computerized transaxial tomography)is being widely used as the most reliablel diagnostic approach for neurologic disorders in childhood. Brain CT provides good anatomic configuration of the brain and its gross disease processes that have as a manifestation alteration in brain density, disturbance in blood-brain barrior, or mass effect etc. We evaluated...
A Clinicopathological Study on Renal Biopsies in Children
Hun Choi, Dae Yeol Lee, Jung Soo Kim
Clin Exp Pediatr. 1992;35(6):744-752.   Published online June 15, 1992
A clinical and histopathologic study was made oin 50 cases of renal biopies in children who admitted to chon buk national university hospital from December 1987 to July 1990. The result were as follows : 1) Among 50 cases, 35 cases were male and 15 cases female. The sex ratio of male to female was 2.3 : 1. The age distribution was...
MIC and MBC of Oral Antimicrobial Agents Against Staphylococcus aureus
Min Hang Kim, Jin Won Park, Yun Joo Chung, Kyung Sik Ryoo, Myung Woong Chang
Clin Exp Pediatr. 1992;35(5):659-666.   Published online May 15, 1992
Antimicrobial susceptibility for 25 stranis of methicillin senitive Staphylococcus (MSSA) and 25 strains of methicillin resistant Staphylococcus aureus (MRSA), isolated from in-patients at Kosin Medical Center from January, 1989 to July, 1990, were tested by the tube dilution method. 1) For MSSA, sensitivity tests showed 21% was sensitive to cefadroxil. Seventy one percent was intermediate and 8% was resistant. 2) 96% of...
A Clinical Study on Duchenne Muscular Dystrophy
Moon Sun Yang, Su Ahn Chae, Ki Joong Kim, Yong Seung Hwang
Clin Exp Pediatr. 1992;35(5):652-658.   Published online May 15, 1992
Twenty-five cases of Duchenne muscular dystrophy(DMD) who were diagnosed in the department of pediatrics, Seoul national university hospital (from Jan. 1985 to June 1991) were reviewed. The results were as follows. 1) All of the patients were male. 2) The onset of symptoms was between two and eight years of age. The peak incidence was at four years of age. 3) Chief complaints...
Inciedence of Sepsis Associated with Total Parenteral Nutrition Solutions Made in the Nursery and Pharmacy
Moon Chan Kim, Jin Won Park, Yun Joo Chung
Clin Exp Pediatr. 1992;35(5):646-651.   Published online May 15, 1992
From 1985 to 1987, when Total Parenteral Nutrition (TPN) solutions was made in the nursery without laminar flow hood and other usual aseptic techniques (method 1), there was sepsis in 27% out of 33. From 1988 to 1990, to prevent high incidence of sepsis, TPN was made in the pharmacy under laminar flow hood and by pharmacist who wore scrub...
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