Journal of the Korean Pediatric Society 1992;35(5):646-651.
Published online May 15, 1992.
Inciedence of Sepsis Associated with Total Parenteral Nutrition Solutions Made in the Nursery and Pharmacy
Moon Chan Kim, Jin Won Park, Yun Joo Chung
Department of Pediatrics, Kosin College of Medicine, Pusan, Korea
약국에서 제조된 Total Parenteral Nutrition의 사용 여부에 따른 패혈증의 발생 빈도에 관한 고찰
김문찬, 박진원, 정윤주
고신의대 소아과학교실
From 1985 to 1987, when Total Parenteral Nutrition (TPN) solutions was made in the nursery without laminar flow hood and other usual aseptic techniques (method 1), there was sepsis in 27% out of 33. From 1988 to 1990, to prevent high incidence of sepsis, TPN was made in the pharmacy under laminar flow hood and by pharmacist who wore scrub suit and gloves (method 2). We compared the rate of sepsis in method 1 and 2. 1) There was sepsis in 9 patients (27%) out of 33 in method 1 and in 3 patients(8%) out of 36 in method 2. The incidence of sepsis was reduced but was not significant statistically. 2) Staphylococcus epidermidis was the most common causative organism of sepsis, in 5 patients (13%) out of 39(method 1 and 2). 3) There was sepsis caused by Candida albicans in one case treated with TPN for 20 days. 4) We speculate that more scrutinized supervision of aseptic techniques on making TPN solution and skin care as well as tubing cares are needed to reduce the high incidence of sepsis.
Key Words: Total Parenteral Nutrition, Sepsis

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