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Original Article
The Soluble Interleukin 2 Receptor Levels in Kawasaki Disease
Keum Chun Kim, Dong Soo Kim
Clin Exp Pediatr. 1992;35(12):1657-1666.   Published online December 15, 1992
Kawasaki disease has been known as an acute febrile mucocutaneous lymph node syndrome since 1967. But its definite pathophysiology still remains unclear. In order to study the immunologic basis for immunologic abnormalities in this disease, we studied the level of soluble interleukin-2 receptor (sIL-2R), interleukin-6 (IL-6) and C-reactive protein (CRP) at the acute and convalescent phases of the disease, comparing...
Gastrofiberscopic Findings and Helicobacter pylori Gastritis in Children with Recurrent Abdominal Pain
Jeong Kee Seo, Je Geun Chi, Eui Chong Kim
Clin Exp Pediatr. 1992;35(12):1646-1656.   Published online December 15, 1992
Gastrofiberscopic findings and the presence of Helicobacter pylori (H. pylori) were studied prospectively in children with recurrent abdominal pain (RAP). Endoscopic findings in 707 children with RAP revealed that 243 children (34.3%) showed abnormal findings including gastritis in 16.9%, duodenitis in 10.4%, esophagitis in 5.7%, duodenal ulcer in 5.7%, and gastric ulcer in 1.1% of children with RAP. Endoscopic biopsy of...
Measles in Previously Vaccinated Children -Rapid Changes in Measles Vaccine Potency by Storage Temperature-
Young Mo Sohn, Seung Kyu Lee, Kyu Hyun Park, Won Young Lee
Clin Exp Pediatr. 1992;35(12):1639-1645.   Published online December 15, 1992
Quantitative Assessment of the Diameters of Tricuspid Valve, Mitral Valve and Great Arteries in the Normal Human Fetus -Cross Sectional Echocardiographic Study-
Jung Yun Choi, Kyung Hee Park, Chung Il Noh, Yong Soo Yun, I Seok Kang, Eun Sook Han
Clin Exp Pediatr. 1992;35(11):1566-1572.   Published online November 15, 1992
In order to assess the growth of the mitral valve, tricuspid valve, and the aortic and pulmonary pathways in the normal human fetus, 181 fetal echocardiograms taken from 127 pregnant women (some women had repeated examinations) were analysed. Diameters were measured from cross sectional images and were correlated with gestational period. The diameter ratios of tricuspid valve/mitral valve, aorta/main pulmonary artery,...
The Normal Serum Total Cholesterol Level in Children
Gyu Eun Whoang, Keun Su Rhee, Young Hun Chung
Clin Exp Pediatr. 1992;35(11):1559-1565.   Published online November 15, 1992
The measurement of serum total cholesterol was made in 1 month to 16 years of age group (total 1505, male 700, female 805) to know the normal value on each age and sex group, and incidence of hypercholesterolemia in children. The results were as follows: 1) Serum total cholesterol levels were 163.12¡¾38.01 mg/dl in male, 165.69¡¾38.24 mg/dl in female, and 164.40¡¾38.12 mg/dl...
A Statistical Study on Obesity, Blood Pressure, Serum Total Cholesterol, Serum Apolipoprotein B and Urine Sodium and Potassium in Middle School Children
Yon Ho Choe, Kang Yong Park, Il Soo Ha, Hae Il Cheong, Yong Choi, Jin Kyu Kim
Clin Exp Pediatr. 1992;35(11):1546-1558.   Published online November 15, 1992
A Significance of the Sinusitis in Asthma of Chileren
Kyong Og Ko, Young Hun Chung
Clin Exp Pediatr. 1992;35(11):1537-1545.   Published online November 15, 1992
It has long been recognized that sinusitis are commonly associated with asthma. Studies have observe a high coincidence of asthma and sinusitis. Despite observations of thease findings, a direct cause and effect relationship remains to be estabilished. So this study was undertaken to evaluate the relationship of bronchial asthma and sinusitis. 96 asthmatics and 127 non-asthmatic controls in children were taken...
Portal Hypertension in Children
Young Sook Kim, Ki Sup Chung
Clin Exp Pediatr. 1992;35(11):1528-1536.   Published online November 15, 1992
Portal hypertension assumes special interest in children due to the large variety of causes, the apparent difficulty of performing surgical portal systemic shunts because of the small size of vessels, the doubt still cast on the long term tolerance of portal systemic shunts and the theoretical possibility of spontaneous regression of varices with growth. Thirty cases of portal hypertension under...
The Treatment Results of Childhood RhaMomyosarcoma
Chuhl-Joo Lyu, Byung Soo Kim, Eui Ho Hwang, Chang Ok Suh, Woo-Hee Cung
Clin Exp Pediatr. 1992;35(11):1520-1527.   Published online November 15, 1992
Rhabdomyosarcoma is a relatively common solid tumor in infants, children and adolescents, according for 4% to 8% of malignant disease in children less than 15 years old. Use of a multimodal approach to treatment has resulted in a dramatic improvement. Yonsei Cancer Center in Korea, since it's establishment in 1975, has been a state of multimodal approach. Thirty-seven cases of childhood...
The Significance of Nucleated Red Blood Cell Counts in Various Conditions Associated with Acute or Chronic Perinatal Asphyxia
Suck Kyu Hur, Moon Sang Park, Mee Kyung Namgoong, Hwang Min Kim, Jae Seung Yang, Baek Keun Lim, Jong Soo Kim, Myung Seo Kang
Clin Exp Pediatr. 1992;35(11):1514-1519.   Published online November 15, 1992
This study was conducted to find out the significance of nucleated red blood cell (NRBC) in neonates, especially associated with acute or chronic perinatal asphyxia. So, we compared NRBC counts in various neonatal groups, such as normal newborn, small for gestational age (SGA), premature, acute perinatal asphyxia, & hyaline membrane disease (HMD). In the first day of life, we examined...
Hypercalciuria Associated with Nephropathy (diagnosis by renal biopsy)
Hyun Ho Shin, Jae Yoon Kim, Chong Woo Bae, Sung Ho Cho, Byoung Soo Cho, Chang Il Ahn, Young Tae Ko, Moon Ho Yang
Clin Exp Pediatr. 1992;35(11):1509-1513.   Published online November 15, 1992
Idiopathic hypercalciuria is defined as excessive urinary excretion of calcium in normocalcemia without any primary cause. We performed the sono-guided percutaneous renal biopsy for patients of recurrent hematuria, persistent microscopic hematuria, proteinuria and RBC cast to evaluate underlying nephropathy. We could obtained the following results 1) The age at the renal biopsy ranged from 3 years to 14 years. Sex ratio is 1.9:1...
Clinical Characteristics in Hemophilia Patients
Kun Soo Lee, Eun Sook Kim, Jang Soo Seo
Clin Exp Pediatr. 1992;35(11):1501-1508.   Published online November 15, 1992
The clinical characteristics and laboratory data in the twenty six patients of hemophilia diagnosed in the Department of Pediatrics, Kyungpook National University Hospital for 8 years from 1983 were evaluated. The following results were obtained: Twenty one cases (80.7%) were diagnosed as hemophilia A and five cases (19.3%) as hemophilia B. Eleven cases (42.3%) were diagnosed under one year of age and the...
Plasma Somatomedin C Levels in Normal Children
Bo Young Yun, Hoan Jong Lee
Clin Exp Pediatr. 1992;35(11):1493-1500.   Published online November 15, 1992
Somatomedin C, the insulin-like growth factor I is suggested to mediate the growth-promoting effect of growth hormone. Sm-C, mostly bound to plasma protein forming an IGF-I protein complex, is slowly cleared from plasma and thus its plasma concentration is quite constant. A single sampling of blood for Sm-C is sufficient for the measurement of its concentration. For the evaluation of...
Septicemia in Children with Neoplastic Disease
Bo Young Yun, Hoan Jong Lee
Clin Exp Pediatr. 1992;35(11):1481-1492.   Published online November 15, 1992
This study reviewed 66 episodes of septicemia occurring in 56 children with neoplastic disease at Seoul National University Children뭩 hospital over 31 month period. The most frequent organisms causing 45 episodes in neutropenic patient were Escherichia coli (28%), Klebsiella species (18%), Pseudomonas species (9%), polymicrobic (9%,), and Staphylococcus aureus (7%). The overal mortality was 13% (5/39). The most frequent organisms...
A Basic Study for Respiratory Syncytial Virus Detection Using Polymerase Chain Reaction
Yong Kweon Kim, Jong Duck Kim
Clin Exp Pediatr. 1992;35(10):1402-1410.   Published online October 15, 1992
Basic experimental approach for rapid and acurate detection of respiratory syncitial virus (RSV) infection at gene level has been performed using polymerase chain reaction (PCR). RSV RNA was extracted by RNAzolB methol from RSV which was cultured in Hep-2 cell line. Of RSV genome having about 8,000 base pairs, base pairs between 3237th and 3522nd were selected to make four...
Clinical and Epidemiologic Features of Respiratory Syncytial Virus Infection
Hoan Jong Lee, Seong Hee Jang
Clin Exp Pediatr. 1992;35(10):1389-1401.   Published online October 15, 1992
Although lower respiratory tract infection is a major cause of childhood morbidity in Korea and respiratory viruses are presumed to be important pathogens, there have been few studies available. We diagnosed RSV infection by virus isolation and immunofluorescence in children with lower respiratory tract infection, seen at Seoul National University Children's Hospital from Nov. 1990 to Jul. 1991. The results were...
Immunohistochemical Studies on Neuroendocrine Markers in Malignant Neuronal Tumors (Neuroblastoma and Ganglioneuroblastoma) in Children
Woo Yeong Chung, Sun Kyung Lee
Clin Exp Pediatr. 1992;35(10):1377-1388.   Published online October 15, 1992
The authors studied 24 cases of malignant neuronal tumors, 14 neuroblastomas and 10 ganglioneuroblastomas, immunohistochemically, using antibodies to neuroendocrine markers including neuron specific enolase (NSE), somatostatin, chromogranin, β-endorphin, and adrenocorticotrophic hormone (ACTH). The tissue specimens were obtained by biopsy or autopsy at Pusan National University Hopital and Pusan Paik Hospital from 1980 to 1989. The positive reactivity of markers in...
Carcinomas in Childhood -A 10-Year Experience in Seoul National University Hospital-
Hong Hoe Koo, Kyung Duk Park, Hye Lim Jung, Sang Kyu Park, Hee Young Shin, Hyo Seop Ahn
Clin Exp Pediatr. 1992;35(10):1369-1376.   Published online October 15, 1992
Carcinomas in childhood differ from those in adults in their frequency, histologic type, and distribution of primary sites. In children, carcinomas are rare and few series have been published containing sufficient mumbers of cases to permit a reliable account of the incidence and survival of children with carcinoma. During a 10-year period, 1982-1991, we observed 40 patients less than 16...
Diagnostic Accuracy of Stable Microbubble Rating Test for the Early Detection of Neonatal Respiratory Distress Syndrome
Jung-Sam Jun, Chy-Hyung Park, Jong-Woo Bae, Chang-Il Ahn
Clin Exp Pediatr. 1992;35(10):1361-1368.   Published online October 15, 1992
Respiratory distress syndrome(RDS) of preterm infants remains a significant cause of morbidity and mortality despite improvements in neonatal intensive care and artificial ventiratory techniques. After identification of the deficiency of pulmonary surfactant is major pathophysiologic basis in RDS, artificial surfactant replacement therapy in RDS was first successfully tested on RDS infants by Fujiwara and co-workers in 1980. Therefore, exogenous surfactant replacement...
Growth Promoting Effect of Recombinant methionyl-Growth Hormone in Children with Chronic Renal Failure
Heon Seok Han, Yong Choi, Hyung Ro Moon
Clin Exp Pediatr. 1992;35(10):1355-1360.   Published online October 15, 1992
The authors studied the growth-promoting effect of yeast-derived methionyl-hGH in short statured children with uremic chronic renal failure. The subjects were prepubertal chronic renal insufficient patients whose height standard deviation scores were below -2.0. Two boys and two girls participated in this study. Chronic renal insufficiency was the only cause for the short stature. HGH was given to the subjects in dose...
Blood Flow Velocity in the Ascending Aorta and Main Pulmonary Artery of Children by Doppler Echocardiography
Young Mi Hong
Clin Exp Pediatr. 1992;35(10):1343-1354.   Published online October 15, 1992
The purpose of this study is to establish normal values for Doppler aortic and pulmonary artery flow velocity measurements, adjusted for age and the other parameters, which might be used for evaluating patients with suspected abnormalities of left and right sided hemodynamics. Blood flow velocity measurements were made in the ascending aorta and proximal main pulmonary artery of 117 pediatric normal...
Dimension of Normal Coronary Arteries Determined by Cross-Sectional Echocardiograph
Jung Yun Choi, Yong Soo Yun, Chung Il Noh, Jong Un Choi, I Seok Kang
Clin Exp Pediatr. 1992;35(10):1336-1342.   Published online October 15, 1992
In order to determine the normal values of coronary arterial dimensions in children, eighty eight children without any cardiovascular diseases were studied with cross-sectional echocardiography. Age ranged from 1 day to 15 years. Four sites (proximal right coronary artery, left main, left anterior descending, and left circumflex coronary artery) were selected to measure the dimensions. The right coronary artery was measured...
The Factors on the Development of Coronary Arterial Involvement in Kawasaki Disease
Sang Yen Kim, Jong Hyun Kim, Jong In Byun, Won Bae Lee, Byung Churl Lee, Kyung Tai Whang, Kyong Su Lee, Sung Hoon Cho
Clin Exp Pediatr. 1992;35(10):1328-1335.   Published online October 15, 1992
In Kawasaki disease, coronary arterial involvement is an important prognostic factor. Many studies have reported about risk factors of coronary artery disease in Kawasaki disease. This study was designed to evaluate factors influencing coronary arterial involvement and to evaluate the effect of intravenous gammaglobulin (IVG) when admitted on the widely used criteria in Korea. Fiftyfour patients meeting the CDC criteria...
Children with Delayed Speech Development
Keun Lee
Clin Exp Pediatr. 1992;35(9):1236-1242.   Published online September 15, 1992
Language disorder is one of the most common developmental disorder, its prevalence being 3~20% according to various reports. Delayed speech development is frequently associated with other type of developmental disorder and, if left untreated, can lead to learning difficulty or school failure. Etiologies of delayed speech development are infantile autism, mental retardation, developmental language disorder, hearing defect, emotional disorder or poor...
Children with Delayed Speech Development
Sang Kee Park, Ho Sung Yoo, Yeong Bong Park
Clin Exp Pediatr. 1992;35(9):1236-1242.   Published online September 15, 1992
The antioxidant enzymes superoxide dismutase, catalase and glutathione peroxidase and the lipid peroxidation were assayed in erythroctyes from the cord blood of 25 fullterm newborn infants and their maternal blood abtained immediatedly after normal delivery. Superoxide dismutase and catalase activites in cor blood erythroctytes were significantly lower when compared with their mothers, but glutathione peroxidase activities were not significantly lower....
Infantile Asthma and Egg Allergy
Sung Hee Lim, Hye Sun Lee, Young Min Ahn
Clin Exp Pediatr. 1992;35(9):1226-1235.   Published online September 15, 1992
Egg is known to be the most common food allergen, which induces various symptoms such as atopic dermatitis, bronchial asthma, urticaria, angioedema, gastrointestinal symproms & anaphylaxis, especially during infancy. To evaluate the clinical course & significance of egg allergy in infantile asthma, we performed diagnostic study on 44 patients who were diagnosed as infantile asthma in our hospital from 1988 to...
Clinical Features of Twelve Coxiellemia Pediatric Patients in Korea
Chuhl-Joo Lyu, Dong Soo Kim, Young Mo Sohn, Ki Sup Chung, Kir-Young Kim, Won Young Lee
Clin Exp Pediatr. 1992;35(9):1220-1225.   Published online September 15, 1992
Coxiella burnetii is a rickettsial organism and extremely infectious for humans animals. The infection caused by this organism is endemic throughout the world. Although it has not been reported in Korea because of the nonspecific clinical manifestations, the difficulties in diagnosis, and the underestimate of this disease. Update this infection has been misdiagnosed as other disease. We experienced twelve cases of...
A Clinical Study of Primay Gastrointestinal Lymphoma in Childhood
Hye Jung Joo, Chuhl-Joo Lyu, Byung Soo Kim, Euy Ho Hwang, Chang Ok Suh, Woo Ick Yang, Woo Hee Chung
Clin Exp Pediatr. 1992;35(9):1210-1219.   Published online September 15, 1992
The 18 cases of primary gastrointestinal lymphoma patients admitted to the Department of Pediatrics and Yonsei Cancer Center, College of Medicine, Yonsei University, during 15 years from January, 1975 to December, 1989 were reviewed on the bases of clinical characteristics, treatment, and survival rates. The results were summarized as follows; 1) The age of patients ranged from 3 years to 14 years,...
Acute Renal Failure Following Cardiac Surgery
Kang Yong Park, Yeon Ho Choi, Tae Sun Ha, Il Soo Ha, Hae Il Cheong, Yong Choi, Kwang Wook Ko, Joon Ryang Rho
Clin Exp Pediatr. 1992;35(9):1198-1209.   Published online September 15, 1992
A retrospective study of 452 patients who undertook cardiac surgery was performed to determine the pevalence, etiology, and clinical features of postoperative acute renal failure(ARF). The overall incidence of ARF following cardiac surgery was 4.65%(21/452). The incidence of ARF following open heart surgery(OHS) was 5.11%, and that following closed heart surgery was 2.50%. Preoperactive risk factors noted in the development...
Postnatal change of Atrial natriuretic peptide in newborn Infants
Eun Sook Kim, Heng Mi Kim
Clin Exp Pediatr. 1992;35(9):1193-1197.   Published online September 15, 1992
Atrial natriuretic peptide(ANP)has been described as a part of the regulatory system of volume homeostasis. The role of ANP in postnatal volume hmestasis was investigated in 27 normal newborn infants during the early postnatal period. Plasma Mean plasma concentration of plasma ANP was 24.7¡¾13.8 pg/13.8pg/ml on the 1st day, 56.2¡¾60.0pg/ml on the 3-5th day and 35.0¡¾22.0pg/ml on the 7th day....
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