| Plasma Somatomedin C Levels in Normal Children |
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Bo Young Yun, Hoan Jong Lee, |
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Department of Pediatrics, Seoul National University College of Medicine, Seoul, Korea |
| 정상 아동에 있어서의 혈중 Somatomedin C의 농도 |
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김정탁, 이환종, 김호성 |
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인천기독병원 소아과 |
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| Abstract |
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Somatomedin C, the insulin-like growth factor I is suggested to mediate the growth-promoting effect of growth hormone. Sm-C, mostly bound to plasma protein forming an IGF-I protein complex, is slowly cleared from plasma and thus its plasma concentration is quite constant. A single sampling of blood for Sm-C is sufficient for the measurement of its concentration. For the evaluation of growth hormone deficient and non-deficient dwarfs, measurements of plasma Sm-C may be a useful adjunct to assessment of growth hormone secretion.
To determine the Sm-C reference ranges of the age-and sex-matched norms in Korea, plasma levels of Sm-C/IGF-I were measured by specific radioimmunossay in 186 children and adolescents between the ages of 7 and 20 years. All subjects were in good health and between the 3rd and 97th percentiles for height by a standard growth chart. Pubertal stages were determind by the method of Tanncr.
The results were as follows;
1) The mean levels of plasma Sm-C gradually increased over the consecutive age groups and reached maximum at the age group of 13~15 years in both males and females.
2) The mean levels of plasma Sm-C in females were significantly higher than those in 7/*-
males t all age groups except over 16 years of age.
3) the mean levels of plasma Sm-C reached maximum at 13 years in females and 14 years in males.
4) According to Tanner stage, the mean levels of plasma Sm-C reached maximum at Tanner stage 4 in both males and females.
5) The mean levels of plasma Sm-C in females were higher than those in males at all Tanner stage.
In conclusion, the plasma Sm-C levels in normal children in our study can be used as a reference value for the diagnosis of growth hormone deficiency and the response '
fter gr |
| Key Words:
Somatomedin C , Insulin-like growth factor I |
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