Clinical and Experimental Pediatrics

Editorial

Neonatology (Perinatology)

Fluconazole prophylaxis for prevention of invasive candidiasis in extremely preterm infants

Chun Soo Kim

Clin Exp Pediatr. 2021;64(4):167-168. Published online July 17, 2020

Web of Science 1 Crossref 2

DOI: https://doi.org/10.3345/cep.2020.00745

Genetics and Metabolism

Improving the lives of children with neurofibromatosis type 1

Yoo-Mi Kim

Clin Exp Pediatr. 2021;64(4):165-166. Published online September 18, 2020

· The early diagnosis of neurofibromatosis type 1 (NF1) could be supported by molecular testing in sporadic NF1 patients and would benefit their health.
· The well-planned surveillance and introduction of newly developed drugs targeting molecular pathways could improve the lives of pediatric NF1 patients.

DOI: https://doi.org/10.3345/cep.2020.01277

Nephrology (Genitourinary)

Inhibition of the renin-angiotensin system during fetal kidney development

Eujin Park

Clin Exp Pediatr. 2021;64(3):121-122. Published online September 22, 2020

Web of Science 2 Crossref 2

· Fetal exposure to renin-angiotensin system (RAS) inhibitors leads to short- and long-term kidney complications.
· Women of reproductive age who are absolutely indicated for RAS inhibitors should be adequately informed of the risks for the duration of treatment.

DOI: https://doi.org/10.3345/cep.2020.01228

Infection

Catheter care bundle and feedback to prevent central line-associated bloodstream infections in pediatric patients

Hye-Kyung Cho

Clin Exp Pediatr. 2021;64(3):119-120. Published online December 8, 2020

Web of Science 3 Crossref 4

• Intravascular catheter-related infection is an important cause of morbidity and mortality in children, and care bundles are effective and cost-saving in pediatric and neonatal patients.
• Providing regular feedbacks to critical care practitioners is helpful to maintain compliance to care bundle.
• Establishing a bundle policy (insertion and maintenance), monitoring compliance, and providing regular feedbacks are necessary for prevention of central line-associated bloodstream infections in pediatric patients.

DOI: https://doi.org/10.3345/cep.2020.01186

Other

Is correcting exposure misclassification bias an additional option in meta-analyses?

Ki Eun Kim

Clin Exp Pediatr. 2021;64(3):117-118. Published online January 14, 2021

Systematic reviews and meta-analyses examine various existing research results. Such studies are conducted according to a technically determined algorithm to minimize errors. It is particularly important to understand basic analytical methods such as the fixed-effect and random-effects models and apply appropriate statistical techniques to verify interstudy heterogeneity. A design that eliminates possible bias from the early stages of the research in a step-by-step manner is required whenever possible.

DOI: https://doi.org/10.3345/cep.2020.00325

Hematology

Time to pay attention to anemia in female adolescents

Jae Min Lee

Clin Exp Pediatr. 2021;64(2):78-79. Published online February 1, 2021

Web of Science 1 Crossref 1

DOI: https://doi.org/10.3345/cep.2020.02117

Cardiology

Where should we start to improve pediatric heart transplantation outcomes?

Jinyoung Song

Clin Exp Pediatr. 2021;64(2):76-77. Published online November 25, 2020

· Pediatric heart transplantation is achieving better outcomes.
· The waitlist mortality is still high, especially in Korea, and should be reduced.
· The use of ventricular assist device is promising and might offer improved waitlist mortality rates.

DOI: https://doi.org/10.3345/cep.2020.00584

Neonatology (Perinatology)

Neutrophil CD11b as a promising marker for early detection of neonatal sepsis

Ju Sun Heo

Clin Exp Pediatr. 2021;64(1):28-30. Published online September 1, 2020

Web of Science 5 Crossref 5

· Neonatal sepsis is a global problem and significant cause of neonatal mortality and adverse short- and long-term outcomes.
· Due to severe limitations diagnosing neonatal sepsis, there is a critical need to identify reliable specific biomarkers for early detection.
· nCD11b might be an accurate and rapid biomarker for the early detection of neonatal sepsis.

DOI: https://doi.org/10.3345/cep.2020.00626

General Pediatrics

Why should we be concerned about early menarche?

Hae Sang Lee

Clin Exp Pediatr. 2021;64(1):26-27. Published online July 13, 2020

Crossref 35

· Early menarche is associated with several health problems in later life.
· Early menarche can be caused by environmental factors such as increased subcutaneous fat, a high body mass index, and sugar-sweetened beverages as well as genetic factors.
· Health education can prevent early menarche by aiming to reduce the consumption of fructose, high concentrations of which are present in sugar-sweetened beverages.

DOI: https://doi.org/10.3345/cep.2020.00521

Allergy

Insights into pediatric pollen food allergy syndrome

Jeong Hee Kim

Clin Exp Pediatr. 2020;63(12):483-484. Published online June 1, 2020

Web of Science 1 Crossref 2

DOI: https://doi.org/10.3345/cep.2019.01179

Neonatology (Perinatology)

Barriers to and enablers of kangaroo mother care

Soon Min Lee

Clin Exp Pediatr. 2020;63(11):431-432. Published online October 10, 2019

DOI: https://doi.org/10.3345/kjp.2019.01039

Nephrology (Genitourinary)

Undescended testis: importance of a timely referral to a surgical specialist

Su Jin Kim

Clin Exp Pediatr. 2020;63(11):429-430. Published online March 23, 2020

Crossref 2

Undescended testes (UDT) is the most common congenital genitourinary abnormality in male infants and associated with decreased fertility and a higher future malignancy risk, especially in cases of delayed orchiopexy after puberty. It is important to timely referral to a surgical specialist and timely surgical correction of UDT to improve fertility and decrease the risk of malignancy.

DOI: https://doi.org/10.3345/cep.2020.00115

Neonatology (Perinatology)

Utility of neonatal early-onset sepsis calculator in risk-based group B Streptococcus screening approach

Myo-Jing Kim

Clin Exp Pediatr. 2020;63(10):393-394. Published online May 22, 2020

Web of Science 1 Crossref 1

· Evaluation of the risk factors for early-onset sepsis (EOS) is important to optimal prevention and treatment.
· The EOS calculator is still valid as part of the risk-based group B Streptococcus (GBS) screening approach.
· The risk factor assessment using the EOS calculator is worth use before the introduction of universal GBS screening.

DOI: https://doi.org/10.3345/cep.2020.00500

Risk factors for in-hospital mortality in premature infants with critical congenital heart disease

Jeonghee Shin

Clin Exp Pediatr. 2020;63(10):391-392. Published online October 6, 2020

Web of Science 1 Crossref 2

The incidence and mortality rates of critical congenital heart disease (CHD) are higher in preterm than in term infants. The risk factors for in-hospital mortality in premature infants with critical CHD are unclear. However, the mortality of preterm infants with critical CHD may be related to CHD complexity as well as gestational age, birth weight, the presence of prematurity-associated comorbidities, and the treatment itself.

DOI: https://doi.org/10.3345/cep.2020.00444

Allergy

Should we prescribe montelukast to allergic pediatric patients?

Yong Mean Park

Clin Exp Pediatr. 2020;63(10):389-390. Published online August 24, 2020

DOI: https://doi.org/10.3345/cep.2019.01662

Infection

What are considerations for neonates at risk for COVID-19?

Soo-Han Choi

Clin Exp Pediatr. 2020;63(9):359-360. Published online July 17, 2020

DOI: https://doi.org/10.3345/cep.2020.01074

Neonatology (Perinatology)

Survival model application for analysis of neonatal length of stay

Eun Joo Lee

Clin Exp Pediatr. 2020;63(9):357-358. Published online May 14, 2020

DOI: https://doi.org/10.3345/cep.2019.01508

Gastroenterology

Dietary role in the development and treatment of inflammatory bowel disease

Jae Young Kim

Clin Exp Pediatr. 2020;63(9):355-356. Published online July 13, 2020

Web of Science 1 Crossref 1

Although the precise pathogenesis of inflammatory bowel disease (IBD) is unclear, dietary factors seem to play a significant role. Dietary modifications including enteral nutrition and the Crohn disease exclusion, specific carbohydrate, and anti-inflammatory diets show a potential ability to downregulate gut inflammation. These nutritional interventions have various degree of efficacies with limited side effects profile for treating pediatric IBD, but data from randomized prospective studies are lacking, and further studies are warranted.

DOI: https://doi.org/10.3345/cep.2020.00080

Nutrition

Pivotal roles of prolactin and other hormones in lactogenesis and the nutritional composition of human milk

Yong Joo Kim

Clin Exp Pediatr. 2020;63(8):312-313. Published online August 15, 2020

Web of Science 8 Crossref 8

DOI: https://doi.org/10.3345/cep.2020.00311

Neurology

Commentary on "Autoimmune encephalitis and epilepsy: evolving definition and clinical spectrum"

Jieun Choi

Clin Exp Pediatr. 2020;63(8):310-311. Published online August 15, 2020

DOI: https://doi.org/10.3345/cep.2020.00353

Allergy

Trends in prevalence of allergic diseases in Korean children: how and why?

Kyung Suk Lee

Clin Exp Pediatr. 2020;63(7):263-264. Published online April 13, 2020

Web of Science 2 Crossref 2

DOI: https://doi.org/10.3345/cep.2020.00213

Gastroenterology

Management of perianal abscess and fistula-in-ano in infants and children

Jinyoung Park

Clin Exp Pediatr. 2020;63(7):261-262. Published online March 23, 2020

Web of Science 11 Crossref 15

DOI: https://doi.org/10.3345/cep.2020.00150

Infection

Pneumococcal conjugate vaccines: choice of schedule and product development

Jin Lee

Clin Exp Pediatr. 2020;63(7):259-260. Published online April 27, 2020

Web of Science 3 Crossref 3

DOI: https://doi.org/10.3345/cep.2019.01739

Neonatology (Perinatology)

Should we regularly evaluate the neurodevelopmental status of moderate and late preterm infants?

Son Moon Shin

Clin Exp Pediatr. 2020;63(6):217-218. Published online June 11, 2020

Crossref 4

DOI: https://doi.org/10.3345/cep.2020.00472

What do we know about the long-term cognitive and behavioral outcomes of school-aged children who were born moderate to late preterm?

Eun Sun Kim

Clin Exp Pediatr. 2020;63(6):215-216. Published online February 5, 2020

Crossref 1

DOI: https://doi.org/10.3345/cep.2019.01340

Allergy

Are you sure that it is a drug allergy?

Eun Hee Chung

Clin Exp Pediatr. 2020;63(6):213-214. Published online June 1, 2020

DOI: https://doi.org/10.3345/cep.2019.01487

Neurology

Next-generation sequencing is a powerful method to enhance diagnostic yield in global developmental delay/intellectual disability

Jon Soo Kim

Clin Exp Pediatr. 2020;63(6):211-212. Published online June 11, 2020

Crossref 1

DOI: https://doi.org/10.3345/cep.2019.01683

Emergency Medicine

Pediatric transport medicine: a yet unknown territory in Korea

Jeong-Min Ryu

Clin Exp Pediatr. 2020;63(5):182-183. Published online May 15, 2020

DOI: https://doi.org/10.3345/cep.2019.01270

Neurology

Targeted temperature management and neuroprotective outcomes of pediatric patients after cardiac arrest

Yun-Jin Lee

Clin Exp Pediatr. 2020;63(5):180-181. Published online April 14, 2020

Web of Science 1 Crossref 1

DOI: https://doi.org/10.3345/cep.2019.01396

Nephrology (Genitourinary)

Dapsone: a steroid-sparing drug for refractory immunoglobulin A vasculitis?

Jin-Soon Suh

Clin Exp Pediatr. 2020;63(5):178-179. Published online April 14, 2020

DOI: https://doi.org/10.3345/cep.2019.01634

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Editorial