- Review Article
- Nutrition
- The Korea Infant Physical Growth Examination Survey (KIPGroS): a study protocol
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Jong Woo Hahn, MinSoo Shin, Jin Gyu Lim, Yoon-Joo Kim, Ki Soo Kang, Narae Lee, Seong Hee Jeong, Mun Hui Jeong, Yeoun Joo Lee, Eui Kyung Choi, Jung Ok Shim, Jee Yoon Park, Chan-Wook Park, Joo Young Kim, Su Jin Jeong, Young Hwa Jung, Jaehyun Kim, Chang Won Choi, Ju Whi Kim, Seung Han Shin, Yun Jeong Lee, Young Ah Lee, Choong-Ho Shin, Seung-sik Hwang, Young Eun Kim, Youn Ha Kang, Kyungwon Oh, Sungha Yun, Jae Sung Ko, Jin Soo Moon
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Clin Exp Pediatr. 2025;68(5):352-358. Published online February 13, 2025
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The suitability of World Health Organization (WHO) growth charts for assessing the growth of children under 3 years of age in all countries remains controversial, and their applicability must be evaluated based on country-specific growth data. The Korea Infant Physical Growth Examination Survey evaluated the suitability of WHO growth charts to contribute to the next revision of growth charts in Korea. |
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- Original Article
- Prevalence and risk factors of the metabolic syndrome in young adults with childhood-onset hypopituitary growth hormone deficiency
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Han Hyuk Lim, Min Jae Kang, In Suk Yun, Young Ah Lee, Choong Ho Shin, Sei Won Yang
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Clin Exp Pediatr. 2010;53(10):892-897. Published online October 31, 2010
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Purpose This study evaluated the prevalence of the metabolic syndrome (MetS) and risk factors for metabolic derangement in young adults with childhood-onset hypopituitary growth hormone deficiency (ACOHGHD). MethodsThirty patients with ACOHGHD who were treated with hormone-replacement therapy, aged 18 to 29 years, who visited the Seoul National University Children's Hospital between September 2009 and February 2010 were enrolled. Height, weight, waist circumference,... |
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- Remission rate and remission predictors of Graves disease in children and adolescents
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Sun Hee Lee, Seong Yong Lee, Hye Rim Chung, Jae Hyun Kim, Ji Hyun Kim, Young Ah Lee, Sei Won Yang, Choong Ho Shin
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Clin Exp Pediatr. 2009;52(9):1021-1028. Published online September 15, 2009
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Purpose : Medical therapy is the initial treatment for children with Graves disease to avoid complications of other treatments. However, optimal treatment for childhood Graves disease is controversial because most patients require relatively long periods of medical therapy and relapse is common after medication discontinuation. Therefore, this study aimed to search clinical or biochemical characteristics that could be used as... |
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- Growth responses to growth hormone therapy in children with attenuated growth
who showed normal growth hormone response to stimulation tests
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Jae Hyun Kim, Hey Rim Chung, Young Ah Lee, Sun Hee Lee, Ji Hyub Kim, Choong Ho Shin, Sei Won Yang
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Clin Exp Pediatr. 2009;52(8):922-929. Published online August 15, 2009
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Purpose:The aim was to investigate the clinical characteristics and responses to growth hormone (GH) therapy in children
with attenuated growth who showed normal GH responses to GH stimulation tests (GHST).
Methods:The study included 39 patients with height velocity (HV) of less than 4 cm/yr and normal GHST results. Clinical
characteristics of patients were analyzed retrospectively.
Results:Eleven were born as small for gestational age (SGA)... |
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- Factors for persistent growth hormone deficiency in young adults with childhood onset growth hormone deficiency
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Young Ah Lee, Hye Rim Chung, Se Min Lee, Jae Hyun Kim, Ji Hyun Kim, Sun Hee Lee, Choong Ho Shin, Sei Won Yang
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Clin Exp Pediatr. 2009;52(2):227-233. Published online February 15, 2009
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Purpose : Growth hormone (GH) replacement after retesting is necessary because impairment of body composition and cardiovascular health has been more severe in adult patients with persistent GH deficiency (GHD) from childhood to adulthood. This study aimed to investigate the factors for persistent GHD and define a highly probable group of persistent GHD in young adults with childhood-onset GHD.
Methods :... |
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- Interpretation of screening for congenital adrenal hyperplasia in preterm infants
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Hye Rim Chung, Choong Ho Shin, Sei Won Yang, Kyong Ah Yun, Young Ah Lee, So Eun Park, Chang Won Choi, Byung Il Kim, Jung Hwan Choi, Junghan Song
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Clin Exp Pediatr. 2008;51(6):616-621. Published online June 15, 2008
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Purpose : This study was undertaken to identify factors that influence 17-OHP levels in preterm infants and to suggest a reasonable follow-up schedule of screening for congenital adrenal hyperplasia (CAH) in preterm infants.
Methods : The 17-OHP concentrations in filter paper blood spots of 427 preterm infants were obtained. The effects of gestational age (GA), systemic diseases, and antenatal dexamethasone... |
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- Case Report
- Pheochromocytoma associated with
cyanotic congenital heart disease
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Seung Joon Chung, Young Ah Lee, Choong Ho Shin, Sei Won Yang, Eun Jung Bae, Jung Il Noh
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Clin Exp Pediatr. 2008;51(1):93-97. Published online January 15, 2008
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Pheochromocytoma is a rare tumor of childhood, arising from adrenal medullary and chromaffin tissue. Because chronic hypoxia may induce pheochromocytoma, there have been several reports of pheochromocytoma development in cyanotic patients after corrective or palliative cardiac surgery. The variable clinical presentation of pheochromocytoma is obscured by both underlying heart disease and medications. If sudden hypertension, aggravation of a heart condition,... |
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- Original Article
- A study and the growth and the development of microvascular complications in patients with type 1 diabetes mellitus
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Young Ah Lee, Kyong-Ah Yun, Choong Ho Shin, Sei Won Yang
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Clin Exp Pediatr. 2007;50(2):190-197. Published online February 15, 2007
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Purpose : Reduced growth and microvascular complications have been recognized as consequences of type 1 diabetes mellitus (T1DM). We assessed the effect of T1DM on growth and factors associated with the development of microvascular complications.
Methods : We conducted a retrospective longitudinal evaluation of 154 patients above 16 years of age. We analyzed factors which affect final height standard deviation scores... |
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- Factors affecting the final adult height in survivors of childhood brain tumors
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Kyong-Ah Yun, Young Ah Lee, Choong Ho Shin, Sei Won Yang, Hee Young Shin, Hyo Seop Ahn, Il Han Kim
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Clin Exp Pediatr. 2007;50(1):65-73. Published online January 15, 2007
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Purpose : Short stature is an important complication that impairs the quality of life in survivors of childhood brain tumors. We studied their final adult height (FAH) to evaluate risk factors for short stature.
Methods : We reviewed the medical data of 95 survivors of childhood brain tumors (64 males and 31 females) who had been followed up from 1982 to... |
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- Case Report
- A case of congenital ductus arteriosus aneurysm
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Sheng Wen Wang, Ji Eun Kim, Young Seok Lee, Young Ah Lee
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Clin Exp Pediatr. 2006;49(12):1363-1366. Published online December 15, 2006
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Aneurysmal dilatation of the ductus arteriosis has been considered a rare but potentially fatal abnormality. The mechanism of ductal aneurysmal formation remains uncertain. Plain chest radiography has proven helpful in the diagnosis of ductus arteriosus aneurysm (DAA), before the application of transthoracic echocardiography. The transthoracic echocardiography is an important tool for the diagnosis and follow-up of DAA. We present a... |
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- A case of pyomyositis due to Mycobacterium tuberculosis
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Yun-Jin Bae, Jin-Sung Choi, Young Ah Lee, Sung-Soo Kim, Seo-Hee Rha, Jin-A Jung
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Clin Exp Pediatr. 2006;49(10):1116-1119. Published online October 15, 2006
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Pyomyositis is a primary bacterial infection of the skeletal muscles. Although infection can affect any skeletal muscle, the large muscle groups such as the quadriceps or gluteal muscles are most often the focus of this disease, and most commonly the inflammation is focal, involving a single muscle. The mechanism of pyomyositis is poorly understood. The local mechanical trauma at the... |
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- Original Article
- Sequential Analysis of Hepatitis Be Antigen Status in Infants
Born to Hepatitis Be Antigen-Positive Mothers
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Eun Sook Park, Hae Kyung Lee, Chang Hee Oh, Sung Ku Kim, Hae Sun Yun, Won Keun Song, Young Ah Lee
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Clin Exp Pediatr. 2002;45(6):727-731. Published online June 15, 2002
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Purpose : The objectives of this study are to evaluate the significance of HBeAg positivity in infants born to HBeAg and HBsAg positive mothers.
Methods : The HBeAg status of 22 HBeAg positive, HBsAg negative infants born to HBeAg and HBsAg positive mothers from December 1996 to March 1999 were evaluated by enzyme immunoassay.
Results : The number of HBsAg positive... |
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- Case Report
- A Recurred Case of Subacute Necrotizing Lymphadenitis(Kikuchi`s Disease) During Childhood
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Jin Sun Park, Chang Hee Oh, Je Woo Kim, Phil Soo Oh, Young Ah Lee, He Sun Yun, Jung Weon Shim
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Clin Exp Pediatr. 2000;43(9):1285-1289. Published online September 15, 2000
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Subacute necrotizing lymphadenitis, or Kikuchi`s disease, primarily affects the cervical lymph nodes of young adults and has a self-limited clinical course. Differential diagnoses are malignant lymphoma and systemic lupus erythematosus. Recurrence rate is low as 3.3%, and there have been a few reports describing the recurrence of the disease. The symptoms in almost all recurrent cases were similar to those... |
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- Original Article
- Intravenous Gamma-globulin Retreatment in Kawasaki Disease
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Young Ah Lee, Hyun Kee Chung
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Clin Exp Pediatr. 2000;43(11):1488-1494. Published online November 15, 2000
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Purpose : This study was designed to determine the outcome and safety of intravenous gamma- globulin(IVGG) retreatment in Kawasaki disease.
Methods : A clinical observation of the therapeutic effects, laboratory findings and echocardiograms was carried out on 72 patients with Kawasaki disease in Kosin University Hospital from 1991 to 1999. 27 patients were treated with 1g/kg/day IVGG for 2 days,... |
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- Case Report
- A Case of Greig Cephalopolysyndactyly Syndrome
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Seon Hee Shin, Je Woo Kim, Young Ah Lee, Hae Sun Yoon, Hyun Chan Cho
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Clin Exp Pediatr. 2000;43(1):128-132. Published online January 15, 2000
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Greig cephalopolysyndactyly syndrome(GCPS) is a disorder characterized by postaxial polydactyly
of the hand, broad or occasionally bifid thumbs, preaxial polydactyly of the feet, broad halluces,
syndactyly of the fingers or toes, macrocephaly, frontal bossing, hypertelorism and a broad nasal
bridge. Intelligence is usually normal, although borderline IQ has been reported. Advanced bone
age, mild hydrocephalus, craniosynostosis and agenesis of the corpus callosum are occasionally
associated... |
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- Two Cases of Thymic Carcinoma in Childhood
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Young Ah Lee, Jin Young Park, Hye Lim Jung, Moon Soo Par, Hyoung Soo Choi, Eun Sun Yoo, Hyo Seop Ah
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Clin Exp Pediatr. 1999;42(3):424-429. Published online March 15, 1999
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Thymic carcinoma is a malignant neoplasm arising from the thymic epithelium, and is known to be extremely uncommon in the pediatric population. The tumor is clinically highly aggressive with frequent local intrathoracic spread and extrathoracic metastases detected in the majority of patients at initial diagnosis and often shows minimal or no response to conventional chemotherapy. We experienced two pediatric patients... |
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- Original Article
- A Seroepidemiologic Study on Hepatitis A in Seoul, Korea
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Dong Woon Yang, Young Ah Lee, Jung Yeon Shim, Jin Young Park, Hye Lim Jung, Moon Soo Park, Dong Hyeuk Keum
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Clin Exp Pediatr. 1999;42(2):180-185. Published online February 15, 1999
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Purpose : The prevalence of hepatitis A(HAV) in a certain community reflects that community’s living standard and hygienic condition. And the pattern of HAV infection differs over time and geography, with varying widely from country to country and even within the same city. Recently a shift in prevalence has been observed in cases from childhood to adulthood. We studied HAV... |
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- A Study of Factors Affecting Time of First Stool in Premature Infants
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Hyeong Doo Cho, Je Woo Kim, Young Ah Lee, Hae Sun Yoon
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Clin Exp Pediatr. 1999;42(12):1645-1650. Published online December 15, 1999
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Purpose : To assess the effect of gestational age and illness severity, and the effect of antenatal exposure to magnesium sulfate, glucocorticoids, and antibiotics, on the timing of the first stool in preterm infants.
Methods : Medical records of all preterm infants admitted to the neonatal ward at Kangnam Sacred Heart Hospital between March 1998 and August 1998 were reviewed. We... |
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- A Clinical Study of Single Umbilical Artery
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Mi Yeon Choi, Young Jun Kim, Young Ah Lee, Ha Joo Choi, Woo Kap Chung, Keun Young Lee
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Clin Exp Pediatr. 1998;41(4):498-504. Published online April 15, 1998
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Purpose : Single umbilical artery(SUA), the most common malformation of the umbilical cord,
has long been of interest because of its association with congenital malformations. This retrospective
study was aimed to evaluate the incidence of SUA and its associated malformations.
Method : The study population was inborn neonates of Kang-Nam Sacred Heart Hospital of
Hallym University. We reviewed retrospectively the medical records of 15... |
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- Survey on Parental Knowledge about Febrile Convulsion
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Sung Koo Kim, Young Jun Kim, Phil Soo Oh, Young Ah Lee, Ha Joo Choi, Hae Sun Yoon
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Clin Exp Pediatr. 1998;41(11):1559-1564. Published online November 15, 1998
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Purpose : We surveyed parental knowlege about febrile convulsion in order to reduce unnecessary use of diagnostic method and management, and to use as an educational guideline.
Methods : The survey composed of four items : etiology, diagnosis and treatment, prognosis, and method management at home. The rate of correct answers on the total questionnaire, and each questionnaires was compared to... |
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- Case Report
- A Case of Band Heterotopia
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Sung Koo Kim, Young Jun Kim, Young Ah Lee, Ha Joo Choi, Woo Kap Chung
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Clin Exp Pediatr. 1997;40(7):999-1003. Published online July 15, 1997
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The “band heterotopia” or “double cortex” is a brain anomaly that is presumed to
result from a premature arrest of neuronal migration. Generalized disorders of neuronal
migration to the cerebral cortex have been recognized since the end of the 19th century.
Recently, development of neuroimaging technique, such as MRI, have permitted easy
diagnosis of generalized neuronal migration disorder. This syndrome is prevalent in
females. Most... |
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- A Case of Dup(3q) Syndrome
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Yo Seop Pahn, Mi Yeon Choi, Young Ah Lee, Woo Kap Chung, Keun Young Lee, Sook Kyoung Oh
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Clin Exp Pediatr. 1997;40(3):408-412. Published online March 15, 1997
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We have experienced a case of dup(3q) syndrome in the neonate who had a multiple
congenital anomalies of hypertrichosis, hypertelorism, upslanting palpaberal fissures, anteverted nostrils, long philtrum, micrognathia, downturned corners of the mouth, highly arched palate, short, webbed neck, clinodactyly, rocker-bottom feet, dermal sinus. Cytogenetic studies showed a duplication 3q21→qter regions. Chromosome study of relatives is extremely important for counseling because... |
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- Original Article
- Diagnosis of Cytomegalovirus Infection in Neonatal and Infantile Periods Using Polymerase Chain Reaction
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Young Ah Lee, Kyoung Lee, In Seong Jo, Woo Gap Chung
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Clin Exp Pediatr. 1996;39(9):1271-1279. Published online September 15, 1996
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Purpose : The aims of present study were to document the incidence of cytomegalovirus
infection in neonatal and infantile periods especially in high-risk patients of associated infection
by nested PCR of DNA from leukocytes and to evaluate the effectiveness of nested PCR in the
diagnosis of congenital cytomegalovirus infection.
Methods : Genomic DNA was extracted from peripheral leukocytes of 204 neonates and infants
during the... |
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- Effect of Recombinant Human Erythropoietin on the Anemia of Premature Infants
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Young Ah Lee, Ki Soo Kim, Young Seo Park, Hyung Nam Moon, Chang Yee Hong
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Clin Exp Pediatr. 1996;39(5):631-640. Published online May 15, 1996
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Purpose : To determine whether the prophylactic treatment with recombinant human
erythropoietin(rHuEPO) for the anemia of prematurity would reduce the need for blood
transfusions.
Methods : We randomly assigned 17 premature infants to therHuEPO group and the
control group. For the rHuEPO group (n=9, birth weight=1210¡¾156 g, gestational
age=31.7¡¾1.9wk), rHuEPO (400U/kg) was given three times a week for 4 weeks, plus
iron (8 mg/kg/day) and vitamin... |
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- Case Report
- Subacute Necrotizing Lymphadenitis in a 3 Year-Old Male Child
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You Mee Heo, Seong Koo Kim, Young Ah Lee, Dae Gil Lee, Ha Ju Choi, Woo Kap Chung, Jung Won Shin
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Clin Exp Pediatr. 1996;39(10):1443-1447. Published online October 15, 1996
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Subacute necrotizing lymphadenitis is a benign form of lymphadenitis that was first described
in Japan by Kikuchi in 1972. It mainly affects young women and usually manifests as fever and
lymphadenopathy. Although it is a benign self-limited lymphadenitis, it has been misdiagnosed as
malignant lymphoma. Histologically, involved lymph nodes contain a necrotizing process
characterized by patch, well-circumscribed area with eosinophilic fibrinoid material. There is... |
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- Two Cases of Congenital TBG Deficiency
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In Seong Jo, Ha Joo Choi, Young Ah Lee, Woo Gap Chung, Youn Bok Chang
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Clin Exp Pediatr. 1995;38(5):697-701. Published online May 15, 1995
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We have experienced 4 and 5-week-old male neonates presented low T4 and normal TSH l-evel by filter paper mothod for neonatal screening, finally diagnosed typical TDG deficiency wit h TBG radioimmunoassay, paper electrophoresis, and autoradiography. Two neonates have ha d no specific complaints and lived well until now.
Congenital TBG deficiency is an X chromosome linked inhcritant disorder characterized by l... |
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- Original Article
- Prevalence of Epstein-Barr Virus (EBV) Antibody in Korean Children
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Sei Ho Oh, Young Ah Lee, Woong Young Moon, Tae Sun Won, Young Seo Park, Hyung Nam Moon, Chang Yee Hong, Dae Won Kim
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Clin Exp Pediatr. 1994;37(6):804-811. Published online June 15, 1994
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Recently, cases with typical clinical manifestations of infectious mononucleosis are increasing in Korea. So, to evaluate the recent epidemiology of EBV infection in Korea, we performed EBV serologic antibody tests for IgG antibody to EBV-viral capsid antigen (VCA) and antibody to EBV-associated nuclear antigen (EBNA) among the 108 healthy Korean infants and children whose ages were from newborn to 15... |
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- Case Report
- A Case of Rett Syndrome Observed with Video-EEG Monitoring
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Hyun Mi Kim, Young Ah Lee, TaecSung Ko, Hyung Nam Moon, Chang Yee Hong
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Clin Exp Pediatr. 1994;37(5):718-725. Published online May 15, 1994
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Rett syndrome is progressive neurodegenerative disorder in female patients, characterized by autistic behavior, mental retardation, loss of purposeful hand skills, sterotypic hand movement, breathing dysfunction, severely impaired language, ataxia, and seizure. The diagnosis of Rett syndrome is based on its characteristic clinical manifestation and course. The electroencephalographic(EEG) findings of Rett syndrome are nonspecific, but a progressive deteriorationin the EEF, characterized... |
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- Original Article
- Hand, Foot and Mouth Disease Associated with the Aseptic Meningitis in Seoul, 1990
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Young Ah Lee, Sei Ho Oh, Soo Jong Hong, Young Hwue Kim, Hyung Nam Moon, Chang Yee Hong
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Clin Exp Pediatr. 1993;36(6):842-849. Published online June 15, 1993
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We performed clinical and virological studies on 79 children with hand, foot and mouth disease(HFMD) who had been admitted or visited to the department of Pediatrics, Asan Medical Center from February to August, 1990.
The results were as follows;
1) There were total of 79 cases with hand, foot and mouth disease during this period. The aseptic meningitis was combined in 18cases(22.8%)
2)... |
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- Clinical analysis on fetal and neonatal arrhythmia.
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Young Ah Lee, Chung Il Noh, Jung Hwan Choi, Jung Yun Choi, Yong Soo Yun, Chong Ku Yun
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Clin Exp Pediatr. 1991;34(4):507-514. Published online April 30, 1991
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저자들은 최근 5년 8개월 동안 서울대학교병원 소아과에서 경험한 태아 및 신생아기의 심부정맥 24
례에 대하여, 이들의 심전도, 심초음파도, 24시간 심전도 소견 및 임상 기록을 통하여,부정맥의 유
형과 여러 연관 요소에 대한 임상적 분석을 시행하였다. 발견된 부정맥은 심실조기수축 7례, 심방조
기수축 5례,상실성 빈맥 7례,동성서맥 2례, 심방조동 1례, 지속적인 1도 방실 블록 1례, 심실 빈맥
1례였다. 심장 이상은 10례(2 ASD : 4례, PDA : 1례,ASD+VSD :... |
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- A clinical observation on chylothorax in childhood.
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Mi Jin Jung, Joon Jai Kim, Young Ah Lee, Chung Il Noh, Jung Hwan Choi, Chong Ku Yun
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Clin Exp Pediatr. 1991;34(4):497-506. Published online April 30, 1991
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Fourteen patients who had developed a chylothorax in childhood during a ten year period, from
Jan. 1979 to July 1989, were reviewed by their hospital records. The chylothoraces occurred most
frequently as complications of cardiothoracic surgeries in eight patients(57%). Four cases followed
extrapericardial operations such as ligation of PDA and take-down of Blalock-Taussig shunt, and
four cases followed intrapericardial operations such as corrective operations... |
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- Clinical study of Kasabach-Merritt syndrome.
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Eun Jung Bae, Young Ah Lee, Hee Young Shin, Hyo Seop Ahn
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Clin Exp Pediatr. 1991;34(3):371-379. Published online March 31, 1991
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A retrospective analysis of clinical findings in 20 patients with Kasabach-Merritt syndrome who
visited Department of Pediatrics, Seoul National University Hospital from January, 1979 to June,
1990 was performed. The average age of occurrence was 6.4 month and male to female ratio was 1:
1.2. The mean size of hemangioma was 11.0x8.5 cm and the locations were cutanous in 18 (extrem-
ities 5, trunk... |
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- Acute pyogenic arthritis of hip in neonate and infant.
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Mi Jung Kim, Young Ah Lee, Young Pyo Chang, Hoan Jong Lee, Jung Hwan Choi, Chong Ku Yun, Hak Jin Min, In Ho Choi
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Clin Exp Pediatr. 1991;34(2):197-205. Published online February 28, 1991
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Acute pyogenic arthritis of hip is a serious infection that can lead to truly devastating complica-
tions especially in neonatal period and infancy. Clinical survey on twelve neonates and infants (14 hip
joints) with acute pyogenic arthritis of hip who were admitted to the Departments of Pediatrics and
Orthopedic Surgery, Seoul National University Hospital from Jan. 1980 to Dec. 1989 were done.
The results... |
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- Two cases of Goldenhar's Syndrome.
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Ah Young Yun, Nam Sun Baik, Young Ah Lee, Hyung Ro Moon
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Clin Exp Pediatr. 1990;33(3):380-385. Published online March 31, 1990
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Goldenhar’s syndrome is a syndrome consisting of (1) epibulbar dermoids and/or lipodermoids (2)
preauricular skin tags and blind-ended fistulas and (3) vertebral anomalies.
Two cases of Goldenhar’s syndrome which showed asymmetric facies, epibubar dermoids, preaur-
icular skin tags blind-ended fistulas in 7 month-old girl and 2 month-old boy were reported. In one of
our cases cleft of vertebrae, hypoplasia of left lung and cyanotic... |
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