| Growth responses to growth hormone therapy in children with attenuated growth
who showed normal growth hormone response to stimulation tests |
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Jae Hyun Kim, Hey Rim Chung, Young Ah Lee, Sun Hee Lee, Ji Hyub Kim, Choong Ho Shin, Sei Won Yang |
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Department of Pediatrics, College of Medicine, Seoul National University, Seoul, Korea |
| 성장호르몬 자극검사가 정상인 성장 장애 소아 환자에게서 성장호르몬 투여에 따른 성장속도의 변화 |
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김재현, 정혜림, 이영아, 이선희, 김지현, 신충호, 양세원 |
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서울대학교 의과대학 소아과학교실 |
Correspondence:
Sei Won Yang, Email: growth@snu.ac.kr
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| Abstract |
Purpose
The aim was to investigate the clinical characteristics and responses to growth hormone (GH) therapy in children
with attenuated growth who showed normal GH responses to GH stimulation tests (GHST).
Methods
The study included 39 patients with height velocity (HV) of less than 4 cm/yr and normal GHST results. Clinical
characteristics of patients were analyzed retrospectively.
Results
Eleven were born as small for gestational age (SGA) and 28 as appropriate for age (AGA). In the SGA group, the
standard deviation score (SDS) of age and height measured at their first visit was significantly low. Sixteen patients were treated
with GH and six of 23 without GH therapy were followed for 1 year after GHST. The mean (range) of HV was 7.7 (4.9 to 11.1)
cm/yr in patients with GH therapy and 3.7 (2.7 to 4.5) cm/yr in those without GH therapy, which was statistically significant
(P<0.001). In the GH-treated group, HV and difference in height SDS during the treatment increased significantly (P<0.001; P<
0.001, respectively). HV increased after 1 year of GH therapy in the SGA and AGA groups (SGA, P=0.043; AGA, P=0.003).
The level of Insulin-like growth factor-I was significantly lower in GH-treated patients with height SDS <-3 than those with ≥3
(P=0.023).
Conclusion
In children with growth failure and normal GHST, HV increases significantly by short-term GH therapy. The
assessment of long-term effects of GH therapy is necessary. Moreover, further studies should be considered to evaluate the
GH-IGF-I axis due to the possibility of GH insensitivity syndrome. |
| Key Words:
Growth disorders, Growth hormone, Growth hormone insensitivity syndrome |
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