- Review Article
- Endocrinology
- Growth plate closure and therapeutic interventions
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Ja Hyang Cho, Hae Woon Jung, Kye Shik Shim
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Clin Exp Pediatr. 2024;67(11):553-559. Published online October 28, 2024
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Height gains result from longitudinal bone growth. Upon adequate growth, growth plate closure limits longitudinal bone growth. To date, gonadotropin-releasing hormone analogs, aromatase inhibitors, C-type natriuretic peptide analogs, and fibroblast growth factor receptor 3 inhibitors have been studied or used as therapeutic interventions to delay growth plate closure and increase human height. The development of more effective therapeutic modalities for short stature, precocious puberty, and skeletal dysplasia is anticipated. |
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- Case Report
- Two cases of female hydrocele of the canal of nuck
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Yu Mi Choi, Gyu Min Lee, Jung Bin Yi, Kyung Lim Yoon, Kye Shik Shim, Chong Woo Bae, Sung Il Choi, Hyun Cheol Kim
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Clin Exp Pediatr. 2012;55(4):143-146. Published online April 30, 2012
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The processus vaginalis within the inguinal canal forms the canal of Nuck, which is a homolog of the processus vaginalis in women. Incomplete obliteration of the processus vaginalis causes indirect inguinal hernia or hydrocele of the canal of Nuck, a very rare condition in women. Here, we report 2 cases of hydrocele of the canal of Nuck that were diagnosed... |
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- Original Article
- Polymorphisms of methylenetetrahydrofolate reductase are not a risk factor for Kawasaki disease in the Korean population
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Kyung Lim Yoon, Jin Hee Ko, Kye Shik Shim, Mi Young Han, Sung Ho Cha, Su Kang Kim, Joo Ho Jung
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Clin Exp Pediatr. 2011;54(8):335-339. Published online August 31, 2011
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Purpose Hyperhomocysteinemia is known as a risk factor for atherosclerosis. Preclinical arteriosclerosis is noted and premature atherosclerosis is known to be accelerated in Kawasaki disease (KD) patients. Genetic polymorphisms in the 5,10-methylenetetrahydrofolate reductase (MTHFR) gene result in elevated plasma homocysteine concentrations and are known to be associated with the development of coronary artery disease. Our hypothesis is that single nucleotide polymorphisms... |
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- Multiple births conceived by assisted reproductive technology in Korea
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Young Sil Park, Sun Hee Choi, Kye Shik Shim, Ji Young Chang, Won Ho Hahn, Yong Sung Choi, Chong-Woo Bae
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Clin Exp Pediatr. 2010;53(10):880-885. Published online October 31, 2010
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Purpose The recent trends of multiple births (MBs) conceived by assisted reproductive technology (ART) in Korea were analyzed as well as the relationship with maternal age, especially advanced maternal age. MethodsData were obtained from the Korean Statistical Information Service and annual ART reports from the ART committee of the Korean Society of Obstetrics and Gynecology. ResultsMBs increased from the early 1990s; there was... |
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- The Correlation Between the TSH Level in Neonatal Screening Test and the Prognosis of Congenital Hypothyroidism
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Hong Sun Park, Kye Shik Shim, Kyuchul Choeh
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Clin Exp Pediatr. 2001;44(1):25-31. Published online January 15, 2001
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Purpose : It is important to diagnose and treat newborn patients with congenital hypothyroidism as soon as possible because of neurodevelopmental outcome. If we can detect more severe forms of congenital hypothyroidism with neonatal screening test, the results of treatment will improve.
Methods : Sixty-four term infants whose TSH levels in neonatal screening test had been higher than 20μIU were recalled.... |
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- Infantile Hypertrophic Pyloric Stenosis Treated with Intravenous Atropine Sulfate
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Jae Woo Lim, Hee Sook Son, Kye Shik Shim, Kyu Chul Choeh, Tae Il Han
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Clin Exp Pediatr. 2000;43(6):763-768. Published online June 15, 2000
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Purpose : The pharmacologic effect of atropine on HPS can be considered to control pyloric muscle spasm. Therefore, we studied the effects of intravenous atropine sulfate on the clinical course of HPS, and periodically observed the ultrasonographic appearance of the pyloric muscles after atropine treatment.
Methods : From April 1998 to May 1999, 14 infants who were diagnosed with HPS were... |
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- Role of Polymorphism in HLA DQ-α and -β Chain Loci in the Pathophysiology of Autoimmune Thyroid Disease in Children with and without Turner Syndrome
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Kye Shik Shim, Kyu Chul Choeh, Sei Won Yang, Sa Jun Chung, Jin Sung Lee, Kyung Tae Lee, Sung Ho Goh, Yong Sung Kim
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Clin Exp Pediatr. 1999;42(7):980-990. Published online July 15, 1999
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Purpose : About 10% of girls with Turner syndrome may have autoimmune thyroid disease(AIT), but the disease's pathophysiology has not yet been elucidated. Accordingly, this study was performed to observe whether the pathogenesis of AIT in children with Turner syndrome and without Turner syndrome correlate with special loci of DQ α and β chain in HLA.
Methods : Blood samples were... |
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- Re-Evaluation of Neonatal Screening Tests for Inborn Errors of
Metabolism with Dried Filter Paper Blood Spots
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Kye Shik Shim, Jin Soon Hwang, Jung Sub Lim, Se Young Kim, Choong Ho Shin, Sei Won Yang, Jung Hwan Choi, Chong Ku Yun, Jung-Han Song
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Clin Exp Pediatr. 1999;42(12):1639-1644. Published online December 15, 1999
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Purpose : There have been high rates of false positive and recall in neonatal screening test using the cut-off points set by the manufacturing company. So, it is necessary to re-evaluate the cut off values to minimize the false positive rates.
Methods : We collected capillary blood in dry filter paper from 996 healthy neonates on the third day in cases... |
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