- Original Article
- Oncology
- Excellent treatment outcomes in children younger than 18 months with stage 4 MYCN nonamplified neuroblastoma
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Chiwoo Kim, Young Bae Choi, Ji Won Lee, Keon Hee Yoo, Ki Woong Sung, Hong Hoe Koo
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Clin Exp Pediatr. 2018;61(2):53-58. Published online February 28, 2018
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Purpose Although the prognosis is generally good in patients with intermediate-risk neuroblastoma, no consensus has been reached on the ideal treatment regimen. This study analyzed treatment outcomes and toxicities in patients younger than 18 months with stage 4 MYCN nonamplified neuroblastoma. MethodsWe retrospectively analyzed 20 patients younger than 18 months newly diagnosed with stage 4 MYCN nonamplified neuroblastoma between January 2009 and... |
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- Prognostic factors in children with extracranial germ cell tumors treated with cisplatin-based chemotherapy
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Jinsup Kim, Na Hee Lee, Soo Hyun Lee, Keon Hee Yoo, Ki Woong Sung, Hong Hoe Koo, Jeong-Meen Seo, Suk-Koo Lee
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Clin Exp Pediatr. 2015;58(10):386-391. Published online October 21, 2015
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Purpose To evaluate the outcomes and prognostic factors in children with extracranial germ cell tumors (GCTs) treated at a single institution. MethodsSixty-six children diagnosed with extracranial GCTs between 1996 and 2012 were included in the study. Primary treatment was surgical excision, followed by six cycles of cisplatin-based chemotherapy. The survival rates were compared according to the International Germ Cell Cancer Cooperative Group... |
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- Review Article
- Treatment of high-risk neuroblastoma
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Ki Woong Sung
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Clin Exp Pediatr. 2012;55(4):115-120. Published online April 30, 2012
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Although high-dose chemotherapy and autologous stem cell transplantation (HDCT/autoSCT) have improved the prognosis for patients with high-risk neuroblastoma (NB), event-free survival rates remain in the range of 30 to 40%, which is unsatisfactory. To further improve outcomes, several clinical trials, including tandem HDCT/autoSCT, high-dose 131I-metaiodobenzylguanidine treatment, and immunotherapy with NB specific antibody, have been undertaken and pilot studies have reported... |
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- Original Article
- Hematopoietic stem cell transplantation in children with acute leukemia: similar outcomes in recipients of umbilical cord blood versus marrow or peripheral blood stem cells from related or unrelated donors
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Eun Sang Yi, Soo Hyun Lee, Meong Hi Son, Ju Youn Kim, Eun Joo Cho, Su Jin Lim, Hee Won Cheuh, Keon Hee Yoo, Ki Woong Sung, Hong Hoe Koo
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Clin Exp Pediatr. 2012;55(3):93-99. Published online March 16, 2012
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Purpose This study compared outcomes in children with acute leukemia who underwent transplantations with umbilical cord blood (UCB), bone marrow, or peripheral blood stem cells from a human leukocyte antigen (HLA)-matched related donor (MRD) or an unrelated donor (URD). MethodsThis retrospective study included consecutive acute leukemia patients who underwent their first allogeneic hematopoietic stem cell transplantation (HSCT) at Samsung Medical Center between... |
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- The metabolic syndrome and body composition in childhood cancer survivors
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Young Bae Sohn, Su Jin Kim, Sung Won Park, Se-Hwa Kim, Sung-Yoon Cho, Soo Hyun Lee, Keon Hee Yoo, Ki Woong Sung, Jae Hoon Chung, Hong Hoe Koo, Dong-Kyu Jin
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Clin Exp Pediatr. 2011;54(6):253-259. Published online June 30, 2011
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Purpose Long-term survivors of childhood cancer appear to have an increased risk for the metabolic syndrome, subsequent type 2 diabetes and cardiovascular disease in adulthood compared to healthy children. The purpose of this study was to investigate the frequency of the metabolic syndrome and associated factors in childhood cancer survivors at a single center in Korea. MethodsWe performed a retrospective review of... |
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- Responses and adverse effects of carboplatin-based chemotherapy for pediatric intracranial germ cell tumors
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Suntae Ji, Hee Won Chueh, Ju Youn Kim, Su Jin Lim, Eun Joo Cho, Soo Hyun Lee, Keon Hee Yoo, Ki Woong Sung, Hong Hoe Koo
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Clin Exp Pediatr. 2011;54(3):128-132. Published online March 31, 2011
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Purpose Cisplatin-based chemotherapy has been commonly used for the treatment of intracranial germ cell tumors (IC-GCTs). However, this treatment exhibits some adverse effects such as renal problems and hearing difficulty. Carboplatin-based chemotherapy was administered to pediatric patients with IC-GCTs from August 2004 at the Samsung Medical Center. In this study, we assessed the responses and adverse effects of carboplatin-based chemotherapy in... |
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- International travel of Korean children and Dengue fever: A single institutional analysis
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Soo Han Choi, Yae Jean Kim, Ji Hun Shin, Keon Hee Yoo, Ki Woong Sung, Hong Hoe Koo
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Clin Exp Pediatr. 2010;53(6):701-704. Published online June 23, 2010
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Purpose Dengue fever occurs in many popular tourist destinations and is increasingly imported by returning travelers in Korea. Since Korea is not an endemic country for dengue fever, pediatricians do not usually suspect dengue fever in febrile children even with typical presentation and exposure history. This study was performed to describe the international travel experiences and dengue fever in Korean children. MethodsTravel... |
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- Outcome of patients with neuroblastoma aged less than 1 year at diagnosis
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Jung Min Suh, Sang Goo Lee, Keon Hee Yoo, Ki Woong Sung, Hong Hoe Koo, Ju Youn Kim, Eun Joo Cho, Suk Koo Lee, Jhingook Kim, Do Hoon Lim
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Clin Exp Pediatr. 2009;52(1):93-98. Published online January 15, 2009
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Purpose : The purpose of this study was to evaluate the clinical characteristics and outcomes of patients with neuroblastoma aged less than 1 year.
Methods : From January 1997 to December 2007, 41 patients aged less than 1 year were diagnosed with neuroblastoma. Patients were divided into 3 risk groups according to the stage of the disease and N-myc amplification. Low-risk... |
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- Review Article
- Differential diagnosis of abdominal masses in children
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Ki Woong Sung
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Clin Exp Pediatr. 2008;51(8):787-791. Published online August 15, 2008
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Enlargement of organs or other solid tissues usually presents as an abdominal mass. Often, abdominal masses in children are found by an unsuspected parent or by a physician during a routine examination. Most masses have no specific signs or symptoms. Abdominal masses in children require immediate attention. History and physical examination may provide clues to the diagnosis. Ultrasound examination is... |
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- Allogeneic Hematopoietic Stem Cell Transplantation in Juvenile Myelomonocytic Leukemia
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Keon Hee Yoo, Dong Kil You, Soo Hyun Lee, Ki Woong Sung, Eun Joo Cho, Hong Hoe Koo
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Clin Exp Pediatr. 2005;48(2):178-185. Published online February 15, 2005
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Purpose : The purpose of this study was to evaluate the outcome of children with juvenile myelomonocytic leukemia(JMML) treated with allogeneic hematopoietic stem cell transplantation(allo- HSCT).
Methods : Eleven JMML patients aged 8-39 months underwent allo-HSCT. The sources of grafts were unrelated donors(n=7), HLA-matched siblings(n=3) and an HLA 1-antigen mismatched familial donor. All patients had received chemotherapy ?13-cis-retinoic acid(CRA) before... |
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- Responses and Toxicities of Risk-adapted Chemotherapy in Pediatric Intracranial Germ Cell Tumors
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Dong Kil You, Soo Hyun Lee, Keon Hee Yoo, Ki Woong Sung, Do Hoon Lim, Hyung Jin Shin, Hong Hoe Koo
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Clin Exp Pediatr. 2005;48(2):186-190. Published online February 15, 2005
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Purpose : The purpose of this study was to evaluate the responses and toxicities of risk-adapted chemotherapy in pediatric intracranial germ cell tumors(IC-GCT).
Methods : Fourteen patients who were diagnosed as IC-GCT from October 2002 to December 2003 received chemotherapy as an initial treatment modality. The low risk(LR) group was defined as follows : Pure germinoma and normal AFP level.... |
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- Case Report
- A Case of Hepatoblastoma with Precocious Puberty
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Chang Won Choi, Hyun Jin Park, Ki Woong Sung, Eun Sun Yoo, Hee Young Shin, Sei Won Yang, Hyo Seop Ahn
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Clin Exp Pediatr. 2000;43(2):288-293. Published online February 15, 2000
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Hepatoblastoma is the most common primary malignant liver tumor in childhood. Most cases are boys generally below three years of age. Hepatoblastoma are associated with various non-metastatic syndromes. Rarely, human chorionic gonadotropin may be produced by the tumor. Ectopic gonadotropin production from this source is a rare cause of precocious puberty in boys. Since a report by Behrendt in 1931,... |
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- Original Article
- Clinical Characteristics of Long-Standing Foreign Body in Airway
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Jin Hwa Jeong, Seon Mi Jin, Yun Ae Jeon, Ki Woong Sung, Young Yull Koh
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Clin Exp Pediatr. 1999;42(2):186-194. Published online February 15, 1999
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Purpose : Although the diagnosis of foreign bodies in the airway can be made early, retained and neglected foreign bodies are a common occurrence. The objective of this study was to characterize the clinical features of children diagnosed beyond 14 days following inhalation of a foreign body, long-standing foreign body in airway(LFB).
Methods : We reviewed the records of 180 cases... |
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- A Result of Treatment of Malignant Germ Cell Tumors in Childhood
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Hyoung Jin Kang, Jun Ah Lee, Hyo Jeong Han, Hyoung Su Choi, Hyeon Jin Park, Ki Woong Sung, Eun Sun Yoo, Hee Young Shin, Hyo Seop Ahn, Kwi Won Park, Byung Keu Cho, Hwang Choi, Chul Woo Kim
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Clin Exp Pediatr. 1997;40(12):1707-1718. Published online December 15, 1997
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Purpose : Germ cell tumors have variable clinical characteristics according to the age,
sex, primary site, and pathologic diagnosis. To provide the therapeutic principle, the
clinical characteristics, response to the treatment, and prognostic factors were analyzed.
Methods : Medical records of 57 children who were diagnosed as malignant germ cell
tumor in Seoul National University Children' s Hospital from January 1986 till June 1996
were... |
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