- Review Article
- Allergy
- Moderate to severe atopic dermatitis in children: focus on systemic Th2 cytokine receptor antagonists and Janus kinase inhibitors
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Jeong Hee Kim, Mona Salem Samra
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Clin Exp Pediatr. 2024;67(2):64-79. Published online June 14, 2023
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· Atopic dermatitis (AD) is characterized by a strong T helper (Th)2 response, although the extents of Th22, Th17/ interleukin (IL)-23, and Th1 responses vary among disease subtypes.
· Children with moderate to severe AD may require early systemic therapy to reduce the systemic inflammation caused by increased Th2 cytokine levels.
· Dupilumab, which blocks IL-4/IL-13 receptor, has equivalent efficacy for extrinsic and intrinsic AD and a favorable safety profile in infants and children aged 6 months and older. |
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- Original Article
- Sensitization rates of airborne pollen and mold in children
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So Hyun Park, Dae Hyun Lim, Byong Kwan Son, Jeong Hee Kim, Young Eun Song, In Bo Oh, Yang Ho Kim, Keun Hwa Lee, Su Young Kim, Sung Chul Hong
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Clin Exp Pediatr. 2012;55(9):322-329. Published online September 14, 2012
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Purpose Aeroallergens are important causative factors of allergic diseases. Previous studies on aeroallergen sensitization rates investigated patients groups that had visited pediatric allergy clinics. In contrast, we investigated sensitization rates in a general population group of elementary school to teenage students in Incheon, Jeju, and Ulsan. MethodsAfter obtaining parental consent, skin-prick tests were performed on 5,094 students between March and June 2010.... |
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- Comparison of air pollution and the prevalence of allergy-related diseases in Incheon and Jeju City
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Su Ho Jeong, Jeong Hee Kim, Byong Kwan Son, Seong Chul Hong, Su Young Kim, Geun Hwa Lee, Dae Hyun Lim
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Clin Exp Pediatr. 2011;54(12):501-506. Published online December 31, 2011
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Purpose A high level of air pollutants can increase the number of patients with allergy-related diseases such as asthma and allergic rhinitis (AR). To analyze the association between air pollution and allergic disease, we investigated 2 areas in Korea: Incheon, an industrial area, and Jeju, a non-industrialized area. MethodsSecond grade students at elementary schools (11 schools in Incheon and 45 schools in... |
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- Comparison between adverse effects of low and usual doses of intravenous aminophylline
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Bok Ki Kim, Dae Hyun Lim, So Hyun Ahn, Jong Hoon Kwa, Jeong Hee Kim, Byong Kwan Son
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Clin Exp Pediatr. 2009;52(4):441-445. Published online April 15, 2009
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Purpose : Some patients develop side effects from theophylline even at low serum concentrations. We designed a prospective study to evaluate the side effects of theophylline.
Methods : A Prospective, controlled trial study was conducted. The low-dose group received an intravenous continuous aminophylline dose of 5 mg/kg/day on the first day and subsequently 10 mg/kg/day on the following two days.... |
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- Therapeutic comparison between low-dose sustained-release theophylline
dry syrup and capsule in children with mild persistent asthma
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Hyun Seung Lee, Hae Kyung Lee, Hi Jeong Kwon, Jeong Hee Kim, Yeong Ho Rha, Jin Tack Kim, Young Ho Kim, Hae Rhan Lee, Bok Yang Pyun
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Clin Exp Pediatr. 2007;50(3):284-291. Published online March 15, 2007
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Purpose : Theophylline has recently been reported to have concurrent anti-inflammatory effects at low therapeutic plasma concentrations which are below the doses at which significants, clinically useful bronchodilatation is evident. Sustained-release formulation in capsule and dry syrup forms were developed to reduce its adverse effects and improve its clinical effects. We compared the therapeutic effects of theophylline dry syrup and... |
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- Case Report
- A Case of Systemic Sclerosis in a Child
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Ji Yeon Chang, Ja Kyoung Kim, Jeong Hee Kim, Dae Hyun Lim, Byong Kwan Son, Jung Soo Song
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Clin Exp Pediatr. 2004;47(2):214-216. Published online February 15, 2004
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Systemic sclerosis is a connective tissue disease involving primarily the skin and subcutaneous tissue but may involve other organ systems such as the lungs, gastrointestinal tract, and heart. Systemic sclerosis is a rare childhood disease. The age of onset for patients with systemic sclerosis has its peak between 30 and 50 years of age. Only 1 to 2% of all... |
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- Original Article
- Clinical Studies of Measles Prevalence in
Western Kyungnam District in 2000
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Byoung O Kwon, Hye Young Ju, Jeong Hee Kim, Hwang Jae Yoo, Chun Soo Kim
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Clin Exp Pediatr. 2002;45(3):331-338. Published online March 15, 2002
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Purpose : To investigate the feature of the range of measles in 2000, we studied epidemics of the measles in western Kyungnam District.
Methods : Among 489 patients under 15 years of age who visited or were admitted to in our hospital from January to December in 2000, we selected 344 patients whose measles IgM antibody was positive. We investigated age,... |
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- The Relation of Food-Specific IgE to Recurrent Wheezing Attack
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Yun Jeong Yang, Jeong Hee Kim, Yoo Mee Choi, Dae Hyun Lim, Sei Woo Chung, Jeong Gyu Kim, Byong Kwan Son
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Clin Exp Pediatr. 1999;42(8):1056-1062. Published online August 15, 1999
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Purpose : There were some reports that IgE-mediated food hypersensitivity is associated with subsequent development of atopic disease in wheezy infants. So we carried out this study to show whether the food specific IgE antibodies are useful to predict recurrent wheezing attack in wheezy infants.
Methods : A total of 190 children younger than 4-year-old were enrolled in this study. They... |
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- Tuberculin Response in Infants after BCG Vaccination during Neonatal Stage
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Jeong Hee Kim, Dae Hyun Lim, Byung Kwan Son, Sei Woo Chung,, Jeong Gyu Kim, Seung Yeon Nam, Sang Il Lee, Jin A Son
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Clin Exp Pediatr. 1999;42(11):1502-1507. Published online November 15, 1999
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Purpose : Mantoux test was widely used to identify the tuberculosis. But no reliable method exists for distinguishing tuberculin reactions caused by previous BCG vaccination from those caused by mycobacterial infections. So we studied Mantoux response in infants who had received BCG vaccination in the first month of life.
Methods : Mantoux testing was carried out in 143 healthy infants... |
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- Original Article
- Use of Erythema as An Interpreting Index of the Skin Prick Test
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Ji Eun Lee, Jeong Hee Kim, Dae Hyun Lim, Sei Woo Chung, Byong Kwan Son
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Clin Exp Pediatr. 1998;41(7):966-973. Published online July 15, 1998
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Purpose : There are many methods to interpret the skin prick test which has been commonly used to find out the causative allergen in allergic disease. Among them two are most frequently used. One is to measure the absolute size of wheal which is caused by the allergen and the other is to compare the size of wheal for allergen... |
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- Ten Cases of Severe Adenoviral Pneumonia in the Spring 1995
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Jeong Hee Kim, Sang Il Lee, Mun Hyang Lee, I Seok Kang, Heung Jae Lee, Bo Kyung Kim, Yeon-Lim Suh
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Clin Exp Pediatr. 1996;39(9):1247-1253. Published online September 15, 1996
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Purpose : In the Spring 1995, there was an outbreak of adenoviral infection, which caused four
death out of ten patients with adenoviral pneumonia in our hospital. Clinical courses of ten
patients with severe pneumonia were similar each other, and two were confirmed as adenoviral
pneumonia by postmortem autopsy. Although not proven, we believe eight patients had adenoviral
pneumonia. Therefore, we report clinical features... |
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- Normal Predicted Value of Airway Resistance by Flow Interrupter Technique in Korean Primary School-Aged Children
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Byong Kwan Son, Dae Hyun Lim, Jeong Hee Kim, Jong Woon Choi, Soon Ki Kim, Sei Woo Chung
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Clin Exp Pediatr. 1996;39(8):1095-1102. Published online August 15, 1996
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Purpose : To get the normal predicted value of airway resistance in Korean primary school-aged
children by using flow interrupter technique which is simple and easy enough to be applicable even
to young children.
Methods : Among all the children of one primary school, we selected 964 (Male 469, Female 495).
Excluded children were out of normal range in growth with Korean standard and/or... |
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- Case Report
- A Case of Pulmonary Blastoma
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Yun Jeong Chang, Jeong Hee Kim, Sun Ki Kim, Byong Kwan Son, Joon Mi Kim, Young Chae Chu
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Clin Exp Pediatr. 1994;37(7):999-1005. Published online July 15, 1994
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Pulmonary blastoma is a rare type of malignant lung tumor comprised of epithelial and mesenchymal elements reminiscent of fetal lung. Mesenchymal element may show various patterns of differentiation toward mature tissue, such as cartilage, smooth muscle, and bone. Rhabdomyoblastic differentiation in pulmonary blastoma is quite rare. Our case of pulmonary blastoma with rhabdomyoblastic differentiation documented by electron microscopy and immunohistochemistry.
Usually... |
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- Original Article
- The Effect of Alfacalcidol in the Treatment of Idiopathic Myelofibrosis in Children
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Soon Ki Kim, Jeong Hee Kim, Dae Hyun Lim, Jong Woon Choi, Byong Kwan Son, Hyo Seop Ahn
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Clin Exp Pediatr. 1994;37(3):339-346. Published online March 15, 1994
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Idiopathic myelofibrosis (IMF), which is characterized by marrow fibrosis, leukoerythroblastic anemia, teardrop poikilocytosis and splenomegaly due to extramedullary hematopoiesis, has known to have no form of therapy.
On the ground of the possibility of reversing collagen deposition in IMF using 1, 25-dihydroxycholecalciferol [1, 25(OH)2D3], we report here our observations of 5 patients (M:F = 1:4) with IMF before and after treatment... |
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- Normal Predicted values of Pulmonary function Test in Korean Primary School-Aged Children
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Dae Hyun Lim, Jeong Hee Kim, Jun Hee Park, Jong Woon Choi, Soon Ki Kim, Byong Kwan Son
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Clin Exp Pediatr. 1994;37(2):240-249. Published online February 15, 1994
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Pulmonary function test is one of the most important tools in the management of patients with respiratory tract diseases and allergic diseases. As with the difficulties in performing the test, it has been seldom used in pediatric field. But with the advent of simple, computerized tools, pediatric pulmonologist and allergist try to manage the patients using PFE. Still the normal... |
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- The Incidence of Allergic Disease among the Pediatric Outpatient
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Jeong Hee Kim, Jun Hee Park, Dae Hyun Lim, Soon Ki Kim, Byong Kwan Son
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Clin Exp Pediatr. 1994;37(1):9-18. Published online January 15, 1994
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The incidence of allergic disease in pediatric outpatient department of a hospital, where primary care is undertaking, was studied from Arp. 1, 1989 to Mar. 32, 1990. The results were as follows,
1) The incidence of respiratory tract disease was the highest with the value of 57.2% of the total patients, followsed by gastrointestinal tract disease (13.9%), infectious disease (6.7%), visit... |
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