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Tuberculin Response in Infants after BCG Vaccination during Neonatal Stage

Journal of the Korean Pediatric Society 1999;42(11):1502-1507.
Published online November 15, 1999.
Tuberculin Response in Infants after BCG Vaccination during Neonatal Stage
Jeong Hee Kim1, Dae Hyun Lim1, Byung Kwan Son1, Sei Woo Chung,1, Jeong Gyu Kim1, Seung Yeon Nam2, Sang Il Lee2, Jin A Son3
1Department of Pediatrics, College of Medicine, Inha University, Incheon, Korea
2Department of Pediatrics, College of Medicine, Sung Kyun Kwan University, Seoul, Korea
3Department of Pediatrics, National Medical Center, Seoul, Korea
신생아 시기에 BCG를 접종받은 영아의 투베르쿨린 반응
김정희1, 임대현1, 손병관1, 정세우1, 김정규1, 남승연2, 이상일2, 손진아3
1인하대학교 의과대학 소아과학교실
2성균관대학교 의과대학 삼성의료원 소아과
3국립의료원 소아과
Correspondence: 
Jeong Hee Kim, Email: 1
Abstract
Purpose
: Mantoux test was widely used to identify the tuberculosis. But no reliable method exists for distinguishing tuberculin reactions caused by previous BCG vaccination from those caused by mycobacterial infections. So we studied Mantoux response in infants who had received BCG vaccination in the first month of life.
Methods
: Mantoux testing was carried out in 143 healthy infants aged from 3 to 15months who had received BCG vaccination in the first month of life. Among them, 81 received Japan 172 strain BCG vaccination with multiple puncture method and 62 Copenhagen 1331 strain with intradermal method
Results
: The mean Mantoux reactions in the Japan 172 strain group were as follows : 10.0mm at 3 months, 9.7mm at 4-6months, 11.4mm at 7-9months, and 10.5mm at 10-15months. The mean Mantoux reactions in the Copenhagen 1331 strain group were as follows : 7.6mm at 3 months, 7.5mm at 4-6months, 7.5mm at 7-9months, and 6.8mm at 10-15months. Infants who received Japan strain had significantly larger sized induration in all ages. About 50% of Japan strain BCG-vaccinated infants had more than 10mm of tuberculin reaction.
Conclusion
: Infants who received Japan strain had significantly larger sized tuberculin reaction in all ages. Although the size of induration is more than 10mm in Tokyo strain BCG-vaccinated child, vaccine effect should be generally considered.
Key Words: BCG vaccine, Tuberculin test, Tuberculin sensitivity


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