- Original Article
- Neonatology (Perinatology)
- Protective effect of recombinant interleukin-10 on newborn rat lungs exposed to short-term sublethal hyperoxia
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Hyeon-Soo Lee, Young-Joon Ryu, Min-Jae Lee
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Clin Exp Pediatr. 2024;67(10):540-549. Published online September 27, 2024
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Lung injury is generated from the early stage of hyperoxia through the biologic effects of cell death and inflammatory response, which eventually leads to evolution of bronchopul-monary dysplasia. Therefore, a protective measure against hyperoxia-induced lung injury is needed. The present study observed that anti-inflammatory cytokine, interleukin-10 had protective effects on newborn rat lungs from injury induced at the early stage of hyperoxia, by preventing cell death and down-regulating inflammatory response. |
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- Case Report
- Transient carnitine transport defect with cholestatic jaundice: report of one case in a premature baby
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Hyun-Seok Cho, Young Kwang Choo, Hong Jin Lee, Hyeon-Soo Lee
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Clin Exp Pediatr. 2012;55(2):58-62. Published online February 14, 2012
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Carnitine (β-hydroxy-γ-trimethylaminobutyric acid) is involved in the transport of long-chain fatty acids into the mitochondrial matrix and the removal of potentially toxic acylcarnitine esters. Transient carnitine transport defect is a rare condition in newborns reported in 1/90,000 live births. In this paper, we describe a case of transient carnitine transport defect found in a premature baby who had prolonged cholestatic... |
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- Original Article
- Comparison of the accuracy of neutrophil CD64 and C-reactive protein as a single test for the early detection of neonatal sepsis
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Young Kwang Choo, Hyun-Seok Cho, In Bum Seo, Hyeon-Soo Lee
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Clin Exp Pediatr. 2012;55(1):11-17. Published online January 31, 2012
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Purpose Early identification of neonatal sepsis is a global issue because of limitations in diagnostic procedures. The objective of this study was to compare the diagnostic accuracy of neutrophil CD64 and C-reactive protein (CRP) as a single test for the early detection of neonatal sepsis. MethodsA prospective study enrolled newborns with documented sepsis (n=11), clinical sepsis (n=12) and control newborns (n=14). CRP,... |
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- Case Report
- 6p23 Deletion Syndrome : Report of a Case in a Preterm Baby
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Hyeon-Soo Lee
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Clin Exp Pediatr. 2003;46(1):83-85. Published online January 15, 2003
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Deletion of the short arm of chromosome 6 is relatively rare, with the characteristic features of craniofacial malformations, hypotonia, and defects of the heart and kidney, with hydrocephalus and eye abnormalities. Here author reports a premature girl with bilateral anophthalmia, bilateral hydrocephalus and marked hypotonia, whose chromosome analysis revealed a 46, XX, del(6)(p23) chromosome constitution. |
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- A Case of Neonatal Alloimmune Thrombocytopenia Related to HLA Antibody
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Mi Seon Lee, Hyeon-Soo Lee, Hyun Ok Kim
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Clin Exp Pediatr. 2001;44(12):1454-1458. Published online December 15, 2001
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Neonatal alloimmune thrombocytopenia(NAIT) is a very rare disease caused by maternal alloantibodies` response to neonatal platelet antigens. Because the most common cause of NAIT is incompatibility for platelet-specific antigens, NAIT cases due to anti-HLA antibodies are very exceptional. The patient was a second born female. She had no petechia or purpura at birth. But her platelet count was 55,000/mm3 and... |
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- Pulmonary Inflammatory Cells in Preterm Infants with Respiratory Distress Syndrome Followed by Surfactant Treatment
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Hyeon-Soo Lee, Myung-Seo Kang
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Clin Exp Pediatr. 1999;42(5):644-649. Published online May 15, 1999
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Purpose : The effect of surfactant treatment on inflammatory cell populations has not been determined. I evaluated the effect of surfactant treatment on a number and distribution of inflammatory cells in bronchoalveolar lavage fluid(BALF) from the preterm infants who were dependent on mechanical ventilation over the 1st week of life.
Methods : This study included 8 preterm infants with respiratory distress... |
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- Inhalation of Bronchodilator Aerosol by Metered-dose Inhaler and Spacer in Neonatal Respiratory Distress Syndrome
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Hyeon-Soo Lee
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Clin Exp Pediatr. 1999;42(12):1668-1675. Published online December 15, 1999
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Purpose : To examine the clinical effects of two bronchodilator agents, salbutamol and ipratropium bromide, administered by metered-dose inhaler(MDIS) to preterm infants with respiratory distress syndrome(RDS) during mechanical ventilation.
Methods : This study included 8 ventilated preterm infants with RDS, at a postnatal age of 1 week. The effects of single doses of salbutamol(2puffs, 200mcg) and ipratropium bromide(2 puffs, 36mcg) and... |
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- Clinical Effect of Bronchoalveolar Lavage in Ventilated Preterm Infants
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Hyeon-Soo Lee
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Clin Exp Pediatr. 1998;41(10):1329-1333. Published online October 15, 1998
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Purpose : Bronchoalveolar lavage(BAL) in ventilated neonates is a modification of routine endotracheal suction and is a potentially useful technique in studying the evolution and resolution of pulmonary inflammation. Therefore, this study is designed to investigate the effects of BAL on blood gases, blood pressure and heart rate in ventilated newborn infants with respiratory disease.
Methods : Fourteen premature infants were... |
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- Effects of Early Dexamethasone Therapy in Neonatal Respiratory Distress Syndrome
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Hyeon-Soo Lee
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Clin Exp Pediatr. 1998;41(1):19-25. Published online January 15, 1998
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Purpose : To examine the clinical effects of early dexamethasone treatment from postnatal age of 1 week to ventilated preterm infants with respiratory distress syndrome.
Methods : 14 one-week-old ventilator-dependent infants were enrolled. Seven received dexamethasone and another 7 did not receive. The doses of dexamethasone used were 0.25mg/kg twice daily for 3 days, 0.125mg/kg twice for 1 day, then 0.125mg/kg... |
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