Journal of the Korean Pediatric Society 2000;43(11):1440-1445.
Published online November 15, 2000.
Short-term Effects of Inhaled Corticosteroid Following Early Systemic Corticosteroid Administration in Premature Babies with Respiratory Distress Syndrome : A Preliminary Report
Hyeon-Soo Lee
Department of Pediatrics and Neonatal Medicine, Daejin Medical Center, Pundang Jesaeng General Hospital, Sungnam, Korea
미숙아 호흡곤란증후군에 있어서 조기 Corticosteroid의 전신적 투여 후 시행한 흡입 투여의 단기적 효과
이현수
분당제생병원 소아과
Correspondence: 
Hyeon-Soo Lee, Email: hyeonsoo@dmc.or.kr
Abstract
Purpose
: To asses the short-term effects of the topical corticosteroid, budesonide administered by metered dose inhaler(MDI) and spacer(Aerochamber MV 15) following systemic corticosteroid in premature babies with respiratory distress syndrome at birth.
Methods
: 19 premature babies <1800gm were randomly assigned to receive steroids(n=9) or not (n=10). The steroid group(n=9, GA[gestational age]=29.6¡¾2.9 weeks, BW[birth weight]=1.29¡¾0.35kg) received systemic dexamethasone for 48 hours since 12-24 hours after birth, followed by inhaled budesonide, 2 puffs per dose(400mcg of total dose), administered three times a day until extubation. The control group(n=10, GA=29.9¡¾2.5 weeks, BW=1.32¡¾0.26kg) did not receive steroids. The parameters of ventilator and arterial blood gases were recorded every 6 hours during the first 8 days of age, and the ventilatorty efficiency index(VEI) and the arterial/Alveolar O2(a/A O2) ratios were calculated before administration, on the 4th and 8th days of age respectively.
Results
: The steroid-treated group showed significant improvements in mean peak inspiratory pressure, fraction of inspired oxygen, VEI and a/A O2 ratio on the 4th and 8th day of age. There were no changes in the control group. The steroid-treated group tended to show a lower incidence of PDA and a lower need for systemic corticosteroids without significant differences, compared with those in the control group.
Conclusion
: Sequential early systemic corticosteroid administration started within 24 hours of age, followed by inhaled budesonide given by MDI and spacer(MDIS) was associated with clinical improvements in respiratory status and ventilator support in premature babies with respiratory distress syndrome.
Key Words: Budesonide, Dexamethasone, Corticosteroid, Metered-dose-inhaler and Spacer, Respiratory distress syndrome, Premature


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