- Original Article
- Other
- Korean parents’ perceptions of the challenges and needs on school re-entry during or after childhood and adolescent cancer: a multi-institutional survey by Korean Society of Pediatric Hematology and Oncology
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Jun Ah Lee, Jae Min Lee, Hyeon Jin Park, Meerim Park, Byung Kiu Park, Hee Young Ju, Ji Yoon Kim, Sang Kyu Park, Young Ho Lee, Ye Jee Shim, Heung Sik Kim, Kyung Duk Park, Yeon-Jung Lim, Hee Won Chueh, Ji Kyoung Park, Soon Ki Kim, Hyoung Soo Choi, Hyo Seop Ahn, Jeong Ok Hah, Hyoung Jin Kang, Hee Young Shin, Mee Jeong Lee
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Clin Exp Pediatr. 2020;63(4):141-145. Published online November 14, 2019
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Question: What are the parental needs and challenges when their children return to school after cancer?
Finding: In addition to scholastic aptitude-oriented programs, emotional and psychosocial support is necessary for a successful return to school.
Meaning: Pediatric oncologists should actively engage in improving oncology practices to better integrate individualized school plans and educate peers and teachers to improve health literacy to make them understand the needs of children with cancer. |
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- Case Report
- Oncology
- Targeted busulfan and fludarabine-based conditioning for bone marrow transplantation in chronic granulomatous disease
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Hee Young Ju, Hyoung Jin Kang, Che Ry Hong, Ji Won Lee, Hyery Kim, Sang Hoon Song, Kyung-Sang Yu, In-Jin Jang, June Dong Park, Kyung Duk Park, Hee Young Shin, Joong-Gon Kim, Hyo Seop Ahn
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Clin Exp Pediatr. 2016;59(Suppl 1):S57-S59. Published online November 30, 2016
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Chronic granulomatous disease (CGD) is a primary immunodeficiency disease caused by impaired phagocytic function. Hematopoietic stem cell transplantation (HSCT) is a definitive cure for CGD; however, the use of HSCT is limited because of associated problems, including transplantation-related mortality and engraftment failure. We report a case of a patient with CGD who underwent successful HSCT following a targeted busulfan and... |
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- Hemophagocytic lymphohistiocytosis diagnosed by brain biopsy
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Hee Young Ju, Che Ry Hong, Sung Jin Kim, Ji Won Lee, Hyery Kim, Hyoung Jin Kang, Kyung Duk Park, Hee Young Shin, Jong-Hee Chae, Ji Hoon Phi, Jung-Eun Cheon, Sung-Hye Park, Hyo Seop Ahn
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Clin Exp Pediatr. 2015;58(9):358-361. Published online September 21, 2015
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Hemophagocytic lymphohistiocytosis (HLH) is characterized by fever, splenomegaly, jaundice, and pathologic findings of hemophagocytosis in bone marrow or other tissues such as the lymph nodes and liver. Pleocytosis, or the presence of elevated protein levels in cerebrospinal fluid, could be helpful in diagnosing HLH. However, the pathologic diagnosis of the brain is not included in the diagnostic criteria for this... |
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- Review Article
- Advancements in the treatment of pediatric acute leukemia and brain tumor - continuous efforts for 100% cure
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Hee Young Ju, Che Ry Hong, Hee Young Shin
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Clin Exp Pediatr. 2014;57(10):434-439. Published online October 31, 2014
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Treatment outcomes of pediatric cancers have improved greatly with the development of improved treatment protocols, new drugs, and better supportive measures, resulting in overall survival rates greater than 70%. Survival rates are highest in acute lymphoblastic leukemia, reaching more than 90%, owing to risk-based treatment through multicenter clinical trials and protocols developed to prevent central nervous system relapse and testicular... |
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- Recent advance in primary immune deficiency disorders
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Hyoung Jin Kan, Hee Young Shin, Hyo Seop Ahn
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Clin Exp Pediatr. 2009;52(6):649-654. Published online June 15, 2009
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The immune system is comprised of cells and molecules whose collective and coordinated response to the introduction of foreign substance is referred to as the immune response. Defense against microbes is mediated by the early reaction (innate immunity) and the late response (adaptive immunity). Innate immunity consists of the epithelial barrier, phagocytes, complement and natural killer cells. Adaptive immunity, a... |
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- Acute lymphoblastic leukemia in children: past, present and future
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Hyoung Jin Kang, Hee Young Shin, Hyo Seop Ahn
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Clin Exp Pediatr. 2007;50(7):601-605. Published online July 15, 2007
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The cure rate of acute lymphoblastic leukemia (ALL) in children dramatically improved over past 5 decades from zero to about 80%. The main cause of improvement is owing to the development of chemotherapy by multicenter clinical trial of large study groups with the understanding of leukemia biology. Recently, pediatric ALL protocols were applied to the treatment of adolescent and even... |
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- Original Article
- Etiological agents isolated from blood in children with hemato-oncologic diseases (2002-2005)
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So-Hee Kim, Young-Ah Lee, Byung-Wook Eun, Nam-Hee Kim, Jin-A Lee, Hyoung Jin Kang, Eun-Hwa Choi, Hee Young Shin, Hoan-Jong Lee, Hyo Seop Ahn
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Clin Exp Pediatr. 2007;50(1):56-64. Published online January 15, 2007
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Purpose : This study was performed to identify the etiologic agents and antimicrobial susceptibility patterns of organisms responsible for bloodstream infections in pediatric cancer patients for guidance in empiric antimicrobial therapy.
Methods : One hundred and ninety-seven episodes of bloodstream infections that developed in 128 pediatric cancer patients were analyzed, which were identified at the Seoul National University Children's Hospital during... |
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- Factors affecting the final adult height in survivors of childhood brain tumors
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Kyong-Ah Yun, Young Ah Lee, Choong Ho Shin, Sei Won Yang, Hee Young Shin, Hyo Seop Ahn, Il Han Kim
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Clin Exp Pediatr. 2007;50(1):65-73. Published online January 15, 2007
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Purpose : Short stature is an important complication that impairs the quality of life in survivors of childhood brain tumors. We studied their final adult height (FAH) to evaluate risk factors for short stature.
Methods : We reviewed the medical data of 95 survivors of childhood brain tumors (64 males and 31 females) who had been followed up from 1982 to... |
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- Review Article
- Immune thrombocytopenic purpura(ITP)
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Hee Young Shin
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Clin Exp Pediatr. 2006;49(8):830-832. Published online August 15, 2006
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Immune thrombocytopenic purpura(ITP) is an autoimmune disease characterized by increased peripheral platelet destruction due to antibody to platelet, which results in thrombocytopenia and cutaneous or mucosal bleeding. Bleeding generally occurs when platelet counts fall to less than 20,000/µL. Children affected with ITP are usually healthy prior to the onset of the disease and typically present suddenly after a viral infection... |
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- Original Article
- Endocrine dysfunction and growth in children with medulloblastoma
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In Suk Yoon, Ji Young Seo, Choong Ho Shin, Il Han Kim, Hee Young Shin, Sei Won Yang, Hyo Seop Ahn
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Clin Exp Pediatr. 2006;49(3):292-297. Published online March 15, 2006
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Purpose : In medulloblastoma, craniospinal radiation therapy combined with chemotherapy improves the prognosis of tumors but results in significant endocrine morbidities. We studied the endocrine morbidity, especially growth pattern changes.
Methods : The medical records of 37 patients with medulloblastoma were reviewed retrospectively for evaluation of endocrine function and growth. We performed the growth hormone stimulation test in 16 patients whose... |
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- Case Report
- Development of Crohn disease in patients with myelodysplastic syndrome : report of two children
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Jeong Ok Shim, Jeong Kee Seo, Hye Ran Yang, Jae Sung Ko, Hee Young Shin, Hyo Seop Ahn, Woo Sun Kim, Gyeong Hoon Kang
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Clin Exp Pediatr. 2006;49(1):107-111. Published online January 15, 2006
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Crohn disease (CD) is rare, but the incidence of CD has been increasing over the past ten years. We found two cases of CD, associated with myelodysplastic syndrome (MDS), for the first time in children. In the first patient, MDS was diagnosed at three years of age and CD developed later at eight years of age. The patient presented with... |
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- Original Article
- Follow-up Study of Children with Anthracycline Cardiotoxicity
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Hyok Joo Kwon, Young Hwan Song, Soo Jung Kang, Hyoung Jin Kang, Hyoung Soo Choi, Eun Jung Bae, Hee Young Shin, Chung Il Noh, Yong Soo Yun, Hyo Seop Ahn
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Clin Exp Pediatr. 2003;46(3):242-249. Published online March 15, 2003
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Purpose : We studied the relationship between anthracycline cumulative dose and anthracycline cardiotoxicity in childhood cancer and followed up 40 children with anthracycline cardiotoxicity.
Methods : A retrospective study was performed in 154 children who received anthracycline chemotherapy between January 1995 to December 2000. Cardiotoxicity was defined when the left ventricular fractional shortening(FS) was below 26%; it was divided into two... |
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- Case Report
- A Case of Hepatoblastoma with Precocious Puberty
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Chang Won Choi, Hyun Jin Park, Ki Woong Sung, Eun Sun Yoo, Hee Young Shin, Sei Won Yang, Hyo Seop Ahn
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Clin Exp Pediatr. 2000;43(2):288-293. Published online February 15, 2000
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Hepatoblastoma is the most common primary malignant liver tumor in childhood. Most cases are boys generally below three years of age. Hepatoblastoma are associated with various non-metastatic syndromes. Rarely, human chorionic gonadotropin may be produced by the tumor. Ectopic gonadotropin production from this source is a rare cause of precocious puberty in boys. Since a report by Behrendt in 1931,... |
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- Original Article
- Clinical Significance of CD7 Expression in Acute Myelocytic Leukemia
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Gye Jin Yoon, Pill Sang Jang, Young Choi, Jun A Lee, Hyo Jung Han, Hyoung Soo Choi, Hee Young Shin, Joong Gon Kim, Hyo Seop Ahn
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Clin Exp Pediatr. 1999;42(3):374-382. Published online March 15, 1999
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Purpose : It has been shown that a considerable number of acute myeloid leukemia(AML) patients had both myeloid and lymphoid antigens. CD7 is a lymphoid antigen, often expressed in AML cells. We investigated 40 AML patients to clarify the relationship between the cellular characteristics and clinical features.
Methods : We reviewed 8 CD7 positive(CD7＋) AML patients and 32 CD7 negative(CD7－)... |
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- Immunomodulation Therapy in Aplastic Anemia : Relapse Rate, Complications
and Long-term Survival During Follow-up for More than 1 Year
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Jun Ah Lee, Hyoung Jin Kang, Hyo Jeong Han, Hyoung Soo Choi, Eun Sun Yoo, Hee Young Shin, Joong Gon Kim, Hyo Seop Ahn
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Clin Exp Pediatr. 1998;41(6):775-784. Published online June 15, 1998
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Purpose : We evaluated the response to immunomodulation therapy, long-term survival and relapse
rate of aplastic anemia during follow-up for more than 1 year.
Methods : Twenty-eight children, with moderate to severe aplastic anemia were followed for more
than one year and 7 children expired after therapy, were analyzed. Antilymphocyte globulin(ALG) or
antithymocyte globulin(ATG) by itself was given to 27 patients, and cyclosporine A(CsA)... |
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- Induction Chemotherapy with BH-AC, Idarubicin, and 6-Thioguanine in Childhood Acute Myelogenous Leukemia
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Hyo Jeong Han, Hyoung Jin Kang, Jun Ah Lee, Hyoung Soo Choi, Hyeon Jin Park, Ki Woong Seong, Eun Sun Yoo, Hee Young Shin, Hyo Seop Ahn
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Clin Exp Pediatr. 1998;41(2):209-215. Published online February 15, 1998
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Purpose : We have undertaken this study to evaluate the effects of induction chemotherapy involving BH-AC, idarubicin, and 6-thioguanine(6-TG).
Methods : BH-AC 300mg/m2/day was administered intravenously over three hours for seven consecutive days. Idarubicin 12mg/m2/day was administered intravenously for three days. 6-TG 100 mg/m2/day was administered orally for seven days. Intrathecal ara-C was administered on the first day of treatment.
Results... |
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- Outcome after Treatment of Retinoblastoma
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Hyoung Soo Choi, Ki Woong Seong, Jae Kyung Lee, Kyung Ha Yoo, Hee Young Shin, Young Suk Yu, Hyo Seop Ahn
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Clin Exp Pediatr. 1997;40(4):519-530. Published online April 15, 1997
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Purpose : Current treatment in retinoblastoma aims to save life and preserve useful vision by using combined modality therapy. This study was performed to determine the outcome after treatment of retinoblastoma.
Methods : Medical records of all cases of retinoblastoma seen at Seoul National University Children's Hospital from September 1986 to April 1995 were reviewed. During this period, the treatment method... |
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- A Result of Treatment of Malignant Germ Cell Tumors in Childhood
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Hyoung Jin Kang, Jun Ah Lee, Hyo Jeong Han, Hyoung Su Choi, Hyeon Jin Park, Ki Woong Sung, Eun Sun Yoo, Hee Young Shin, Hyo Seop Ahn, Kwi Won Park, Byung Keu Cho, Hwang Choi, Chul Woo Kim
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Clin Exp Pediatr. 1997;40(12):1707-1718. Published online December 15, 1997
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Purpose : Germ cell tumors have variable clinical characteristics according to the age,
sex, primary site, and pathologic diagnosis. To provide the therapeutic principle, the
clinical characteristics, response to the treatment, and prognostic factors were analyzed.
Methods : Medical records of 57 children who were diagnosed as malignant germ cell
tumor in Seoul National University Children' s Hospital from January 1986 till June 1996
were... |
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- Mucormycosis in Leukemic Children
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Seung Ghon Nam, Eun Wha Choi, Jin Young Park, Jong Jae Kim, Hee Young Shin, Hoan Jong Lee, Hyo Seop Ahn
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Clin Exp Pediatr. 1996;39(3):379-388. Published online March 15, 1996
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Purpose : Mucormycosis is an opportunistic fungal infection caused by one of the ubiquitous fungi of the order Mucorales, occurring almost exclusively in immunocompromised hosts such as patients with diabetes, leukemia and lymphoma. Recently the incidence of mucormycosis is rising associated with the increasing predisposing factors such as cytotoxic drugs and immunosuppressive agents. Though mucormycosis is frequently fatal, there has... |
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- Infections in Children with Neoplastic Disease
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Eun Hwa Choi, Jin Won Pyo, Jin Young Park, Kyung Bae Kwon, Bo Young Yun, Hee Young Shin, Hoan Jong Lee, Hyo Seop Ahn
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Clin Exp Pediatr. 1995;38(3):366-377. Published online March 15, 1995
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Purpose : Infection is a major complication in patients with malignant disease. This study was performed to identify the causes and the etiologic agents of febrile infections and to characterize the clinical courses including the response to antimicrobial agents inpediatric cancer patients.
Methods : This study reviewed 274 febrile episodes occurring in 163 children with neoplastic disease which were indentified prospectively... |
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- Results of Chemotherapy of Hepatoblastoma and Hepatocellular
Carcinoma in Children
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Kyung Duk Park, Gi Woong Seong, Jae Kyung Lee, Hong Hoe Koo, Hee Young Shin, Hyo Seop Ahn
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Clin Exp Pediatr. 1995;38(2):195-206. Published online February 15, 1995
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Purpose : Surgical excision has been the primary treatment for hepatoblastoma and hepatocellular carcinoma. However, at presentation, only one third of such tumors are surgically resectable. Without operation, the disease is fatal. Therefore, neoadjuvant chemotherapy has been introduced for conversion of the unresectable tumors into the resectable ones. We studied th e effects of chemotherapy for hepatic malignancy in children.
Methods... |
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- Primary Cutaneous Aspergillosis in Leukemic Children
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Jin Young Park, Mee Ran Kim, Hee Young Shin, Hoan Jong Lee, Hyo Seop Ahn, Je Guen Chi
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Clin Exp Pediatr. 1994;37(4):520-526. Published online April 15, 1994
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Primary cutaneous aspergillosis is rare. In this report we describe primary skin infection by Aspergillus in 9 children with leukemia. The skin lesion was characterized clinically by erythematous macule and papule associated with pain and itching, followed by a rapid progression to ulcer and central black eschars with raised erythematous border at the site of venipuncture, insertion of intravenous cannula,... |
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- Antilymphocyte Globulin Therapy for Aplastic Anemia in Children
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Soo Jong Hong, Hee Young Shin, Hyo Seop Ahn
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Clin Exp Pediatr. 1994;37(11):1526-1539. Published online November 15, 1994
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Immunosuppressive therapy based on the use of antilymphocyte globulin (ALG) has become standard therapy for patients with aplastic anemia who are not eligible for bone marrow transplantation. In this study, T cell subsets before and after ALG therapy, hematologic responses, complications and prognostic factors were analysed.
Eleven (42%) out of twenty-six patients treated with ALG showed response, but... |
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- A Clinical Study of Childhood Soft Tissue Sarcoma
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Hye Lim Jung, Hong Heo Koo, Hee Young Shin, Hyo Seop Ahn
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Clin Exp Pediatr. 1993;36(9):1258-1270. Published online September 15, 1993
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Medicine, Seoul, Korea Department of Pediatrics, Seoul National University College of Medicine, Seoul, Korea
To study the clinical characteristics and treatment results of childhood soft tissue sarcoma, the retrospective study was performed on 67 patients with soft tissue sarcoma, experienced at the Department of Pediatrics, Seoul National University Hospital from January, 1982 to July, 1990.
The... |
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- A Prospective Study of Totally Implanted Venous Access System in 19 Children with Cancer
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Kyung Duk Park, Eun Sil Dong, Seong Hoon Ha, Hong Hoe Koo, Hee Young Shin, Hyo Seop Ahn, Seong Eun Jun, Gui Won Park
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Clin Exp Pediatr. 1993;36(5):687-692. Published online May 15, 1993
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A totally implanted venous access system was inserted in 19 children with cancer. The devices were utilized for the administration of antineoplastic drug, parenteral fluids, antibiotics, and blood products. Total duration of implantation was 4,046 days for 23 implanted system (range 7-445 days). Complications included cather infection (0.247/100 catheter day), occlusion (0.692/100 catheter days), and dislodgement of needle (0.643/100 catheter... |
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- Case Report
- Recurrent Rhinocerebral Mucormycosis - A Case Report
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Ho Sung Kim, Jin Young Park, Bo Young Yun, Eun Sil Dong, Hee Young Shin, Hoan Jong Lee, Hyo Seop Ahn, Je Geun Chi, Myung Whun Sung
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Clin Exp Pediatr. 1993;36(4):589-595. Published online April 15, 1993
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A case of recurrent rhinocerebral mucormycosis that has occurred during an induction chemotherapy for acute megakaryocytic leukemia in a 10 year-old boy is reported. He had suffered from high fever, proptosis, right eye ball pain and necrotic inflammation of hard palate during the chemotherapy of leukemia. CT scan of the paranasal sinus showed inflammatory change of right ethmoid and maxillary... |
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- Original Article
- Acute Megakaryoblastic Leukemia in Children
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Hong Hoe Koo, Sang Kyu Park, Eun Sil Dong, Hye Jung Park, Hee Young Shin, Hyo Seop Ahn
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Clin Exp Pediatr. 1993;36(1):9-16. Published online January 15, 1993
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We analyzed the clinical and laboratory features of ten children with acute megakaryoblastic leukemia (M7) and compared the findings with those reported in the literature. The diagnosis was supported by ultrastructural examination of platelet peroxidase or immunophenotyping for glycoprotein Iib/IIIa. Of the ten children, five were girls and five were boys. The median age at diagnosis was 13 months. Two... |
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- Case Report
- Three Cases of Brain Tumors with Bone Metastasis
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Eun Joo Kim, Kyung Duk Park, Eun Sil Dong, Hye Jung Park, Hong Hoe Koo, Hee Young Shin, Hyo Seop Ahn, Je Geun Chi
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Clin Exp Pediatr. 1992;35(3):381-389. Published online March 15, 1992
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Medulloblastoma and primitive neuroectodermal tumor(PNET) are relatively common intracranial neoplasms in childhood. Their extracranial metastasis were thought to be rare occurrences. But they are more frequent compared to other intracranial tumors. The most frequent site of metastasis deposits in medulloblastoma is bone, and metastasis to lymph node, peritoneum, liver or lung have been reported infrequently. The authors experienced three cases... |
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- Original Article
- Carcinomas in Childhood -A 10-Year Experience in Seoul National University Hospital-
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Hong Hoe Koo, Kyung Duk Park, Hye Lim Jung, Sang Kyu Park, Hee Young Shin, Hyo Seop Ahn
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Clin Exp Pediatr. 1992;35(10):1369-1376. Published online October 15, 1992
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Carcinomas in childhood differ from those in adults in their frequency, histologic type, and distribution of primary sites. In children, carcinomas are rare and few series have been published containing sufficient mumbers of cases to permit a reliable account of the incidence and survival of children with carcinoma. During a 10-year period, 1982-1991, we observed 40 patients less than 16... |
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- Incidence Estimation of Leukemia among Korean Children
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Hong Hoe Koo, Hee Young Shin, Hyo Seop Ahn, Yoon-Ok Ahn
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Clin Exp Pediatr. 1992;35(1):80-87. Published online January 15, 1992
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Leukemia is a neoplasm arising from the malignant transformation of hematopoietic cells. The incidence data of leukemia have not been available for Korean as a whole. The present study was therefore undertaken in order to estimate the incidence of childhood leukemia among Korean. The study population of this investigation was the
beneficiaries of the Korea Medical Insurance Corporation(KMIC) during the period... |
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- Clinical Considerations of the Mediastinal Tumors in Children
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Eun Joo Kim, Hye Lim Jung, Hong Hoe Koo, Hee Young Shin, Hyo Seop Ahn
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Clin Exp Pediatr. 1992;35(1):98-107. Published online January 15, 1992
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Mediastinal tumors of children constitute a heterogeneous group of malignant and benign neoplasms because they originated from a variety of structures. But they show some characteristics in type of tumor according to location, relative frequency of masses, clinical manifestations. Management and long-term reusult. We observed 82 patients less than 16 years of age who were evaluated and treated for a... |
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- A case of bone marrow necrosis in acute lymphoblastic leukemia.
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Mee Ran Kim, Hye Lim Jung, Hong Hoe Koo, Hee Young Shin, Hyo Seop Ahn
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Clin Exp Pediatr. 1991;34(8):1163-1168. Published online August 31, 1991
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Bone marrow necrosis is a rare complication most commonly encountered in patients with leuke-
mia, metastatic tumor in marrow, sickle cell disease, DIC and severe infections.
Recently it is regarded as a more common finding frequently overlooked and carrying not so poor
prognosis. We reported here a boy with ALL who showed marrow necrosis on biopsy at the time of
diagnosis and achieved complete... |
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- Morphological study on the development of human fetal kidney.
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Hee Young Shin, Kwang Wook Ko, Je Geun Chi
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Clin Exp Pediatr. 1991;34(8):1045-1056. Published online August 31, 1991
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A total of 293 human fetal kidneys, including those of 42 embryos are studied for the elucidation
of temporal development of the kidney. These specimens were interpreted as normal by thorough
postmortem examinations. The age of the specimens was determined by developmental horizon
criteria in embryos and by correlating crown-rump length in fetuses. Embryos were embedded in toto,
cut in various planes and reconstructed... |
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- A case of pancytopenia associated with mycoplasmal pneumonia.
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Young Mee Yoo, Beom Soo Park, In Sang Jeon, Hee Young Shin, Hyo Seop Ahn, Se Jung Sohn
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Clin Exp Pediatr. 1991;34(6):826-831. Published online June 30, 1991
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Mycoplasma pneumoniae infection is manifestated as pneumonia and extra-pulmonary symptoms
such as hematologic, neurologic, gastrointestinal, musculoskeletal, dermatologic and cardiac manifes-
tations. Among the hematologic changes, hemolytic anemia is most frequently seen. Throm-
bocytopenic purpura, lymphocytosis or rarely lymphopenia, elevated erythrocyte sedimentation rate,
positive direct Coombs test, reticulocytosis and DIC are known hematologic features.
This 12 years old female patient was presented with pneumonia and pancytopenia.... |
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- A case of acute lymphoblastic leukemia complicating neuroblastoma in remission.
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Dong Woo Son, Bum Soo Park, Jun Jae Kim, Hong Hoe Koo, Hee Young Shin, Hyo Seop Ahn
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Clin Exp Pediatr. 1991;34(5):720-729. Published online May 31, 1991
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As childhood cancer survivors are now increasing in number owing to the improvements in
diagnosis, staging, and treatment, concerns have been raised regarding the quality of survival of these
patients. One of the limitation to quality and length of survival has been the development of second
malignant neoplasm (SMN). In Korea, only one case of SMN has been reported. However, one can
expect that... |
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- Two cases of nasopharyngeal carcinoma in children.
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Tae Sun Ha, Chul Ho Jang, Hee Young Shin, Hyo Seop Ahn
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Clin Exp Pediatr. 1991;34(4):587-593. Published online April 30, 1991
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Nasopharyngeal carcinoma is a primary malignancy of nasopharyngeal epithelium, firstly de-
scribed as a separate entity by Regaud and Schmincke in 1921. Although it is a rare tumor, reprsent-
ing less than 1% of pediatric malignancies, it accounts for 9% of the nasopharyngeal neoplasms of
childhood, and has not been reported in Korean child.
We experienced two cases of nasopharyngeal carcinoma in a 10... |
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- Malignant Schwannomas in children.
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Joon Jai Kim, Dong Joo Shin, Dong Won Son, Hong Hoe Koo, In Sang Jeon, Hee Young Shin, Hyo Seop Ahn
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Clin Exp Pediatr. 1991;34(4):525-531. Published online April 30, 1991
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Six pediatric patients who were diagnosed as malignant Schwannoma and treated at Seoul
National University Children’s Hospital from Aug. 1981 to Jun. 1990 were reviewed.
Mean age was 11 years and 1 month and all cases except one were over 10 years old. Of six cases,
three (50%) were associated with von Recklinghausen’s disease. Overall male to female ratio was 1 :
2. In... |
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- Clinical study of Kasabach-Merritt syndrome.
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Eun Jung Bae, Young Ah Lee, Hee Young Shin, Hyo Seop Ahn
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Clin Exp Pediatr. 1991;34(3):371-379. Published online March 31, 1991
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A retrospective analysis of clinical findings in 20 patients with Kasabach-Merritt syndrome who
visited Department of Pediatrics, Seoul National University Hospital from January, 1979 to June,
1990 was performed. The average age of occurrence was 6.4 month and male to female ratio was 1:
1.2. The mean size of hemangioma was 11.0x8.5 cm and the locations were cutanous in 18 (extrem-
ities 5, trunk... |
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- Clinical considerations of acute leukemia or transient myeloprolifo- rative disorder in Down syndrome.
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Eun Sil Dong, Sung Hee Jang, Hong Hoe Koo, Hye Lim Jung, Hee Young Shin, Hyo Seop Ahn
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Clin Exp Pediatr. 1991;34(1):74-82. Published online January 31, 1991
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Children with Down syndrome have an increased incidence of acute leukemia. Infants with Down
syndrome are also at risk of developing a transient myeloproliferative disorder indistinguishable from
acute nonlymphocytic leukemia (ANLL) except by its eventual clinical recovery. We observed 11
patients with acute leukemia or transient myeloproliferative disorder in Down syndrome who had
admitted to the Departmetn of Pediatrics, Seoul National University Children’s Hospital,... |
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- A case of Second Malignant Neoplasm Complicating Hodgkin's Disease in Remission.
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Hong Hoe Koo, Jong Woon Choi, Sang Oh Na, Il Soo Ha, Hee Young Shin, Hyo Seop Ahn, Yeon Lim Suh, Chul Woo Kim, Je Geun Chi
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Clin Exp Pediatr. 1990;33(4):564-572. Published online April 30, 1990
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Recent advances in the treatment of cancer have resulted in increased survival and possible cure for
many malignant disorders, particularly childhood cancers. There has been a marked improvement in
the treatment of childhood Hodgkin’s disease, and five-year survival rates for even advanced stages
of Hodgkin’s disease approach or exceed more than 75% with modern treatment policies. However,
successful therapy in childhood cancer is frequently... |
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- A case of congenital dyserythropoietic Anemia.
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Sang Oh Na, Seong Hoon Ha, Hong Hoe Koo, Hee Young Shin, Il Soo Ha, Hyo Seop Ahn, Doek Ja Oh, Myoung Hee Park
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Clin Exp Pediatr. 1990;33(3):410-415. Published online March 31, 1990
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The congenital dyserythropoietic anemia refers to a group of hereditary disorders of erythropoiesis
characterized by ineffective erythropoiesis, multinuclearity of erythroblasts, and secondary hemo-
chromatosis. The authors report a case of anemia in a 4 month-old girl whose bone marrow showed
dyserythropoietic features. A brief review of referential literatures was made. |
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- Burkitt Lymphoma in Children.
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Soo Jong Hong, Dong Kyu Jin, Hee Young Shin, Hyo Seop Ahn, Chang Yee Hong, Je G Chi
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Clin Exp Pediatr. 1988;31(4):482-491. Published online April 30, 1988
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Seventeen cases of Burkitt lymphoma under 15 years of age who were admitted to Dept, of Ped.,
Seoul National University Hospital from Jan. 1979 to Dec. 1986 were reviewed and analysed. One
hundred and six cases of non-Hodgkin lymphoma were seen during the same period.
1) Burkitt lymphoma accounted for 16% of non-Hodgkin lymphoma.
2) The age ranged from 10/12 year to 15 5/12 years, with... |
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- Captopril in Children with Renovacular Hypertension.
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Yong Choi, Hoan Jong Lee, Hee Young Shin, Kwang Wook Ko, Chang Yee Hong
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Clin Exp Pediatr. 1985;28(1):58-67. Published online January 31, 1985
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Captopril, a kind of converting enzyme inhibitors, is a promising anti-hypertensive drug, which is developed recently, and studied mainly in adult patients. We administered captopril to 4 children with renovascular hypertension, three of them accompanied Takayasu's arteritis and the remainder had isolated lesion. Three to five times of initial trials were performed on each patient with 12.5 mg of captopril.... |
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- Renal Disease in Children-A Ten-Years Experience.
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Hee Young Shin, Hae Il Cheong, Yong Choi, Kwang Wook Ko
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Clin Exp Pediatr. 1983;26(7):681-686. Published online July 31, 1983
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Statistical analysis of inpatients of Seoul National University Hospital from 1972 to 1981
who had renal diseases was performed with respect to their disease pattern, annual incidence
of each disease, and age distribution.
From 1972 to 1981 renal disease was found in 831 patients among 11,226 total inpatients
(7.4%). Male to female ratio of renal disease patients was 2.2 to 1, while male to... |
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- CNS Lesions in Tuberculous Meningitis.
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Hee Young Shin, Jung Hwan Choi, Jeong Kee Seo, Kyung Mo Yeon, Kwang Wook Ko, Hahn Woong Choe
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Clin Exp Pediatr. 1983;26(3):213-219. Published online March 31, 1983
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Clinical features of 20 patients who were diagnosed as tuberculous meningitis at Seoul
National University Hospital from Jan. ’82 to Dec. ’82 were analyzed with special respect
to their computed tomographic findings of the brain. Age at the onset of the disease ranged from 7 month.
to 12 9/12 year with the mean age of 3 11/12 year. Fifteen cases were under... |
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