- Original Article
- Neonatology (Perinatology)
- Perinatal risk factors for hemodynamically significant patent ductus arteriosus in very low birth weight infants
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Jie Hee Jue, So Young Shin, Jae Hyun Park, Chun Soo Kim, Hee Joung Choi
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Clin Exp Pediatr. 2026;69(4):313-321. Published online December 22, 2025
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Question: What perinatal factors influence patent ductus arteriosus (PDA) in and improve outcomes of preterm infants?
Finding: Lower birth weight, frequent surfactant treatment, and maternal hypertension increased hemodynamically significant PDA risk in very low birth weight infants, whereas chorioamnionitis and premature rupture of membranes protected against it. A lower birth weight and incomplete antenatal steroid use increased the risk of surgical ligation, whereas small for gestational age reduced it.
Meaning: Recognizing these factors may enable early, targeted intervention and reduce the need for surgical management. |
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- Effects of carnosine and hypothermia combination therapy on hypoxic-ischemic brain injury in neonatal rats
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Jun Chul Byun, Seong Ryong Lee, Chun Soo Kim
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Clin Exp Pediatr. 2021;64(8):422-428. Published online February 24, 2021
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Question: How can we further improve the neuroprotective effects of hypothermia in newborns with hypoxic-ischemic (HI) brain injury?
Finding: Combination carnosine and hypothermia therapy effectively reduced brain damage in neonatal rats. The in situ zymography, terminal deoxynucleotidyl transferase-mediated dUTP nick end-labeling assay, and immunofluorescence study results showed that neuroprotective effects were achieved with combination therapy only.
Meaning: Carnosine and hypothermia have synergistic neuroprotective effects against brain damage following HI injury |
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- Original Article
- Neonatology (Perinatology)
- Clinical features and prognostic factors of early-onset sepsis: a 7.5-year experience in one neonatal intensive care unit
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Se Jin Kim, Ga Eun Kim, Jae Hyun Park, Sang Lak Lee, Chun Soo Kim
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Clin Exp Pediatr. 2019;62(1):36-41. Published online September 27, 2018
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Purpose: In this study, we investigated the clinical features and prognostic factors of early-onset sepsis (EOS) in neonatal intensive care unit (NICU) patients.
Methods: A retrospective analysis was conducted on medical records from January 2010 to June 2017 (7.5 years) of a university hospital NICU.
Results: There were 45 cases of EOS (1.2%) in 3,862 infants. The most common pathogen responsible for... |
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- Neuroprotective effects of erythropoietin against hypoxic injury via modulation of the mitogen-activated protein kinase pathway and apoptosis
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Ji Eun Jeong, Jae Hyun Park, Chun Soo Kim, Sang Lak Lee, Hai Lee Chung, Woo Taek Kim, Eun Joo Lee
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Clin Exp Pediatr. 2017;60(6):181-188. Published online June 22, 2017
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Purpose Hypoxic-ischemic encephalopathy is a significant cause of neonatal morbidity and mortality. Erythropoietin (EPO) is emerging as a therapeutic candidate for neuroprotection. Therefore, this study was designed to determine the neuroprotective role of recombinant human EPO (rHuEPO) and the possible mechanisms by which mitogen-activated protein kinase (MAPK) signaling pathway including extracellular signal-regulated kinase (ERK1/2), JNK, and p38 MAPK is modulated in... |
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- Review Article
- Congenital and perinatal cytomegalovirus infection
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Chun Soo Kim
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Clin Exp Pediatr. 2010;53(1):14-20. Published online January 15, 2010
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Cytomegalovirus (CMV) is currently the most common agent of congenital infection and the leading infectious cause of brain damage and hearing loss in children. Symptomatic congenital CMV infections usually result from maternal primary infection during early pregnancy. One half of symptomatic infants have cytomegalic inclusion disease (CID), which is characterized by involvement of multiple organs, in particular, the reticuloendothelial and... |
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- Case Report
- Changes in N-terminal pro-B-type natriuretic peptide in a neonate with symptomatic isolated left ventricular noncompaction
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Ji Hyeun Song, Yeo Hyang Kim, Chun Soo Kim, Sang Lak Lee, Tae Chan Kwon
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Clin Exp Pediatr. 2009;52(1):129-132. Published online January 15, 2009
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We describe here our experience with a neonate presenting with cyanosis, grunting, and cardiomegaly, who was diagnosed with isolated left ventricular noncompaction (IVNC) by echocardiography. The patient had high levels of N-terminal pro-B-type natriuretic peptide (NT pro-BNP) and symptoms of heart failure including poor feeding and tachypnea. During the period in which NT pro-BNP levels steadily increased, the patient suffered... |
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- Supraventricular tachycardia in a neonate with
cardiac rhabdomyoma and tuberous sclerosis
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In Kug Bang, Yeo Hyang Kim, Chun Soo Kim, Sang Lak Lee, Tae Chan Kwon
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Clin Exp Pediatr. 2008;51(7):766-770. Published online July 15, 2008
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Primary tumors of the heart are uncommon among pediatric patients. Rhabdomyoma is the most frequent cardiac tumor in infants and children, which is commonly associated with tuberous sclerosis. Tuberous sclerosis is a neurocutaneous syndrome affecting the brain, heart, skin, and other organs. Cardiac rhadomyomas are reported in 50-64% of infants with tuberous sclerosis. Tuberous sclerosis involves multiple locations in the... |
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- Original Article
- Bacteremia in pediatric cancer patients : A single center study
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Sun Mi Park, Byung Kyu Choe, Chun Soo Kim, Joon Sik Kim, Heung Sik Kim, Nam-Hee Ryoo
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Clin Exp Pediatr. 2006;49(8):882-888. Published online August 15, 2006
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Purpose : Bacteremia is one of the major concerns in the treatment of pediatric cancer patients. This study was to determine the etiologic agents and the pattern of antibiotic susceptibilities in a single tertiary medical center.
Methods : We retrospectively reviewed the medical records of the cases of bacteremia in pediatric cancer patients from 1998 to 2005 in Keimyung University Dongsan... |
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- Clinical Findings of Sepsis-Associated Cholestasis in the Neonates
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Soo Jung Yoon, Chun Soo Kim, Sang Lak Lee
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Clin Exp Pediatr. 2004;47(4):380-385. Published online April 15, 2004
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Purpose : Bacterial endotoxins or inflammatory cytokines are known to be important causes of cholestasis in patients with systemic infections such as sepsis. This study was undertaken to investigate the clinical features of cholestasis in newborn infants with sepsis.
Methods : This study included 17 neonates with cholestasis diagnosed at the time of septicemia who had no previous history of cholestasis.... |
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- Case Report
- A Case of Weaver Syndrome
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Jun Chul Byun, Chun Soo Kim, Sang Lak Lee, Tae Chan Kwon, Hee Jung Lee
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Clin Exp Pediatr. 2004;47(11):1216-1219. Published online November 15, 2004
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Weaver syndrome is a very rare overgrowth syndrome with accelerated skeletal maturation, unusual facies and clinodactyly. We experienced an extremely rare case of Weaver syndrome in Korea. The clinical manifestations were macrocephaly, unusal facies, simian crease, clinodactyly, decreased muscle tone, accelerated bone age and congenital heart diseases. We report this with a brief review of related literature. |
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- Original Article
- The Significance of the Early Electroencephalographic Findings in
Severely Asphyxiated Newborn Infants
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Jong Uk Lee, Won Joung Choi, Chun Soo Kim, Sang Lak Lee, Jun Sik Kim
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Clin Exp Pediatr. 2003;46(8):784-788. Published online August 15, 2003
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Purpose : Perinatal asphyxia occurring in newborn is one of the major causes of acute mortality and chronic neurological disability in survivors. We have studied the relationship between early electroencephalography(EEG) findings and clinical course and neurologic outcome in severe asphyxiated neonates.
Methods : Between the period of July 1999 and June 2002, 25 neonates who were diagnosed with severe perinatal asphyxia(1-minute... |
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- Clinical Studies of Measles Prevalence in
Western Kyungnam District in 2000
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Byoung O Kwon, Hye Young Ju, Jeong Hee Kim, Hwang Jae Yoo, Chun Soo Kim
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Clin Exp Pediatr. 2002;45(3):331-338. Published online March 15, 2002
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Purpose : To investigate the feature of the range of measles in 2000, we studied epidemics of the measles in western Kyungnam District.
Methods : Among 489 patients under 15 years of age who visited or were admitted to in our hospital from January to December in 2000, we selected 344 patients whose measles IgM antibody was positive. We investigated age,... |
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- Megakaryocyte Colony Formation of Fetal Liver Cells
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Byung O Kwon, Hye Young Ju, Chun Soo Kim, Dong Seok Jeon, Jong In Kim, Heung Sik Kim
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Clin Exp Pediatr. 2002;45(2):247-255. Published online February 15, 2002
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Purpose : This study was undertaken to obtain basic data about the megakaryocyte colony formation of fetal liver cells by using immunocytochemical staining and ex vivo culture with growth factors.
Methods : The mononuclear cells were isolated from fetal liver and bone marrow with idiopathic thrombocytopenic purpura(ITP) and pancytopenia. These mononuclear cells were cultured in MegaCultTM-C(Stem Cell Tech, Canada) media in... |
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- Incidence of Congenital Heart Disease in Neonate by Color Doppler Echocardiography
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Tae Chan Kwon, Joon Sik Kim, Sang Lak Lee, Myung Sung Kim, Geun Soo Park, Chun Soo Kim, In Joo Kim, Bin Ahn
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Clin Exp Pediatr. 1998;41(3):363-368. Published online March 15, 1998
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Purpose : Many reports exist about the frequency of congenital heart disease(CHD) in the world, but according to the definition of CHD and subjects of study group, many differences existed between the reports. We conducted this study to evaluate the incidence and frequency of CHD by color Doppler echocardiography in neonate, and to suggest a preliminary model of incidence of... |
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- Case Report
- A Case of Ectopia Cordis
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Sun A Kim, Chun Soo Kim, Geun Soo Park, Myung Sung Kim, Sang Lak Lee, Joon Sik Kim, Tae Chan Kwon
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Clin Exp Pediatr. 1997;40(3):413-416. Published online March 15, 1997
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Ectopia cordis is a very rare cardiac anomaly that the heart is partially or totally
outside the thorax, and it was classified anatomically as 5 types-cervical, thoracocervical, thoracic (most commontype), thoracoabdominal, abdominal types.
We experienced a case of ectopia cordis(thoracic type) in a newborn who had the
symptom of generalized cyanosis since birth, and expired during operation due to
recurrent bradycardia and hypotension.
The brief... |
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- Original Article
- Normal Values of Left Ventricular Mass by Echocardiography in Korean Children
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Eun A Kim, Chun Soo Kim, Geun Soo Park, Myung Sung Kim, Sang Lak Lee, Joon Sik Kim, Tae Chan Kwon
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Clin Exp Pediatr. 1996;39(6):797-802. Published online June 15, 1996
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Purpose : Determination of left ventricular myocardial mass with echocardiography is
feasible and validated. American Society of Echocardiography(ASE) issued recommendations for the quantitation of the left ventricle by M-mode echocardiography. The purpose of this study is to determine the mean value of left ventricular mass in Korean children.
Methods : We measured left ventricular mass in 498 subjects(male 289, female 209)
using ASE... |
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