Search
- Page Path
-
- HOME
- Search
- Original Article
- Adolescence Medicine
- Relationship between inflammatory biomarkers and insulin resistance in excess-weight Latin children
- Mariano Nicolás Aleman, María Constanza Luciardi, Emilce Romina Albornoz, María Cristina Bazán, Adela Victoria Abregú
- Clin Exp Pediatr. 2024;67(1):37-45. Published online December 21, 2023
-
Question: What is the prevalence of insulin resistance (IR) in excess-weight Latin children, and can proinflammatory biomarkers predict it?
Finding: IR prevalence was elevated and tumor necrosis factor- α, interleukin-6, monocyte chemoattractant protein- 1, soluble CD40 ligand, and high-sensitivity C-reactive protein levels were increased in excess-weight Latin children. However, none predicted IR status.
Meaning: These inflammatory biomarkers were unable to predict IR status. Therefore, further investigations are necessary.
- Review Article
- Metabolic complications of obesity in children and adolescents
- Hyunjin Park, Jung Eun Choi, Seunghee Jun, Hyelim Lee, Hae Soon Kim, Hye Ah Lee, Hyesook Park
-
The global prevalence of childhood and adolescent obesity, exacerbated by the COVID-19 pandemic, is affecting not only school-aged children but also preschoolers. Early-onset obesity, along with a higher risk of metabolic complications, may contribute to a lower age of onset of cardiovascular disease (CVD). As metabolic diseases such as diabetes, dyslipidemia, and non-alcoholic fatty liver disease (NAFLD) observed in adulthood... -
DOI: https://doi.org/10.3345/cep.2023.00892 [Accepted]
- Endocrinology
- Nonalcoholic fatty liver disease and insulin resistance in children
- Kyungchul Song, Ho-Seong Kim, Hyun Wook Chae
- Clin Exp Pediatr. 2023;66(12):512-519. Published online January 9, 2023
-
· The prevalence of pediatric nonalcoholic fatty liver disease (NAFLD) increased from 8.2% in 2009 to 12.1% in 2018 in Korea.
· Laboratory tests, biomarkers, and imaging studies are used for the early detection of NAFLD.
· Insulin resistance is closely related to NAFLD.
- Original Article
- Infection
- Prevalence of methicillin-resistant Staphylococcus aureus in Iranian children: a systematic review and meta-analysis
- Farhad Sarrafzadeh, Seyed Mojtaba Sohrevardi, Hamid Abousaidi, Hossein Mirzaei
- Clin Exp Pediatr. 2021;64(8):415-421. Published online November 20, 2020
-
The pooled prevalence of methicillin-resistant Staphylococcus aureus (MRSA) was 42% among culture-positive cases of S. aureus, 51% in hospitalized children, and 14% in healthy children. The high prevalence of MRSA in Iranian children may be due to insufficient infection control measures in hospitals, inappropriate use of methicillin, inadequate staff training, and over-prescription of antibiotics in Iran.
- Febrile urinary tract infection in children: changes in epidemiology, etiology, and antibiotic resistance patterns over a decade
- Woosuck Suh, Bi Na Kim, Hyun Mi Kang, Eun Ae Yang, Jung-Woo Rhim, Kyung-Yil Lee
- Clin Exp Pediatr. 2021;64(6):293-300. Published online October 14, 2020
-
Question: How has the antibiotic susceptibility of urinary pathogens changed and what does it imply?
Finding: A yearly increase in multidrug-resistant and extended-spectrum β-lactamase (ESBL)–producing pathogens was observed. A higher recurrence rate was observed in cases of febrile urinary tract infection caused by ESBL producers in patients with underlying vesicoureteral reflux (VUR).
Meaning: The initial empirical antibiotic should reflect the changing susceptibility patterns and underlying VUR status.
- Review Article
- Endocrinology
- Early menarche and its consequence in Korean female: reducing fructose intake could be one solution
- Ji Hyun Kim, Jung Sub Lim
- Clin Exp Pediatr. 2021;64(1):12-20. Published online May 14, 2020
-
In Korea, the average age of menarche has declined sharply. Early menarche is associated with psychosocial and behavioral problems and cardiometabolic disease. Excess fructose intake has been suggested as one cause of early menarche in recent studies, so reducing fructose intake may be one solution.
- Original Article
- Endocrinology
- Influence of subclinical hypothyroidism on metabolic parameters in obese children and adolescents
- Ozlem Kara
- Clin Exp Pediatr. 2020;63(3):110-114. Published online March 6, 2020
-
Question: Does subclinical hypothyroidism in obese children and adolescents affect metabolic parameters?
Finding: Insulin, HOMA-IR, and TG levels were higher and the HDL-C level was lower in patients with SH.
Meaning: A clear association is observed between SH, and insulin resistance and dyslipidemia in obese children. It can be said that the TSH may be evaluated as a metabolic risk factor in obese patients.
- Review Article
- Pulmonology
- Benefits and risks of therapeutic alternatives for macrolide resistant Mycoplasma pneumoniae pneumonia in children
- Hyeon-Jong Yang
- Clin Exp Pediatr. 2019;62(6):199-205. Published online March 15, 2019
-
Although Mycoplasma pneumoniae pneumonia (MPP) has been generally susceptible to macrolides, the emergence of macrolide-resistant MPP (MRMP) has made its treatment challenging. MRMP rapidly spread after the 2000s, especially in East Asia. MRMP is more common in children and adolescents than in adults, which is likely related to the frequent use of macrolides for treating M. pneumoniae infections in children....
- Predictors and management of intravenous immunoglobulin-resistant Kawasaki disease
- Min Seob Song
- Clin Exp Pediatr. 2019;62(4):119-123. Published online March 15, 2019
-
Kawasaki disease (KD) is a systemic vasculitis that mainly affects younger children. Intravenous immunoglobulin (IVIG) resistant cases are at increasing risk for coronary artery complications. The strategy on prediction of potential nonresponders and treatment of IVIG-resistant patients is now controversial. In this review the definition and predictors of IVIG-resistant KD and current evidence to guide management are discussed.
- Trends in the use of antibiotics among Korean children
- Young June Choe, Ju-Young Shin
- Clin Exp Pediatr. 2019;62(4):113-118. Published online March 4, 2019
-
Inappropriate antibiotic use is the most important factor causing increased bacterial resistance to antibiotics, thus affecting patient outcomes. Multidrug-resistant bacteria have become a serious public health threat, causing significant morbidity and mortality worldwide. In Korea, the burden of antibioticresistant bacteria has become an important public health issue. There is increasing evidence of overuse and misuse of antibiotics in Korea, as...
- Original Article
- Adolescence Medicine
- Serum alanine aminotransferase levels are closely associated with metabolic disturbances in apparently healthy young adolescents independent of obesity
- Ki Eun Kim, Kyung Suk Baek, Sol Han, Jung Hyun Kim, Youn Ho Shin
- Clin Exp Pediatr. 2019;62(2):48-54. Published online November 23, 2018
-
Purpose: Liver metabolism plays a pivotal role in the development of metabolic disorders. We aimed to investigate the clinical and laboratory risk factors associated with alanine aminotransferase (ALT) levels in young adolescents from an urban population in Korea. Methods: A population of 120 apparently healthy adolescents aged 12–13 years was included in the cross-sectional design study; 58 were overweight or obese...
- Pulmonology
- Increased procalcitonin level is a risk factor for prolonged fever in children with Mycoplasma pneumonia
- Ji Eun Jeong, Ji Eun Soh, Ji Hee Kwak, Hye Lim Jung, Jae Won Shim, Deok Soo Kim, Moon Soo Park, Jung Yeon Shim
- Clin Exp Pediatr. 2018;61(8):258-263. Published online August 15, 2018
-
Purpose: Macrolide-resistant Mycoplasma pneumoniae pneumonia (MPP) is characterized by prolonged fever and radiological progression despite macrolide treatment. Few studies have examined serum procalcitonin (PCT) level in children with MPP. We aimed to investigate the association of acute inflammation markers including PCT with clinical parameters in children with MPP. Methods: A total of 147 children were recruited. The diagnosis of MPP...
- Review Article
- Pulmonology
- Mechanism of resistance acquisition and treatment of macrolide-resistant
Mycoplasma pneumoniae pneumonia in children - Hyeon-Jong Yang, Dae Jin Song, Jung Yeon Shim
- Clin Exp Pediatr. 2017;60(6):167-174. Published online June 22, 2017
-
Mycoplasma pneumoniae pneumonia (MPP) is one of the most common forms of community-acquired pneumonia in children and adolescents. Outbreaks of MPP occur in 3- to 7-year cycles worldwide; recent epidemics in Korea occurred in 2006–2007, 2011, and 2015–2016. Although MPP is known to be a mild, self-limiting disease with a good response to macrolides, it can also progress into a...
- Original Article
- Pulmonology
- Prevalence and clinical manifestations of macrolide resistant
Mycoplasma pneumoniae pneumonia in Korean children - Eun Lee, Hyun-Ju Cho, Soo-Jong Hong, Jina Lee, Heungsup Sung, Jinho Yu
- Clin Exp Pediatr. 2017;60(5):151-157. Published online May 31, 2017
-
Purpose Macrolide resistance rate of
Mycoplasma pneumoniae has rapidly increased in children. Studies on the clinical features between macrolide susceptible-M. pneumoniae (MSMP) and macrolide resistant-M. pneumoniae (MRMP) are lacking. The aim of this study was to identify the macrolide resistance rate ofM. pneumoniae in Korean children withM. pneumoniae penupmonia in 2015 and compare manifestations between MSMP and MRMP.Methods Among 122...
- Endocrinology
- Lipopolysaccharide-binding protein plasma levels as a biomarker of obesity-related insulin resistance in adolescents
- Ki Eun Kim, Young Sun Cho, Kyung Suk Baek, Lan Li, Kwang-Hyun Baek, Jung Hyun Kim, Ho-Seong Kim, Youn Ho Sheen
- Clin Exp Pediatr. 2016;59(5):231-238. Published online May 31, 2016
-
Purpose Lipopolysaccharide-binding protein (LBP) is a 65-kDa acute phase protein, derived from the liver, which is present in high concentrations in plasma. Data regarding the association between circulating plasma LBP levels and obesity-related biomarkers in the pediatric population are scarce. We aimed to determine whether there was a difference in plasma LBP levels between overweight/obese and normal-weight adolescents and to assess...
- Review Article
- Endocrinology
- Catch-up growth and catch-up fat in children born small for gestational age
- Won Kyoung Cho, Byung-Kyu Suh
- Clin Exp Pediatr. 2016;59(1):1-7. Published online January 22, 2016
-
Infants born small for gestational age (SGA) are at increased risk of perinatal morbidity, persistent short stature, and metabolic alterations in later life. Recent studies have focused on the association between birth weight (BW) and later body composition. Some reports suggest that fetal nutrition, as reflected by BW, may have an inverse programing effect on abdominal adiposity later in life....
- Case Report
- Inhaled iloprost for the treatment of patient with Fontan circulation
- Yong Hyun Kim, Moon Hee Chae, Deok Young Choi
- Clin Exp Pediatr. 2014;57(10):461-463. Published online October 31, 2014
-
Decreased exercise capacity after Fontan surgery is relatively common and the failure of the Fontan state gradually increases with age. However, there is no further treatment for patients with Fontan circulation. Pulmonary vasodilation therapy is an effective method to solve this problem because pulmonary vascular resistance is a major factor of the Fontan problem. Inhaled iloprost is a chemically stable...
- Original Article
- Predictive value of C-reactive protein in response to macrolides in children with macrolide-resistant
Mycoplasma pneumoniae pneumonia - Young Ho Seo, Jang Su Kim, Sung Chul Seo, Won Hee Seo, Young Yoo, Dae Jin Song, Ji Tae Choung
- Clin Exp Pediatr. 2014;57(4):186-192. Published online April 30, 2014
-
Purpose The prevalence of macrolide-resistant
Mycoplasma pneumoniae (MRMP) has increased worldwide. The aim of this study was to estimate the proportion of MRMP in a tertiary hospital in Korea, and to find potential laboratory markers that could be used to predict the efficacy of macrolides in children with MRMP pneumonia.Methods A total of 95 patients with
M. pneumoniae pneumonia were enrolled in...
- Review Article
- Antibiotics resistance of
Helicobacter pylori and treatment modalities in children withH. pylori infection - Ji-Hyun Seo, Hyang-Ok Woo, Hee-Shang Youn, Kwang-Ho Rhee
- Clin Exp Pediatr. 2014;57(2):67-71. Published online February 24, 2014
-
Pediatric infection with
Helicobacter pylori may occur early in childhood and persist lifelong. Global pediatric clinical studies have reported a decreasing tendency in the overall rate ofH. pylori eradication. In pediatric patients withH. pylori infection, pediatric patients with peptic ulcer, and the first-degree relatives of patients with a history of gastric cancer, it is commonly recommended thatH....
- Original Article
- Early-onset sepsis in a neonatal intensive care unit in Beni Suef, Egypt: bacterial isolates and antibiotic resistance pattern
- Sameh Samir Fahmey
- Clin Exp Pediatr. 2013;56(8):332-337. Published online August 27, 2013
-
Purpose To identify the frequency of bacterial isolates in early-onset neonatal sepsis (EONS) and their antimicrobial resistance pattern.
Methods A retrospective study of EONS was conducted at the Beni Suef University Hospital from September 2008 to September 2012. A case of EONS was defined as an infant who had clinical signs of infection or who was born to a mother with risk factors...
- Occurrence and characterization of oseltamivir-resistant influenza virus in children between 2007-2008 and 2008-2009 seasons
- Seoung Geun Kim, Yoon Ha Hwang, Yung Hae Shin, Sung Won Kim, Woo Sik Jung, Sung Mi Kim, Jae Min Oh, Na Young Lee, Mun Ju Kim, Kyung Soon Cho, Yeon Gyeong Park, Sang Kee Min, Chang Kyu Lee, Jun Sub Kim, Chun Kang, Joo Yeon Lee, Man Kyu Huh, Chang Hoon Kim
- Clin Exp Pediatr. 2013;56(4):165-175. Published online April 22, 2013
-
Purpose There was a global increase in the prevalence of oseltamivir-resistant influenza viruses during the 2007-2008 influenza season. This study was conducted to investigate the occurrence and characteristics of oseltamivir-resistant influenza viruses during the 2007-2008 and 2008-2009 influenza seasons among patients who were treated with oseltamivir (group A) and those that did not receive oseltamivir (group B).
Methods A prospective study was conducted...
- Review Article
Mycoplasma pneumoniae pneumonia in children- You-Sook Youn, Kyung-Yil Lee
- Clin Exp Pediatr. 2012;55(2):42-47. Published online February 14, 2012
-
Mycoplasma pneumoniae (MP), the smallest self-replicating biological system, is a common cause of upper and lower respiratory tract infections, leading to a wide range of pulmonary and extra-pulmonary manifestations. MP pneumonia has been reported in 10 to 40% of cases of community-acquired pneumonia and shows an even higher proportion during epidemics. MP infection is endemic in larger communities of the...
- Original Article
- Reference values for respiratory system impedance using impulse oscillometry in healthy preschool children
- Jye Hae Park, Jung Won Yoon, Youn Ho Shin, Hye Mi Jee, Young Sun Wee, Sun Jung Chang, Jung Hwa Sim, Hye Yung Yum, Man Yong Han
- Clin Exp Pediatr. 2011;54(2):64-68. Published online February 28, 2011
-
Purpose The normal values for lung resistance and lung capacity of children, as determined by impulse oscillometry (IOS), are different for children of different ethnicities. However, reference values there is no available reference value for Korean preschool children have yet to be determined. The aim of the present study was to determine the normal ranges of IOS parameters in Korean preschool...
- Detection of genetic mutations associated with macrolide resistance of Mycoplasma pneumoniae
- Chi Eun Oh, Eun Hwa Choi, Hoan Jong Lee
- Clin Exp Pediatr. 2010;53(2):178-183. Published online February 15, 2010
-
Purpose : The aim of this study was to identify mutations associated with macrolide resistance in Mycoplasma pneumoniae (MP) and to establish a cultural method to determine antimicrobial susceptibility. Methods : Nasopharyngeal aspirates (NPAs) were collected from 62 children diagnosed with MP pneumonia by a serologic method or polymerase chain reaction. The 23S rRNA and L4 ribosomal protein genes of MP... -
- Oseltamivir efficacy, side effects, and safety in children with influenza
- Eun Sun Seo, Geun Hwa Park, Sung Won Kim, Sung Won Kim, Woo Sik Jung, Kyung Soon Cho, Yeon Gyeong Park, Chang Kyu Lee, Chun Kang, Joo Yeon Lee, Woo Young Choi
- Clin Exp Pediatr. 2010;53(1):56-66. Published online January 15, 2010
-
Purpose : Although oseltamivir is widely used for treatment of influenza, few clinical studies of its efficacy and resistance have been performed in Korea. We evaluated the safety, side effects, and efficacy of oseltamivir treatment in Korean pediatric patients. Methods : We analyzed 321 children diagnosed with influenza at Busan St. Mary's Medical Center, Korea, between January 2008 and June... -
- Microbiological spectrum and antibiotic susceptibility pattern in more than 24-month-old children with urinary tract infection: A6-year retrospective, single center experience
- Jeong Hee Ko, Jee Hyung Lee, Eun Jung Shim, Do jun Cho, Ki Sik Min, Ki Yang Yoo, Dae Young Lee, Hee Jung Kang
- Clin Exp Pediatr. 2009;52(10):1147-1152. Published online October 15, 2009
-
Purpose : To characterize the pathogens and their antibiotic susceptibilities in more than 24-month-old children with urinary tract infection (UTI) and to study the Escherichia coli antimicrobial susceptibility trend. Methods : We retrospectively reviewed the record of more than 24-month-old children with UTI between January 2003 and December 2008. Positive results for 1 bacterial species with a colony count of... -
- Salmonellosis in children: Analysis of 72 Salmonella-positive culture cases during the last 10 years
- Sung Hoon Noh, Ka Young Yu, Jung Soo Kim, Pyoung Han Hwang, Dae Sun Jo
- Clin Exp Pediatr. 2009;52(7):791-797. Published online July 15, 2009
-
Purpose : We aimed to investigate the clinical manifestations of and antibiotic resistance in culture-proven childhood salmonellosis. Methods : Clinical manifestations and laboratory data of and antibiotic use in subjects with culture-proven childhood salmonellosis, who were treated at the Chonbuk National University Hospital between September 1998 and August 2008, were analyzed retrospectively. Patients with underlying diseases or concomitant illnesses were excluded. Results... -
- Serum leptin, adiponectin and resistin levels in obese children and their correlations with insulin resistance
- Min Young Park, Sun A Ahn, Won Kyoung Cho, Kyoung Soon Cho, So Hyun Park, Seung Hoon Hahn, Min Ho Jung, Byung-Kyu Suh
- Clin Exp Pediatr. 2009;52(7):766-771. Published online July 15, 2009
-
Purpose : The objective of this study was to compare the levels of adipocytokines in obesity group with those in control group and examine their correlation with insulin resistance. Methods : We enrolled 36 obese children (male:female [M:F]=17:19; age, 9.3±1.9 yrs) with ≥95th percentile body mass indexes (BMIs) (obesity group) and 35 healthy children (M:F=16:19; age, 9.1±2.1 yrs) with 25th-75th percentile... -
- Review Article
- Pediatric tuberculosis and drug resistance
- Yae-Jean Kim
- Clin Exp Pediatr. 2009;52(5):529-537. Published online May 15, 2009
-
Drug-resistant tuberculosis in children has important implications for both the patients and tuberculosis control programs. In Korea, among all new patients, the isoniazid resistance rate was 9.9% and multidrug-resistant tuberculosis rate was 2.7% in 2004 (in patients aged 10-19 yr, the multidrug-resistant tuberculosis rate reached 2.1%). Tuberculosis in pediatric patients is difficult to diagnose because many children have nonspecific clinical... -
- Original Article
- Development of metabolic syndrome and its correlation with insulin resistance in adult patients with Turner syndrome
- Joo Hwa Kim, Min Jae Kang, Choong Ho Shin, Sei Won Yang
- Clin Exp Pediatr. 2009;52(3):370-375. Published online March 15, 2009
-
Purpose : The risk of metabolic syndrome (MS) and cardiovascular disease in Turner syndrome (TS) patients is high. We analyzed metabolic factors in adults with TS and evaluated the metabolic risk of insulin resistance. Methods : Forty-three adults with TS were enrolled. The frequency of MS and the values of the metabolic factors were analyzed. Patients were divided into insulin... -
-
-
-
-
-
Impact Factor4.2
-
6.52022CiteScore92nd percentilePowered by
