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Original Article
Report of Nationwide Epidemiology of Aseptic Meningitis Outbreak in 1993 in Korea
Sung Hee Oh, Moo-Song Lee, Jin Han Kang, Chang Hwi Kim, Chong Young Park, Young Mo Sohn, Hoan Jong Lee, Chung Sik Chun, Sang Mann Shin
Clin Exp Pediatr. 1996;39(1):42-52.   Published online January 15, 1996
Purpose : There has been no nationwide report pertaining to the epidemiology of aseptic meningitis, although a great numer of patients have been diagnosed of the illness. Therefore, we report an explosive outbreak of aseptic meningitis occured in a nationwide scale in 1993. Methods : Aseptic meningitis epidemiology surveillence was performed retrospectively on the patients diagnosed of aseptic meinigitis from January...
Case Report
A Case of Acyclovir Induced Acute Tubular Necrosis
Mi Ya Park, Mee Kyung Namgoong, Hwang Min Kim, Baek Keun Lim, Sun Hee Jung
Clin Exp Pediatr. 1995;38(9):1283-1287.   Published online September 15, 1995
Acyclovir is generally regarded as a safe and highly effective antiviral agent in normal, as well as in immunocompromised hosts. Major renal complication was unusual. However, reversible renal dysfunction has been reported. The impairment of renal nephropathy resulting from crystal formation in the renal tubules or the collecting ducts. But we experienced a case of immunocompetent patient who developed severe...
Subacute Necrotizing Lymphadenitis (Kikuchi's Disease) in a Child with Atopic Asthma
Dong Jun Kim, Seong Yeoub Moon, Ha Baik Lee, Yeong Hae Koh
Clin Exp Pediatr. 1995;38(8):1141-1145.   Published online August 15, 1995
Subacute necrotizing lymphadenitis (Kikuchi's disease) is an increasingly recognized cause of cervical lymphadenitis since it has been described by Japanese doctors in 1972. It generally follows a benign course, when symptoms and signs of the disease are resolved usually within 1 to 6 months. We experienced a case of subacute necrotizing lymphadenitis in a 12 year-old boy with atopic bronchial asthma...
A Case of Chéiak-Higashi Syndrome
Soo Jin Kim, Soo Kyung Choi, Kyung Hee Park, Ghee Young Jung, Young Ok Lee
Clin Exp Pediatr. 1995;38(7):983-987.   Published online July 15, 1995
Chéiak-Higashi syndrome is a rare autosomal recessive disease characterised by partial oculocutaneous albinism, frequent pyogenic infections and abnormal large lysosomal granules in leukocytes and other granule containing cells. We experienced a case of Chéiak-Higashi syndrome in a twenty days old male who show-ed partial albinism, recurrent infections and characteristic abnormal large granules in granuloc-ytes on peripheral blood smear and bone marrow...
Original Article
Acute Hemorrhagic Cystitis(AHC) in Children -Etiology and Clinical Characteristics-
Jin Won Pyo, Eun Hwa Choi, Jin Young Park, Hoan Jong Lee, Hae Il Cheong, Il Soo Ha, Yong Choi, Kwang Myung Kim, Hwang Choi, Je Geun Chi
Clin Exp Pediatr. 1995;38(2):207-215.   Published online February 15, 1995
Purpose : AHC characterized by sudden onset of gross hematuria, dysuria and frequency oc curs in children and young adults as a self-limited disease that should be differentiated from se rious renal disorders. We have performed this study to establish the cause and characterize the clinical features of this illness in Korean children. Methods : 19 cases collected prospectively for 30...
Case Report
A Case of Remission of Systemic Juvenile Rheumatoid Arthritis (Still's Disease) Treated with High-dose Intravenous Gammaglobulin
Yon Sook Rho, Yun Woo Lee, Sang woo Kim
Clin Exp Pediatr. 1994;37(12):1767-1772.   Published online December 15, 1994
High dose intravenous gammaglobuline (IVIG) therapy is effective in some of the autoimmune diseases. Although the exact mechamism of action of IVIG is uncertain, the action as a neutralizing antibody against unknown etiologic agents, the action of blocking of Fc receptors of effector cells, or the action as a antiidiotypic antibody are suggested. We report a case of 12 year old...
Original Article
A Study on Prognostic Factors in Children with Encephalopathy
Jin Nyoung Park, In Joon Seol
Clin Exp Pediatr. 1994;37(12):1738-1745.   Published online December 15, 1994
To elucidate the clinical characteristics-especially its clinical pattern and outcome of chidren with encephalopathy, we carried out a retrospective review on medical records of 45 patients who were intially diagnosed as encephalopathy except mumps meningitis, Reye's syndome and neonatal hypoxic ischemic encephalopathy at the Department of pediatrics, Hanyang University children's hospital from January 1986 to February 1994. The results were summerized...
Case Report
A Case of Acute Tubular Necrosis Induced by paraquat (Gramoxon®) Intoxication
Young Guk Kim, Dong Gun Park, Kee Hwan You, Keun Haeng Cho, Young Sook Hong, Soon Kyum Kim
Clin Exp Pediatr. 1994;37(8):1143-1148.   Published online August 15, 1994
Paraquat (1, 1'-dimethy1-4, 4'dipyridium chlorde: Gramoxon￠c) was first discovered in England in 1955. It has been widely distributed for use in Korea since 1970 as a pesticide and also often the cause of accidental intoxications. The authors would like to report the following case of paraquat intoxication in a 13 year old female child admitted via emergency room with complaints...
Original Article
The Effect of Cranial Irradiation on Growth of Children with Lymphatic Origin Tumors
Jin Seoup Jung, Yon Sook Rho, Sang Woo Kim
Clin Exp Pediatr. 1994;37(5):666-671.   Published online May 15, 1994
A retrospective study was conducted to investigate the effects of CNS prophylaxis with 1,800cGy cranial irradiation on standing height growth of children with acute lymphoblastic leukemia(ALL). Seventeen longterm survivors (DFS over 5 years) of ALL and Non-Hodgkins Lymphoma who had been admitted at pediatric department of Inje University Seoul Paik Hospital from January 1982 to September 1988 were studied. The long term...
Acute Tubular Necrosis Associated with typhoid Fever
Pill-Jin Shin, Ho-Sung Lee, Byoung-Soo Cho, Chang-Il Ahn, Mun-Ho Yang
Clin Exp Pediatr. 1994;37(2):250-256.   Published online February 15, 1994
Acute tubular necrosis has been rarely reported as a complication of typhoid fever in the literature. We experienced four cases of acute tubular necrosis associated with typhoid fever in children. Patients showed significant titer of widal reaction associated with acute renal failure and one of them rised in 2 months after onset of clinical symptoms. Renal biopsy findings were compatible with acute...
Renal size as a Prognostic Factor in Childhood Acute Lymphocytic Leukemia
Soo Kyung Yun, Chang Hyun Yang, Chuhl Joo Lyu, Seung Hwan Oh, Kir Young Kim, Myung Joon Kim
Clin Exp Pediatr. 1994;37(2):174-179.   Published online February 15, 1994
The Kidney size is of special interest during the diagnostic work up of acute lymphocytic leukemia. But is still uncertain whether a finding of kidney enlargement at presentation has long-term prognostic value. We therefore reviewed the kidney size in children with acute lymphocytic leukemia by abdominal ultrasonograms at the time of diagnosis (n=54) and examined if there was any statistical...
Case Report
Three Cases of Acute Suppurative Thyroiditis in children
Min Joong Kwon, Ho Seong Kim, Duk Hi Kim, Duk Hi Kim
Clin Exp Pediatr. 1993;36(9):1320-1324.   Published online September 15, 1993
Acute suppurative thyroiditis is uncommon in children. The relative rarity of thyroid infection is thought to reflect its complete fibrous encapsulation, generous vascular and lymphatic supply and high local iodine level. the bacterial involvement include the normal oropharyngeal microflora, and broad spectrum antibiotic therapy including anaerobic coverage should be utilized initially. We have experienced three cases of acute suppurative throiditis. All...
Original Article
Intermittent Central Nervous System Irradiation and Intrathecal Chemotherapy for Recurrent Central Nervous System Leukemia in Children
Joon Ho Bang, Nak Gyun Chung, Woo Gun Choi, Hack Ki Kim, Kyong Su Lee, Man Kyu Yang
Clin Exp Pediatr. 1993;36(8):1067-1072.   Published online August 15, 1993
Between 1986 and 1990, four children with recurrent CNS leukemia who had previous NS prophylaxis therapy were treated with intermittent central nervous system irradiation and intrathecal chemotherapy (IIC). There was no isolated CNS recurrence. One patient died from bone marrow relapse. Three patients are alive without evidence of disease for 33/12 year to 36/12 years after the diagnosis of recurrence...
Atypical Presentation of Acute Glomerulonephritis
Hyun Ho Shin, Thy Hyung Park, Sung Ho Cha, Byoung Soo Cho, Chang Il Ahn, Young Tae Ko, Moon Ho Yang
Clin Exp Pediatr. 1993;36(7):987-993.   Published online July 15, 1993
Form March 1982 to December 1991, 110 cases of typical post-streptococcal glomerulonephritis and 25 cases of Atypical acute glomerulonephritis were clinically investigated at Department of pediatrics, Kyung Hee University Hospital, and follwing Data were obtained. 1) Male to Femal ratio was 1.8:1 (Atypical AGN). Peak incidence was from 7 to 12 years. 2) The most common preceding infections were upper respiratory infection,...
Plasma Levels of Oral Methotrexate in Children Receiving Maintenance Chemotherapy for Acute Lymphocytic Leukemia
Soo Kwan Lee, Kih Yeon Song, Young Hee Hwang, Young Hwan Lee, Jeong Ok Hah, Chun Dong Kim
Clin Exp Pediatr. 1993;36(7):936-943.   Published online July 15, 1993
This study was conducted to investigate plasma levels of oral methotrexate in rabbits and children receiving maintenance chemotherapy for acute lymphocytic leukemia. Eight New Zealand white rabbits, weighing 2kg in body weight, were divided into 3 groups and 5mg of methotrexate from 3 different manufactorying company was administered to the each group rabbits via nasogastric tube. Time to peak concentration ranged from...
A Clinical Study of Testicular Relapse in Childhood Acute Lymphocytic Leukemia
Hye Ok Roh, Chuhl Joo Lyu, Seung Hwan Oh, Chang Hyun Yang, Kir Young Kim, Byung Soo Kim
Clin Exp Pediatr. 1993;36(5):680-686.   Published online May 15, 1993
From January 1984 to June 1991, we studied testicular relapsed patients among 105 cases of acute lymphocytic leukemia in children who were admitted to the Department of Pediatrics and Yonse Cancer Center, Yonsei University Severance Hospital. The results were as follows: 1) 15 out of 105(14.4%) cases of acute lymphocytic leukemia were diagnosed as testicular relapse. According to the prevalence by the...
Clincal Observation on Guillain-Barré Syndrome in Children
In Cheol Park, In Seung Park, Jeh Hoon Shin, In Joon Seol, Ha Baik Lee
Clin Exp Pediatr. 1993;36(5):634-642.   Published online May 15, 1993
Clinical observation was performed on 23 children with Guillain-Barré syndrome which were hospitalized at the Pediatric ward of Han Yang University Hospital, from July 1975 through May 1991. The results were as follows: 1)The ratio of male patient to female was 2.8:1 and 47.8% of total GBS patients were between the ages 1to 5 years. 2)The highest seasonal incidence of GBS was seen...
Case Report
Recurrent Rhinocerebral Mucormycosis - A Case Report
Ho Sung Kim, Jin Young Park, Bo Young Yun, Eun Sil Dong, Hee Young Shin, Hoan Jong Lee, Hyo Seop Ahn, Je Geun Chi, Myung Whun Sung
Clin Exp Pediatr. 1993;36(4):589-595.   Published online April 15, 1993
A case of recurrent rhinocerebral mucormycosis that has occurred during an induction chemotherapy for acute megakaryocytic leukemia in a 10 year-old boy is reported. He had suffered from high fever, proptosis, right eye ball pain and necrotic inflammation of hard palate during the chemotherapy of leukemia. CT scan of the paranasal sinus showed inflammatory change of right ethmoid and maxillary...
2 Cases of Acute Disseminated Encephalomyelitis
Hyun Cheol Lee, Mee Kyung Namgoong, Hae Yong Lee, Hwang Min Kim, Jae Seung Yang, Jong Soo Kim
Clin Exp Pediatr. 1993;36(4):568-573.   Published online April 15, 1993
Acute disseminated encephalomyelitis(ADEM) is an acute inflammatory demyelinating disease of the central nervous system. It is thought to be an autoimmune mediated disorder which occurs usually after viral or bacterial infections, or after immunization. The clinical manifestations reflect sudden onset of the diffuse involvement of the brain, spinal cord and the meninges. We experienced two cases of acute disseminated encephalomyelitis. The...
Original Article
A Clinical Study of Myelodysplastic Syndrome in Children
Seong Hoon Hah, Hyo Seop Ahn
Clin Exp Pediatr. 1993;36(4):556-567.   Published online April 15, 1993
Myelodysplastic syndrome is a heterogeneous disease complex which is basically a clonal disorder and has characteristics of cytopenia of one or more cell series in peripheral blood and of dyspoiesis of precurosirs in bone marrow. Since the nature of this disease in childhooh is very different from that in adults, retrospective clinical study was performed with 17 confirmed patients who...
Acute Megakaryoblastic Leukemia in Children
Hong Hoe Koo, Sang Kyu Park, Eun Sil Dong, Hye Jung Park, Hee Young Shin, Hyo Seop Ahn
Clin Exp Pediatr. 1993;36(1):9-16.   Published online January 15, 1993
We analyzed the clinical and laboratory features of ten children with acute megakaryoblastic leukemia (M7) and compared the findings with those reported in the literature. The diagnosis was supported by ultrastructural examination of platelet peroxidase or immunophenotyping for glycoprotein Iib/IIIa. Of the ten children, five were girls and five were boys. The median age at diagnosis was 13 months. Two...
Acute Renal Failure Following Cardiac Surgery
Kang Yong Park, Yeon Ho Choi, Tae Sun Ha, Il Soo Ha, Hae Il Cheong, Yong Choi, Kwang Wook Ko, Joon Ryang Rho
Clin Exp Pediatr. 1992;35(9):1198-1209.   Published online September 15, 1992
A retrospective study of 452 patients who undertook cardiac surgery was performed to determine the pevalence, etiology, and clinical features of postoperative acute renal failure(ARF). The overall incidence of ARF following cardiac surgery was 4.65%(21/452). The incidence of ARF following open heart surgery(OHS) was 5.11%, and that following closed heart surgery was 2.50%. Preoperactive risk factors noted in the development...
Case Report
A Case of Acute Disseminated Encephalomyelitis -Magnetic Resonance Imaging Findings-
Soo Jong Hong, Hyung Nam Moon
Clin Exp Pediatr. 1992;35(7):1019-1025.   Published online July 15, 1992
Acute disseminated encephalomyelitis(ADEM) is an acute inflammatory demyelinating disease of the central nervous system. We experienced a case of ADEM in an 8 year-old boy who showed headache, vomiting, weakness of lower extremities and visual disturbance. Brain magnetic resonance imaging demonstrated multiple patch high signal intensity in both optic nerves, both thalamus, splenium of corpus callosum, and subcortical white matter...
Acute Tubular Necrosis Associated with Typhoid Fever
Sung-Yoon Cho, Kyu-Young Lee, Sung-Ho Cha, Byoung-Soo Cho, Chang-Il Ahn, So-Yeon Yu, Mun-Ho Yang, Soon-Don Hong
Clin Exp Pediatr. 1992;35(6):867-872.   Published online June 15, 1992
Acute tubular necrosis has been rarely reported in typhoid fever. We experienced a case of acute tubular necrosis due to typhoid fever in a 5 years old male patient. The patient showed significant titer of widal reaction associated with acute renal failure. Renal boipsy finding was compatible with acute tubular necrosis and immune complex was not deposited. Clinical and urinary...
Acute Disseminated Encephalomyelitis
So Young Kim, Jong Woo Bae, Byung Churl Lee
Clin Exp Pediatr. 1992;35(5):671-677.   Published online May 15, 1992
Acute disseminated encephalomyelitis is an uncommon immune mediated inflammatory disorder of the central nervous system. It may be defined as a monophasic encephalitis or myelitis of abrupt onset characterized by symptoms and signs indicative of damage chiefly of the white matter of the brain or spinal cord. The process may be severe and even fatal or mild and evanescent. The...
Subacute Necrotizing Encephalomyelopathy (=Leight's Disease)
So Young Kim, Heung Ki Min, Byung Churl Lee
Clin Exp Pediatr. 1992;35(3):395-398.   Published online March 15, 1992
Subacute necrotizing encephalomyelopathy or Leigh's disease is a familial neurodegenerative disorder characterized by focal bilateral and usually symmetric lesions of both gray and white matter in the brain and the spinal cord. The lesions are strikingly similar to those of thiamine deficiency encephalopathy. The diagnosis of subacute necrotizing encephalomyelopathy was usually made by typical clinical manifestation and typical bran CT...
A Case of Leigh's Disease
Il Jung Joo, Hyun Cheol Hwang, Sang Woo Kim, Yong Seung Hwang
Clin Exp Pediatr. 1992;35(2):234-239.   Published online February 15, 1992
We experienced a case of Leigh's disease (subacute necrotizing encephalomyelopathy) in a 3-year old boy who was presented with hypertension and showed progressive respiratory arrest after giving chloral hydrate or ketamine. Almost all diagnostic tests including brain CT showed normal findings. The diagnosis could be made by MRI and TFCA (Transfemoral carotid angiography). A review of literature was also made...
Original Article
Acute Appendicitis in Children
Min Hang Kim, Tae Geun Soon, Jae Sun Park, Chung Han Lee
Clin Exp Pediatr. 1992;35(1):51-59.   Published online January 15, 1992
A retrospective study was performed with 61 cases of acute appendicitis in children under the age of fifteen years in Kosin Medical Center from January, 1980 to April, 1991. All the patients had received surgery and biopsies of resected appendices were proved to the histological diagnosis of appendicitis The following results were obtained 1) The overall incidence of acute appendicitis...
A case of acute megakaryoblastic leukemia with Down syndrome.
Sung Jin Chang, Sung Min Sohn, Heung Sik Kim, Chin Moo Kang, Dong Seok Jeon
Clin Exp Pediatr. 1991;34(12):1730-1735.   Published online December 31, 1991
We experienced a case of acute megakaryoblastic leukemia (M7) with Down syndrome. The patient was admitted due to premature SGA, which revealed characteristic facial figure of Down syndrome. M7 was diagnosed with PB smear which showed abundant megakaryoblast and confirmed by using the monoclonal antiplatelet glycoprotein IIb/IIIa antibody (J 15). On 25th hospital day, the patient gained weight but discharged without further treatment of M7. Authors...
The effects of 1800 vGy cranial irradiation on intellectual function of children with acute lymphocytic leukemia.
Soo Ho Ahn, Jeong Ok Hah, Jung Hoon Lee
Clin Exp Pediatr. 1991;34(12):1683-1688.   Published online December 31, 1991
This study was conducted to investigate the effects of CNS prophylaxis with 1800 cGy cranial irradiation and intrathecal methotrexate (MTX) chemotherapy on intellectual function of the chil- dren with acute lymphocytic leukemia (ALL). Thirteen longterm survivors with ALL who were treated with 1800 cGy cranial irradiation and intrathecal MTX for CNS prophylaxis at pediatric department of Yeungnam University Hospital from May, 1983 to November, 1988...
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