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A Clinical Study of Testicular Relapse in Childhood Acute Lymphocytic Leukemia
Hye Ok Roh, Chuhl Joo Lyu, Seung Hwan Oh, Chang Hyun Yang, Kir Young Kim, Byung Soo Kim
Clin Exp Pediatr. 1993;36(5):680-686.   Published online May 15, 1993
From January 1984 to June 1991, we studied testicular relapsed patients among 105 cases of acute lymphocytic leukemia in children who were admitted to the Department of Pediatrics and Yonse Cancer Center, Yonsei University Severance Hospital. The results were as follows: 1) 15 out of 105(14.4%) cases of acute lymphocytic leukemia were diagnosed as testicular relapse. According to the prevalence by the...
Clinical Observation of Neonatal Sepsis
Jin A Son, Soon Wha Kim, Don Hee Ahn, Keun Chan Sohn
Clin Exp Pediatr. 1993;36(5):671-679.   Published online May 15, 1993
Ninety two cases of culture proved neonatal sepsis who had been admitted to pediatric department, National medical Center, during 7 years from Jan, 1984 to Dec, 1990 were reviewed clinically and the following results were obtained. 1) The frepuency of neonatal sepsis was 3.1% and male to female sex ratio was 1.9:1, Sepsis was more prevalent in prenature infants (9.9%) than...
A Study of Serum and Spinal Fluid Enzyme Such as CPK and LDH as Predictors of Neurologic Disability Following Perinatal Asphyxia
Min Hye Kim, Hye Jin Lee, Gyoung Hee Kim
Clin Exp Pediatr. 1993;36(5):664-670.   Published online May 15, 1993
Perinatal asphyxia is an insult to fetus or newborn due to lack of oxygen or perfusion to various organsm especially to brain, resulting in the important complication known as hypoxic inchemic encephalopathy. A clinical study was conducted on 30 newborns with perinatal asphyxia, who were admitted to Pediatric department of Ewha Women's University Hospital during 19 months period from Sep. 1990...
The Change of Anti-HBs Titer after Hepatitis B Vaccination in Newborn According to Dosage and Time
Joon Young Lee, Yong Sik MIn, Chang hwi Kim, Sang Jhoo Lee
Clin Exp Pediatr. 1993;36(5):656-663.   Published online May 15, 1993
We studied anti-HBs titer, positive and effective rate in relation to dosages(5, 10) and time interval after third vaccination in 23 infants born to HBsAg negative mother. The babies were divided into two groups. In one group(n=12), 5 of Hepavax was administered intramusculary at 1 month, 2 months and 6 months age, in other group (n=11), 10 of Hepavax at...
Gastrofiberscopic Findings in Children Complaining of Upper Gatrointestinal Symptoms
Jeong Wan Seo
Clin Exp Pediatr. 1993;36(5):649-655.   Published online May 15, 1993
A gastrofiberscopic evaluation was performed on 65 children complaining of upper gastrointestinal symptoms who visited the pediatric department of Hanil hospital from March 1991 to September 1992. Gastrofiberscopy was done without local anesthesia of pharynx and heavy sedation. To identify H. pylori infection, biopsy specimen was taken from the gastric antrum since Feb. 1992. The specimens were examined using the rapid...
Comparative Evaluation of Biochemical and Microscopic Urinalysis in Pediatric
Hwa Jeong Lee, Soo Young Lim, Seung hee Mok, Heui Jeong Kwon, In Sil Lee
Clin Exp Pediatr. 1993;36(5):643-649.   Published online May 15, 1993
The authors determined the value of performing urine microscopy on biochemically negative urine sepcimens in a pediatric population. The 746 urine specimens of patients who were either visited or admitted to the Department of Pediatrics, National Police Hospital, from March 1991 to July 1992 were reviewed on the basis of comparative evaluation of biochemical and microscopic urine analysis. Eight reactions...
Clincal Observation on Guillain-Barré Syndrome in Children
In Cheol Park, In Seung Park, Jeh Hoon Shin, In Joon Seol, Ha Baik Lee
Clin Exp Pediatr. 1993;36(5):634-642.   Published online May 15, 1993
Clinical observation was performed on 23 children with Guillain-Barré syndrome which were hospitalized at the Pediatric ward of Han Yang University Hospital, from July 1975 through May 1991. The results were as follows: 1)The ratio of male patient to female was 2.8:1 and 47.8% of total GBS patients were between the ages 1to 5 years. 2)The highest seasonal incidence of GBS was seen...
Detection of Cytomegalovirus DNA in Urine Culture Using Polymerase Chain Reaction
Young Mo Sohn, Won Young Lee
Clin Exp Pediatr. 1993;36(5):626-633.   Published online May 15, 1993
Polymerase chain reaction(PCR) amplication was used to detect cytomegalovirus (CMV) in tissue culture from the ruine of newborns and patients who was suspected CMV infection. Synthetic oligonucleotide primer pairs were used to amplify DNA from the magor immediate-early and the phosphoprotein 150 genes of CMV AD 169. Amplified products were detected by gel electrophoresis and by dot-blot hybridization with oligonucleotide...
The Statistical Observations for Pediatric Inpatients (1971-1990)
Hwa Ja Kim, Yong Min Jung, Sang Kyu Park, Ho Jin Park, Mi Ja Shin, Suk Chul Kang
Clin Exp Pediatr. 1993;36(5):615-625.   Published online May 15, 1993
We observed the patients admitted to the department of pediatrics Seoul Red Cross Hospital during the past twenty years from Jan. 1971 to Dec. 1990 The results were as follows: 1) The total number of pediatric inpatients during 20 years was 15,800, of which 9,683 were male, 6,117 were female and male to female ratio was 1.58:1 2) On age distribution, neonates and...
A Clinical Study of Myelodysplastic Syndrome in Children
Seong Hoon Hah, Hyo Seop Ahn
Clin Exp Pediatr. 1993;36(4):556-567.   Published online April 15, 1993
Myelodysplastic syndrome is a heterogeneous disease complex which is basically a clonal disorder and has characteristics of cytopenia of one or more cell series in peripheral blood and of dyspoiesis of precurosirs in bone marrow. Since the nature of this disease in childhooh is very different from that in adults, retrospective clinical study was performed with 17 confirmed patients who...
Nonsurgical Closure of Patent Ductus Arteriosus with the Rashkind PDA Occluder System
Yong Soo Yun, Jung Yun Choi, Jung Il Noh
Clin Exp Pediatr. 1993;36(4):550-555.   Published online April 15, 1993
The first successful application of a transcatheter occlusion of patent ductus arteriosus (PDA) was performed in 1977. Since that time, with continuing improvement and modification of the equipment as well as in the implantation technique, a clinical success rate of abont 84% was accomplished. In children's hospital, Seoul National University, since March 1992, 29 children with simple PDA were treated with...
Morphlolgical Analysis of the Congenital Heart Disease Associated with Infrahepatic Interruption of IVC with Azygos Contnuation
Jun Hee Sul, Jong Kyun Lee, Sung Kyu Lee
Clin Exp Pediatr. 1993;36(4):543-549.   Published online April 15, 1993
Infrahepatic interruption of the inferior vena cava with azygos continuation is elatively infrequent cardiovascular developmental anomaly occurring both in association with congenital heart disease and as an isolated anomaly of no hemodynamic importance. During the past 5years, we observed 38cases of infrahepatic interruption of IVC with azygos continuation out of 2,397 cases of congenital heart disease catheterized at Yonsei...
Tuberculin Skin Test and Measles Vaccination
Mi Sung Chung, Young Mi Kim, Hyung Ja Park, Shinna Kim
Clin Exp Pediatr. 1993;36(4):537-542.   Published online April 15, 1993
Although the incidence of tuberculosis in Korea in general has declined in recent years, it remains an important health problem, especially in children. Inspite of the recent controversy over the necessity of tuberculin skin test prior to measles vaccination, this brief report shows 13.8% of positive skin test at 9 and 15 months of age at the time of measles...
Anemia due to Prolonged Breast Feeding without Weaning Diet or Supplement Food
Kyung Hee Kim, Kun Rae Lee, Hyun Lee, Yoon Suck Suh, Baek Lin Eun
Clin Exp Pediatr. 1993;36(4):528-536.   Published online April 15, 1993
The paramount importance of breast feeding for the health of the infants has been recognized by nutritionists and physicians. Although many advantages of the breast feeding, exclusive breast feeding without weaning diet or supplement food during prolonged period in infants may produce iron deficiency anemia. This study was conducted to find out the hematologic state in exclusively prolonged breast-fed infants among...
Factors Related to the Outcome of Treatment of the Intussusception in Children
Young Joon Kim, Chan-Yung Kim
Clin Exp Pediatr. 1993;36(4):521-527.   Published online April 15, 1993
A statistical study was undertaken in 253 cases of intussusception treated in Pediatrics and General Surgery Departments in Pusan National University Hospital from January 1985 to December 1990. To investigate guidelines for the choice of the treatment and the outcome in intussusception, 10 factors related to the outcome of the treatment were analyzed. The results of study were as follow; 1)...
The Usefulness of Measuring Serum α-fetoprotein and Thyroxine-binding Globulin to Differentiate between Neonatal Hepatitis and Congenital Extrahepatic Biliary Atresia
Soo Kyoung Lee, Ki Sup Chung
Clin Exp Pediatr. 1993;36(4):512-520.   Published online April 15, 1993
Together, neonatal hepatitis and biliary atresia make up approximately 70 to 80% of the causes of neonatal cholestasis. Biliary atresia must be differentiated from neonatal hepatitis as soon as possible in order to institute early surgical intervention. We performed this study to examine whether the measurement of the serum α-fetoprotein(AFP) and thyroxine-binding globulin(TBG) was useful for differentiating these two conditions....
Aseptic Meningitis in 1991 - isolation of causative agent -
Yoon Ah Park, Eun Young Cho, Ki Soo Kim, Young Seo Park, Hyung Nam Moon, Chang Yee Hong
Clin Exp Pediatr. 1993;36(4):506-511.   Published online April 15, 1993
To know the causative agent of asptic meningitis, we performed blood and cerebrospinal fluid study on 24 children who had been admitted to the department of Pediatrics, Asan Medical Reference Laboratory, Japan. The most of the patients were young infants, and 15 cases of them were under 3 months of age. The male to female ratio was 1:1.4. We observed the main symptoms...
Effect of Cyclosporin, Indomethacin and Methylprednisolone on Puromycin-Aminonucleoside Induced Nephrosis in Rats
Hong Bae Kim, Hae Lee Chung, Cheol Woo Ko, Ja Hoon Ko, Jung Sik Gwak
Clin Exp Pediatr. 1993;36(4):495-505.   Published online April 15, 1993
This experimental study was conducted to evaluate the effect of indomethacin and methylprednisolone on PAN-induced nephrosis in rats. Sprague-Dawley rats weighing 150∼200gm were used and divided into controls, group Ⅰ(PAN intraperitoneally), group Ⅱ(PAN intraperitoneally, followed by indomethacin peritoneally for 12 days), group Ⅲ(PAN intraperitoneally, followed by methylprednisolone peritoneally for 12 days) and group Ⅳ(PAN intraperitoneally, followed by cyclosporin subcutaneously for...
A Clinical Study on Aseptic Meningitis Combined with Polio-Like Paralysis
Woong Young Moon, Ki Soo Kim, Young Seo Park, Hyung Nam Moon, Chang Yee Hong, Dae Chul Suh, Si Joon Yu, In Young Seong, Young Min Ahn
Clin Exp Pediatr. 1993;36(4):485-494.   Published online April 15, 1993
We clinically reviewed four patients who were suffering from aseptic meningitis combined with polio-like paralysis and performed radiological, neurological and virological studies on them. Three patients were admitted to the department of Pediatrics. Asan Medical Center from March to August 1990, and one patient was admitted to the department of Pediatrics, Kangnam General Hospital. The results were as follows: 1) During the period...
Clinical Significance of Urinary Growth Hormone Measurement in patients with Growth Hormone Deficien
Ho Seong Kim, Duk Hi Kim, Min-Seok Cheon
Clin Exp Pediatr. 1993;36(4):478-484.   Published online April 15, 1993
Urinary growth hormone (GH) excretion was quantitated in 12-hr overniaght urine collections obtained from 13 children with complete growth hormone deficiency(CGHD), 6 children with partial growth hormone deficiency(PGHD), 5 children with short stature and normal GH provocation tests(NSC), and 5 normal control children (NC) to investigate whether the measurement of urinary GH can clearly separate the PGHD and CGHD groups...
A Clinical Study on Neonatal Exchange Transfusion
Eun Ju Park, Eun Wui Kim, Yang Sook Choi, Son Sang Seo
Clin Exp Pediatr. 1993;36(4):469-477.   Published online April 15, 1993
Clinical observation was perfumed on 81 cases who were received exchange transfusion at Ilsin Christian Hospital from January, 1986 to December, 1990. The results obtained were as follows: 1) Among 6,388 cases of neonatal jaundice, the exchange transfusion was performed on 81 cases(1.27%) 2) There was no sex predominance (male 40, female 41). The birth weight of 75 cases(92.6%) ranged from 2,500 gm...
Inteleukin-6 Level in Systemic Lupus Erythematosus
Young Nae Yim, Dong Soo Kim
Clin Exp Pediatr. 1993;36(3):386-393.   Published online March 15, 1993
Systemic lupus erythematousus(SLE) is a disease affecting blood vessels and connective tissue, which are damaged by deposition of pathogenic autoantibodies and immune complexes.Although a complex disease, SLE provides a number of insights into autoimmune pathogenesis. Autoimmune disease, in general, is characterized by B cell hyperactivity which results in hypergammaglobulinemia and production of a variety of autoantibodies reactive to organ-nonspecific antigens...
Influenza Epidemic in the Pediatric Patients in Seoul 1991
Hyun Mi Kim, Se Ho Oh, Eun Young Cho, Ki Soo Kim, Young Seo Park, Hyung Nam Moon, Chang Yee Hong, Young Suhn Kim, Kee Duk Park
Clin Exp Pediatr. 1993;36(3):379-385.   Published online March 15, 1993
Influenza virus culture was performed in 149 patients with influenza-like illness who were admitted or visited to the Department of Pediatrics, Asan Medical Center from january 1991 to March,1991. The results were as follows : 1) Of the total 149 patients, influenza virus were isolated in the 15 cases. : 15 isolates were characterized by the WHO Collaborating Center for influenza : 7...
A Study of Serum CK-BB Activity as a Diagnostic Method and a Predictor of Neurologic Out come in Asphyxiated Infants
Clin Exp Pediatr. 1993;36(3):371-378.   Published online March 15, 1993
Asphyxia is the most important perinatal cause of neurologic morbidity in infants. Recently, elevated levels of CK-BB have been demonstrated in serum after asphyxic insult in infants. To evaluate the possibility of using serial measurements of CK-BB activity as a diagnostic method and a predictor of neurologic outcome in asphyxiatic infants. We studied CK-BB activity in serum of asphyxiated infants(16...
A Clinical Survey of Prematurity
Jee Won Lee, Sang Hee Lee, Ock Seung Jeong, Son Sang Seo
Clin Exp Pediatr. 1993;36(3):364-370.   Published online March 15, 1993
A clinical observaton was performed on 2,122 cases of premature infants who were admitted to Ilsin Christian during the past 5 years from Jan. 1986 to Dec. 1990. The results were as follows ; 1) The incidence of prematurity was 5.7%, overall mortality rate was 15.8%, and the sex ratio of male to female was 1.5:1. ...
Neonatal Mortality
Min Jeong Kim, Eun Eui Kim, Ock Seung Jeong, Son Sang Seo
Clin Exp Pediatr. 1993;36(3):356-363.   Published online March 15, 1993
A review of all 919 perinatal deaths occuring in Il Sin Christian Hospital From 91985 to 1989 was carried out. The results of clinical analysis were as follows : 1) The overall perinatal mortality rate was 26.30 per 1,000 birth. 2) The perinatal mortality rate was lowest in the gestation group between 37~41 week and in the weight group between 2,501~4,000gm. 3) The perinatal...
Clinical Study on Infants of Diabetic Mothers
Eun Eui Kim, Min Jeong Kim, Yang Sook Choi, Son Sang Seo
Clin Exp Pediatr. 1993;36(3):347-355.   Published online March 15, 1993
A clinical observation was performed on the 80 cases of neonates born from diabetic mothers among the total of 34,936 neonates delivered at Il Sin Christian Hospital from January 1985 to December 1989. The results were as follows : 1) The incidence of infants of diabetic mothers was 0.23%, among whom gestational diabetic mothers were 63 cases(78.7%) and overt diabetic mothers...
Obesity in Elementary School Children
Ji Hee Park, Chang Sung Son, Joo Won Lee, Young Chang Tockgo
Clin Exp Pediatr. 1993;36(3):338-346.   Published online March 15, 1993
Obesity has been implicated as a significant risk factor for multiple medical condition including hypertention, glucose intolerance, hyperlipidemia, hyperisulinemia and fatty liver. Furthermore, obesity in childhood is believed to be a reliable predictor of a similar condition in adulthood. During the recent yars, there has been a rapid rise in the incidence of childhood obesity in Korea due to increased...
A Study of Valproic Acid Therapy in Epileptic Children
Hae Jin Choi, Keon Su Rhee
Clin Exp Pediatr. 1993;36(3):328-337.   Published online March 15, 1993
A study was made on 50 cases of epileptic children who had been observed at the pediatric department of Chungnam National University Hospital and Taejeon Eul Ji Hospital during the period from July, 1986 to June, 1991 The result are as follows : 1) Epilepsy was most frequent in children from 1 yar to 10 year of age(80%). Epilepsy was commoner in...
The Side Effects of Antiepileptic drugs in Epileptic Children Treated withMonotherapy
Kon-Hee Lee, Hae-Sun Yoon
Clin Exp Pediatr. 1993;36(3):320-327.   Published online March 15, 1993
The goal of therapy of epileptic children is to control of seizures with minimal side effects of antiepileptic drug(AED). The relationship between side effects, serum levels and doses of AED were examined prospectively in 72 epileptic children who received monotherapy with phenobarbital, phenytoin, valproate, or carbamazepine for 6 to 26 months. Our results were as follows: 1) Side effects were observed in...
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