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The Change of Anti-HBs Titer after Hepatitis B Vaccination in Newborn According to Dosage and Time

Journal of the Korean Pediatric Society 1993;36(5):656-663.
Published online May 15, 1993.
The Change of Anti-HBs Titer after Hepatitis B Vaccination in Newborn According to Dosage and Time
Joon Young Lee, Yong Sik MIn, Chang hwi Kim, Sang Jhoo Lee
Department of Pediatrics, Soon Chun Hyang University, College of Medicine, Seoul, Korea
신생아가 B형 간염 예방접종 후 용량 및 시간경과에 따른 항체가 변동에 관한 연구
이준영, 민용식, 김창휘, 이상주
순천향대학교 의과대학 소아과학교실
Abstract
We studied anti-HBs titer, positive and effective rate in relation to dosages(5, 10) and time interval after third vaccination in 23 infants born to HBsAg negative mother. The babies were divided into two groups. In one group(n=12), 5 of Hepavax was administered intramusculary at 1 month, 2 months and 6 months age, in other group (n=11), 10 of Hepavax at same time interval. And the anti-HBs was studied at 2 months and 3 year after third vaccination by radioimmunoassay. The results were as follows. 1) The anti-HBs positive rate was 100% in two groups at 2 months and 3 years after vaccination. 2) The geometric mean anti-HBs titer at 2 months after third vacciantion was 9418.3±13041.5 IU/L in 5㎍ group and 12750.0±23895.5 IU/L in 10㎍ group, and 3 year after vaccination, 949.4 ±1404.0 IU/L in 5㎍group, 1067.4±1067.7 IU/L in 10㎍group. There were no significant difference between two groups, although mean anti-HBs titer decreased significantly after 3 years. 3) The effective rate at 3 years after vaccination was 66.7% in 5㎍group and 72.8% in 10㎍ group. There was no statistical significant difference between two groups.
Key Words: Hepatitis B vaccine, immunogenecity


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