| The Change of Anti-HBs Titer after Injection of HBIG and HBV in Newborn Delivered from HBsAg Carrier Mothers |
|
Qoae Suk Roh, Jin Young Jung |
|
Department of Pediatrics, Ulsan University Hospital, Ulsan, Korea |
| B형 간염 바이러스 보균산모에서 출생한 신생아에서 HBIG과 백신투여후 항체역가의 변화에 대한 연구 |
|
노쾌석, 정진영 |
|
울산대학교병원 소아과학교실 |
|
|
|
|
| Abstract |
Purpose
: We studied prevention effects of vertical transmission of Hepatitis B with
follow-up, through the change of Anti-HBs titers during 9 months after injection of
Hepatitis B immunoglobulin(HBIG) and Hepatitis B vaccine(HBV) at birth in newborn
delivered from Hepatitis antigen carrier mothers.
Methods
: This study was performed on newborn delivered from HBsAg carrier
mothers at Hae Sung Hospital from Feb. 1995 to May 1996. These newborn were
injected intramuscularly with HBV and HBIG after evaluation of HBsAg and Anti-HBs
titer directly at birth. Regular Hepatitis vaccination was given at 1 month, 6 months as
well as HBsAg and Anti-HBs titer were evaluated at 24 hours, 1 month, 3 months, 6
months, and 9 months.
Results
: The incidence of Hepatitis B carrier mothers is 5.6%, and newborn babies
born to HBsAg carrier mothers showed HBsAg in 10.6%. In most newborn, Anti-HBs
titer maintained in 100-1,000mIU/ml after injection of HBIG and HBV at birth, and
mean Anti-HBs titer decreased a little at 1 month, but therafter increased gradually by
regular Hepatitis vaccination. HBsAg positive newborn maintained mean HBsAg titers
below 2(S/N) until 9 months old after injection of HBIG and HBV.
Conclusion
: A screening test for Hepatitis B must be performed on all pregnant
women, and that infants of Hepatitis B carrier mothers must be immunized by HBIG
and HBV directly at birth. |
| Key Words:
Hepatitis B immunoglobulin(HBIG), Hepatitis B vaccine(HBV), Anti-HBs titer |
|
PDF Links
Download Citation
