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A Clinical Study on Prematurity Who received Blood Transfusion
Chul Soon Park, Myung Ik Lee, Soon Wha Kim, Don Hee Ahn
Clin Exp Pediatr. 1993;36(10):1389-1394.   Published online October 15, 1993
A clinical study was made on 85 cases of prematurity under 37 weeks of gestational age who had history of blood transfusion during their admission at the National Medical Center from January 1989 to June 1992. The results were as follows: 1) Among 339 prematurity patients, 85 patients (25.1%) received blood transfusion once at least. 2) Male to female ration was 1.13:1 and...
Cow Milk Allergy in Infant Who Neonatal Onset
Seung Hee Park, Myung Ik Lee, Don Hee Ahn, Seung Hee Park
Clin Exp Pediatr. 1993;36(10):1383-1388.   Published online October 15, 1993
Cow milk allergy can be defined as an adverse immunologic reactions to cow milk protein. The term is often mistakenly applied to other causes of milk intolerence, such as lactase deficiency and galactosemia, which must be differenciated and excluded. We have experienced 10 children of cow milk allergy at neonatal onset who had suffered from G-I symtons, such as diarrhea, irritability,...
Arterial Blood Gas Analysis in Asthmatic Children
Dae Young Choi, Kyeong Cheol Yoon, Kang Woo Park, Sung Won Kim
Clin Exp Pediatr. 1993;36(10):1375-1382.   Published online October 15, 1993
The purpose of this study is to verify severity of asthma in asthmatic patients through the arterial blood gas analysis. Subjects were consisted of 103 patients (74 boys and 29 girls), between 2~13 years of ages. Clinically, asthmatic patients were classified into 6 groups, i.e., group 0(no rhonchi), group 1(rhonchi only), group 2(mild attack), group 3(moderate attack), group 4(severe attack), group...
A Clinical Study on Wheezing of Mycoplasma Pneumoniae Pneumonia in Children
Jeong Eun Kwon, Jun Ho Yoon, Jae Ook Lee, Im Ju Kang
Clin Exp Pediatr. 1993;36(10):1366-1374.   Published online October 15, 1993
The relationship between respiratory infections and exacerbations of wheezing in patients with wheezy bronchitis or asthma has been described. Most respiratory infections were viral or Mycoplasma pneumoniae. This study was performed to evaluate the effect of Mycoplasma pneumoniae infection on bronchial reactivity and atopic background. 106 patients with Mycoplasma pneumoniae pneumonia who were admitted to the department of pediatrics, Fatima Hospital,...
Growth Pattern and Final Height in Congeital Adrenal Hyperplasia
Ho Seong Kim, Duk Hi Kim
Clin Exp Pediatr. 1993;36(10):1359-1365.   Published online October 15, 1993
Clinical characteristics and growth pattern were evaluated in 42 patients with classical congenital adrenal hyperplasia treated since diagnosis. And final height was evaluated in 16 patients who had reached final adult height with regard to clinical form, degree of hormonal control, and age of initial treatment. The results were as follows; 1) Among 42 patients with classical congenital adrenal hyperplasia, the male...
Comparative Value of Cardiac MRI and Echocardiography in the Assessment of Congenital Heart Lesions
Young-Hwue Kim, #NAME? Park, Chang-Yee Hong, Shi-Joon Yoo, Tae-Hwan Lim
Clin Exp Pediatr. 1993;36(10):1343-1350.   Published online October 15, 1993
To examine the usefulness of cardiac MRI in assessing patients (pt) with congenital heart diseases (CHD), informations obtained from MRI and echocardiogrphy (echo) were compared in 91 consecutive pt with CHD and was correlated with findings at cardiac catheterization(53pt) and at surgery (71pt). Pt were studied with 1.5Tesla MRI unit and multiplanar images of the heart and great vessels were...
Comparison of Tuberculin Skin Test Results and Adberse Reactions Following BCG Vaccination In Various Infant Groups of Different Ages
In Seung Park, Dong Ki Han, Ho Joon Lim, Sung Hee Oh, Hahng Lee
Clin Exp Pediatr. 1993;36(9):1300-1307.   Published online September 15, 1993
Most authorities including WHO recommended immununizing infants with BCG as early as possible in areas prevalent with tuberculosis, however the optimal time for immunization has not well been characterized. Therefore the investigation was undertaken by vaccinating various infant groups of different ages with BCG and subsequently evaluating for adverse effects and tuberculin reactions, in order to contribute to undestanding the...
A Clinical Study of Bronchial Asthma in Children
Seung Hee Park, Myung Ik Lee, Don Hee Ahn, Keun Chan Sohn
Clin Exp Pediatr. 1993;36(9):1291-1299.   Published online September 15, 1993
This report is a clinical analysis and comparative study with previous report of bronchial asthma at National Medical Center on bronchial asthma in children who were admitted to the MP dept. of national Medical Center from January 1987 to December 1990. The results of the study were as follows: 1) The out-break ratio of bronchial asthma is 3.7% of hopitalized children which...
Changes in Somatostatin Immunoreactive Neurons in Rat Corebral Cortes after Systemic Kainic acid Administration
Myung Yeun Lee, Sa Jun Chung, Chang Il Ahn
Clin Exp Pediatr. 1993;36(9):1279-1290.   Published online September 15, 1993
This study was aimed to clarify the effects of systemic kainic acid(KA) administration(10mg/kg i.p.) on somatostatin containing neurons, and to examine the distribution of somatostain immunoreactive neurons in the cerebral cortex of the rats. Animals were sacrificed at three time points at the two, six, and ten days after the injection of KA. Thirty-six rats were observed by using the free-floating immunohistochemical...
The Risk of Seizure Recurrence of Pediatric Epileptic Patients While Receiving Anticonvulsant Drugs Treatment
Dae Sung Hwang, Byung Hyun Kim, Kwang Soo Oh, Yeon Kyun Oh, Hyang Suk Yoon, Jong Duck Kim
Clin Exp Pediatr. 1993;36(9):1271-1278.   Published online September 15, 1993
To evaluate the risk and factors associated with seizure recurrence on children with epilepsy while receiving the adequate anticonvulsant treament, we studied 58 patients with newly diagnosed epilepsy who were followed prospectively for a median of 26 months (range 7 to 54). The results were as follows: 1) Forty-four of the 58 patients (75.9%)had recurrence...
A Clinical Study of Childhood Soft Tissue Sarcoma
Hye Lim Jung, Hong Heo Koo, Hee Young Shin, Hyo Seop Ahn
Clin Exp Pediatr. 1993;36(9):1258-1270.   Published online September 15, 1993
Medicine, Seoul, Korea Department of Pediatrics, Seoul National University College of Medicine, Seoul, Korea To study the clinical characteristics and treatment results of childhood soft tissue sarcoma, the retrospective study was performed on 67 patients with soft tissue sarcoma, experienced at the Department of Pediatrics, Seoul National University Hospital from January, 1982 to July, 1990. The...
Neurologic Complications after Open-Heart Surgery in Children
Tae Sung Ko, Ki Joong Kim, Dong Wook Kim, Yong Seung Hwang, Yong Jin Kim, Joon Ryang Rho
Clin Exp Pediatr. 1993;36(9):1245-1257.   Published online September 15, 1993
Neurologic complications after open-heart surgery are not only relatively common but also often fatal. In order to know the clinical characteristics and carsative risk factors, we carried out the retrospective study on 655 patients who had been admitted and undergone OHS at Seoul National University Children's Hospital during 2-year period from July 1990 to June 1992. The results...
A Clinical Survey of Prolonged Q-T Syndrome among Korean Children with Congenital Deafness
Kang Woo Lee, Kyung Bum Kim, Chang Sung Son, Joo Won Lee, Young Chang Tockgo
Clin Exp Pediatr. 1993;36(9):1236-1244.   Published online September 15, 1993
The clinical symptom complex characterized by syncopal attacks and sudden death in patients with electrocardiographic anomalies, especially a prolonged Q-t interval is known as the Romano-Ward syndrome. When a similar syptom complex is accompanied by congenital deafness, it is called Jervell and Lange-Nieisen syndrome. This study was underataken to investigate the incidence of the latter syndrome in the...
A Clinical Study of Congenital Anomalies in Births associated with Hydramnios
Eun Sil Shin, Min Jeong Kim, Ock Seung Jeong, Son Sang Seo
Clin Exp Pediatr. 1993;36(9):1227-1235.   Published online September 15, 1993
A study was made in the congenital anomalies in 137 babies born to 120 mothers with hydramnios, delivered at Ilsin Christian Hospital between Jan. 1st 1981 and Dec. 31th 1990. The results were as follows; 1) The incidence of hydramnios was 16/1000 deliveries, 120 cases in total 73,129 deliveries. 137 infants was born and of...
Postnatal Changes of Cretine Kinase and Isoenzyme Activities in Normal and Asphyxiated Newborns
Ki Young Koo, Nam Geun Heo, Heng Mi Kim
Clin Exp Pediatr. 1993;36(9):1219-1226.   Published online September 15, 1993
This study was conducted to evaluate the postnatal changes of serum creatine kinase (CK)and its isoenzymes in normal and asphyxiated newborns. In normal newborns total CK, CK-MM and CK-MB reached a plateau between 2 and 24 hr after birth whereas the serum CK-BB remained stable after birth. CK-MM, CK-MB and CK-BB respectivily composed 90~94%, 5~7% and 1~5%...
Indirect Measurement of Blood Pressure in Neonates Using an Automatic Noninvasive Oscillometric Monitor
Jung Hea Park, Hea Jin Choeh, Eun Sik Kang, Chong Sung Chung, Kyuchul Choeh
Clin Exp Pediatr. 1993;36(9):1211-1218.   Published online September 15, 1993
The measurement of blood pressure in neonates is an important diagnostic procedure. But the measurement of blood pressure has not been performed routinely because of difficulty in measuring blood pressure and varable normal range according to measuring apparatus. Recently some accurate and convenient apparatus of measuring blood pressure have been introduced in neonatal care, so the reference values...
Effects of Equiseti Herba Water-heating Extract on the Kidney and liver of Rats
Yoon Jong Yoo, Eun Gyeoung Jung, Kap Seoung Kim, Kyeong Rae Moon, Sang Kee Park, Young Bong Park, Keun Hong Kee
Clin Exp Pediatr. 1993;36(9):1203-1210.   Published online September 15, 1993
The effects of Equiseti Herba water-heating extract on the kidey & liver of rats were studied in 25male Sprague-Dawley rats evenly divided into five groups, i.e., 5 rats each. The group I, which served as control and the group II, III, IV, were fed 300 mg/kg, 500mg/kg, 1000mg/kg of Eqiseti Herba water-heating extract daily for one week, respectively. The group...
Changes of IgG Subclasses in the Sera of the Children with Kawasaki Disease
Seog Beom Cho, Sun Kyu Park, Pyoung Han Hwang, Jung Soo Kim, Sa Hyoung Choi
Clin Exp Pediatr. 1993;36(9):1197-1202.   Published online September 15, 1993
Kawasaki disease is an acute vasculitis of infancy and early childhood characterized by high fever, rash, mucositis, lymphadenopathy and coronary artery damage. The failure to indentify a causative organism using convetional culture and serological techniques, and the lack of response to antibiotics indicate that the disorder is probably not due to any known bacterial or viral pathogens. During...
A Study of HLA-DQA Genotyping of Hair DNA Using the PCR Method
Jae Hong You, Keon Su Lee, Jong Woo Park
Clin Exp Pediatr. 1993;36(8):1156-1164.   Published online August 15, 1993
The characterization of genetic variation at the level of DNA has generated significant advances in gene mapping and disease diagnosis, and forensic identification of individuals. It is now possible to identify individual DNA from various tissue specimens, like hair, using the PCR and oligonucleotide probes. To date, however, the number of hairs needed, the preservation conditions, and the kinds of hair...
A Study of Serum Transaminase Level and It's Correlation with Several Symptoms in Children with HRV Gastroenteritis
Gang Youl Bae, Eui Tak Oh, Woo Sik Jung, Kil Seo Kim
Clin Exp Pediatr. 1993;36(8):1146-1155.   Published online August 15, 1993
The retrospective study was taken to study the serum trasnsaminase level and it's correlation with several symptoms in human rotavirus gastroenteritis. 494 children, who admitted to the Department of Pediatrics in Dae Dong Hospital from January 1991 to December 1991 with chief complaints of waterdy diarrhea were included in studies. The 1 st stool specimen on admission was tested for rotavirus Ag...
The Effectf Zonisamide in Children with Refractory Epilepsies
Ki Joong Kim, Soo Ahn Chae, Tae Sung Ko, Dong Wook Kim, Yong Seung Hwang
Clin Exp Pediatr. 1993;36(8):1139-1145.   Published online August 15, 1993
Zonisamide was amministered to 20 patients with refractory epileptic seizures. The mean duration of the administration was 6 months, and the mean dosage was 7.2mg/kg/day. The efficacy of zonisamide was rated remarkable in 15% of the cases, improvement in 40%, and no change in 45%. The response rates of zonisamide were 62.5% for myoclonic seizures, 50% for tonic-clonic seizures, 80% for...
Throid Nodules in Children
Su-Yung Kim
Clin Exp Pediatr. 1993;36(8):1133-1138.   Published online August 15, 1993
30 cases of patients with nodule on the thyroid who visited Pediatric Clinic in PUN Hospital from Jan. 1985 till Dec. 1990 were studied and evaluated. All records of the patients were reviewed in regard to the physical examination, thyroid function test, radionuclide scanning, ultrasonogram and pathological findings of the tissues gained by fine needle aspiration or operation. The following results...
Clinical Studies of Henoch-Schölein Purpura Which was Considered as Acute Abdomen
Seong Young Jeong, Seong Yun Cho, Chio Heong Park, Seong Ho Cha, Byoung Soo Cho, Chang Il Ahn
Clin Exp Pediatr. 1993;36(8):1124-1132.   Published online August 15, 1993
Henoch-Schölein purpura is a common pediatric disease presenting most frequently with skin, gastrointestinal, joint and renal manifestations. But in cases are infrequently only severe gastointestinal manifestations. It is hard to diagnose promptly and exactly. Clinical manifestations and laboratory findings were observed and analyzed in 20 cases with Henoch-Schölein purpura which were considered as acute abdomen, hospitalized at Kyung Hee university Hospital...
Production and Characterization of Monoclonal Antibodies to Perchloric Acid Soluble Antigen of M. tuberculosis(TB-II)
Kyung Hyo Kim, Dong Soo Kim
Clin Exp Pediatr. 1993;36(8):1116-1123.   Published online August 15, 1993
Mycobacteria cause diseases which occur the world over and whoich carry a considerable burden in morbidity, mortality and social problems. A battery of monoclonal antibodies specific for mycobacterial antigens would provide a useful tool for rapid diagnosis of mycobacterial diseases. Fourtenn monoclonal antibodies to perchloric acid soluble antigne of M. tuberculosis were produced. Immunoglobulin isotypes of monoclonal antibodies were ten...
Production, Characterization, and Clinical Application of Perchloric Acid Soluble M. tuberculosis Antigen (TB-I)
Kyung Hyo Kim, John Linton, Yunsop Chong, Dong Soo Kim
Clin Exp Pediatr. 1993;36(8):1107-1115.   Published online August 15, 1993
The immune response to M. tuberculosis engages T-cell medicated reactions which determine the degree of resistance and also the clinical pattern of disease. Although antibodies produced by the infected host have yet no proven protection, they are appilicable for alternative diagnostic tests in tuberculosis. Preparation of purified antigens from Mycobacteria with specific antigenic determinants would improve serological diagnosis in tuberculosis. The...
Ultrasonographic Measurement of the Neonatal Adrenal Glands
Hae Kyung Lee, Jae Ock Park, Chang Hwi Kim, Sang Man Shin, Sang Jhoo Lee
Clin Exp Pediatr. 1993;36(8):1101-1106.   Published online August 15, 1993
To determine the normal neonatal adrenal gland size, ultrasonographic examinations were performed in 145 newborn infants. They were divided into 3 groups according to the days of age. The group I is 1~3 days, group II is 6~9days and group III is 21~50days of age. 1) The adrenal gland size was as follows. In group I, the length was 29.05mm and the...
The Relationship between Spontaneous Diuresis and Changes of Pulmonary Function in Infants with Respiratory Distress Syndrome
Byeong Hyun Kim, Jae Kag Choi, Yeon Kyun Oh, Kwang Soo Oh, Hyang Suk Yoon, Chong Cuk Kim
Clin Exp Pediatr. 1993;36(8):1094-1100.   Published online August 15, 1993
To evaluate the relationship between spontaneous diuresis and improvement of pulmonary function in respiratory distress syndrome, 15 premature neonates requiring mechanical ventilation for RDS, who admitted in NICU of Wonkwang University Hospital from January 1990 to June 1992, were studied. The results were as follows(results are mean¡¾SEM) 1) Mean birth weight of study infants was 1.82¡¾0.08Kg, and mean gestational age was 32.80¡¾0.54...
Statistical Observation on Neonate
Dong Il Park, Chel Gi Kim, Jin Bok Hwang, Chang Ho Han, Hye Le Chung, Young Dae Kwon
Clin Exp Pediatr. 1993;36(8):1080-1093.   Published online August 15, 1993
A statistical obsevation was performed on 13,317 cases of neonates who had been delivered at Taegu Catholic Hospital during the past 3 years from Jan. 1 st 1988 to Dec. 31 st 1990. The results obtained were as follows: 1) Among 13,317 neonates, the male was 7,234 and the femlae 6,083, with the sex ratio of male to female being 1.19:1 2) Percentage...
High-Dose Intravenous Immune Globulin Therapy for Hyperbilirubinemia Caused by ABO Incompatibility
Dong Sung Kim, Dong Un Kim, Ji Whan Han, Sung Soo Whang, Kyung Yil Lee, Man Kyu Yang
Clin Exp Pediatr. 1993;36(8):1073-1079.   Published online August 15, 1993
Four newborn infants with hyperbilirubinemia, caused by ABO blood group incompatibility, were treated with high-dose intravenous immune globulin (IVIG). As soon as the diagnosis was clinically suspected, these infants received conventional treatment including phototherapy and were monitored closely for bilirubin levels. When bilirubin concentrations reached the risk point in spite of pjototherapy, IVIG was given at a dose of 1g/kg for...
Intermittent Central Nervous System Irradiation and Intrathecal Chemotherapy for Recurrent Central Nervous System Leukemia in Children
Joon Ho Bang, Nak Gyun Chung, Woo Gun Choi, Hack Ki Kim, Kyong Su Lee, Man Kyu Yang
Clin Exp Pediatr. 1993;36(8):1067-1072.   Published online August 15, 1993
Between 1986 and 1990, four children with recurrent CNS leukemia who had previous NS prophylaxis therapy were treated with intermittent central nervous system irradiation and intrathecal chemotherapy (IIC). There was no isolated CNS recurrence. One patient died from bone marrow relapse. Three patients are alive without evidence of disease for 33/12 year to 36/12 years after the diagnosis of recurrence...
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