| Postnatal Changes of Cretine Kinase and Isoenzyme Activities in Normal and Asphyxiated Newborns |
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Ki Young Koo, Nam Geun Heo, Heng Mi Kim |
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Department of Pediatrics, College of Medicine, Kyung-Pook National University, Taegu, Korea |
| 정상 신생아와 가사 신생아에 있어서의 Ceatine Kinase의 출생후 변화 |
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구기영, 허남근, 김행미 |
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경북대학교 의과대학 소아과학교실 |
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| Abstract |
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This study was conducted to evaluate the postnatal changes of serum creatine kinase (CK)and its isoenzymes in normal and asphyxiated newborns.
In normal newborns total CK, CK-MM and CK-MB reached a plateau between 2 and 24 hr after birth whereas the serum CK-BB remained stable after birth. CK-MM, CK-MB and CK-BB respectivily composed 90~94%, 5~7% and 1~5% of total CK during study period.
In asphyxiated newborns total CK, CK-MM and CK-MB reached maximal value at 12hr after birth whereas CK-BB decreased after birth.
There were no significant differences between normal and asphyxiate newborns in total CK, CK-MM and CK-MB during study period (up to 24 hrs after birth). But CK-BB of asphyiated newborn was elevated significantly(p<0.05)within 6 hrs after birth compared to normal newborns.
There were no significant differences of CK and its isoenzymes between patients evaluated by 5min Apgar scores(0~3, 4~6 and 7~10) or degree of HIE (HIE stage 0~Ⅰ, Ⅱand Ⅲ).
According to these results, the serum CK-BB is elevated in asphyxiated newborns during 1st 6hrs after birth but has no predictive values of the extent of cerebral damage. |
| Key Words:
Asphyxia, Creatine kinase |
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