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The Effect of Milk on the Bioavailability of 6-mercaptopurine
Sun Kyu Park, Ran Ju Kim, Pyoung Ha Hwang, Soo Chul Cho, Jung Soo Kim
Clin Exp Pediatr. 1994;37(12):1732-1737.   Published online December 15, 1994
The purine antimetabolite 6-Mercaptopurine (6-MP) has been in clinical use for over 30 years and is still a widely used agent in the treatment of childhood acute lymphoglastic leukemia. The bioavailibility, clinical effecacy and toxicity of 6-MP administered orally for maintenance therapy of children with acute lymphoblastic leukemia are highly variable in many studies, as well as at different times...
Causes of Anemia Less Than 7 Days of Age
Man Seong Ko, Jina Sohn, Jae Wook Ko, Soon Wha Kim, Don Hee Ahn
Clin Exp Pediatr. 1994;37(12):1725-1731.   Published online December 15, 1994
Purpose : Within a few days from birth, newborn infants are under conitions of normal physiologic changes. During this period, the certain newborn infants are confronted with a severe life-threatenling hematologic problems such as anemia. Therefore, prompt diagnosis of anemia and accurate identification of underlying causes would rather be essential to provide appropriate menagement. Methods : Eighty three newborn infants who...
Comparison of Therapeutic Result of Oral Corticosteroid Versus Intravenous Gammaglobulin in Childhood Acute ITP
Jong-Hwan Kim, Hae-Won Kim, Hong-Ja Kang, Woo-Sik Chung, Kil Seo Kim
Clin Exp Pediatr. 1994;37(12):1717-1724.   Published online December 15, 1994
A clinical study was conducted to compare effectiveness of IV Globulin with that of steriod in childhood acute ITP. We carried out an experiment to 36 patients of acute ITP who recovered over 50,000/mm3 of platelet count and not to recur in 6 months. Study group consist of 10 children who were treated with steriod only (Group A), 13 children who were...
Body Composition of Children and Adolescents with Insulin-dependetn Diabetes Mellitus
Hye Young Kang, Mi Jung Park, Duk Hi Kim, You Kyung Park, Jong Ho Lee, Ho Seong Kim
Clin Exp Pediatr. 1994;37(12):1709-1716.   Published online December 15, 1994
Bodycomposition measurement is useful in the diagnosis of pathoogy, assessment of disease process and response to treatment in many endoclonologic and metabolic diseases. The Techniques used currently are mostly indirect, often expensive, difficult and time-consuming. A new method for estimation of body composition, infrared interactance, is rapid, safe, noninvasive, and may be useful in research ad clinical studies. Body composition was...
House Dust Mites Sensitivity in Korean Atopic children; Correlation between Skin Reaction and Relative Concentration of Specific IgE by ELISA
Ji Hong Kim, Soo Young Lee, Byeung Ju Jeung, Kye Earn Kim, Dong Soo Kim, Ki Young Lee
Clin Exp Pediatr. 1994;37(12):1701-1708.   Published online December 15, 1994
House dust mites, Dermatophagoides farinae and Dermatophagoides pteronyssius, have been identified as the main sources of house dust allergen and are considersed the most important causative allergen in the etiology of allergic respiaratory disease and allergic rhinitis. To evaluate the incidence of positive skin reactivity to house dust mites and relationship between total serum IgE levels and specific IgE antibody to...
Comparative Study on the Allergy Skin Test and RAST in Allergic Patients
Il Tae Whang, Young Mi Hong, Gyoung Hee Kim
Clin Exp Pediatr. 1994;37(12):1693-1700.   Published online December 15, 1994
The allegic skin test and RAST are used commonly to demonstrate the presence of skin sensitizing IgE antibody in the diagnosis of allergic disease. To evaluate the agreement rate and correlation between results of skin test and RAST (radioallergosorbent test) in allergic subject, 83 allergic childgood with positive skin test (bronchial asthma: 26, allergic rhinitis: 27, atopic dermatitis and urticaria: 6...
The Variations of CSF Glucose-To-Blood Glucose Ratio according to the Time of Blood Sampling in Asepetic Meningitis
Dong Gui Jang, Yong Seok Choi, Mee Kyoung Lee, Chang Hee Kim, Dong Jin Lee
Clin Exp Pediatr. 1994;37(12):1687-1692.   Published online December 15, 1994
The Measurement of CSF glucose and CSF glucose-to-blood glucose ratio is a very useful laboratory test for the differential diagnosis of meningitis. We have observed the change of blood glucose & CSF glucose-to-blood glucose ratio according to the time of blood sampling in 84 patients with aseptic meningitis who had been admitted to the department of peditrics, Dong Kang hospital...
Clinical Observation of Neonatal Sepsis according to Onset of Disease
Young Chul Han, Soon Kyung Baik, Chang Sung Lim, Dong Jin Lee
Clin Exp Pediatr. 1994;37(12):1676-1686.   Published online December 15, 1994
Acinetobacter Infection in Neonatal Intensive Care Units(NICU)
Won-Gyu Bum, In-Suk Kim, Young-Hee Kim, Young-Youn Choi, Jae-Sook Ma, Tai-Ju Hwang
Clin Exp Pediatr. 1994;37(12):1669-1675.   Published online December 15, 1994
Purpose : Acinetobacter becomes one of the important organisms in hospital infection especially intensive care units. Recently we experienced four times of outbreaks of Acinetobacter infection in Neonatal Intensive Care Units(NICU), Chonnam University Hospital. Clinical and epidemiologic study was performed to emphasize the importance of hospital infection. Methods : During the period from November 1992 to July 1993, twenty-one patiencts of...
A Survey on the Present Status of Infant Feeding
Seung Joo Lee, Jae Ok Park, Chang Sung Sohn, Hae Ran Lee, Jae Hoon Shin, Hae Il Chung, Seung Il Kim
Clin Exp Pediatr. 1994;37(12):1657-1668.   Published online December 15, 1994
A Survey on the Present Status of Weaning
Seung Joo Lee, Jae Ok Park, Chang Sung Sohn, Hae Ran Lee, Jae Hoon Shin, Hae Il Chung, Seung Il Kim
Clin Exp Pediatr. 1994;37(12):1643-1656.   Published online December 15, 1994
Purpose : To add proper solid food during the ideal weaning period is very important to supply adequate nutrition for the rapid growt and to achieve proper feeding habits in later infancy. We tried to survey the problems in weaning in Korea. Methods : The Present status of infant weaning was sutneyed 6 university hospital in Seoul and 4 rural goverment...
EEG Abnormalities in Henoch-Schölein Purpura
Hae Wom Cheon, Dong Gun Park, Kee Hwan Yoo, Joo Won Lee, Soon Kyum Kim
Clin Exp Pediatr. 1994;37(11):1600-1606.   Published online November 15, 1994
Schölein-Henoch purpura is a generalized small vessel vasculitis characterized by non-thrombocytopenic purpura, arthritis, abdominal pain and nephritis. In 1913 Osler described an allergic purpura associated with hemiplegia. After then Lewis et al. Reported the cases of Schölein-Henoch purpura associated with convulsion, coma, confusion, intracranial hemorrhage, and chorea, CNS complication has been reported in 1-8% of children and subsided spontaneously in...
Ultrasonographic Diagnosis by Pyloric Volume Measurement in Congenital Hypertrophic Pyloric Stenosis
Soon Kil Lee, Jae Wha Oh, Yeon Kyun Oh, Chang Guhn Kim
Clin Exp Pediatr. 1994;37(11):1595-1599.   Published online November 15, 1994
Real-time ultrasonogram was performed in 31 Pt. With CHPS, who was admitted at the pediatric department of Wonkwang University hospital from January 1991 to June 1993. Those who had positive results of pyloric volume for diagnosis of CHPS and were confirmed by surgery. The results were at follows, 1) The average ultrasonographic measurements of pyloric muscle thickness, pyloric diameter, pyloric length were...
A Study for Menstruation of School Girl in Ansan
Ae Yeon Lim, Dae Hun Pee, Baik Lin Eun, Sang Hee Park, Soon Kyum Kim
Clin Exp Pediatr. 1994;37(11):1586-1595.   Published online November 15, 1994
Purpose : Menstruation is a great part as the procedure for physiological, psychological development and physical growth, and menstrual disorders are very common problems in adolescence period. These problems can be resolved by interview or appropriate education of normal pubertal development. However unlike other developed countries, systematic report or appropriate education for menstruation may not be performed in our country....
Serum Total Cholesterol and HDL Levels in Healthy Korean School Children: Do They Correlate with Obesity?
Jae Geon Sim, Mi Za Chun, Moses Whang
Clin Exp Pediatr. 1994;37(11):1579-1585.   Published online November 15, 1994
Purpose : The cut-off value for hypercholesterolemia and normal HDL levels for Korean children are still not established despite increasing hypercholesterolemia with recent socioeconomic change. One of the aims of this study its to screen the serum total cholesterol and HDL levels in normal Korean school children, and another is to evaluate the relationships between serum lipid levels and obesity. Methods...
Clinical Significance of Septal Malalignment in Ventricular Septal Defect
Dae-Keun Moon, Jae-Sook Ma
Clin Exp Pediatr. 1994;37(11):1565-1572.   Published online November 15, 1994
Purpose : Depending on the direction and degree of the septal deviation, the patient with malalignment-type VSD present with a variety of clinical syndrome. It is the purpose of this study to examine clinical characteristics of malalignment-type VSD, and to emphasize the clinical significance of septal malalignment in VSD and thus to increase the awareness for it. Methods : We analyzed...
Clinical Significance of Septal Malalignment in Ventricular Septal Defect
Wan-Yong Shin, Sa-Jun Chung, Chang-Il Ahn
Clin Exp Pediatr. 1994;37(11):1565-1573.   Published online November 15, 1994
Purpose : Depending on the direction and degree of the septal deviation, the patient with malalignment-type VSD present with a variety of clinical syndrome. It is the purpose of this study to examine clinical characteristics of malalignment-type VSD, and to emphasize the clinical significance of septal malalignment in VSD and thus to increase the awareness for it. Methods : We analyzed...
Diagnosis of Thoracic Lesions in Children by Fine Needle Aspiration Biopsy
Dong Nam Kim, Nam Su Kim, Hahng Lee, Jong Sung Kim, Suk Chul Jeon
Clin Exp Pediatr. 1994;37(11):1559-1564.   Published online November 15, 1994
To elucidate the clinical availability of FNAB, we reviewed retrospectively medical records of 30 patients who had infiltrative pulmonary lesion or pulmonary nodule of mediastinal mass, and got percutaneous fine needle aspiration biopsy using Wescott needle, 20~22 gauge, at the department of Pediatrics, Hanyang university hospital from July, 1986 to June, 1993. The obtained results were as follow: 1) There were 30...
Characteristics of Insulin-Like Growth Factor I in Serum; Pattern of Insulin-Like Growth Factor Binding Protein (Large Complex) in Short Stature Patients with Complete Growth Hormone Deficiency
Jin Nyoung Park, Byung Deok Seo, Jeh Hoon Shin, Soo Ji Moon, Sung Yeoul Chang
Clin Exp Pediatr. 1994;37(11):1548-1559.   Published online November 15, 1994
To elucidate the complex of insulin-like growth factor binding proteins (IGF-BPs) in short stature patients, we carried out a prospective study on three patients who were diagnosed as complete GH deficiency at the department of pediatrics form July 1992 to June 1993. The results were summarized as follows: 1) Two circulating IGFs complexed to specific binding protein existed in normal serum. Binding...
Analysis of Platelet Membrane Glycoprotein Ⅱb-Ⅲa complex in Whole Blood of Glanzmann's Thrombasthenia by Flow Cytometry
Byoung Geun Lee, Man Choon Kang, Jong Man Park, Pyung Han Hwang, Jung Soo Kim
Clin Exp Pediatr. 1994;37(11):1540-1547.   Published online November 15, 1994
Glanzmann's thrompasthenia is a rare autosomal recessive hemorrhagic disorder characterized by prolonged bleeding time, and deficient or absent clot retraction in the presence of normal platelet count. The major underlying abnormality in this disease is grossly defective first-phase aggregation of platelet, which are unresponsive to ADP or other platelet agonists such as epinephrine, collagen, thrombin in any concentration. This disability...
Antilymphocyte Globulin Therapy for Aplastic Anemia in Children
Soo Jong Hong, Hee Young Shin, Hyo Seop Ahn
Clin Exp Pediatr. 1994;37(11):1526-1539.   Published online November 15, 1994
Immunosuppressive therapy based on the use of antilymphocyte globulin (ALG) has become standard therapy for patients with aplastic anemia who are not eligible for bone marrow transplantation. In this study, T cell subsets before and after ALG therapy, hematologic responses, complications and prognostic factors were analysed. Eleven (42%) out of twenty-six patients treated with ALG showed response, but...
A Study on the Serum Triglyceride Values in Children
Sang Won Cha, Young Hun Chung
Clin Exp Pediatr. 1994;37(11):1519-1525.   Published online November 15, 1994
The concentration of serum triglyceride values were studied at department of pediatrics, Chungnam National University Hospital. With the total 742 cases, among them 462 boys and 280 girls who were at the age of 2 months through 15 years old. Serum triglyceride values were measured to determine the distribution of values and evaluated on the basis of sex, age, height...
Evaluation of Development of Normal Infants Using Bayley Developmental Test
Young Mi Chung, Chul Lee, Kook In Park, Ran Namgung, Dong Gwan Han
Clin Exp Pediatr. 1994;37(11):1508-1518.   Published online November 15, 1994
From April to September 1992, 40 infants with age 6 months to 8 months who had been born in Yongdong Severanve Hospital were studied for evaluation of their development using Bayley developmental test. The result obtained were as follow: 1) Mean mental developmental index(MDI) is higher than mean psychomotor developmental index (PDI) and the values are 101.9¡¾8.2 and 105.5¡¾9.8 respectively. 2) As...
Diagnostic Value of Stable Microbubble Rating Test and Shake Test for the Early Detection of Respiratory Distress Syndrome in Prematurity
Sung Eun Lee, Sang Lak Lee, Chin Moo Kang
Clin Exp Pediatr. 1994;37(11):1500-1507.   Published online November 15, 1994
Respiratory distress syndrome (RDS) of newborn is a disease revealed high morbidity and mortality rate, especially in premature infant. To evaluate the predictive value of Stable Microbubble Rating (SMR) and Shake test on RDS in premature infant, the anthors carried out the gastric aspirates Shake test and SMR test at birth, 3 and 6 hours after birth respectively on 124 premature...
A Clinical Study on Urinary Tract Infection in Infants and Children
Yoon Hwa Cha, Hee Ran Choi, Seong Hee Jang, Young Min Ahn
Clin Exp Pediatr. 1994;37(11):1488-1499.   Published online November 15, 1994
This is a report of clinical study on the 63 patients of symptomatic urinary tract infection who were hospitalized at the Department of Pediatrics in Kangnam General Hospital during the period between the May of 1989 and the September of 1992. The observation results were as follows: 1) The frequency of urinary tract infection (UTI) was the highest in children...
Etiological Classification of Mentally Retarded Children Enrolled in a Special Educational Institution
Seon-Kyeong Yoo, Han-Wook Yoo
Clin Exp Pediatr. 1994;37(10):1437-1448.   Published online October 15, 1994
Mental retardation(MR) is classically deficits in adaptive behavior and manifest during the developmental period. The causes of mental retardation were not understood in many cases. This study was undertaken to identify the etiologies of mentally retarded children enrolled in a special educational institution under the hypothesis that clarifying causes of MR can not only provide basic epidemiological data on MR in...
The Growth Hormone-Binding Proteins in Human Serum: Partial characterization and Regulation
Ji Young Suh, Bu Hun Lee, Jeh Hoon Shin, Hang Lee, Seong Ryul Jang
Clin Exp Pediatr. 1994;37(10):1427-1436.   Published online October 15, 1994
We assessed abotu growth homone binding proteins(GHP|BP) activity which was measured eluted biotin GH fraction with alkaline phosphatase-streptavidine in children with insulin dependent diabetes mellitus(IDDM), short stature due to growth hormone deficiency(GHD), chronic renal failure, short stature due to nutritional deficiency. Hypothyroidism, and noraml control groups using high pressure liquid chromatography protein pak 300 sw column. The following results are observed: 1)...
Clinical and Epidemic Studies of Aseptic Meningitis
Dong Yoon Kim, Koo Pong Jung, Heung Keun Oh, Chang Ok Soh, Jin Young Jung
Clin Exp Pediatr. 1994;37(10):1420-1426.   Published online October 15, 1994
Effect of IVIG Treatment on Renal Function in Neonates
So Yeon Kim, Haeng Mi Kim
Clin Exp Pediatr. 1994;37(10):1414-1419.   Published online October 15, 1994
This study was conducted to evaluate the effect of intraveneous immunoglobulin(IVIG) infusion on renal function in neonates. IVIG has provided quite safe in neonates given therapeutic doses. But nephrotoxicity is not a recognized adverse events of IVIG therapy, only several previous adult cases having been described. A total twenty five neonates suspected sepsis was randomely assigned to IVIG(n=12) or control(n=13) group. Neonates...
Safety and Immunogenicity of Live Attenuated Varicella Virus Vaccine(MAV/06 strain)
Young Mo Sohn, Chong Young Park, Kyu Kye Hwang, Gyu Jin Woo, Song Yong Park
Clin Exp Pediatr. 1994;37(10):1405-1413.   Published online October 15, 1994
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