Clinical and Experimental Pediatrics

Original Article

Measurement of Malonate Concentration using Malonyl-CoA Synthetase and its Relationship with Disease

Seung-Kyoo Han, Jeung-Kyu Kim, Seung-Ryeoul Paik, Chung-Soon Chang, Yu-San Kim

Clin Exp Pediatr. 1995;38(9):1167-1175. Published online September 15, 1995

Purpose : Malonate is an effective competitive inhibitor of succinate dehydrogenase isolated from brain and other organs. It has been shown that malonate level is proportional to the growth of fetal rat brain. However, little is known about its biological effects on central nervous system and other organs. In this communication. we have measured malonate levels in neonates and patients...

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Brain Magnetic Resonance Imaging(MRI) in Neurologic Disorders of Children

Jin Hee Yun, Jae Guk Cha, Ki Sic Min, Jong Wan Kim, Kwang Nam Kim, Ki Yang Ryoo, Ho Chul Kim

Clin Exp Pediatr. 1995;38(8):1132-1140. Published online August 15, 1995

Purpose : This study was performed to be helpful in early diagnosis and treatment of the children with neurologic disorders. Methods : One hundred and eighty-five pediatric patients with neurologic disorder were studied from May 1991 to March 1994, ranging in age from neonate to 15 years old. All patients were imaged with MRI. We observed age and sex distribution, frequency...

Diagnostic Significance of Urinary Growth Hormone Measurement in Patients with Growth Hormone Deficiency

No Hyun Kim, Woo Yeong Chung, Soon Yong Lee

Clin Exp Pediatr. 1995;38(8):1124-1131. Published online August 15, 1995

Purpose : To investigate the diagnostic significance of urinary growth hormone measurement and compare with the urinary GH values in different methods of urine collection, this study was performed in patients with short stature. Methods : Measurement of urinary GH excretion was performed in 9 children with complete growth hormone deficiency (GCD), in 19 children with partial growth hormone deficiency (GPD)...

Characteristics of Childhood Diabetes

Mi Jung Park, Wook Chang, Hyun Chul Lee, Duk Hi Kim, Ho Seoung Kim

Clin Exp Pediatr. 1995;38(8):1116-1123. Published online August 15, 1995

Purpose : Because of weternized life style, environmental air pollution and infection, the incidence of childhood diabetes is increasing daily. This study was attempted to evaluate charateristics of childhood diabetes. Methods : We evaluated 117 patients diagnosed with Diabetes at Yonsei and Ewha University College of medicine from 1985 to 1994. Results : 1) The majority of patients were diagnosed as IDDM(86%)....

Antibody Response to Capsular Polysaccharide Vaccine of Streptococcal Pneumonia in Patients with Nephrotic Syndrom

Ji Young Choi, Jae Ho Lee

Clin Exp Pediatr. 1995;38(8):1107-1115. Published online August 15, 1995

Purpose : Although the etiology and pathogenesis of child with nephrotic syndrome remains uncertain, it has been suggested from indirect evidence that this syndrome may represent deficiency in T-cell function and abnormal humoral immune response to antigens or immynoglobulin. Children with nephrotic syndrome are susceptible to pneumococcal infection. Now, we performed this study to evaluate pneumococcal anticapsular antibody concentration and...

The Effects of Adriamycin on Ionic Currents in Single Cardiac Myocytes of the Rabbit

Sejung Sohn

Clin Exp Pediatr. 1995;38(8):1093-1106. Published online August 15, 1995

Purpose : The study objective was to elucidate the possible pathophysiologic mechanism of Ca overload by adriamycin (ADR) which is associated with ADR- induced cardiotoxicity. Methods : The effects of ADR on ionic currents were studied using the whole cell voltage clamp technique in single cardiac myocytes of the rabbit. Results : The magnitude of the inward tail current, recorded at -70mV...

Effects of Main Pulmonary Artery Constriction on the Right Ventricle in Rabbits

Chan Uhno Joo, Dong Geun Lee

Clin Exp Pediatr. 1995;38(8):1087-1092. Published online August 15, 1995

Purpose : constriction or banding of the pulmonary artery tocreate pulmonalry artery stenosis is a palliative procedure designed to limit pulmonary blood flow in congenital cardiac malformation with unrestricted shunt flow from the systemic to pulmonary circuit. Increased pressure-load with the procedure results in ventricular hypertrophy in right ventricle. We studied effects of the pulmonary artery constriction on the right ventricle...

Detection of Mycoplasma pneumoniae in clinical Samples from Pediatric Patients by Polymerase Chain Reaction

Baik-Lin Eun, Sang Hee Park, Young Chang Dockgo, Sang Chul Seong

Clin Exp Pediatr. 1995;38(8):1077-1086. Published online August 15, 1995

Purpose : Mycoplasma pneumoniae is a common cause of a wide rage of upper and lower respiratory tract infections, especially in children and young adults. Routine laboratory diagnosis of M.pneumoniae infection is based mainly on serology and, to lesser extent, on cultivation. The cultivation of M.pneumoniae, a fastidious microorganism, is time-consuming and may require 1-3 weeks for results. Serological procedures...

Clinical and Histologic Findings and their Correlations in Children with Nodular Gastritis

Ki Moon Cha, Gi Euin Won, Hann Tchah, Ho Jin Park, Mi Kyoung Shin

Clin Exp Pediatr. 1995;38(8):1069-1076. Published online August 15, 1995

Purpose : Recently, a wide application of gastrofiberscopy in the pediatric group have revealed that nodular gastritis is an unique disease in children and associated with Helicobacter pylori. The aim of this prospective study was to investigate the clinical and histologic features in children with nodular gastritis, and to assess corelation between both. Methods : During a period of 44 months(May 1991-December...

Upper Limit of Normal Value for Antistreptolysin O Titer of Healthy Children in Seoul

Sung Ho Cha, Yong Mook Choi, Sei Won Yang, Dong Hwan Lee, Chong Guk Lee, Chang Ho Hong

Clin Exp Pediatr. 1995;38(8):1061-1068. Published online August 15, 1995

Purpose : We have found somewhat high titer of antistreptolysin O (ASO) accidentally when we had delineated normal carrier rate of beta hemolytic streptococci in rural area of Kangwon Province in 1991(1). We would like to know upper limit of normal value of ASO and re-valuated results which might be changed with different geographic areas, age, and prevalent rate...

Auditory Evoked Potentials in Fullterm Infants with Birth Asphyxia and Premature Infants

Ha Shin Park, Myung Suk Song, Sun Jun Kim, Hea Jin Choeh, Kyu Chul Choeh

Clin Exp Pediatr. 1995;38(8):1054-1060. Published online August 15, 1995

Purpose : Auditory evoked potentials(AEP) are sensitive electrophysiological technique which accurately assesses the functional integrity of the auditory pathway in the brainstem. As a test of brainstem function, AEP have the advantages that the procedure is standardized, the results are reproducible, the norms for neonated have been estsblished, and the equipment to perform the test is widely available. Our study...

Doxapram in the Treatment of Idiopathic Apnea of Prematurity Unresponsive to Aminophylline

Jung Hoon Park, Hee Sup Kim, Sang Hee Kim, Gil Hyun Kim, Hak Soo Lee

Clin Exp Pediatr. 1995;38(8):1046-1053. Published online August 15, 1995

Purpose : Recurrent apnea of prematurity is a very common and troublesome problem despite treatment with aminophylline, and is often associated with a poor developmental outcome. Recently doxapram, a potent respiratory stimulant in adults, has been used to overcome idiopathic apnea of prematurity. This study was to evaluate the efficacy, safety and optimal dosage of doxapram in idiopathic apnea refractory to aminophylline. Methods...

Auditory Brainstem Responses in Premature and Fullterm Infants

Hyun Mi Kim, Tae Sung Ko, Ki Soo Kim, Moo Song Lee, Kyung Hee Kim

Clin Exp Pediatr. 1995;38(8):1036-1045. Published online August 15, 1995

Purpose : We tried to know normal range of auditory brainstem responses in premature and fullterm infants who have no rksk factor during perinatal period and to determine that the abnormal ABR in premature and fullterm infants may predict developmental delay. Methods : ABR evaluations were performed on 283 premature and fullterm infants from NICU of the Asan Medical Center during...

Study on Anti-neutrophil Cytoplasmic Antibodies in Children with Henoch-Schölein Purpura

Shin Jong Lee, Woo Yeong Chung, Chul Ho Kim, Jeong Nyeo Lee

Clin Exp Pediatr. 1995;38(7):970-975. Published online July 15, 1995

The presence of IgG, IgA and IgM antineutrophil cytoplasmic antibodies(ANCA) were inves-tigated in 32 children with Henoch-Schölein Purpura(HS purpura), in 14 children with HS pur-pura nephritis who were confirrned by renal biopsy and in 12 control children using flow cytom-etry(FASCan, Beckton-Dickinson, Co, USA) and indirect immunofluorescence technique(Sigma Diagnostics, USA). There were no evidence of IgG, IgA or IgM cytoplasmic ANCA(p-ANCA),...

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Sex Hormone Binding Globulin Levels in Children with Insulin Dependent Diabetes Mellitus

Duk Hi Kim, Mi Jung Park, Ho Sung Kim

Clin Exp Pediatr. 1995;38(7):963-969. Published online July 15, 1995

Purpose : Sex hormone binding globulin(SHBG) is produced in liver and binds to testostero-ne and estradiol. Plasma SHBG levels are increased by estrogen and thyrotoxicosis and decreased by testostrone, insulin, growth hormone, prolactin, obesity and noninsulin dependent diabetes mellitus. SHBG levels in patients with NIDDM is known to be higher than normal, but SHBG levels in children with IDDM is controversial....

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Effects of Cyclosporine on the Renal Sympathetic Nerve Activity and Baroreflex Function in Rabbits

Chan Uhng Joo, Tae Hee Park, Moon Hwan Lee, Jung Soo Kim

Clin Exp Pediatr. 1995;38(7):955-962. Published online July 15, 1995

Purpose : The immunosuppresive drug cyclosporine(CS) is a novel agent that has greatly enhanced long-term survival after organ transplantation and has proved beneficial in the treat-ment of many autoimmune diseases. However, CS has emerged as a new cause of hypertens-ion. Although the causes of the hypertension are undoubtedly multifactorial, there are evidenc-es to suggest that sympathetic overactivity is involved. We...

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Intractable Diarrhea in Early Infancy : Clinical Features on Admission and A Nutritional Management

Jong Won Shin, Kyung Won Hwang, Young Ho Ahn, Jin Bok Hwang, Chang Ho Han, Hai Lee Chung, Young Dae Kwon

Clin Exp Pediatr. 1995;38(7):936-945. Published online July 15, 1995

Purpose : We studied to assess the value of clinical findings on admission in screening of intractable diarrhea in early infancy(IDI) and the efficiency of early trial of semi-elemental form-ula (protein hydrolysate) as a nutritional management in IDI. Methods : We carried out a retrospective review of medical records of twenty-eight early infants with diarrhea and malnutrition who were diagnosed as...

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Studies on Mechanism of Vascular Hyporeactivity of Mesenteric Artery from Septic Rats

Man Chul Ha, Hee Ju Park, Ki Whan Hong

Clin Exp Pediatr. 1995;38(7):922-935. Published online July 15, 1995

Purpose : Septic shock due to gram negative bacterial infection is characterized by vasodil-ation, hypotension, and myocardial depression due to the effect of lipopolysaccharide (LPS). In spite of extensive studies, the mechanisms for the vascular effects of endotoxemia are not clear. Recently, it has been proposed that nitric oxide (NO) synthesized from L-arginine by nitric oxide synthase contributes to the...

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Double Chambered Right Ventricle-Review of Clinical Findings

Jin Young Song, Jun Tac Ko, Ho Sung Kim, Jung Il Rho, Jung Yeun Choi, Yong Soo Yun

Clin Exp Pediatr. 1995;38(7):914-921. Published online July 15, 1995

Purpose : The DCRV is a cardiac anomaly in which the right ventricle is divided into two dif-ferent pressure chambers by aberrant hypertrophied muscle bundles arising from the lower infundibular septal region. DCRV may be associated with other congenital cardiac anomalies and surgical treatment is required because we know that this obstruction is progressive. In this report, we reviewed clinically...

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Clinical Studies of Measles in Infancy - Emphasizing on Measles Specific IgG Antibody -

Jae Ho Lee, Shin Hye Moon

Clin Exp Pediatr. 1995;38(7):907-913. Published online July 15, 1995

Purpose : This study was investigated the efficacy of maternal measles specific IgG antibody and the optimal age for measles vaccination in susceptable infant during epidemics Methods : We evaluated the clinical manifestations and complications of 50 measles infants who were clinically and serologically diagnosed as measles and had not been vaccinated acco-rding to the presense of measles specific IgG antibody...

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Epidemic Aseptic Meningitis in 1993 -Focused on Virus Culture-

Ji Yeon Cho, Hyang Ju Kim, Ghee Young Jung, Jin Keun Pang, Du Bong Lee

Clin Exp Pediatr. 1995;38(7):901-906. Published online July 15, 1995

Purpose : Aseptic meningitis is relatively common disease caused by virus, however in most of casesthe main causes are unnoticed since virus culture and isolation is quiet difficult in our country. Authors of this thesis have conducted virus culture and isolation test to figure out cause of aseptic meningitis that was prevalent through out the country from June to July...

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Appraisal of the Results of Throat Swab Culture Obtained from Pediatric Outpatient Clinic

Sung-Ho Cha, Byoung-Soo Cho, Hwan-Jo Suh, Jin-Tae Suh, Seon-Ju Kim

Clin Exp Pediatr. 1995;38(7):895-900. Published online July 15, 1995

Purpose : We can meet a lot of patients with the upper respiratory tract infection in outpatient clinic, most of them are caused by viral in origin, which make us consider prudent prescribing antibiotics. But on the other hand, the accurate diagnosis and proper treatment of group A streptococcal upper respiratory infection should be emphasized concerning about possible development of...

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A Clinical Observation of 23 Cases of Necrotizing Enterocolitis

Ok Young Kim, Eun Ju Jeong, Min Jeong Kim, Mi Yeon Park, Son Sang Seo

Clin Exp Pediatr. 1995;38(7):886-894. Published online July 15, 1995

Purpose : We observed risk factors, clinical findings, diagnosis and treatment of NEC in 23 cases in order to try to prevent developement of, and improve the prognosis of necrotizing enterocolitis(NEC) in the future. Methods : 23 cases of NEC who were admitted to the NICU of Ilsin Christian Hospital between Jan 1992 and June 1994 were studied. Data about birth...

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Comparison Between 24-hour Integrated Growth Hormone Concentrations and Pharmacological Provocation Tests in Children with Short Statue

Mi Jung Park, Duk Hi Kim, Ho Seong Kim

Clin Exp Pediatr. 1995;38(6):835-842. Published online June 15, 1995

Purpose : The ability to respond to pharmacologial provovation tests may not necessary reflect actuaol secretory patterns of growth hormone. Therefore, the aim of this study in to evaluate the 24-h IC-GH and compare this with their resposnses to standard pharmacological provocation tests for growth hormone comcentrations and to evaluate peak frequency and peak amplitude during 24-h IC-GH in children...

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Clinical Study on Insulin Dependent Diabetes mellitus

Seog Beom Cho, Kwang Rae Lee, Chang Beom Shin, Oh Kyung Lee, Chong Duk Kim, Oh Kyung Lee

Clin Exp Pediatr. 1995;38(6):827-834. Published online June 15, 1995

Purpose : Insulin dependet diabetes mellitus(IDDM) is a rare disease in children, but it will progress rapidly and falls into a diabetic ketoacidosis or coma. Unfortunately, the characteristics and prevalence rate of children with IDDM are not well known in Korea. With a view to recognizing its importance, we studied clinical course of IDDM patients in Chonbuk province, Korea. Methods : From...

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Stem Cell Transplantation in Umbilical Cord Blood(II) Characteristics of T-Lymphocyte Subpopulation in Umbilical Cord Blood

Kyung Ha Ryu, So Young Ahn

Clin Exp Pediatr. 1995;38(6):819-826. Published online June 15, 1995

Purpose : Homatopoietic stem cells, which have the ability to undergo self-renewal as well as to develop into multipotential differentiations, have been consistantly demonsteraten in human umbilical cord blood. Recently, there have been a few studies using the umbilical cord blood as a source of stem cell transplantation. However it remains unclear whether umbilical cord blood in safe with regards to...

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Fetal Cardiac Malformation : types and associated anomalies

Ho Sung Kim, Jeong Wook Seo, Chung Il Noh, Jung Yun Choi, Yong Soo Yun

Clin Exp Pediatr. 1995;38(6):811-818. Published online June 15, 1995

Purpose : The relative incidence of fetal cardiac anomalies and associated extracardiac anomalies in Korean fetuses were studied. Methods : Findings in fetal echocardiography and autopsy were reviewed using 129 fetuses with cardiac anomalis detected at a gestational period under 38 weeks from 1991 Jan. to 1994 June. Results : The most common fetal cardiac anomaly was isolated atrial septal defect(28 cases...

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The Effect of ACTH on Mouse Heart

Sang Young Seo, Joo Won Lee, Chang Sung Son, Young Chang Tockgo

Clin Exp Pediatr. 1995;38(6):804-810. Published online June 15, 1995

Purpose : Adrenocorticotropic Hormone(ACTH) therapy is useful in the treatment of patients with infantile spasm. However, serious side effects including Cushing syndrome, infections, hypertension, and electrolyte imbalance must be encountered. Moreover, hypertrophic cardiomyopathy in association with ACTH therapy has recently reported. We performed thiw study to evaluate the effect of ACTH on heart muscle. Methods : We administered ACTH subcutaneously to...

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A Clinical Observation of Kawasaki Meningitis and Viral Meningitis

Jae-Ho Hyun, Young-Hoon Kim, Ji-Whan Han, Jong-Wan Kim, Kyung-Tai Whang

Clin Exp Pediatr. 1995;38(6):794-803. Published online June 15, 1995

Purpose : This study was performed to investigate the clinical characteristics in Kawasaki meningitis and viral meningitis. Methods : A clinical observation and comparison were carried out on 37 patients of Kawasaki disease with meningitis(group A) and 28 patients of Kawasaki disease without meningitis (group B) who were admitted to Catholic Medical Center from July, 1991 to June, 1993 and 100...

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Prevalence of Rubella Antibodies in the Southern Central Korea

Koo Pong Jeong, Mi Ryeung Kim, Hyang Ok Woo, Hee Sang Youn, Kohji Ueda

Clin Exp Pediatr. 1995;38(6):786-793. Published online June 15, 1995

Purpose : In front of the nation wide project of 15-year-old girl rubella immunization plan we performed a seroepidemiologic study to find out the age specific prevalence rate of rubella antibodies in the Southern Central Korea. Methods : Total 600 serum specimens from 20 cord bloods and patients of 400 children and 180 adults were obtained at the Geyongsang National University...

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Original article