| Clinical Studies of Measles in Infancy - Emphasizing on Measles Specific IgG Antibody - |
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Jae Ho Lee, Shin Hye Moon |
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Department of Pediatrics, College of Medicine Chungnam National University, Taejon, Korea |
| 유아기 홍역질환의 임상증상 비교- 홍역 IgG항체유무를 중심으로 - |
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이재호, 문신혜 |
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충남대학교 의과대학 소아과학교실 |
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| Abstract |
Purpose
: This study was investigated the efficacy of maternal measles specific IgG antibody and the optimal age for measles vaccination in susceptable infant during epidemics
Methods
: We evaluated the clinical manifestations and complications of 50 measles infants who were clinically and serologically diagnosed as measles and had not been vaccinated acco-rding to the presense of measles specific IgG antibody from Nov.1993 to Jan.1994 in Taejon.
Results
: 1) Out of 50 patients, 31 patients(62%) were measles specific IgG antibody positive (positi-ve group) and 19 patients(38%) were measles specific IgG negative (negative group). Peak age of measles patients were each 7 - 9 month old in positive group and 5-7 month old in negative group(p>0.05).
2) Fever usually developed 2 days prior to the appearance of rash in both positive and negative group. Duration of fever was less than 3 days in 18 cases(58%) of positive group and 4 - 6 days in 12 cases(63%) of negative group(p>0.05).
3) Duration of cough was more than 10 days in 24 cases(77%) of positive group and 7 cases(37%) of negative group(p<0.05).
4) Complications such as pneumonia, otitis media, gastroenteritis, and hepatitis were noted in 39 cases(78%) of all patients and more common in positive group (p>0.05).
Conclusion
: Clinical manifestations and complications were not significantly differed betw-een measles specific IgG positive group and negative group in this study. Measles specific IgG antibody was not detected from 5 month old infants and measles could be infected from 5 mo-nths of age. Early vaccination should be recommended on this age during measles epidemics and revaccination should also be done at 15 month old age. |
| Key Words:
Measles, Maternal measles specific IgG, Vaccination |
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