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Original Article
Radiologic Findings of Hands in Turner Syndrome
Young Sim Han, Moo Young Oh, Young Joon Lee, Woo Yeong Chung
Clin Exp Pediatr. 2001;44(7):817-822.   Published online July 15, 2001
Purposes : Radiologic findings of hands in Turner syndrome(TS) which have been reported were metacarpal sign(MS), carpal sign(CS), phalangeal sign(PS), osteopenia, and delayed bone maturation. The aim of this study is to evaluate the difference of radiologic findings in TS, idiopathic short stature(ISS), and growth hormone deficiency(GHD). Methods : Sixty girls with short stature were studied for chromosome analysis, and...
The Effect of Imipramine and Desmopressin for the Treatment of Enuresis in Attention Deficit Hyperactivity Disorder Children
Yong Hoon Park, Eun Sil Lee, Han Ku Moon, Hyung Bae Park
Clin Exp Pediatr. 2001;44(7):808-816.   Published online July 15, 2001
Purpose : Attention Deficit Hyperactivity Disorder(ADHD) is one of the most common childhood psychiatric diseases and nocturnal enuresis is also a common involuntary disorder, whose symptoms can appear more than 2-3 times per month even after the age of 5. The incidence of nocturnal enuresis is believed to be increasing in ADHD patients. This study investigates the effectiveness of desmopressin...
IGF-I on the Expression of Gene Associated with Hypoxic Ischemic Brain Injury in the Neonatal Rats
Hyung-Shin Lee, Sang-Hyun Byun, Ren Zhe Ann, Kyu-Sang Song, Young-Ik Lee, Yoo-Jung Hahn, Yong-Hun Chung
Clin Exp Pediatr. 2001;44(7):796-807.   Published online July 15, 2001
Purpose : To investigate the effect of intraperitoneal injection of IGF-I after hypoxic ischemic brain injury on neuronal cell necrosis, apoptosis and expression of proapoptotic and antiapoptotic proteins bax and bcl-2, respectively. Methods : The right carotid artery was cut between the double ligation. Then allowed to recover for 30 minutes followed by exposure to 8% oxygen at 37℃ for...
Childhood Obstructive Sleep Apnea Syndrome : Clinical and Polysomnographic Findings
Yang Jun Park, Dae Kyun Koh, Jin Hee Oh, Soo Jung Lee
Clin Exp Pediatr. 2001;44(7):786-795.   Published online July 15, 2001
Purpose : Although pediatricians may see a lot of patients with clinically suspected obstructive sleep apnea syndrome(OSAS), the actual incidence, clinical and polysomnographic manifestations of OSAS in children have not well been recognized and reported cases are rare. The objective of this study was to evaluate the efficacy of polysomnography in the diagnosis of OSAS in children and to analyze...
The Changes of Biochemical Bone Markers in Pediatric Epileptic Children Who Received Long-term Antiepileptic Drugs and Usefullness Thereof
Eun Kyung Choi, Kyung Hee Kim, Sun Jun Kim
Clin Exp Pediatr. 2001;44(7):778-785.   Published online July 15, 2001
Purpose : Long-term administration of anticonvulsants for pediatric epileptic patients may cause changes of bone metabolism. This study was performed to evaluate the influence of antiepileptics on the bone metabolism and growth in pediatric patients who received antiepileptics. Methods for early detection of adverse bone metabolism were also evaluated. Methods : Forty-eight epileptic patients were enrolled in this study....
The Effectiveness of Propofol on Pediatric Cardiac Catheterization and Electrophysiologic Study
Woo Saeng Park, Myung Chul Hyun
Clin Exp Pediatr. 2001;44(7):773-777.   Published online July 15, 2001
Purpose : Our purpose was to evaluate the effectiveness of propofol on pediatric cardiac catheterization or radiofrequency catheter ablation. Methods : We measured the serial changes of arterial oxygen saturation, heart rate, systolic and diastolic blood pressure at 4 stages, a baseline(during normal sleep), stage 1(just after loading of propofol 2 mg/kg over 10 minutes), stage 2(10-15 minutes after propofol continuous...
Effect of Vitamin E on Cerebral Hypoxia-Ischemia in Neonatal Rats
Jung Eun Seok, Yeon Kyun Oh, Seung Taek Park
Clin Exp Pediatr. 2001;44(7):764-772.   Published online July 15, 2001
Purpose : In order to evaluate the hypoxia-ischemia induced neurotoxic effect and the protective effect of vitamin E as an antioxidant, cell number and cell viability were measured in cerebral neurons and astrocytes derived in neonatal rats. Methods : 7-day old neonatal rats were subjected to unilateral common carotid artery occlusion, and exposed to hypoxic condition for 3 hours. The protective...
Clinical Features of Food Protein-Induced Enterocolitis Syndrome
Jeong Sik Seo, Hai Lee Chung
Clin Exp Pediatr. 2001;44(7):758-763.   Published online July 15, 2001
Purpose : Food protein-induced enterocolitis syndrome(FPIES) is a symptom complex of severe vomiting and diarrhea which is known as a food-related gastrointestinal hypersensitivity disorder without evidence of IgE-mediated sensitivity. We described the clinical characteristics of FPIES in young infants. Methods : Twenty-eight patients, aged 7 to 120 days, were included who were diagnosed as FPIES by clinical criteria and food challenges....
Colonic Transit Time in Chronic Constipated Patients
Je Eun Choi, Im Jeong Choi, Jung A Lee, Sung Mi Kim, Jin Hwa Jeong, Jeong Ho Lee
Clin Exp Pediatr. 2001;44(7):752-757.   Published online July 15, 2001
Purpose : In most instances, constipation is considered as idiopathic or functional. The total colonic transit time, traced by radio-opaque markers, makes possible the identification of the colon segment that has the motility alteration that causes constipation. We measured the total and segmental colonic transit time in children with chronic idiopathic constipation and compared the results with those without constipation...
Study on Hepatitis B Virus Pre-S/S Gene Mutations in Children with Chronic Hepatitis B Infection
Byeong Hee Son, Yeong Hong Park, Woo Yeong Chung
Clin Exp Pediatr. 2001;44(7):741-751.   Published online July 15, 2001
Purpose : Hepatitis B virus(HBV) with various mutations has been reported. The aims of this study were to investigate the frequency and manifestation of HBV pre-S/S mutations in children with chronic hepatitis B infection. Methods : Sera from 17 children with chronic hepatitis B infection were analyzed by direct sequencing of polymerase chain reaction amplification of HBV DNA. Results : Seventeen...
Clinical Manifestations of Group A β-Hemolytic Streptococcal Pharyngits and Usefulness of Rapid Antigen Test
Youn Jeong Shin, Seong Hee Jang, Eun Sil Dong, Young Min Ahn, Myung Suk Ku
Clin Exp Pediatr. 2001;44(7):732-741.   Published online July 15, 2001
Purpose : Accurate diagnosis of group A streptococcal(GAS) pharyngitis and appropriate antimicrobial therapy are important, particularly to prevent nonsuppurative sequelae and to reduce the improper use of antibiotics. Because the clinical presentation of pharyngitis does not reliably predict the etiologic agent, when GAS infection is suspected, diagnosis should be based on the result of a throat swab culture or antigen-detection...
The Optimum Dose of Oral Diazepam to Reduce Seizure Attack in Febrile Seizure Patients During Febrile Illness
Im Jeong Choi, Je Eun Choi, Jung A Lee, Pil Ju Jeong, Sung Mi Kim, Jin Hwa Jeong, Jeong Ho Lee
Clin Exp Pediatr. 2001;44(6):677-682.   Published online June 15, 2001
Purpose : Febrile seizure is the most common type of seizure affecting 3-4% of children. The recurrence rate of febrile seizure is approximately 33%. About 16% of children with a febrile seizure during the febrile illness have a recurrent seizure attack within 24 hours. This study aimed to investigate the optimum dose of diazepam to reduce the recurrence of febrile...
Risk Factors for Fatty Liver in Obese Children
Ki Won Park, Jong Eun Lee, Kyung Ha Ryu, Kyung Hyo Kim, Young Mi Hong, Gyung Hee Kim, Keun Lee, Jeong Hyun Yoo
Clin Exp Pediatr. 2001;44(6):669-676.   Published online June 15, 2001
Purpose : The incidence of obese patients has increased recently in Korea. Obesity is associated with hypertension, hyperlipidemia, insulin resistance, and fatty liver. Since recent investigators have revealed that not only fat accumulation but also fibrosis and nonspecific hepatitis can be found in the livers of obese children, fatty liver is currently considered as an important complication. The purpose of...
Mean Corpuscular Hemoglobin Concentration as a Discriminating Tool between Hereditary Spherocytosis and Intravascular Hemolysis
Hae Young Park, Hwang Min Kim, Kyoung Ah Lee, Dong Il Won, Sei Myeng Park, Seok Won Park, Baek Keun Lim, Kil Young Kim
Clin Exp Pediatr. 2001;44(6):664-668.   Published online June 15, 2001
Purpose : The purposes of this study were to elucidate the diagnostic significance of mean corpuscular hemoglobin concentration(MCHC) for various kinds of hemolytic anemia, the mechanism of elevated MCHC in hereditary spherocytosis(HS). Methods : The subjects consisted of 39 cases of HS(group 1), 31 cases of intravascular hemolysis (IH) such as DIC, snake bite or hemolytic uremic syndrome(group 3), and sex...
Anti-angiogenesis and Anti-metastasis Characteristics of the Novel Tumor Suppressor Gene PTEN
Pyoung Han Hwang, Ho Keun Yi, Myoung Hee Han, Dae Yeol Lee, Dae Yeol Lee, Jung Soo Kim
Clin Exp Pediatr. 2001;44(6):654-663.   Published online June 15, 2001
Purpose : The tumor suppressor gene PTEN/MMAC1 is mutated in a variety of advanced and metastatic cancers, strongly suggesting that PTEN/MMAC1 alterations may be involved in tumor progression and the formation of metastases. However, the roles of PTEN in tumor growth and metastasis and its functional mechanisms are not fully understood. We evaluated the tumor suppressor function of PTEN/MMAC1 gene...
Survey on Upper Respiratory Tract Infections in Children
Seok Won Park, Hwang Min Kim, Jong Soo Kim, Kyu Earn Kim
Clin Exp Pediatr. 2001;44(6):642-653.   Published online June 15, 2001
Purpose : Recently, the numbers of non-pediatric doctors' giving medical treatment to children has shown a tendency to increase, especially in case of upper respiratory infection(URI) and it's complications such as tonsillitis, sinusitis and otitis media. Therefore we surveyed parents on children's URI and complications to find out parents' general understandings on pediatric treatment, what kind of pediatric treatment they...
Evaluation of Health Status and Growth and Developmental Outcome of Intrauterine Growth-Retarded Infants
Il Tae Hwang, Eun Ae Park, Ho Seong Kim, Gyoung Hee Kim
Clin Exp Pediatr. 2001;44(6):635-641.   Published online June 15, 2001
Purpose : Although many children born with intrauterine growth retardation demonstrate significant catch-up growth in early childhood, substantial weight and height deficits remain in others. In addition, children with IUGR may demonstrate developmental deficits. The aims of this study are to evaluate the health status, growth and deveolpmental outcome of intrauterine growth retarded infants. Methods : Sixty five intrauterine growth retarded...
A Clinical Study for Risk Factors of Cystic Periventricular Leukomalacia
Ji Eun Kim, Su Jin Kim, Woo Taek Kim
Clin Exp Pediatr. 2001;44(6):627-634.   Published online June 15, 2001
Purpose : It is very important to study the individual risk factors which cause periventricular leukomalacia(PVL) and those which affect the process of cystic formation from liquefied periventricular white matter, in order to prevent and permit early diagnosis of cystic PVL that contributes to mortality and neurologic sequelaes in preterm infants. Therefore, the present study was designed to assess the...
Effect of Parenteral Nutrition Guideline Changes on Neonatal Sepsis in Premature Infants
Chang-Ryul Kim, Jae-Won Oh, Myung-Kul Yum, Soo-Jee Moon
Clin Exp Pediatr. 2001;44(6):620-626.   Published online June 15, 2001
Purpose : We hypothesized that decreased parenteral nutrition would lower the incidence of neonatal sepsis in premature infants. Methods : The study involves 223 premature infants who were admitted to the neonatal intensive care unit of Hanyang University Kuri Hospital from July 1995 to January 1999. Infants were divided into two groups based on different parenteral nutrition guidelines : Old...
A Study of Acute Poisoning in Korean Children
Chan Sook Park, Song Hyeun Eun, Mi Hwa Yang, Jin A Son, Jung Yun Hwang, Jae Wook Ko, Don Hee Ahn
Clin Exp Pediatr. 2001;44(6):614-619.   Published online June 15, 2001
Purpose : The National Medical Center has been conducting a study as a Poison Control Center since 1998. The data was analyzed to illustrate the general aspects of acute poisoning in Korean children. Methods : The primary sources of data were collected from the Medical Insurance Records of 1997 and death records of the same period obtained from the Korea National Statistical Office. A total...
Factors Related to the Development of Microalbuminuria in Children and Adolescents with Type 1 Diabetes Mellitus
Min Ho Jung, Pei Tai Wan, Choong Ho Shin, Sei Won Yang
Clin Exp Pediatr. 2001;44(5):577-586.   Published online May 15, 2001
Purpose : We observed the prevalence rate of microalbuminuria(MA) and its relationship with the various clinical factors in children and adolescents with type 1 diabetes mellitus(DM). Methods : Seventy two children and adolescents(26 males and 46 females, 17.1±3.0 years) were included. MA was defined as 24 hour urine microalbumin >30mg/day(20μg/min). Subjects were classified into three groups(normoalbuminuria, transient MA, or persistent MA)....
Identification of Novel Mutations and Three Most Common Mutations in the Human ATP7B Gene of Korean Patients with Wilson Disease
Han-Wook Yoo, Gu-Hwan Kim, Ji-Won Chung, Chang-Yeon Lee, Kyung-Mo Kim
Clin Exp Pediatr. 2001;44(5):569-576.   Published online May 15, 2001
Purpose : Wilson disease is an autosomal recessive disorder of copper transport, which is probably the most common inherited metabolic disorder in Korea. It is characterized by defective biliary excretion of copper and impairment in the corporation of copper into ceruloplasmin. In Wilson disease, synthesis of a defective copper transporting enzyme leads to the accumulation of copper in the liver, brain and kidney. The...
The Usefulness of Emergency Brain Computerized Tomography in Children with First Seizures
Hyun Kyung Park, In Joon Seol
Clin Exp Pediatr. 2001;44(5):562-568.   Published online May 15, 2001
Purpose : This study was performed to discover whether emergency brain computerized tomography(CT) is useful for the diagnosis and management of patients with first seizure. Methods : We studied retrostpectively all children(under 15-year-old) without a history of neurologic illness who visited Hanyang University Hospital and took a brain CT because of a first seizure attack between January 1996 and June 1999....
Surgically Treated Intractable Child Epilepsy with Focal Cortical Dysplasia : Clinical and Electroencephalographic Findings
So Hee Chung, Ho Young Lee, Mun Hyang Lee, Hye Kyung Yoon, Bo Kyung Kim, Seung Chyul Hong
Clin Exp Pediatr. 2001;44(5):552-561.   Published online May 15, 2001
Purpose : Widespread use of MRI now gives us increased insights into the different expressions of cortical malformations. We carried out this study to characterize the clinical and EEG features of focal cortical dysplasia(FCD) which also caused intractable epilepsy requiring surgical treatment. Methods : A retrospective analysis was conducted in 8 children. The history of seizures, imaging studies, electroencephalographic findings,...
The Effect of the Maternal Hypertension on the Lipid Peroxidation and Antioxidant Status in the Newborn Rat Lung
You Jin Jung, So-Young Kim, In Kyung Sung, Chung Sik Chun
Clin Exp Pediatr. 2001;44(5):545-551.   Published online May 15, 2001
Purpose : The aim of this study was to investigate the effect of the maternal hypertension on the lipid peroxidation and antioxidant status of the newborn rat lung. Methods : We used adult female SHR(essential hypertension, 1b, A, 6-8 weeks), Sprague-Dawley white rats as a model of hypertensive dams. Breeding was accomplished by allowing female and male rats to cohabit overnight....
Neuro-developmental Assessment of Patients with Transposition of the Great Arteries by Localized 1H-Magnetic Resonance Spectroscopy
Ki-Soo Kim, Jee-Yeon Min, So Young Yoon, Young Hwue Kim, Jae Kon Ko, In Sook Park, Ki-Soo Kim, Dong Man Seo, Sang-Tae Kim, Jung Hee Lee, In Kyung Sung
Clin Exp Pediatr. 2001;44(5):533-544.   Published online May 15, 2001
Purpose : The purpose of this study was to evaluate the hemodynamic effect of transposition of the great arteries(TGA) on neuro-development by measuring the cerebral metabolites before and 1 year after open heart surgery(OHS) by localized in vivo 1H-magnetic resonance spectroscopy(1H- MRS) along with Bayley scales of infants development II(BSID II). Methods : Full-term newborns(N=13) with TGA and intact ventricular septum...
Studies on Functional Differentiation of Small Intestinal Epithelial Cells
Ho Keun Yi, Su Mi Oh, Dae Yeol Lee, Jung Soo Kim, Pyoung Han Hwang
Clin Exp Pediatr. 2001;44(5):523-532.   Published online May 15, 2001
Purpose : We investigated compounds from food sources given to children that may induce the differentiation of small intestinal epithelial cells in order to signal pathways that induce the proliferation and differentiation of small intestinal epithelial cells. Methods : We analyzed small intestinal epithelial cell differentiation using in vitro IEC-6 cells model. The growth curve of IEC-6 cells was obtained...
A Clinical Study of Shigellosis Epidemics over 10 Years in the Kyung Nam Area
Ji-Young Hwang, Ji-Hyoun Seo, Su-Jin Lee, Myoung-Bum Choi, Chan-Hoo Park, Hyang-Ok Woo, Hee-Shang Youn, Jung-Hee Kim, Eun-Jung Kim, Chul Kyu Kim, Yang-Suk Jung, Dong-Jin Lee
Clin Exp Pediatr. 2001;44(5):517-522.   Published online May 15, 2001
Purpose : The occurrence of shigellosis patients has increased radically in 2 recent years. For this, the authors investigated the epidemic aspect of shigellosis by regional groups to know whether the epidemic aspect of shigellosis is a general situation which occurs identically in various areas of Kyung Nam. Methods : We reviewed pediatric patients who were hospitalized in Ulsan(eastern), in Masan(central),...
Carriage and Antimicrobial Susceptibility of Haemophilus influenzae Isolated from Oropharynges of Children
Kyung Hyo Kim, Kyoung Ah Lim, Il Tae Whang, Young Mi Hong, Eun Sook Kang, Ki Sook Hong
Clin Exp Pediatr. 2001;44(5):509-516.   Published online May 15, 2001
Purpose : Haemophilus influenzae, one of the normal flora of the upper respiratory tract, can cause such infections as otitis, sinusitis, pneumonia, and meningitis in children. The oropharyngeal flora has therefore mainly been analyzed as a reservoir for pathogens. This study was performed to reveal the colonization rate of H. influenzae in the upper respiratory tract, their biotypes, their antimicrobial...
Whole Blood and Plasma Vitamin C Concentrations in Children of 1-6 Years of Age in the Chinju Area
Hyang-Ok Woo, Jin-Su Jun, Ji-Hoe Park, Young-Suk Kim, Eun-A Kim, Jae-Young Lim, Myoung-Bum Choi, Chan-Hoo Park, Hee-Shang Youn, Gyung-Hyuck Ko, Chan-Hoo Park, Woo-Kon Lee, Myung-Je Cho, Kwang-Ho Rhee
Clin Exp Pediatr. 2001;44(5):501-508.   Published online May 15, 2001
Purpose : Vitamin C among antioxidants in human is a physiological antioxidant for protection against diseases. We measured the vitamin C concentrations of whole blood and plasma among children in early childhood at normal condition in order to know the presence of vitamin C deficiency. Methods : The venous blood was collected from 471 subjects at 1-6 years of ages in...
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