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Original Article
Follow-up in Adult after Total Repair of Tetralogy of Fallot
Gi Young Jang, Sun Young Kim, Joo Ryung Moon, Joon Huh, I-Seok Kang, Seung Woo Park, Tae Gook Jun, Pyo Won Park, Heung Jae Lee
Clin Exp Pediatr. 2003;46(7):661-667.   Published online July 15, 2003
Purpose : This study was performed to find the chief clinical problems associated with the ages of adult patients of tetralogy of Fallot(TOF) who had undergone total correction. Methods : Of the 30 patients who were registered at the Grown-Up Congenital Heart Disease (GUCH) Clinic of Samsung Medical Center for TOF, a retrospective investigation was carried out on 28 patients who...
Correlation between Chest Radiographic Findings and Respiratory Indices in Neonates with Respiratory Distress Syndrome
Yong-Hwan Chung, Youn-Jin Park, Chong-Woo Bae, Dong-Wook Sung
Clin Exp Pediatr. 2003;46(7):655-660.   Published online July 15, 2003
Purpose : The relationship between chest X-ray findings and respiratory indices, including the arterial-alveolar oxygen partial pressure ratio(a/APO2) and the ventilatory index(VI), indicators of the clinical respiratory status in neonates with respiratory distress syndrome(RDS), was examined in the present study. Methods : The records of 50 neonates, randomly chosen from 174 neonates treated with pulmonary surfactant(PS) in the Neonatal Intensive Care...
A Questionnaire on Using Informed Consents of Parents or Guardians in Vaccination of Children
Seung-Hi Paik, Eun Hee Chung, Mie Ryung Uhm, Son Moon Shin, Woo Gill Lee, Mi Na Lee, Hoan Jong Lee
Clin Exp Pediatr. 2003;46(7):647-654.   Published online July 15, 2003
Purpose : This study was done to evaluate the parents' or guardians' compliance of obtaining individual informed consent before vaccination and the possible problems of using informed consent. Methods : One hundred and twelve children were randomly selected among 2,820 children who visited Samsung Cheil Hospital during July 2002. A questionnaire about using informed consent of vaccination was given to all...
A Follow-up Survey of Mothers' Antenatal Breast-feeding Plans
Hae Soon Kim, Jeong Wan Seo, Yong Joo Kim, Kee Hyoung Lee, Jae Young Kim, Jae Sung Ko, Sun Hwan Bae, Hye Sook Park
Clin Exp Pediatr. 2003;46(7):635-641.   Published online July 15, 2003
Purpose : To investigate the success rate and factors that influence breast-feeding among women having antenatal breast-feeding plans. Methods : Questionnaires included items on success in breast-feeding, reasons for failure and perinatal factors. It was done by telephone calls to 152 randomly selected women having antenatal breast-feeding plans at 4 months after delivery. The questionnaires were analysed by bivariate χ2-...
Clinical Characteristics of Kawasaki Disease in Infants Younger than 3 Months of Age
Soo Jeong Lee, So Jung Kim, Hae Soon Kim, Sejung Sohn
Clin Exp Pediatr. 2003;46(6):591-596.   Published online June 15, 2003
Purpose : Kawasaki disease(KD) is rare in infants <3 months of age. In this younger group, the diagnosis may be delayed due to lack of most of the clinical criteria, resulting in a high risk of cardiac complications. We examined clinical characteristics in these patients for early recognition and treatment. Methods : We conducted a retrospective study on the infants...
Autonomic Neuropathy in Adolescents with Diabetes Mellitus
Eun-Gyong Yoo, Sun-Young Ahn, Duk Hee Kim
Clin Exp Pediatr. 2003;46(6):585-590.   Published online June 15, 2003
Purpose : This study is designed to determine the prevalence of cardiovascular autonomic neuropathy and its relationship to risk factors in adolescents with diabetes mellitus(DM). Methods : Ninety-two diabetic patients(80 with type 1 DM and 12 with type 2 DM), ranging from eight to 26 years of age, were studied for cardiovascular autonomic function, and the relationship to age, duration...
Henoch-Scholein Purpura Presenting with Acute Abdominal Pain Preceding Skin Rash : Review of 23 Cases
Ju Young Chang, Yong Joo Kim, Kyo Sun Kim, Hee-Ju Kim, Jeong Kee Seo
Clin Exp Pediatr. 2003;46(6):576-584.   Published online June 15, 2003
Purpose : For the early diagnosis of Henoch-Schonlein purpura(HSP) presenting with acute abdominal pain preceding skin rash. Methods : The clinical, endoscopic and radiological records of 23 cases of HSP, presenting with gastrointestinal symptoms preceding skin rash were reviewed. Results : The intervals from the onset of abdominal pain to the development of the skin rash were one day to 30 days(median...
Endoscopic Findings of Children with Henoch-Schonlein Purpura
Dong Hoon Lee, Chul Han Park, Ji Min Park, Geun Soo Park, Heung Sik Kim, Chin Moo Kang
Clin Exp Pediatr. 2003;46(6):572-575.   Published online June 15, 2003
Purpose : This study was performed to analyze the endoscopic findings in Henoch-Schonlein purpura patients, and to compare the differences in endoscopic findings according to age and gastrointestinal symptoms. Methods : We examined children with Henoch-Schonlein purpura aged 3 to 15 years between September 1996 and October 2002. The total number studied was 65, consisting of 41 boys and 24...
Leukoencephalopathy after CNS Prophylactic Therapy in Pediatric Hematologic Malignancy
Jun Hwa Lee, Sun Min Lee, Eun Jin Choi, Kun Soo Lee
Clin Exp Pediatr. 2003;46(6):566-571.   Published online June 15, 2003
Purpose : Leukoencephalopathy(LE) is one of the most serious complications in children with hematologic malignancies during the course of treatment. Early recognition is important to reduce the impact and sequelae from LE. We therefore investigated the clinical features of LE following central nervous system(CNS) prophylaxis in children with hematologic malignancies and evaluated the significance of regular check-ups of brain MRI. Methods...
Recurrence and Follow-up after Urinary Tract Infection
Ji Hee Kim, Hye Kyung Shin, Kee Hwan Yoo, Young Sook Hong, Joo Won Lee, Soon Kyum Kim
Clin Exp Pediatr. 2003;46(6):561-565.   Published online June 15, 2003
Purpose : Urinary tract infection(UTI) is the most common bacterial infectious disease that may induce severe renal injury unless early diagnosis and appropriate treatment are performed. If recurrent UTI is prevented, renal injury can be also reduced. Therefore, we studied the risk factors of recurrent UTI in children. Methods : We performed a retrospective study of 168 children(58 girls and 110...
Experimental Study for the Teratogenic Effect of Gamma-ray on the Heart of Chick Embryo
Yong Whan Jo, Nam Su Kim, Sung Yup Moon, Myeng Gul Yum, Sung Hoon Kim, Ha Chung Chun, Yong Joo Kim, Hahng Lee
Clin Exp Pediatr. 2003;46(6):554-560.   Published online June 15, 2003
Purpose : To investigate the teratogenic effect of gamma-ray on the heart of chick embryo. Methods : 50 rad, 100 rad, 150 rad, 200 rad, 250 rad, and 300 rad of gamma-ray were used to irradiate three days old chick embryos. The control group was not irradiated. After three weeks, the embryos were sacrificed and examined for cardiovascular malformation. Results :...
Increased Matrix Metalloproteinase-9 and Tissue Inhibitor of Metalloproteinase-1 Levels in the Cerebrospinal Fluid from Children with Aseptic Meningitis
Ju Hee Yang, Min Hyuk Park, Jung-Yeon Shim, Hye Lim Jung, Moon Soo Park, Dong Hyuck Keum
Clin Exp Pediatr. 2003;46(6):548-553.   Published online June 15, 2003
Purpose : Matrix metalloproteinase(MMP)-9 is known to breakdown the blood-brain barrier by degrading the extracellular matrix of the subendothelial basement membrane in meningitis. Tissue inhibitor of metalloproteinase(TIMP)-1, a known inhibitor of MMP-9, has been postulated to inhibit the proteolytic activity of MMP-9 by bindng to MMP-9, but their interaction has not been fully understood yet. So far, there have been...
Novel Gap Junction Molecules, Connexin 37, Enhances the Bystander Effect in HSVtk/GCV Gene Therapy
Sun Young Kim, Ho Keun Yi, Jung Chang Lee, Dong Jin Hwang, Pyoung Han Hwang, Dae Yeol Lee, Soo Chul Cho
Clin Exp Pediatr. 2003;46(6):541-547.   Published online June 15, 2003
Purpose : Gap junction intercellular communication(GJIC) is an important mechanism of the bystander effect in herpes simplex thymidine kinase/ganciclovir(HSVtk/GCV) gene therapy Therefore, we attempted to enhance the bystander effect in vitro by exogenous overexpressing connexin 37(Cx37) in cells to increase GJIC. Methods : NIH3T3 cells were transfected with the Cx37 and HSVtk gene or the HSVtk gene alone by the calcium...
Immunocytochemical Study for Lactalbumin in Alveolar Macrophage of Human Milk Aspirated Mouse
Byoung Kil Han, Young Hun Chung
Clin Exp Pediatr. 2003;46(6):536-540.   Published online June 15, 2003
Purpose : Aspiration of foreign material into the lungs can cause acute or chronic pulmonary diseases. It is difficult to detect small amounts of aspiration due to the lack of safe, sensitive and specific diagnostic tests. Recently, in animal or human studies, it has been reported that immunochemistry for lactalbumin can be used to detect the minimal aspiration. So, the...
The Clinical and Laboratory Features of Kawasaki Disease with Nonresponsibility to the Acute Antiinflammatory Treatment
Eun-Jung Kim, Myung-Eun Hong, Chang-Woo Lee, Yeon-Geun Oh, Jong-Duk Kim, Hyang-Suk Yoon
Clin Exp Pediatr. 2003;46(5):500-504.   Published online May 15, 2003
Purpose : To assess the clinical features and laboratory findings in Kawasaki patients with nonresponsibility to the acute antiinflammatory treatment, and identify the risk factors for the nonresponsibility, we reviewed the medical records of patients with Kawasaki disease. Methods : A retrospective study of 177 patients with Kawasaki disease at Wonkwang University Medical Center from June, 1997 to June, 2002, was...
Differential Excretion of Urinary Eosinophil Protein X after Methacholine Challenge Test in Children with Asthma
Su-A Shin, Jae-Won Oh, Ha-Baik Lee
Clin Exp Pediatr. 2003;46(5):495-499.   Published online May 15, 2003
Purpose : Eosinophil is one of the important inflammatory cell involved in the airway inflammation in childhood asthma. It has been demonstrated that markers of eosinophil activation, including eosinophil cationic protein or eosinophil protein X(EPX), are increased in childhood asthma. Furthermore, they are related to disease activity and are assumed to be helpful in monitoring the treatment effect as urinary...
Screening Test for Heart Diseases in the First Grade Elementary School Children in Busan
Jae Min Oh, Hee Ju Park
Clin Exp Pediatr. 2003;46(5):490-494.   Published online May 15, 2003
Purpose : We'd like to determine the incidence of congenital heart disease and arrhythmia in elementary school children in Busan, and to provide adequate prevention and treatment. Methods : A total of 23,802(male 12,909, female 10,893) 1st grade elementary school children living in Busan were studied. All children were 7-8 years old. We obtained their medical history by questionnaire and checked...
Echocardiographic Parameters of Pulmonary Atresia with Intact Ventricular Septum(PA/IVS)
Young Seok Lee, Yeo Hyang Kim, Myung Chul Hyum, Sang Bum Lee
Clin Exp Pediatr. 2003;46(5):484-489.   Published online May 15, 2003
Purpose : To understand morphologic and hemodynamic variations in patients with pulmonary atresia with intact ventricular septum(PA/IVS), and to decide the best treatment modalities, we measured right ventricular volume, inflow, and outflow valvular annulus size in these patients and compared them with those of normal newborns. Methods : Eight patients with PA/IVS diagnosed by echocardiography from January to December 2001...
Clinical Significance of C-reactive Protein in Measles
Sang-Lim Choi, Kyung-Yil Lee, Hyung-Shin Lee, Ja-Hyun Hong, Kyung-Tai Whang
Clin Exp Pediatr. 2003;46(5):480-483.   Published online May 15, 2003
Purpose : We evaluated clinical manifestations and laboratory findings in patients with measles according to C-reactive protein(CRP) concentration. Methods : A retrospective analysis was performed using the medical records of patients with measles at The Catholic University of Korea, Daejeon St. Mary's Hospital from October 1999 to May 2000. We divided the patients with measles into four groups according to CRP...
Pattern of Occurrence of Mycoplasma pneumoniae Pneumonia in Admitted Children : Southern Central Korea, from 1989 to 2002
Ki Su Kang, Hyang-Ok Woo
Clin Exp Pediatr. 2003;46(5):474-479.   Published online May 15, 2003
Purpose : The determination of exposure and prevalence of Mycoplasma pneumoniae pneumonia of any region should be helpful for clinical diagnosis. We studied the pattern of occurrence of M. pneumoniae pneumonia among children living in southern central Korea during the last 13 years. This area has a relatively small population and less mobility compared with metropolitan areas. Methods : We performed...
A Study of Epstein-Barr Virus, and Human Leukocyte Antigen Typing in Children with Acute Infectious Mononucleosis
Seung-Hoon Hahn, Wan-Shik Shin, Hoon Han, Jin-Han Kang
Clin Exp Pediatr. 2003;46(5):467-473.   Published online May 15, 2003
Purpose : The Epstein-Barr virus(EBV), gamma herpesvirus, is an important pathogen that is widespread around the world. The EBV causes various diseases depending on the geographic location, and on the immunity or the premorbid condition of the person exposed to EBV. To evaluate EBV typing may be the most important step to figure out the pathogenesis of EBV associated diseases,...
Causative Pathogens and Therapeutic Assessment of Cefprozil in Acute Otitis Media
Jin-Han Kang, Jong Hyun Kim, Yong-Soo Park, Young-Chul Choi, Heil Noh, Hoon Shik Yang, Kyu Sung Kim, Yeon Sook Moon, Young Jin Hong
Clin Exp Pediatr. 2003;46(5):459-466.   Published online May 15, 2003
Purpose : AOM is the most common bacterial URI in children. The bacteriology and antibiotic Tx of AOM in children has been studied in many countries. But, there is few study of causative pathogens and antibiotic Tx of AOM in our country. In this aspect, we performed prospective clinical study to confirm the causative pathogens and assess the clinical responses...
The Difference between Clinical Manifestations and Feeding or Delivery Methods in Healthy Full-term Neonates and Those with Nosocomial Rotaviral Infection
So Young Lee, Hyun Ji Kim, Mi Young Kim, Won Duck Kim, Dong Seok Lee, Doo Kwun Kim, Sung Min Choi
Clin Exp Pediatr. 2003;46(5):454-458.   Published online May 15, 2003
Purpose : Rotavirus is the main cause of infantile diarrheal disease worldwide. The purpose of this study is to assess the difference between clinical manifestations and feeding or delivery methods in healthy full-term neonates and those with nosocomially-acquired rotaviral infection. Methods : The study was conducted on 348 babies who were delivered in Dongguk University Kyongju Hospital from Jan 1...
Complications and Perinatal Factors According to the Birth Weight Groups in the Infants of Diabetic Mothers
Kyung-Ran Son, Hee-Jo Back, Chang-Yee Cho, Young-Youn Choi, Tae-Bok Song, Chun-Hak Park
Clin Exp Pediatr. 2003;46(5):447-453.   Published online May 15, 2003
Purpose : This study was performed to compare complications and perinatal factors according to the birth weight groups in the infants of diabetic mothers(IDM). Methods : Three hundred and one singleton diabetic mothers and their babies of more than 30 weeks' gestational age admitted in the department of Pediatrics, Chonnam University Hospital from January 1996 to March 2002 were enrolled....
Galactosemia Detected by Neonatal Screening Test
Il Sung Park, Hye Jung Cho, Dong Hwan Lee, Jung Hwan Song
Clin Exp Pediatr. 2003;46(5):440-446.   Published online May 15, 2003
Purpose : The genetic disturbance of galactosemia is expressed as a cellular deficiency of either galactose-1-phosphate uridyltransferase(GALT) or galactokinase(GALK) or UDP galactose 4-epimerase(GALE). To find-out the pattern of galactosemia in Korea, we retrospectively analyzed cases of galactosemia detected by neonatal screening program. Methods : We analyzed medical records of patients who visited Soonchunhyang University Hospital at age of 1...
Plasma G-CSF and GM-CSF Concentration and Amount of Their Receptors on the Granulocyte in Kawasaki Disease
Young-Kyoung Yoo, Gibum Lee, Hyun-Hee Kim, Soo-Young Kim, You-Jeong Kim, Wonbae Lee
Clin Exp Pediatr. 2003;46(4):376-381.   Published online April 15, 2003
Purpose : This study aimed to demonstrate the possible pathogenesis of granulopoiesis in patients of Kawasaki disease(KD) using quantitative analysis of G-CSF, GM-CSF and their CSFr. Methods : The plasma levels of G-CSF, GM-CSF, G-CSFr and GM-CSFr were studied in 14 patients in the acute phase of KD; 13 children with normal peripheral white blood cell counts were used as the...
The Relationship between House Dust Mite Sensitization and Month Birth Distribution in Children with Respiratory Allergy
Eun Kyeong Kang, Kyu Min Na, Hee Kang, Young Yoo, Young Yull Koh
Clin Exp Pediatr. 2003;46(4):370-375.   Published online April 15, 2003
Purpose : It has been suggested that the exposure to aeroallergens during early infancy after birth is important in the subsequent development of sensitization and allergic diseases. In Korea, the level of house dust mites as one of the important aeroallergens is known to be the highest in autumn. The aim of this study was to test whether the distribution...
Overnight Growth Hormone Secretions and Sleep Patterns in Idiopathic Short Stature Children
Sang Young Seo, Kee Hyoung Lee, Baik Lin Eun, Chang Sung Sohn, Young Chang Tockgo, Chol Shin, Baek-Hyun Kim
Clin Exp Pediatr. 2003;46(4):363-369.   Published online April 15, 2003
Purpose : Pharmacologic provocation test of growth hormone(GH) is a non-physiologic method and has several limitations for diagnosing growth hormone(GH) deficiency. Spontaneous GH release studies could be important in understanding the pathophysiology of children with poor growth but normal responses to GH provocation tests. Also, the relationship between nocturnal GH secretions and sleep patterns in short stature children is poorly...
Comparison of Effectiveness between Two Different Protocols of Treatment of IV γ-globulin in Idiopathic Thrombocytopenic Purpura
Jae Ho Jang, Moonsouk Lee, Mira Park, Kyuchul Choeh
Clin Exp Pediatr. 2003;46(4):358-362.   Published online April 15, 2003
Purpose : Several methods of IV γ-globulin(IVG) infusion are effective in the treatment of autoimmune disease, including idiopathic thrombocytopenic purpura(ITP). But it is not known which method is more effective in the treatment of ITP. The effectiveness of these two methods of IVG infusion was studied in terms of platelet recovery rate, side effects and recurrence rate. Methods : Forty seven...
A Clinical and Radiologic Study of Acute Focal Bacterial Nephritis in Children
Kum Ho Song, Kwon Hoe Huh, Ok Yeon Cho, Jae Hoon Sim, Do Jun Cho, Dug Ha Kim, Ki Sik Min, Ki Yang Yoo, Kwan Seop Lee
Clin Exp Pediatr. 2003;46(4):351-357.   Published online April 15, 2003
Purpose : To raise awareness of the clinical importance of, and the need for proper management of acute focal bacterial nephritis(AFBN), we analyzed 22 AFBN patients and 22 other upper urinary tract infection patients by use of comparative studies. Methods : From January 2000 to May 2002, 22 AFBN patients aged from 1 month to 12 months were selected. As a...
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