Journal of the Korean Pediatric Society 2003;46(4):358-362.
Published online April 15, 2003.
Comparison of Effectiveness between Two Different Protocols of Treatment of IV γ-globulin in Idiopathic Thrombocytopenic Purpura
Jae Ho Jang1, Moonsouk Lee1, Mira Park2, Kyuchul Choeh3
1Department of Pediatrics, School of Medicine, Eulji University, Daejeon, Korea
2Department of Premedicine(Statistics), School of Medicine, Eulji University, Daejeon, Korea
3URII Children's Clinic, Daejeon, Korea
특발성 혈소판 감소성 자반증에서 정주용 감마 글로불린의 투여 방법에 따른 효과 비교
장재호1, 이문숙1, 박미라2, 최규철3
1을지의과대학교 소아과학교실
2을지의과대학교 의예과(통계학)
3우리i소아과
Correspondence: 
Jae Ho Jang, Email: jjh1270@hanmail.net
Abstract
Purpose
: Several methods of IV γ-globulin(IVG) infusion are effective in the treatment of autoimmune disease, including idiopathic thrombocytopenic purpura(ITP). But it is not known which method is more effective in the treatment of ITP. The effectiveness of these two methods of IVG infusion was studied in terms of platelet recovery rate, side effects and recurrence rate.
Methods
: Forty seven patients with acute ITP in the department of pediatrics, Eulji University Hospital from January 1995 to June 2001 were enrolled. We assesssed the treatment effects of 47 patients blindly selected; IV γ-globulin 2 g/kg/day in one day(treatment group A, n=25), 400 mg/ kg/day in five days(treatment group B, n=22).
Results
: Treatment group A increased platelet count more rapidly on the 2nd, 4th and 6th day of treatment than treatment group B. Side effects like fever, chill and vomiting were more frequent in treatment group A than treatment group B. The platelet count on the sixth day of treatment showed a greater increase in the cases which had side effects than in the cases which did not. There was no difference between the two groups in the recurrence rate.
Conclusion
: IV γ-globulin 2 g/kg/day in one day increases platelet count more rapidly than 400 mg/kg/day in five days, and is favorable for the prevention of a severe hemorrhagic episode like early intracranial hemorrhage.
Key Words: IV γ-globulin, Idiopathic thrombocytopenic purpura


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