| An effect of IV methylprednisolone in acute idiopathic thrombocytopenic purpura. |
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Jin Kuk Kim, Kyeong Hee Hong, Tae Gyu Whang, Soon Yong Lee |
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Department of Pediatrics, College of Medicine, Inje University, Busan, Korea |
| Acute Idiopathic Thrombocytopenic Purpura 환아들에 있어서
Methylprednisolone 정주치료의 효과 |
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김진국, 홍경희, 황태규, 이순용 |
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인제의대 부산백병원 소아과학교실 |
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Received: 21 February 1991 • Accepted: 3 June 1991 |
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| Abstract |
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The major goal in the treatment of acute idiopathic thrombocytopenic purpura (ITP) is to increase
the platelet count above the critical level of 20,000/mm3 to avoid intracranial hemorrhage.
We have treated eighteen children with acute ITP whose platelet count were below 20,000/mm3 at
initial diagnosis. Thirteen of 18 patients (group A) received IV methylprednisolone (IVMP) 10〜20
mg/kg/day for 5 days from the day of diagnosis. The remaining 5 patients, who were treatment
failures with IV gammaglobulin 400 mg/kg/day for 5 days, were also treated with IVMP as the same
in group A.
Thirteen patients (69%) of group A and 3 patients (60%) of group B showed complete recovery after
1 course of IVMP therapy. Two patients (15%) of group A and one (20%) of group B required one
more course of IVMP therapy for complete recovery and another one patient of group A required two
more course of IVMP therapy. The remaining cases were impossible to make follow-up.
In summary, IVMP therapy was very effective in the management of acute ITP to increase platelet
count above the critical level of 20,000/mm3 and to reduce the risk of intracranial hemorrhage. And
it was less expensive than IV gammaglobulin therapy. |
| Key Words:
ITP, Methylprednisolone |
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