Journal of the Korean Pediatric Society 2003;46(4):363-369.
Published online April 15, 2003.
Overnight Growth Hormone Secretions and Sleep Patterns in Idiopathic Short Stature Children
Sang Young Seo1, Kee Hyoung Lee1, Baik Lin Eun1, Chang Sung Sohn1, Young Chang Tockgo1, Chol Shin2, Baek-Hyun Kim3
1Department of Pediatrics, College of Medicine, Korea University, Seoul, Korea
2Department of Internal Medicine, Korea University, Seoul, Korea
3Department of Radiology, Korea University, Seoul, Korea
특발성 저신장 아동의 야간 성장호르몬 분비와 수면양상
서상영1, 이기형1, 은백린1, 손창성1, 독고영창1, 신철2, 김백현3
1고려대학교 의과대학 소아과학교실
2고려대학교 의과대학 내과학교실
3고려대학교 의과대학 방사선과학교실
Correspondence: 
Kee Hyoung Lee, Email: khlee218@kumc.or.kr
Abstract
Purpose
: Pharmacologic provocation test of growth hormone(GH) is a non-physiologic method and has several limitations for diagnosing growth hormone(GH) deficiency. Spontaneous GH release studies could be important in understanding the pathophysiology of children with poor growth but normal responses to GH provocation tests. Also, the relationship between nocturnal GH secretions and sleep patterns in short stature children is poorly understood. The aim of this study is to determine whether there are differences in sleep patterns and nocturnal GH secretory profiles between idiopathic short stature children and a normal stature group.
Methods
: Spontaneous nocturnal GH secretions and sleep patterns were evaluated in 12 prepubertal idiopathic short stature children with normal responses to provocation tests and 9 normal stature controls. Blood samples were taken every 30 minutes from 22:00-06:30 and sleep patterns were analyzed by polysomnography.
Results
: The mean GH level during sleep was significantly lower in short stature children than in controls. The peak GH level after sleep, coincident with the first slow wave sleep, was lower in the short stature group. The slow wave sleep times of short stature children were decreased compared with those of normal subjects.
Conclusion
: These results suggest that overnight serial GH sampling is helpful to identify short stature children with subnormal GH secretions, and sleep structure differences may be associated with decreased overnight GH secretions in short stature children.
Key Words: Idiopathic short stature, Overnight growth hormone, Sleep


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