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Original Article
The Efficacy of Proximal Esophageal 24-hour pH Monitoring in Infants with Chronic Cough
Yun Hee Kim, Ja Kyoung Kim, Jung Hee Kim, Dae Hyun Lim, Byong Kwan Son
Clin Exp Pediatr. 2003;46(12):1242-1247.   Published online December 15, 2003
Purpose : Gastroesophageal reflux disease(GERD) is known as one of the most common causes of chronic cough, especially in children. The purpose of this study is to evaluate the efficacy of parameters from proximal esophageal 24-hr pH monitoring through its comparison with those of distal esophageal 24-hr pH monitoring that we generally use for diagnosis of GERD. Methods : We performed...
Comparison of the Characteristics of 16 Commercial Nebulizer/Compressor Combinations Used in Korea
Hyun Jung Kim, Cho Ae Lee, Eun Kyung Hwang, Man Young Han, Uk Sung Ann, Young Min Cho
Clin Exp Pediatr. 2003;46(12):1235-1241.   Published online December 15, 2003
Purpose : We assessed the dynamic characteristics of 16 nebulizer/compressor combinations currently available in Korea. Methods : The 16 nebulizer/compressor combinations(Pariboy Type 38/Long life, Pariboy Type N/ Long life, Pariboy Type N/Salter 8900, Pariboy Type N/LC, Devilbiss pulmoaid-LT/Hudson, Devilbiss pulmoaid/Hudson, Mesmed neb-300/Own, San-up 3040/Hudson, Midas(Basic)/Own, AirJolie 2/ Hudson, Thomas 1127/Salter 8900, Noel NE-2000/Salter 8900, Omron CX3/Hudson, Chang Woo CWN-100/Salter 8900, Voyage/Mefar,...
The Utilities of Lung Biopsy in Pediatric Lung Disease
Jae Hee Lee, So Yeon Lee, Ja Hyung Kim, Bong Sung Kim, Soo-Jong Hong
Clin Exp Pediatr. 2003;46(12):1230-1234.   Published online December 15, 2003
Purpose : The aim of this study is to evaluate the value of lung biopsies for the management of children with lung disease. Methods : We retrospectively reviewed 19 lung biopsies done at Asan Medical Center, Seoul between 1993 and 2001. Data gathered included demographic information, underlying conditions, diagnosis before biopsy, final diagnosis, change in therapy, morbidity and mortality. Results : Nineteen...
Clinical Study of Group B β-Hemolytic Streptococcal Meningitis
Seo-Young Lee, Sou-Jeong You, Deok-Soo Kim, Tae-Sung Ko
Clin Exp Pediatr. 2003;46(12):1224-1229.   Published online December 15, 2003
Purpose : Bacterial meningitis is a serious disease, especially in the neonatal period, and it carries a significant degree of mortality and morbidity. Group B streptococcus(GBS) is a common cause of neonatal bacterial meningitis. The purpose of this study was to evaluate the clinical manifestations, treatment results and complications of GBS meningitis. Methods : We analyzed 29 cases retrospectively who had...
Pediatrician Perspectives on the Evaluation and Treatment of Acute Gastrointestinal Infections, Jeonbuk, South Korea, 2002
So Hee Lim, Yang Sim Koe, Dae Sun Jo, Sin Jae Lee, Pyoung Han Hwang, P. Kilgore, B. Nyhambat, Jung Soo Kim
Clin Exp Pediatr. 2003;46(12):1217-1223.   Published online December 15, 2003
Purpose : This study was conducted to assess clinical practices related to the evaluation and treatment of patients with acute gastrointestinal infection(AGI) in infants and children. This survey also evaluated the current opinion regarding the use of rotavirus vaccine. Methods : This survey was conducted using a self-administered questionnaire provided to 82 pediatricians in private clinics of Jeonbuk province. From April...
Fat Content in Stool of Children with Rotaviral Enteritis
Joon Sup Song, So Chung Chung, Kyo Sun Kim
Clin Exp Pediatr. 2003;46(12):1212-1216.   Published online December 15, 2003
Purpose : Rotavirus is a leading cause of severe gastroenteritis in infants and young children around the world. The aim of this study is to investigate the fat content in stools of patients with rotaviral enteritis compared to the stools of children who had no gastroenteritis. Methods : Seventy two patients who were admitted to Konkuk University Hospital, College of...
Plasma L-Arginine Concentration, Oxygenation Index and Pulmonary Artery Pressure in Premature Infants with Respiratory Distress Syndrome
Kyong Ah Jeong, Soon Ju Lee, In Kyung Sung, Chung Sik Chun
Clin Exp Pediatr. 2003;46(12):1207-1211.   Published online December 15, 2003
Purpose : This study was performed to observe the relationship of plasma L-arginine level and the severity of disease and pulmonary artery pressure in respiratory distress syndrome of premature infants. Methods : Peripheral blood samples were obtained at 1st, 3rd and 7th day from 21 premature infants with respiratory distress syndrome to analyze the L-arginine concentration. Oxygenation index (OI), an indicator...
A Study on the Effects of the Early Use of Nasal CPAP in the Weaning of Mechanical Ventilators
Yeoung Ju Kim, Byun Kyung Jung, Sang Geel Lee
Clin Exp Pediatr. 2003;46(12):1200-1206.   Published online December 15, 2003
Purpose : This study was conducted for the use of nasal continuous positive airway pressure (CPAP), by comparing the early use of non-invasive nasal CPAP with low intermittent mandatory ventilation(low IMV) and endotracheal CPAP in weaning a mechanical ventilator from infants with moderate respiratory distress syndrome(RDS). Methods : Thirty infants in the study group, with moderate RDS from November 2001 to...
Change in the Limit of Viability of Fetal Infants
Chang Won Choi, Jong Hee Hwang, Jae Won Shim, Sung Sin Kim, Sun Young Ko, Eun Kyung Lee, Yun Sil Chang, Won Soon Park
Clin Exp Pediatr. 2003;46(12):1194-1199.   Published online December 15, 2003
Purpose : To determine the change in the limit of viability in fetal infants and the incidence of major complications in neonatal intensive care unit(NICU) at Samsung Medical Center(SMC). Methods : Sevety-three infants weighing less than 800 g at birth and 117 infants born earlier than 27 weeks gestational age, who were admitted to NICU at SMC between November 1994...
1-β-D-Arabinofuranosyl-cytosine Induces Chromosomal Breaks in vitro
In-sang Jeon
Clin Exp Pediatr. 2003;46(12):1186-1193.   Published online December 15, 2003
Purpose : Fragile sites are points on chromosomes which tend to break non-randomly when exposed to specific chemical agents or conditions of tissue culture. The chromosomal break induced by the antineoplastic drug, 1-β-D-arabinofuranosyl-cytosine(Ara-c), was investigated to study the laboratory conditions in which the incidence of chromosomal break could be enhanced. Besides, the fragile sites induced by Ara-C were investigated...
A Clinical Study of Childhood Henoch-Sch nlein Purpura
Tae-Sun Ha, Hyun-Hoe Koo
Clin Exp Pediatr. 2003;46(11):1118-1123.   Published online November 15, 2003
Purpose : Henoch-Sch nlein purpura(HSP) is a systemic vasculitis, characterized by cutaneous purpura, abdominal pain, arthralgia and renal involvement. The clinical features of HSP have been reasonably well documented but there are still many gaps in our understanding of HSP. The aim of this study was to present the clinical features of 125 children with HSP and compare them with...
CNS Complications in Childhood Cancer
Yoo Jin Jeong, Yeon Kyong Seo, Seung Ah Hong, Heung Sik Kim, Jun Sik Kim, Hee Jung Lee
Clin Exp Pediatr. 2003;46(11):1112-1117.   Published online November 15, 2003
Purpose : Recent advances in the methods of treating cancer in young patients have led to both an increased frequency of CNS complications as well as prolonged life expectancy. We intend to analyze the clinical aspects and laboratory findings of patients with CNS complications during and after treatment. Methods : We reviewed the medical records of 174 childhood cancer...
Pathologic Change and Prognosis after Combination Therapy in Advanced Neuroblastoma
Yeon Kyong Seo, Yu Jin Jung, Joon Sik Kim, Heung Sik Kim, Woo Hyun Park, Soon Ok Choi, Byung Yook Lee, Kun Young Kwon
Clin Exp Pediatr. 2003;46(11):1107-1111.   Published online November 15, 2003
Purpose : Neuroblastoma is a malignant neoplasm which arises from primitive sympathetic neuroblasts, and occasionally can matured from a malignant neuroblastoma into a benign ganglioneuroma. It has the highest rate of spontaneous regression of any pediatric tumor. We performed a retrospective study of pathologic features after combination therapy in advanced neuroblastoma. Prognostic effects of the individual morphologic feature and prognostic...
Neuroprotective Effects of Minocycline in Rat Brain Cortical Cell Culture Induced by Hypoxia
Kyung A Ha, Bum Seok Yang, Jin Kyung Kim, Hong Tae Kim, Sung Jin Ha, Jong Won Lee, Hai Lee Chung, Woo Taek Kim
Clin Exp Pediatr. 2003;46(11):1101-1106.   Published online November 15, 2003
Purpose : In vivo, minocycline appears to be neuroprotective. Thus, the neuroprotective effects of minocycline were studied in a rat brain cortical cell culture induced by hypoxia. Methods : Cultured cells from the brains of Sprague-Dawley rats were divided into two sets of groups : normoxia groups treated with 5% CO2 and hypoxia groups treated with 1% CO2. After several...
A Clinical Study of Acute Colonic Diverticulitis in Children
Jae Hoon Sim, Keum Ho Song, Yun Jung Sim, Do Jun Cho, Dug Ha Kim, Ki Sik Min, Ki Yang Yoo, Hae Ran Lee, Kwan Seop Lee
Clin Exp Pediatr. 2003;46(11):1095-1100.   Published online November 15, 2003
Purpose : Children with acute colonic diverticulitis(ACD), can be misdiagnosed with acute appendicitis. Methods : We reviewed 15 cases of ACD during five years, from January 1998 to June 2002 retrospectively. Results : Most patients(80%) with ACD in children presented with right lower quadrant pain. The primary diagnosis on admission was mostly acute appendicitis(87%), and all ACD in children occurred in...
Efficacy and Safety of Polyethylene Glycol(PEG) with Electrolytes for Disimpaction in Children with Chronic Functional Constipation
Hong Seop So, Sun Hwan Bae, Hei Sun Yoon, in Soon Hwang
Clin Exp Pediatr. 2003;46(11):1089-1094.   Published online November 15, 2003
Purpose : Polyethylene glycol(PEG) with electrolytes has been used for intestinal clearance for colonoscopy and operations in children. But its efficacy and safety for disimpaction in children with chronic functional constipation has been studied little. Methods : This study enrolled 26 patients with chronic functional constipation(11 children had failed to disimpaction by conventional management at OPD) who were admitted to the...
Causative Organisms in Children with Bacterial Meningitis(1992-2002)
Hyun-Jung Kim, JI-Won Lee, Kyung-Yil Lee, Hyung-Shin Lee, Ja-Hyun Hong, Seung-Hoon Hahn, Kyung-Tai Whang
Clin Exp Pediatr. 2003;46(11):1085-1088.   Published online November 15, 2003
Purpose : This study was performed to assess the difference of organisms causing bacterial meningitis according to time. Methods : We analyzed retrospectively 40 medical records of bacteriologically proven meningitis from 1992 to 2002. We divided them into two groups; neonate's group(14 cases), and children's group(26 cases). The results of the neonate's group were compared with those of previously reported articles...
Comparison of Clinical Courses According to the Existence of Patent Ductus Arteriosus in Respiratory Distress Syndrome
Ju Hee Seong, Hyeon Joo Lee, Hyun Kee Hong, Chong-Woo Bae, Yong-Mook Choi
Clin Exp Pediatr. 2003;46(11):1080-1084.   Published online November 15, 2003
Purpose : To compare perinatal characteristics, clinical courses, and overall morbidity between respiratory distress syndrome(RDS) with patent ductus arteriosus(PDA) and RDS without PDA in neonates. Methods : Eighty-three neonates who were diagnosed and treated for RDS in the neonatal intensive care unit(NICU) from Jan. 2000 to Dec. 2002 were included in this study. RDS was complicated with PDA(group A) in...
A Study on the Changes in Ventilator Care Rate and Outcome of Very Low Birth Weight Infants During Last Four Years
Byun Kyung Jung, Yeoung Ju Kim, Sang Geel Lee
Clin Exp Pediatr. 2003;46(11):1073-1079.   Published online November 15, 2003
Purpose : Recently there has been a decrease in ventilator care rate and duration of very low birth weight infants(VLBWI) in Fatima Hospital. The aims of this study were to survey the frequency and duration of ventilation in VLBWI and to develop a non-invasive neonatal intensive care unit (NICU) policy. Methods : We performed a retrospective study of 284 newborn of...
A Clinical Study of Non-Accidental Intracranial Hemorrhage in Children
Kwon Hoe Huh, Keum Ho Song, Ki Sik Min, Ki Yang Yoo
Clin Exp Pediatr. 2003;46(11):1067-1072.   Published online November 15, 2003
Purpose : Non-accidental intracranial hemorrhage in children is not low in incidence and results in high mortality and serious sequelae. So, the authors have researched the distribution of sex and age, causes, symptoms and signs, hemorrhagic types, mortality rate and sequelae of the patients hospitalized with non-accidental intracranial hemorrhage at Hallym University Sacred Heart Hospital. Methods : The medical records of...
A Study of the Relationship between Childhood Obesity and Beverage Intake
Ji Hyun Oh, In Keun Kwak, Seung Yang, Il Tae Hwang, Ji Ah Jung, Hae Ran Lee
Clin Exp Pediatr. 2003;46(11):1061-1066.   Published online November 15, 2003
Purpose : The rising prevalence of childhood obesity may be due to an energy imbalance between food intake and energy expenditure. Recently, consumption of beverages in children has increased. The aim of this study is to provide useful information for the prevention and the control of childhood obesity by assessment of variable beverage consumption. Methods : Fight hundred seventy seven children(M...
Safety and Efficacy of Early Treatment with Intravenous Immunoglobulin in Patients with Kawasaki Disease
Hyun Jin Kim, Hae Won Yom, Hae Soon Kim, Sejung Sohn
Clin Exp Pediatr. 2003;46(10):1019-1023.   Published online October 15, 2003
Purpose : To determine the differences in clinical characteristics, blood chemistry and coronary artery complications between patients with Kawasaki disease who received intravenous immunoglobulin (IVIG) within the fourth day of illness and after the fifth day of illness. Methods : A retrospective chart review was conducted of all children with Kawasaki disease who were admitted to Ewha Mokdong Hospital between January...
Peripheral Blood Eosinophil Counts and Serum ECP in Adolescents with Long-term Asthma Remission and Persistent Bronchial Hyperresponsiveness : Comparison with Adolescents with Symptomatic Asthma
Hee Kang, Young Yoo, Jinho Yu, Yang Park, Young Yull Koh
Clin Exp Pediatr. 2003;46(10):1013-1018.   Published online October 15, 2003
Purpose : Bronchial hyperresponsiveness(BHR) in asthma is thought to be a consequence of underlying airway inflammation. But the mechanism responsible for persistent BHR in adolescents with long-term asthma remission is poorly understood. The aim of this study was to examine whether BHR in adolescents with asthma remission is associated with peripheral blood eosinophilia and/or increased serum levels of eosinophil cationic...
Lumbar Puncture in Patients Who Experienced First Seizure with Fever
Jung Kim, Jun Su Lee, Sang Eun Lee, Wan Suk Choi, Sung Ryoung Han, Kyunglae Cho
Clin Exp Pediatr. 2003;46(10):1008-1012.   Published online October 15, 2003
Purpose : We aimed to ascertain whether lumbar punctures should be done to prove febrile seizure, and to study what conditions can delay or abolish lumbar puncture. Methods : This retrospective study was done for four years, from January, 1996 to December, 1999. The subjects were the patients who visited Masan Samsung Hospital for the first convulsion with fever, and...
Relationship between Admission and Clinical Features of Children Who Visited the Emergency Department with Seizures
Sung Kwan Yoon, Eun Young Kim, Eun Seok Yang, Kyung Rye Moon, Sang Kee Park, Young Bong Park, Young Il Rho, Soo Hyeong Cho
Clin Exp Pediatr. 2003;46(10):1003-1007.   Published online October 15, 2003
Purpose : To review the seizure-related complaints and analyze the relationship between admission rates and clinical features in children who had visited the emergency department with seizures. Methods : Retrospectively, we reviewed 180 patients(male 100, female 80) suffering from seizures, who had visited to the emergency department of Chosun University Hospital from January 2000 to June 2002. We have analyzed the...
Heart Rate Variability and Autonomic Activity in Patients Affected with Rett Syndrome
Deok Young Choi, Jin Ha Chang, Hee Jung Chung
Clin Exp Pediatr. 2003;46(10):996-1002.   Published online October 15, 2003
Purpose : In Rett syndrome patients, the incidence of sudden death is greater than that of the general population, and cardiac electrical instability including fatal cardiac arrhythmia is a main suspected cause. In this study, we are going to find out the possible cause of the higher risk of sudden death in Rett patients by the evaluation of heart rate...
The Effect of Postnatal Dexamethasone Treatment on Hypoxic-Ischemic Brain Injury in Neonatal Rats
Chang Ro Park, Kyung Pil Park, Heng Mi Kim, Yoon Kyung Sohn
Clin Exp Pediatr. 2003;46(10):989-995.   Published online October 15, 2003
Purpose : Dexamethasone is frequently administered to prevent or treat chronic lung disease in human neonates who are also prone to hypoxic-ischemic(HI) insults. Recently, meta-analysis of the follow-up studies reveals a significantly increased odd ratio for the occurrence of cerebral palsy or an abnormal neurologic outcome, and there is conflicting evidence regarding the impact of dexamethasone exposure on HI brain...
Change of Cerebral Blood Flow during Tilt Tests in Children with Vasovagal Syncope
Su Jung Kim, Hye Won Yom, Young Mi Hong, Jung Hyen Yoo, Sook Hee Lee, Chong Hee Kim
Clin Exp Pediatr. 2003;46(10):983-988.   Published online October 15, 2003
Purpose : Syncope appears to be common. However, the mechanism of syncope is not clear. Increased vagal activity and withdrawal of sympathetic stimulation cause hypotension, bradycardia and finally loss of consciousness. The purpose of this study was to evaluate changes of cerebral blood flow velocity, blood pressure, and heart rate during tilt test in children with vasovagal syncope. Methods : Sixty...
Urinary Excretion of Various Urinary Proteins in Children with Vesicoureteral Reflux
Da Eun Jung, Ja Wook Koo
Clin Exp Pediatr. 2003;46(10):977-982.   Published online October 15, 2003
Purpose : This study aimed to examine the excretion of various urinary proteins in children with a history of urinary tract infection(UTI), with or without vesicoureteral reflux(VUR) or reflux nephropathy, and to identify means of predicting the severity of VUR or the presence of reflux nephropathy as indicated by these markers, and to know how these markers are changed after...
A Five-year Epidemiologic Study of Childhood Leukemia in Busan City, 1996 to 2000
Jae Hoon Moon, Soon Yong Lee, Jong Beom Sinn, Jae Sun Park, Young Ho Lee, Young Tak Lim, Su Eun Park
Clin Exp Pediatr. 2003;46(10):972-976.   Published online October 15, 2003
Purpose : For the control of childhood leukemia, of which the mortality is still high, the basic data for the incidence has a great importance. The authors analyzed the data from 133 new patients with childhood leukemia between 1996-2000 in Busan, Korea. Methods : The data were obtained from 133 new cases(87 males and 46 females from 0 to 15 years...
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