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Original Article
Pulse wave velocity and ankle brachial index in obese adolescents
Ji Hye Kim, Hee Sun Koo, Young Mi Hong
Clin Exp Pediatr. 2007;50(11):1078-1084.   Published online November 15, 2007
Purpose : The prevalence of childhood obesity has doubled over the last 30 years. Obesity-associated sequelae in the vasculature begins in the early stages of life. The purpose of this study was to investigate how pulse wave velocity (PWV) and ankle brachial index (ABI) change with height, weight and body mass index (BMI) in obese adolescents. Methods : Seventy-nine obese...
Incidence of breast milk jaundice in healthy full-term infants
Yong Ho Yoon, Kyong Eun Choi, Kyung Ah Kim, Sun Young Ko, Yeon Kyung Lee, Son Moon Shin
Clin Exp Pediatr. 2007;50(11):1072-1077.   Published online November 15, 2007
Purpose : It has been described that the incidence of breastfeeding jaundice is 13% and that of breast milk jaundice is 2%. The incidence in Korea was believed to be higher, but there were no studies to prove this assumption. The purpose of this study was to investigate the incidence of jaundice of healthy breastfed full-term infants in Korea. Methods :...
Improved survival rate with decreased neurodevelopmental disability in extreme immaturity
Ga Won Jeon, Myo Jing Kim, Sung Shin Kim, Jae Won Shim, Yun Sil Chang, Won Soon Park, Mun Hyang Lee
Clin Exp Pediatr. 2007;50(11):1067-1071.   Published online November 15, 2007
Purpose : The aim of this study was to determine whether improved survival of extremely low birth weight infants (ELBWI) was associated with decreased neurodevelopmental disability later in life, and also to identify the factors influencing this disability. Methods : ELBWI admitted to the neonatal intensive care unit of Samsung Medical Center, survived, and followed up until the corrected age...
The ages and stages questionnaire: screening for developmental delay in the setting of a pediatric outpatient clinic
Eun Young Kim, In Kyung Sung
Clin Exp Pediatr. 2007;50(11):1061-1066.   Published online November 15, 2007
Purpose : Early identification of developmental disabilities allows intervention at the earliest possible point to improve the developmental potential. The Ages and Stages Questionnaire (ASQ), a parent- completed questionnaire, can be used as a substitute for formal screening tests. The purpose of this study was to evaluate the validity of the Korean version of the ASQ (K-ASQ) as a screening...
The optimal conditions to improve retrovirus-mediated transduction efficiency to NIH 3T3 cells
Jun Ah Lee, Kang-Min Lee, Hyun Jae Lee, Yun Jeong Lee, Dong Ho Kim, Jung Sub Lim, Kyung-Duk Park
Clin Exp Pediatr. 2007;50(10):1011-1017.   Published online October 15, 2007
Purpose : We tried to assess the optimal conditions to improve low transduction efficiency and their effect on target cells. Methods : Cultured NIH 3T3 cells were incubated with retroviral vectors bearing an enhanced green fluorescent protein (eGFP) gene. We varied the ratio of viral vectors to target cells (1:1-1:8) and the number of transfections (X1, X2), and compared transduction...
Clinical characteristics and progress of Kawasaki disease patients who had early treatment with intravenous immune globulin
So-Yoon Park, Young Hwan Lee
Clin Exp Pediatr. 2007;50(10):1005-1010.   Published online October 15, 2007
Purpose : To determine the optimal time of high dose intravenous immune globulin (IVIG) treatment, we analysed the clinical characteristics and progress of a group of Kawasaki disease patients who had early treatment with IVIG. Method : A retrospective study was conducted of 188 patients with Kawasaki disease who were admitted to Yeungnam University Medical Center from January 2000 to December...
Clinical significance of serum vascular endothelial growth factor in Kawasaki disease
Ho Seok Lee, Sin Weon Yun, Young Soo Jung, Soo Ahn Chae, In Seok Lim, Dong Keun Lee, Eung Sang Choi, Byung Hoon Yoo, Mi Kyung Lee
Clin Exp Pediatr. 2007;50(10):995-1004.   Published online October 15, 2007
Purpose : Kawasaki disease is a systemic vasculitis, leading cause of pediatric acquired heart disease. Vascular endothelial growth factor (VEGF) has functions as vascular permeability factor, plays an important role in coronary artery lesion (CAL). We studied the clinical significance of serum VEGF in Kawasaki disease. Methods : Kawasaki group was 49 patients, and control group was 15 patients. Diagnosis followed...
Clinical significance of acanthosis nigricans in children and adolescents with obesity induced metabolic complications
Hee Won Chueh, Gyu Rang Cho, Jaeho Yoo
Clin Exp Pediatr. 2007;50(10):987-994.   Published online October 15, 2007
Purpose : This study investigated the clinical significance of AN in children and adolescents with obesity induced metabolic complications. Methods : Forty-nine patients who had obesity induced metabolic complications were participated in this cross-sectional study. Obesity induced metabolic complications are as follows: hypertension, dyslipidemia, impaired fasting glucose (IFG), impaired glucose tolerance (IGT), nonalcoholic steatohepatitis (NASH), homeostasis model assessment of insulin...
Change of absolute neutrophil count after intravenous immunoglobulin administration for the children with idiopathic thrombocytopenic purpura
Hyun Jung Shin, In Kug Bang, Byung Kyu Choe, Jin-Bok Hwang, Jun Sik Kim, Heung Sik Kim
Clin Exp Pediatr. 2007;50(10):982-986.   Published online October 15, 2007
Purpose : Intravenous immunoglobulin (IVIG) is effective for the treatment of idiopathic thrombocytopenic purpura (ITP) in children. Recently, several reports have been published that show its impact on the absolute neutrophil count. The present study was performed to confirm these findings. Methods : Data on 26 ITP patients were analyzed. Patients with febrile illness or increased C-reactive protein levels...
Late aortic root dilatation and aortic regurgitation in repaired tetralogy of fallot
Jeong Eun Kim, Kyong Hur, Hae Sik Kwon, Byung Won Yoo, Jae Young Choi, Jun Hee Sul
Clin Exp Pediatr. 2007;50(10):976-981.   Published online October 15, 2007
Purpose : Aortic valve or aortic root (AoRo) replacement is occasionally required because of AoRo dilatation and aortic regurgitation (AR) in repaired tetralogy of Fallot (TOF). We evaluated AoRo size and possible factors associated with its hemodynamic nature in patients with repaired TOF. Methods : We investigated 130 repaired TOF patients more than 15 years of age who followed-up by...
Comparison of defect size measured by transthoracic and transesophageal echocardiography with balloon occlusive diameter measured during transcatheter closure of atrial septal defect
Kyong Hur, Jeong Eun Kim, Yuria Kim, Hae Sik Kwon, Byung Won Yoo, Jae Young Choi, Jun Hee Sul
Clin Exp Pediatr. 2007;50(10):970-975.   Published online October 15, 2007
Purpose : Accurate measurement of defect size is important in transcatheter closure of atrial septal defect (ASD). We performed this study to analyze the difference between the measured ASD size and balloon occlusive diameter (BOD) by transthoracic (TTE) or transesophageal echocardiography (TEE). Methods : We investigated 78 patients who underwent transcatheter closure of ASD. The defect size and the distance between...
Normal antistreptolysin O titers of children by age group in the Gyeonggi-Incheon region
Jihun Lee, Yoo Jung Kim, Joong Hyun Bin, Ja Young Hwang, Seong Hoon Hahn, So Young Kim, Hyun Hee Kim, Wonbae Lee
Clin Exp Pediatr. 2007;50(10):965-969.   Published online October 15, 2007
Purpose : Measurement of antistreptolysin O (ASO) is often necessary to confirm a clinical diagnosis of recent streptococcal infection, especially in patients suspected of rheumatic fever and acute glomerulonephritis. Standard normal ranges for ASO should be established locally for each age group. We analyzed ASO to determine the upper limit of normal (ULN) ASO in children in the Gyeonggi-Incheon area. Methods...
Clinical observation of meconium aspiration syndrome and effect of suctioning through endotracheal intubation on prognosis of meconium aspiration syndrome
Yong Ho Yoon, Kyung Ah Kim, Sun Young Ko, Yeon Kyung Lee, Son Moon Shin
Clin Exp Pediatr. 2007;50(10):959-964.   Published online October 15, 2007
Purpose : The purpose was to investigate the clinical considerations of patients affected by meconium aspiration syndrome (MAS) and the effect of suctioning through endotracheal intubation immediately after delivery on the prognosis of MAS. Methods : A total of 44 inpatients diagnosed as MAS in the Neonatal Intensive Care Unit (NICU) at Cheil Hospital were selected from January 2004 to...
Factors influencing birth weight premature infants
Ji A Aum, Hee Jin Jung, Jae Won Huh, Su Young Hong
Clin Exp Pediatr. 2007;50(10):954-958.   Published online October 15, 2007
Purpose : The purpose of this study was to identify factors influencing premature infants who are small for their gestational ago. Methods : The medical records of 1,010 premature infants of 26 to 35 weeks of gestational age born at Il-Sin Christian Hospital, Busan from January 2000 to August 2006 were reviewed. We collected data on gestational age, birth weight, infant...
Serum ghrelin and leptin concentrations in children with cancer : comparisons with normal children
So Hyun Park, Min Ho Jung, Nac Gyun Chung, Byung-Kyu Suh, Byung Churl Lee
Clin Exp Pediatr. 2007;50(9):905-911.   Published online September 15, 2007
Purpose : Ghrelin, being secreted from the stomach, stimulates growth hormone secretion and controls energy homeostasis by increasing appetite. Leptin, being secreted from the adipocytes, controls weight and energy homeostasis by decreasing appetite. Leptin concentration is reported to increase after childhood cancer therapy. This study was aimed to compare ghrelin and leptin concentrations in normal children and children who received...
Clinical and Radiological Analysis of Reversible Posterior Leukoencephalopathy Syndrome in Children
Hae-Ri Lim, Hye-Eun Seo, Sun-Hak Kwon
Clin Exp Pediatr. 2007;50(9):901-904.   Published online September 15, 2007
Purpose : Reversible posterior leukoencephalopathy syndrome is a complex disorder with characteristic clinical and radiologic findings that mainly involve the white/gray matter of the parieto-occipital lobes. The purpose of this study was to determine its clinical and radiological characteristics. Methods : A total of 15 pateints were involved in the study. Their medical records and radiological features of brain MRI were...
Acoustic differences according to the epileptic focus in benign partial epilepsy with centrotemporal spikes patients
Jung Tae Kim, Sang Hoon Choi, Sun Jun Kim
Clin Exp Pediatr. 2007;50(9):896-900.   Published online September 15, 2007
Purpose : The aim of this study was to investigate the speech problems in benign rolandic epilepsy (BRE) according to the seizure focus in EEG and semiology. Methods : Twenty three patients [right origin (13 patients) or left side (10 patients)] who met the BRE criteria by International League Against Epilepsy (ILAE) were prospectively enrolled. We excluded the patients who...
Clinical characteristics and prognosis of acute disseminated encephalomyelitis based on the lesions on MRI
Sunghoon Chung, Sungsin Park, Sajun Chung
Clin Exp Pediatr. 2007;50(9):891-895.   Published online September 15, 2007
Purpose : Acute disseminated encephalomyelitis (ADEM) is a demyelinating disease of the central nervous system and mostly develops after viral illness or vaccinations. We investigated the clinical differences and neurologic outcomes according to the distribution of the lesions on brain MRI. Methods : The study group was composed of 21 patients from January 1995 to August 2003 in Kyunghee University hospital....
A pilot study of neuroprotection with umbilical cord blood cell transplantation for preterm very low birth weight infants
Kyu Young Chae, Kyu Hyung Lee, So-Hee Eun, Byung Min Choi, Baik-Lin Eun, Hoon-Chul Kang, Myung Jae Chey, Nam Keun Kim, Doyeun Oh
Clin Exp Pediatr. 2007;50(9):882-890.   Published online September 15, 2007
Purpose : Preterm very low birth weight infant have high rate of adverse neurodevelopmental sequale. Recently, there have been lots of reports that human umbilical cord blood transplantation ameliorates functional deficits in animal models as hypoxic ischemic injury. This pilot study was undertaken to determine the clinical efficacy and safety of autologous umbilical cord blood cell transplantation for preventing neurodevelopmental...
Chromosomal analyses of 4,500 cases of the peripheral blood : An experience in a single hospital for 25 years
Hye-Eun Seo, Ji Hye Lee, Ji Yoon Kim, Dong Ha Lee, Heung Kyo Lee, Kun Soo Lee
Clin Exp Pediatr. 2007;50(9):875-881.   Published online September 15, 2007
Purpose : Chromosome analysis is important in genetic study and genetic counseling. This study was performed to evaluate the type and incidence of chromosome abnormalities in a single hospital for 25 years. Methods : Chromosome analyses were performed on peripheral blood lymphocytes, obtained from 4,856 patients with suspected chromosomal aberrations, referred to cytogenetic laboratory in Department of Pediatrics, Kyungpook National...
Clinical characteristics of congenital myotonic dystrophy diagnosed by molecular genetic method
Sook Hyun Nam, Young Bae Son, Bo Lyun Lee, Jeehun Lee, Chang-seok Ki, Munhyang Lee
Clin Exp Pediatr. 2007;50(9):868-874.   Published online September 15, 2007
Purpose : We performed this study to investigate the perinatal and developmental features of the patients with congenital myotonic dystrophy (CDM) confirmed by the molecular genetic method and the clinical characteristics of their mother, and to identify the relation between the number of CTG repeats and the clinical severity. Methods : A retrospective review of the medical records and the results...
Reference values for respiratory system impedance using impulse oscillometry in school-aged children in Korea
Young Sun Wee, Hyoung Yun Kim, Da Wun Jung, Hye Won Park, Yoon Ho Shin, Man Yong Han
Clin Exp Pediatr. 2007;50(9):862-867.   Published online September 15, 2007
Purpose : The impulse oscillometry (IOS) is applicable to young children because it requires minimal cooperation and a non-invasive method to measure the mechanics of respiratory system. This study aimed to develop the reference values in school-aged children in Korea, using IOS which is a modification of forced oscillation technique (FOT). Methods : Measurements were performed in 92 previously untrained healthy...
Isolation rate of 4 type virus of acute gastroenteritis in full-term neonates during neonatal period
Soo Kyoung Moon, Jae In Lee, Hye Sun Yoon, Young Min Ahn
Clin Exp Pediatr. 2007;50(9):855-861.   Published online September 15, 2007
Purpose : The most common causes of acute viral gastroenteritis in newborn period are rotavirus, astrovirus, norovirus and enteric adenovirus. This study was designed to investigate the clinical characteristics, clinical symptoms, isolation rate and distribution of these viruses in full-term neonates during neonatal period. We also studied the influence on the viral isolation rate by postnatal care place and feeding...
Usefulness of auditory brainstem response as early predictor of kernicterus in early breast-feeding jaundice
Jae Won Jang, Gil Sang Lee, Dae Keun Song, Sung Hee Kim, Won Duck Kim, Sang Geel Lee
Clin Exp Pediatr. 2007;50(9):848-854.   Published online September 15, 2007
Purpose : The present study examined the etiology and risk factors of the early breast-feeding jaundice and the usefulness of auditory brainstem response test as early predictor of kernicterus. Methods : Medical records of neonatal jaundice in newborn admitted to Daegu Fatima Hospital between September 2005 and May 2006 were analyzed prospectively. Infants were grouped according to feeding method : breast...
Plasma B-type natriuretic peptide (BNP): a useful marker for anthracycline-induced cardiotoxicity in Korean children with cancer
Hyun Dong Lee, Jae Min Lee, Yong Jik Lee, Young Hwan Lee, Jeong Ok Hah
Clin Exp Pediatr. 2007;50(8):774-780.   Published online August 15, 2007
Purpose : The anthracyclines (AC) are widely used chemotherapeutic agents for pediatric cancers. However, the therapeutic use of these agents is limited by their cardiotoxicity. The aim of the present study was to investigate the usefulness of plasma B-type natriuretic peptide (BNP) levels as a marker for AC-induced cardiotoxicity compared to echocardiography in Korean children with cancer. Methods : Fifty-five pediatric...
Alteration of insulin resistance and serum adiponectin levels after one year follow-up of obese children and adolescents
Min Jee Jeoung, Jung Yeon Shin, Soo Young Kim, Jung Hwa Lee, Kee-Hyoung Lee, Joo Won Lee
Clin Exp Pediatr. 2007;50(8):767-773.   Published online August 15, 2007
Purpose : Obesity has become a pandemic and especially the prevalence of childhood obesity has increased remarkably over the past years. Childhood obesity is often accompanied by the expected morbidities such as hyperlipidemia, fatty liver and glucose intolerance. We evaluated the pattern of alteration in the body mass index (BMI), serum adiponectin concentration, insulin resistance (HOMA-IR), and complication rates after...
A study for post-diagnostic lumbar puncture headache in children
Gook Chan Jang, Eun Seok Yang, Kyung Rye Moon, Young Bong Park, Young Il Rho
Clin Exp Pediatr. 2007;50(8):761-766.   Published online August 15, 2007
Purpose : Post-lumbar puncture headache is common complaint. A study of post-diagnostic lumbar puncture headache in children is rare. Various factors that might influence the occurrence of post- diagnostic lumbar puncture headache in children exist. The purpose of this prospective study was to assess the frequency and risk factors for post-diagnostic lumbar puncture headache in children. Methods : From March 2005...
Unprovoked seizures in children with complex febrile convulsion; short-term outcome
Ji Yeon Choi, Eun Jung Cheon, Young Hyuk Lee
Clin Exp Pediatr. 2007;50(8):757-760.   Published online August 15, 2007
Purpose : Febrile convulsions (FC) were considered to be a benign seizure syndrome that is distinct from epilepsy. But it is thought that children with complex features i.e., partial or prolonged seizures or multiple episodes of FC would bear a higher risk of developing unprovoked seizures. The aim of this study is to look into the relative significance of each...
Comparison of polyethylene glycol 4000 and lactulose for treatment of chronic functional constipation in children
Ji Hyun Uhm
Clin Exp Pediatr. 2007;50(8):752-756.   Published online August 15, 2007
Purpose : The aim of this study was to compare 2 laxatives, namely, polyethylene glycol 4000 without electrolytes and lactulose, evaluating the efficacy and safety for the treatment of constipation in children. Methods : Fifty-six children with chronic functional constipation were randomly assigned to receive polyethylene glycol 4000 (24 patients) or lactulose (32 patients). Patients or their parents reported defecation frequency,...
Correlation of serum total hydroperoxide levels and diseases of prematurity
Shin-Hye Kim, Hae Young Hur, Kyu Hyoung Lee, Ja Young Moon, Kyu Young Chae
Clin Exp Pediatr. 2007;50(8):746-751.   Published online August 15, 2007
Purpose : Total hydroperoxide (TH), free radical-mediated oxidation product can be used as a measure of free radical injury. The aim of the present study was to see if preterm newborns are at increased risk for oxidative stress compared with term newborns, and to determine whether oxidative stress during postnatal first 1 week is associated with clinical outcomes in preterm...
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