Korean Journal of Pediatrics 2007;50(9):901-904.
Published online September 15, 2007.
Clinical and Radiological Analysis of Reversible Posterior Leukoencephalopathy Syndrome in Children
Hae-Ri Lim, Hye-Eun Seo, Sun-Hak Kwon
Department of Pediatrics, college of Medicine, Kyungpook National University, Daegu, Korea
소아에서 가역성 후두부 백질 뇌증 증후군의 임상적, 방사선학적 특성에 대한 고찰
임해리, 서혜은, 권순학
경북대학교 의과대학 소아과학교실
Correspondence: 
Sun-Hak Kwon, Email: shkwon@knu.ac.kr
Abstract
Purpose
: Reversible posterior leukoencephalopathy syndrome is a complex disorder with characteristic clinical and radiologic findings that mainly involve the white/gray matter of the parieto-occipital lobes. The purpose of this study was to determine its clinical and radiological characteristics.
Methods
: A total of 15 pateints were involved in the study. Their medical records and radiological features of brain MRI were retrospectively reviewed and analyzed.
Results
: Fifteen pateints were involved. (9 males and 5 females). The patients' ages ranged from 2-20 years (mean age : 10 years). The brain MRI revealed fairly symmetric areas of increased T2 signal involving both white and gray matter of parieto-occipital regions. The condition seemed to be associated with cyclosporin A and steroid therapy or a variety of other conditions in which blood pressure rises acutely.
Conclusion
: Reversible posterior leukoencephalopathy syndrome is a complicated neurological condition, but a better understanding of this complex syndrome may obviate unnecessary investigations and lead to prompt and appropriate management of the associated problems.
Key Words: Leukoencephalopathy, Seizure, Cyclosporin, Steroid


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