Clinical and Experimental Pediatrics

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Original Article

The neuroprotective effect of recombinant human erythropoietin via an antiapoptotic mechanism on hypoxic-ischemic brain injury in neonatal rats

Moon Sun Kim, Yoo Kyung Seo, Hye Jin Park, Kye Hyang Lee, Kyung Hoon Lee, Eun Jin Choi, Jin Kyung Kim, Hai Lee Chung, Woo Taek Kim

Clin Exp Pediatr. 2010;53(10):898-908. Published online October 31, 2010

Crossref 8

Purpose

The neuroprotective effects of erythropoietin (EPO) have been recently shown in many animal models of brain injury, including hypoxic-ischemic (HI) encephalopathy, trauma, and excitotoxicity; however, limited data are available for such effects during the neonatal periods. Therefore, we investigated whether recombinant human EPO (rHuEPO) can protect against perinatal HI brain injury via an antiapoptotic mechanism.

Methods

The left carotid artery was ligated...

DOI: https://doi.org/10.3345/kjp.2010.53.10.898

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