- Original Article
- Developmental and Behavioral Medicine
- Neonatal risk factors associated with autism spectrum disorders: an umbrella review
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Amir Mohammad Salehi, Erfan Ayubi, Salman Khazaei, Ensiyeh Jenabi, Saeid Bashirian, Zohreh Salimi
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Clin Exp Pediatr. 2024;67(9):459-464. Published online July 19, 2024
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Question: What are the neonatal risk factors for autism spectrum disorder (ASD)?
Findings: Significant effect sizes were observed for congenital heart disease (odds ratio [OR], 1.35), macrosomia (OR, 1.11), low birth weight (OR, 1.63), very low birth weight (OR, 2.25), small for gestational age (OR, 1.17), jaundice (OR, 1.74), male sex (OR, 1.47), and Apgar score (OR, 1.40).
Meaning: These factors were identified as risk factors for ASD. |
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- Nutrition
- Not breastfeeding and risk of autism spectrum disorders among children: a meta-analysis
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Ensiyeh Jenabi, Saeid Bashirian, Amir Mohammad Salehi, Salman Khazaei
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Clin Exp Pediatr. 2023;66(1):28-31. Published online July 19, 2022
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This study aimed to determine whether there is an association between not breastfeeding (versus breastfeeding) and the risk of autism spectrum disorders (ASD) among children. We found that the risk of ASD associated with not breastfeeding had an odds ratio of 1.81 (95% confidence interval, 1.35–2.27; I2=0 %). These findings suggest the importance of breastfeeding in decreasing the risk of ASD among children. |
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- Developmental and Behavioral Medicine
- Is meconium exposure associated with autism spectrum disorders in children?
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Ensiyeh Jenabi, Erfan Ayubi, Salman Khazaei, Saeid Bashirian, Mojtaba Khazaei
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Clin Exp Pediatr. 2021;64(7):341-346. Published online October 4, 2020
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• Meconium exposure is weakly associated with an increased risk of autism spectrum disorder (ASD) development in children.
• More evidence based on large prospective cohort studies is required to conclude whether meconium exposure is associated with an increased risk of ASD. |
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- Other
- Association between pesticide and polychlorinated biphenyl exposure during pregnancy and autism spectrum disorder among children: a meta-analysis
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Fereshteh Mehri, Saeid Bashirian, Salman khazaei, Ensiyeh Jenabi
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Clin Exp Pediatr. 2021;64(6):286-292. Published online July 27, 2020
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· This meta-analysis analyzed the association between pesticide and polychlorinated biphenyl (PCB) exposure during pregnancy and autism spectrum disorders (ASD) risk among children.
· A significant association was noted between PCB and pesticide exposure during pregnancy and ASD risk among children (odds ratio [OR], 1.80; 95% confidence interval [CI], 1.26–2.34 and OR, 1.20; 95% CI, 1.02–1.39), respectively.
· Pesticide and PCB exposure during pregnancy may affect ASD risk among children. |
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- Neurobehavior
- Association between assisted reproductive technology and autism spectrum disorders in Iran: a case-control study
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Ensiyeh Jenabi, Mahdieh Seyedi, Ronak Hamzehei, Saeid Bashirian, Mohammad Rezaei, Katayoon Razjouyan, Salman Khazaei
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Clin Exp Pediatr. 2020;63(9):368-372. Published online March 27, 2020
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Background: Autism spectrum disorder (ASD) is a neurodevelopmental disorder defined by impairments in social interaction and verbal and nonverbal communication.
Purpose: Determine the association between use of assisted reproduction technology (ART) and the risk of ASD among children.
Methods: This case-control study included 300 participants (100 cases, 200 controls). The control group included women with a child aged 2–10 years without ASD,... |
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- Systematic review and meta-analysis
- Neurobehavior
- Association between neonatal jaundice and autism spectrum disorders among children: a meta-analysis
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Ensiyeh Jenabi, Saeid Bashirian, Salman Khazaei
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Clin Exp Pediatr. 2020;63(1):8-13. Published online November 7, 2019
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Autism spectrum disorder is a common neurodevelopmental disorder with an unknown etiology. The correlation between neonatal jaundice and the risk of developing autism spectrum disorder was investigated previously. Some studies showed significant associations, whereas others demonstrated no association. In this meta-analysis, we pooled the results of observational studies to examine the association between neonatal jaundice and the risk of autism... |
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- Original Article
- The association between preeclampsia and autism spectrum disorders among children: a meta-analysis
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Ensiyeh Jenabi, Manoochehr Karami, Salman Khazaei, Saeid Bashirian
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Clin Exp Pediatr. 2019;62(4):126-130. Published online December 24, 2018
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Purpose: In this meta-analysis, relevant case-control and cohort studies were pooled to evaluate the association between preeclampsia and the risk of autism spectrum disorders (ASDs) in children.
Methods: A search for relevant studies in major databases, including Web of Science, PubMed, and Scopus, was performed up to May 2018. The odds ratios (ORs) or rate ratios (RRs) with 95% confidence intervals... |
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