- Original Article
- Clinical outcome of acute necrotizing encephalopathy in related to involving the brain stem of single institution in Korea
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Cha Gon Lee, Ji Hye Kim, Munhyang Lee, Jeehun Lee
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Clin Exp Pediatr. 2014;57(6):264-270. Published online June 30, 2014
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Purpose Acute necrotizing encephalopathy (ANE) is a fulminant disease of the brain characterized by bilateral thalamic lesions, and is prevalent among children in East Asia. The prognosis of ANE is usually poor with a high mortality rate and neurological sequelae. This study aimed to delineate the clinical characteristics and prognostic factors of ANE. MethodsWe retrospectively analyzed clinical data of 399 pediatric patients... |
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- Review Article
- The use of ketogenic diet in special situations: expanding use in intractable epilepsy and other neurologic disorders
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Munhyang Lee
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Clin Exp Pediatr. 2012;55(9):316-321. Published online September 14, 2012
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The ketogenic diet has been widely used and proved to be effective for intractable epilepsy. Although the mechanisms underlying its anti-epileptic effects remain to be proven, there are increasing experimental evidences for its neuroprotective effects along with many researches about expanding use of the diet in other neurologic disorders. The first success was reported in glucose transporter type 1 deficiency... |
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- Original Article
- Clinical characteristics of congenital myotonic dystrophy diagnosed by molecular genetic method
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Sook Hyun Nam, Young Bae Son, Bo Lyun Lee, Jeehun Lee, Chang-seok Ki, Munhyang Lee
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Clin Exp Pediatr. 2007;50(9):868-874. Published online September 15, 2007
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Purpose : We performed this study to investigate the perinatal and developmental features of the patients with congenital myotonic dystrophy (CDM) confirmed by the molecular genetic method and the clinical characteristics of their mother, and to identify the relation between the number of CTG repeats and the clinical severity.
Methods : A retrospective review of the medical records and the results... |
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- Single Cell Dissociation Methods for Flow Cytometric Cell Death Analysis of Hypoxia-Ischemia Injured Newborn Rat Pup Brain
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Jong Hee Hwang, Dong Kyung Sung, Chang Won Choi, Saem Kang, Yun Sil Chang, Won Soon Park, Munhyang Lee
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Clin Exp Pediatr. 2005;48(5):545-550. Published online May 15, 2005
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Purpose : Newborn brain tissue has to be dissociated into a single cell suspension for flow cytometric analysis of cell death during hypoxia-ischemia. Thus the development of a method to dissociate cells from the brain tissue with least damage and maintenance of membrane and antigen integrity remains the challenge for the in vivo application of this technique. We evaluated the... |
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- Clinical Manifestations of Dysphagia in Children
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So Hee Chung, Nam Seon Beck, Munhyang Lee, Sang Il Lee, Heung Jae Lee, Jung Yun Choe, Hyun Suk Kim
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Clin Exp Pediatr. 1999;42(1):60-68. Published online January 15, 1999
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Purpose : In children, dysphagia is a common cause of recurrent pneumonia and malnutrition and can be fatal. However, till now no studies were performed concerning the clinical investigation of dysphagia in Korea.
Methods : In this study we evaluated the clinical manifestations of dysphagia in children with an age range between 1 month and 12 years by reviewing the... |
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- Case Report
- A Case of Congenital Insensitivity to Pain with Anhidrosis
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Munhyang Lee, Nam Seon Beck, Dongkyu Jin, Yeon-Lim Suh
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Clin Exp Pediatr. 1997;40(11):1621-1626. Published online November 15, 1997
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Congenital insensitivity to pain with anhidrosies (CIPA) is one of the exceedingly rare
hereditary sensory autonomic neuropathies (HSAN). There are five types of HSAN
according to hereditary transmission, natural history, clinical manifestations, and
pathologic findings. The CIPA corresponds to type IV and is characterized by episodes of
recurrent fever with generalized anhidrosis, insensitivity to pain and temperature with
self-multilation, and mental retardation.
We report a 14... |
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- Original Article
- Constipation in Children-Colonic Transit Time and the Barr-Score
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Nam-Seon Beck, I Sok Kang, Dong Kyu Jin, Munhyang Lee, Sang Il Lee, Heung Jae Lee, Bokyung Kim, Tae Sung Park
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Clin Exp Pediatr. 1997;40(10):1427-1434. Published online October 15, 1997
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Purpose : We have assessed the clinical usefulness of solid maker transit technique and
Barr-score in 31 patients with idiopathic constipation (male:female; 17:14, mean age; 6.7 years,
range 1.4-12 years).
Methods : All patients underwent full history taking and physical examination including rectal
examination. On first visit to gastroenterology clinic a plain abdominal film was taken for
Barr-score which evaluated by two observers without the... |
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