- Original Article
- Serum level of the adiponectin and adiponectin I164T polymorphism in hypertensive adolescents
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Jung Ah Lee, Joo Hyun Gil, Young Mi Hong
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Clin Exp Pediatr. 2009;52(2):187-193. Published online February 15, 2009
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Purpose : Adiponectin is a molecule that plays an important role in the metabolic syndrome. In addition, its concentration is known to be decreased in obesity, type 2 diabetes, and coronary artery disease. Although a relationship between hypertension and serum adiponectin concentrations has been reported by several authors, such findings continue to be debated. We investigated whether hypoadiponectinemia is related... |
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- Angiotensinogen gene M235T polymorphism as a predictor of cardiovascular risk in hypertensive adolescents
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Joo Hyun Gil, Jung Ah Lee, Eun Young Park, Young Mi Hong
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Clin Exp Pediatr. 2009;52(1):36-43. Published online January 15, 2009
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Purpose : The renin-angiotensin system (RAS) has been demonstrated to play a major role in regulating blood pressure. Therefore, components of the RAS are likely candidate genes that may predispose an individual to essential hypertension and cardiovascular complications. Among them, the M235T polymorphism of the angiotensinogen gene has been speculated to be associated with elevated circulating angiotensinogen concentrations and essential... |
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- Leptin, adiponectin, interleukin-6 and
tumor necrosis factor- in obese adolescents
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Joo Hyun Gil, Jung Ah Lee, Ji Young Kim, Young Mi Hong
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Clin Exp Pediatr. 2008;51(6):597-603. Published online June 15, 2008
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Purpose : Obesity is associated with insulin resistance. Insulin resistance and the presence of pro-inflammatory mediators are thought to cause a state of vascular endothelial dysfunction, an abnormal lipid profile, hypertension, and vascular inflammation. These chronic inflammatory responses, which are characterized by abnormal cytokine production, lead to activation of a pro-inflammatory signaling pathway. Leptin is an important mediator of inflammatory... |
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