- Review Article
- Infection
- Etiological and pathophysiological enigmas of severe coronavirus disease 2019, multisystem inflammatory syndrome in children, and Kawasaki disease
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Jung-Woo Rhim, Jin-Han Kang, Kyung-Yil Lee
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Clin Exp Pediatr. 2022;65(4):153-166. Published online November 23, 2021
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· Severe cases of coronavirus disease, Kawasaki disease (KD), and multisystem inflammatory syndrome in children (MIS-C) share similar findings: a protracted clinical course, multiorgan involvement, and similar activated biomarkers.
· Here we propose etiological agents in KD and MIS-C as species in the microbiota and introduce a common pathogenesis through the protein-homeostasis-system hypothesis.
· Early proper dose of corticosteroids and/or intravenous immunoglobulin may help to reduce morbidity and mortality in these diseases. |
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- Immunology
- Immunopathogenesis of COVID-19 and early immunomodulators
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Kyung-Yil Lee, Jung-Woo Rhim, Jin-Han Kang
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Clin Exp Pediatr. 2020;63(7):239-250. Published online June 18, 2020
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The novel coronavirus disease 2019 (COVID-19) is spreading globally. Although its etiologic agent is discovered as severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2), there are many unsolved issues in COVID-19 and other infectious diseases. The causes of different clinical phenotypes and incubation periods among individuals, species specificity, and cytokine storm with lymphopenia as well as the mechanism of damage to organ... |
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- Original Article
- Epidemiological comparison of three Mycoplasma pneumoniae pneumonia epidemics in a single hospital over 10 years
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Eun-Kyung Kim, You-Sook Youn, Jung-Woo Rhim, Myung-Seok Shin, Jin-Han Kang, Kyung-Yil Lee
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Clin Exp Pediatr. 2015;58(5):172-177. Published online May 22, 2015
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Purpose Mycoplasma pneumoniae (MP) pneumonia epidemics have occurred in 3- to 4-year cycles in Korea. We evaluated the epidemiologic characteristics of MP pneumonia in Daejeon, Korea, from 2003 to 2012. MethodsWe retrospectively analyzed 779 medical records of children (0-15 years of old) with MP pneumonia admitted to our institution and compared the data from 3 recent epidemics. ResultsIn 779 patients, the mean age... |
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- Review Article
- Effectiveness and safety of seasonal influenza vaccination in children with underlying respiratory diseases and allergy
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Jin-Han Kang
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Clin Exp Pediatr. 2014;57(4):164-170. Published online April 30, 2014
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Influenza causes acute respiratory infections and various complications. Children in the high-risk group have higher complication and hospitalization rates than high-risk elderly individuals. Influenza prevention in children is important, as they can be a source infection spread in their communities. Influenza vaccination is strongly recommended for high-risk children with chronic underlying circulatory and respiratory disease, immature infants, and children receiving... |
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- Original Article
- Causative Pathogens and Therapeutic Assessment of Cefprozil in Acute Otitis Media
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Jin-Han Kang, Jong Hyun Kim, Yong-Soo Park, Young-Chul Choi, Heil Noh, Hoon Shik Yang, Kyu Sung Kim, Yeon Sook Moon, Young Jin Hong
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Clin Exp Pediatr. 2003;46(5):459-466. Published online May 15, 2003
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Purpose : AOM is the most common bacterial URI in children. The bacteriology and antibiotic Tx of AOM in children has been studied in many countries. But, there is few study of causative pathogens and antibiotic Tx of AOM in our country. In this aspect, we performed prospective clinical study to confirm the causative pathogens and assess the clinical responses... |
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- A Study of Epstein-Barr Virus, and Human Leukocyte Antigen Typing in Children with Acute Infectious Mononucleosis
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Seung-Hoon Hahn, Wan-Shik Shin, Hoon Han, Jin-Han Kang
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Clin Exp Pediatr. 2003;46(5):467-473. Published online May 15, 2003
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Purpose : The Epstein-Barr virus(EBV), gamma herpesvirus, is an important pathogen that is widespread around the world. The EBV causes various diseases depending on the geographic location, and on the immunity or the premorbid condition of the person exposed to EBV. To evaluate EBV typing may be the most important step to figure out the pathogenesis of EBV associated diseases,... |
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- A Comparative Study of Measles According to Age
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Eun-Sung Eun, Sang-Lim Choi, Kyung-Yil Lee, Hyung-Shin Lee, Ja-Hyun Hong, Jin-Han Kang, Kyung-Tai Whang
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Clin Exp Pediatr. 2003;46(1):33-36. Published online January 15, 2003
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Purpose : We evaluated clinical manifestations and laboratory findings in patients with measles according to age distribution.
Methods : Retrospective analyses were performed using medical records of patients with measles admitted to The Catholic University of Korea, Daejon St. Mary's Hospital from October 2000 to May 2001. We divided the patients with measles into three age groups, i.e., those who were... |
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- Clinical Study of Recurrent Parotitis in Children
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Sam-Hwa Yim, Kye-Nam Yoon, Kyung-Yil Lee, Sang-Won Cha, Dong-Jun Lee, Ji-Whan Han, Jin-Han Kang, Kyung-Tai Whang
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Clin Exp Pediatr. 2000;43(5):619-624. Published online May 15, 2000
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Purpose : Recurrent parotitis is defined as a recurrent parotid inflammation, generally associated with sialectasis of the parotid gland. It can often be misdiagnosed as recurrent mumps. We studied the clinical and laboratory features of recurrent parotitis.
Methods : Outpatient clinical records of 23 cases were analyzed retrospectively between April 1993 and March 1999. Follow-up after the last outpatient clinic... |
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- Molecular Epidemiologic Analysis of a Cluster of Klebsiella Pneuminiae Infection in Neonatal Intensive Care Unit
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Sung Soo Jin, Jong Hyun Kim, Jae Kyun Hur, Jin-Han Kang
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Clin Exp Pediatr. 2000;43(4):477-483. Published online April 15, 2000
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Purpose : Klebsiella pneumoniae is a major nosocomial pathogen in neonatal intensive care unit (NICU). Sequential outbreaks of K. pneumoniae infection in NICU could occur due to antibiotic resistant strains or persistent environmental sources in NICU. When these outbreaks are happen, epidemiological analysis must be performed to discover the nosocomial sources and clarify the nature of the outbreaks strains. We... |
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- A Clinical Study of Atypical Kawasaki Disease - A Rate of Coronary Artery Involvement -
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Jin-Sook Kim, Young-Yoo Kim, Jong-Wan Kim, Won-Bae Lee, Jin-Han Kang, Kyung-Tai Whang
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Clin Exp Pediatr. 2000;43(1):70-77. Published online January 15, 2000
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Purpose : Without a specific diagnostic method, the clinical diagnostic criteria for atypical Kawasaki
disease is known as the presence of coronary artery changes in a patient who did not meet
the already estabilished clinical criteria. With this criteria, we are put into dilemma because
atypical Kawasaki disease should exhibit coronary artery disease. So, we demonstrated the rate of
coronary artery involvement in atypical... |
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- Immune Responses and Efficacy of Hepatitis B Vaccine in Neonates Born from Hepatitis B Carrier Mothers : Focus on HBV-DNA
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Jong-Hyun Kim, Jin-Han Kang, Chang-Kyu Oh
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Clin Exp Pediatr. 1998;41(11):1498-1508. Published online November 15, 1998
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Purpose : The aim of this study was to elucidate the pathogenesis of vertical transmission of hepatitis B virus(HBV), and to study the protective efficacy of the vaccine and hepatitis B immune globulin(HBIG).
Methods : Eighty-two infants born from HBV carrier mothers were studied. HBV plasma-derived vaccine and HBIG were administered to their neonates. Then, changes of viral markers, anti-preS2... |
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- Seroepidemiology of Hepatitis A in Taejon, Korea 1996
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Kyung-Yil Lee, Ki-Hun Song, Jin-Han Kang
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Clin Exp Pediatr. 1998;41(1):53-61. Published online January 15, 1998
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Purpose : We experienced an outbreak of hepatitis A in Taejon, Korea for the summer of 1996.
Recently a shift in hepatitis A incidence from children to adults has been well noted in Korea. For
the purpose of possible measures in preventing hepatitis A, we studied a seroepidemiology of
hepatitis A in Taejon.
Methods : We measured IgG anti-HAV antibody(HAVAB MEIA, Abbott) from 722... |
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- Clinical Study of Mycoplasmal Pneumonia Syndrome in Children
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Hyeon-Hi Kim, Hung-Ki Min, Seung-Hoon Han, Jin-Han Kang, Joon-Sung Lee, Sung-Hoon Cho
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Clin Exp Pediatr. 1992;35(4):451-458. Published online April 15, 1992
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Between September 1, 1989 and August 31, 1990, we studied 142 cases of mycoplasmal p neumonia syndrome in children who were admitted to the pediatric department of Catholic University Medical College.
The results were as follows;
1) The highest incidence was in the age of 6 years in 27 cases and the male to female ratio... |
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